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Angabin Matin, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

  • Germ cell tumors
  • Biology of germ cells
  • Genetic dissection of disease susceptibility
  • Mouse models

My laboratory studies the genetics of testicular germ cell tumor development in mice. Testicular germ cell tumors originate from primordial germ cells and develop within the testis during fetal development. These tumors resemble aspects of testicular cancer in humans.

Testicular germ cell tumors occur spontaneously at an appreciable frequency only in the 129 family of inbred strains of laboratory mice, suggesting strong genetic control. Germ cell tumors in the 129 mouse model were the first tumor models where the tumor cell of origin and the time of transformation were precisely defined. This makes them a very useful model system to study the biology and genetics of testicular tumor development.

Evidence indicates that a large number of genes are responsible for germ cell tumor susceptibility. My laboratory is pursuing several approaches to identify the genes involved in tumor development. We are using chromosome substitution strains (CSS) and congenic strains derived from CSS to map and identify germ cell tumor loci on mouse chromosome 19. Another approach in the lab is based on analyzing single gene mutations in mice that affect germ cell biology and tumor susceptibility. Using positional cloning approaches, we identified a gene called deadend whose inactivation increases incidence of testicular germ cell tumors. Work in my laboratory is geared towards unraveling the function of dead end in primordial germ cells and in testicular cancer. Identification of the genes involved in testicular tumor development and study of their function provides us with fascinating leads both into primordial germ cell biology as well as in tumor development.

 View a complete list of Dr. Matin's publications. 

Office Address

The University of Texas MD Anderson Cancer Center
Department of Genetics, Unit 1010
1515 Holcombe Blvd.
Houston, TX 77030
Room Number: Room S11.8116B
Phone: 713-834-6335
Email: amatin@mdanderson.org

Education & Training

Degree-Granting Education

1993 University of Texas, Graduate School of Biomedical Sciences, Health Science Center at Houston, Houston, TX, PHD, Cancer Biology

Postgraduate Training

1997-1998 Postdoctoral fellow, Case Western Reserve University, Cleveland, OH, Dr. Joseph H. Nadeau
1994-1996 Postdoctoral fellow, McGill University, Montreal, Canada, Dr. Joseph H. Nadeau
1/1993-8/1994 Postdoctoral fellow, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Mien-Chie Hung

Selected Publications

Peer-Reviewed Original Research Articles

1. Som A, Zhu R, Guo CC, Efstathiou E, Xiao L, Pisters LL, Matin A, Tu SM.. Recurrent seminomas: Clinical features and biologic implications. Urol Oncol 30(4):494-501, 2012. e-Pub 9/2010. PMCID: PMC20822932.
2. Zhu R, Heaney J, Nadeau JH, Ali S, Matin A. Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res 70(18):7264-72, 9/2010. e-Pub 8/2010. PMCID: PMC2940986.
3. Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LHJ, Bardwell VJ & Zarkower D. The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc. Natl. Acad. Sci. 106:22323-22328, 2009.
4. Bhattacharya C, Aggarwal S, Kumar M, Ali A, Matin A. Mouse Dead-end (DND1) interacts with apolipoprotein B editing complex 3 (APOBEC3). PLoS One 355(5):e2315, 2008. PMCID: PMC2384002.
5. Hammond S, Zhu R, Youngren KK, Lam J, Anderson P, Matin A. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome 18(12):832-838, 12/2007. e-Pub 11/2007. PMCID: PMC2647741.
6. Zhu R, Ji Y, Xiao L, Matin A. Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Mamm Genome 18(8):584-595, 8/2007. e-Pub 8/2007. PMCID: PMC2647748.
7. Bhattacharya C, Aggarwal S, Zhu R, Kumar M, Zhao M, Meistrich ML, Matin A. The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun 355(1):194-9, 3/2007. e-Pub 2/2007. PMCID: PMC1855146.
8. Youngren KK, Coveney D, Peng X, Bhattacharya C, Schmidt LS, Nickerson ML, Lamb BT, Deng JM, Behringer RR, Capel B, Rubin EM, Nadeau JH, Matin A. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. Nature 435(7040):360-364, 5/2005. PMCID: PMC1421521.
9. Youngren KK, Nadeau JH, Matin A. Testicular cancer susceptibility in the 129.MOLF-Chr19 mouse strain: additive effects, gene interactions and epigenetic modifications. Hum Mol Genet 12(4):389-398, 2/2003. PMID: 12566386.
10. Matin A, Collin GB, Asada Y, Varnum D, Nadeau JH. Susceptibility to testicular germ-cell tumours in a 129.MOLF-Chr 19 chromosome substitution strain. Nat Genet 23(2):237-240, 10/1999. PMID: 10508525.

Last updated: 4/14/2014