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Ann M. Killary

Present Title & Affiliation

N/A

Research Interests

  • Tumor suppressor genes
  • Breast and Pancreatic Cancer
  • Cancer genetics 

Little is known about the genetic pathways that discriminate breast cancer in young women from those that occur more commonly in the general population with later age of onset.   Suppression subtractive hybridization has identified a novel gene DEAR1 which maps into a region of high frequency loss of heterozygosity (LOH) in a number of histologically diverse human cancers and for which we have evidence of its role in the evolution of breast cancer and for its potential as a prognostic marker in early onset breast cancer. A major project in the laboratory involves the characterization of DEAR1 function to elucidate its role in development and cancer.

Our laboratory is also a biomarker discovery laboratory funded by the Early Detection Research Network of the National Cancer Institute. Goals in this regard are focused on the use of functional genomic strategies to identify pathways aberrant in pancreatic cancer from which novel biomarkers for the early detection of pancreatic cancer can be identified. 

Office Address

Phone: (713) 834-6395
Email: akillary@mdanderson.org

Education & Training

Degree-Granting Education

1981 The University of Texas Graduate School of Biomedical Sciences, Houston, TX, PHD, Genetics

Experience/Service

Academic Appointments

Professor, Department of Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2006-2008

Selected Publications

Peer-Reviewed Original Research Articles
1. Padalecki SS, Johnson-Pais TL, Killary AM, Leach RJ. Chromosome 18 suppresses the tumorigenicity of prostate cancer cells. Genes Chromosomes Cancer 30(3):221-9, 3/2001. PMID: 11170278.
2. Kruzelock RP, Cuevas BD, Wiener JR, Xu FJ, Yu Y, Cabeza-Arvelaiz Y, Pershouse M, Lovell MM, Killary AM, Mills GB, Bast RC, Jr. Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer. Oncogene 19(54):6277-85, 12/2000. PMID: 11175342.
3. Lovell M, Lott ST, Wong P, El-Naggar A, Tucker S, Killary AM. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Res 59(9):2182-9, 5/1999. PMID: 10232606.
4. Lott ST, Lovell M, Naylor SL, Killary AM. Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3p12. Cancer Res 58(16):3533-7, 8/1998. PMID: 9721855.
5. Sanchez Y, Lovell M, Marin MC, Wong PE, Wolf-Ledbetter ME, McDonnell TJ, Killary AM. Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11. Proc Natl Acad Sci U S A 93(6):2551-6, 3/1996. PMID: 8637912.
6. Woloshin P, Song K, Degnin C, Killary AM, Goldhamer DJ, Sassoon D, Thayer MJ. MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids. Cell 82(4):611-20, 8/1995. PMID: 7664340.
7. Sanchez Y, el-Naggar A, Pathak S, Killary AM. A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci U S A 91(8):3383-7, 4/1994. PMID: 8159756.

Last updated: 9/10/2009