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Anshu B Mathur, PhD

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Plastic Surgery - Research, Division Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

 Dr. Mathur's research encompasses a new and upcoming area of Engineered Biologics and their applications in Regenerative Medicine and Nanomedicine. Her doctoral training in Biomedical Engineering from Duke University with Master's training in the area of Polymer Chemistry at NC State University provided her an opportunity to develop unique expertise and apply them in the area of reconstructive therapy for cancer patients. 

Her current work at MD Anderson Cancer Center is highly applied and translational for repair and reconstruction of cancer patients. The laboratory that she heads is called Tissue Regeneration and Molecular Cell Engineering Labs (TRAMCEL). The work in the laboratory is focused in many areas of regenerative medicine such as musculofascia, bone, trachea, and microvascular guidance. There are various groups in the laboratory that comprise of a clinical trainee and a bioengineering trainee who study and develop Engineered Scaffold Design per clinical application, Characterize the physical and mechanical properties of cells and scaffolds at the nanoscale and macro scale, Investigate Stem Cell-scaffold interactions, Study tissue remodeling in various animal models (rats, sheep, guinea pig), and Fabricate and Characterize Nanotherapeutics for Delivery via a Reconstructive Tissue Flap.

 Not only are the "engineered scaffolds" customizable, but they also eliminate the need for harvesting material from a human or animal source. Dr. Mathur coined the name "engineered biologics" for the scaffolds. "They are biologically derived, but we're engineering the structure (nano to macro)," she explained. Dr. Mathur has been testing these scaffolds since 2004 in animal studies.

 In the area of Nanomedicine, Dr. Mathur is applying biological materials to make biodegradable nanoparticles containing therapeutic agents against cancer; results thus far indicate that the efficacy of drugs encapsulated in the material is increased using this delivery method in association with higher intra-cellular retention and increased bioavailability. A patent for the formulation is pending. "It's a multifunctional material because of its biomimetic properties," Dr. Mathur noted.

Rebuilding What Cancer Has Ravaged

 http://www2.mdanderson.org/depts/oncolog/articles/09/4-apr/4-09-1.html

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 602
Houston, TX 77054
Room Number: ER1.409
Phone: (713) 563-7568
Fax: (713) 563-0231

Education & Training

Degree-Granting Education

2001 Duke University, Durham, NC, PHD, Biomedical Engineering
1999 Duke University, Durham, NC, MS, Biomedical Engineering
1995 North Carolina State University, Raleigh, NC, MS, Textile Chemistry
1994 North Carolina State University, Raleigh, NC, BS, Biochemistry
1993 North Carolina State University, Raleigh, NC, BS, Textile Chemistry

Postgraduate Training

2001-2002 Postdoctoral Fellowship, Duke University, Durham, NC

Experience/Service

Academic Appointments

Assistant Professor, Biomedical Engineering, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2006-2009
Adjunct Professor, Bioengineering Department, Rice University, Houston, TX, 2005-2011
Adjunct Assistant Professor, Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2005-2010
Assistant Professor, Plastic Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2003-2010
Adjunct Professor, The University of Texas at Austin, Austin, TX, 2003-2009

Administrative Appointments/Responsibilities

Director of Research, Tissue Regeneration and Molecular Cell Engineering Lab, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2007-present
Director of Research, Tissue Regeneration and Molecular Cell Engineering Lab, Plastic Surgery and Biomedical Engineering, Division of Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 2007-2009

Other Appointments/Responsibilities

Visiting Professorship, ETH Zurich Department of Health Sciences and Technology - Laboratory of Applied Mechanobiology, Zurich, Switzerland, 2/2014-8/2014
Past President and Council Nominating Chair, Biomedical Engineering Society-Cellular and Molecular Bioengineering SIG, Landover, MD, 2012-2013
President, Society for Physical Regulation in Biology and Medicine, Houston, TX, 2011-2012
Vice President, Society for Physical Regulation in Biology and Medicine, Houston, TX, 2010-2011
Council Member, Society for Physical Regulation in Biology and Medicine, Houston, TX, 2007-present
Patent Technology Analyst, SPORE, LLC, Raleigh, NC, 2002-2003

Consultantships

Guidepoint, Global, Boston, Massachusetts, 2008-present

Institutional Committee Activities

Member, Faculty Senate, 2007-2008
Member, Institutional Animal Care and Use Committee (IACUC), 2006-present

Honors and Awards

2010-2011 President, Society for Physical Regulation and Biology and Medicine
2010 Iwao Yasuda Award, Society for Physical Regulation in Biology and Medicine
2001 Cellular and Biosurface Engineering Certificate, Duke University
2000 Cell Culture Engineering-Fellowship Award, United Engineering Foundation
1999 Graduate Student Research Award, Biomedical Engineering Society
1994 Magna Cum Laude in Biochemistry, BS Degree, North Carolina State University
1993 Magna Cum Laude in Polymer Chemistry, BS Degree, North Carolina State University
1990-1994 Honors Certificate, College of Physical and Mathematical Sciences
1989-1993 North Carolina State Scholars Program Recognition Award, North Carolina State University

Professional Memberships

Alliance for NanoHealth
Member, 2005-present
ASTM International Standards Committee on Medical and Surgical Materials and Devices SubCommittee Tissue Engineered Medical Products (TEMPs)
Member, 2008-present
Biomedical Engineering Society, BMES
Member, 1998-present
Cellular and Molecular Biomedical Engineering Society (CMBE SIG, BMES)
Member, 2012-present
Nanobiomedical Research Group
Member, 2011-present
Plastic Surgery Research Council, (PSRC)
Member, 2005-present
Society for Biomaterials, SFB
Member, 1997-present
Society for Biomaterials: Special Interest Group, Engineering Cells and Their Microenvironments, (SFB, SIG)
Member, 2013-2015
Society for Physical Regulation in Biology and Medicine, (SPRBM)
Member, 2005-present
The University of Texas Center for Biomedical Engineering
Member, 2003-2006
Tissue Engineering and Regenerative Medicine International Society, (TERMIS)
Member, 2005-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Mishra D, Hubenak J, Mathur AB. Nanoparticle system as tools to improve drug delivery and therapeutic efficacy. Journal of Biomedical Materials Research Part A - JBMR - 34642(2013 Jul 22. doi: 10.1002), 12/2013.
2. Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. Cellular and Molecular Bioengineering: A Tipping Point. Cellular and Molecular Bioengineering 5(3):239-253, Epub 2012 Aug 24, 9/2012.
3. Rios CN, Skoracki RJ, Mathur AB. GNAS1 and PHD2 Short-interfering RNA Support Bone Regeneration in Vitro and in an in Vivo Sheep Model. Allograft Research and Transplantation-Clinical Orthopaedics and Related Research 9(470):2541-53, doi: 10.1007/s11999-012-2475-4, 9/2012. PMID: DOI 10.1007/s11999-012-2475-4.
4. Zang M, Zhang Q, Davis G, Huang G, Jaffari M, Ríos CN, Gupta V, Yu P, Mathur AB. Perichondrium Directed Cartilage Formation in Silk Fibroin and Chitosan Blend Scaffolds for Tracheal Transplantation. Acta Biomater 7(9):3422-31, 9/2011. e-Pub 5/2011. PMID: 21640205.
5. Gupta V, Mun GH, Choi B, Aseh A, Mildred L, Patel A, Zhang Q, Price JE, Chang D, Robb G, Mathur AB. Repair and reconstruction of a resected tumor defect using a composite of tissue flap-nanotherapeutic-silk fibroin and chitosan scaffold. Ann Biomed Eng 39(9):2374-87, 9/2011. e-Pub 6/2011. PMCID: PMC3149665.
6. Campbell KT, Burns NK, Rios CN, Mathur AB, Butler CE. Human versus non-cross-linked porcine acellular dermal matrix used for ventral hernia repair: comparison of in vivo fibrovascular remodeling and mechanical repair strength. Plast Reconstr Surg 127(6):2321-32, 6/2011. PMID: 21617466.
7. Butler CE, Burns NK, Campbell KT, Mathur AB, Jaffari MV, Rios CN. Comparison of cross-linked and non-cross-linked porcine acellular dermal matrices for ventral hernia repair. J Am Coll Surg 211(3):368-76, 9/2010. e-Pub 7/2010. PMID: 20800194.
8. Gupta V, Davis G, Gordon A, Altman AM, Reece GP, Gascoyne PR, Mathur AB. Endothelial and stem cell interactions on dielectrophoretically aligned fibrous silk fibroin-chitosan scaffolds. J Biomed Mater Res A 94(2):515-23, 8/2010. PMID: 20186770.
9. Campbell, KT, Burns, NK, Rios, CN, Mathur AB, Butler, CE. In Vivo Comparison of Human Acellular Dermal Matrix and Non-Cross-Linked Porcine Acellular Dermal Matrix. Plastic and Reconstructive Surgery 125(6S):111, 6/2010.
10. Altman AM, Gupta V, Ríos CN, Alt EU, Mathur AB. Adhesion, Migration, and Mechanics of Human Adipose Tissue Derived Stem Cells on Silk Fibroin-Chitosan Matrix. Acta Biomater 09(4):S1742-7061, 4/2010. e-Pub 10/2009. PMID: 19861180.
11. Burns NK, Jaffari MV, Rios CN, Mathur AB, Butler CE. Non-Cross-Linked Porcine Acellular Dermal Matrices for Abdominal Wall Reconstruction. Plast Reconstr Surg 125(1):[Epub ahead of print], 1/2010. PMID: 19910855.
12. Ríos CN, Skoracki RJ, Miller MJ, Satterfield WC, Mathur AB. In vivo bone formation in silk fibroin and chitosan blend scaffolds via ectopically grafted periosteum as a cell source: a pilot study. Tissue Engineering Part A 15(9):2717-25, 9/2009.
13. Nathwani BB, Jaffari M, Juriani AR, Mathur AB, Meissner KE. Fabrication and characterization of silk-fibroin-coated quantum dots. IEEE Trans Nanobioscience 8(1):72-7, 3/2009. e-Pub 3/2009. PMID: 19304498.
14. Altman AM, Yan Y, Matthias N, Bai X, Rios C, Mathur AB, Song YH, Alt EU. IFATS collection: Human adipose-derived stem cells seeded on a silk fibroin-chitosan scaffold enhance wound repair in a murine soft tissue injury model. Stem Cells 27(1):250-8, 1/2009. PMID: 18818439.
15. Burns NK, Jaffari M, Rios CN, Mathur AB, Butler CE. Evaluation of visceral adhesions and mechanical strength of abdominal wall reconstructions with porcine acellular dermal matrix vs. polypropylene mesh. Plastic and Reconstructive Surgery 6S(76):76, 2009.
16. Gupta V, Aseh A, Ríos CN, Aggarwal BB, Mathur AB. Fabrication and characterization of silk fibroin derived curcumin nanoparticles for cancer therapy. Int J Nanomedicine 4:115-122, 2009. e-Pub 4/2009. PMCID: PMC2720745.
17. Burns NK, Gupta V, Rios CN, Rasmussen M, Butler CE, Mathur AB. Silk fibroin fibrillogenesis via decorin: effect on microstructure and mechanical properties. Plastic and Reconstructive Surgery 6S(123):113, 2009.
18. Cheema SK, Gobin AS, Rhea R, Lopez-Berestein G, Newman RA, Mathur AB. Silk fibroin mediated delivery of liposomal emodin to breast cancer cells. Int J Pharm 329(1-2):221-229, 8/2007. e-Pub 4/2007. PMID: 17499461.
19. Mathur AB, Reichert WM, Truskey GA. Flow and high affinity binding affect the elastic modulus of the nucleus, cell body and the stress fibers of endothelial cells. Ann Biomed Eng 35(7):1120-30, 7/2007. e-Pub 3/2007. PMID: 17385045.
20. Cheema SK, Chen E, Shea LD, Mathur AB. Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism. Wound Repair Regen 15(3):286-295, May-Jun, 5/2007. PMID: 17537114.
21. Radhakrishnan RS, Radhakrishnan HR, Xue H, Moore-Olufemi SD, Mathur AB, Weisbrodt NW, Moore FA, Allen SJ, Laine GA, Cox CS. Hypertonic saline reverses stiffness in a Sprague-Dawley rat model of acute intestinal edema, leading to improved intestinal function. Crit Care Med 35(2):538-43, 2/2007. PMID: 17205008.
22. Wright A, Wu X, Frye C, Mathur AB, Patrick Jr CW. A ten-year assessment of a biomedical engineering summer research internship within a comprehensive cancer center. JSTEM 8:28-39, 2007.
23. Gobin AS, Butler CE, Mathur AB. Repair and regeneration of the abdominal wall musculofascial defect using silk fibroin-chitosan blend. Tissue Eng 12(12):3383-94, 12/2006. PMID: 17518675.
24. Gobin AS, Rhea R, Newman RA, Mathur AB. Silk-fibroin-coated liposomes for long-term and targeted drug delivery. Int J Nanomedicine 1(1):81-7, 2006. PMCID: PMC2426758.
25. Rios C, Augustine JN, Mathur AB. The effect of processing temperature on mechanical properties of novel silk fibroin and chitosan blend scaffolds for muscuskeletal regeneration. Mol Cell Biomech 3:173-174, 2006.
26. Choi MG, Koh H, Kluess D, O'Connor D, Mathur AB, Truskey G, Rubin J, Zhou DX, Sung KL. Effects of titanium particle size on osteoblast functions in vitro and in vivo. Proc Natl Acad Sci U S A 102:4578-4583, 2005.
27. Gobin A, Newman R, Mathur AB. Silk-fibroin coated liposomes for long term and targeted delivery. Int J Nanomedicine 1:81-87, 2005.
28. Gobin AS, Froude VE, Mathur AB. Structural and mechanical characteristics of silk fibroin and chitosan blend scaffolds for tissue regeneration. J Biomed Mater Res A (*Cover Illustration) 74:465-73, 2005. PMID: 15983992.
29. Mathur AB, Chan BP, Truskey GA, Reichert WM. High-affinity augmentation of endothelial cell attachment: long-term effects on focal contact and actin filament formation. J Biomed Mater Res A 66(4):729-37, 9/2003. PMID: 12926023.
30. Mathur AB, Truskey GA, Reichert WM. Synergistic effect of high affinity binding and flow preconditioning on endothelial cell adhesion. J Biomed Mater Res A 64(1):155-163, 1/2003. PMID: 12483708.
31. Mathur AB, Collinsworth AM, Reichert WM, Kraus WE, Truskey GA. Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. J Biomech 34:1545-53, 2001. PMID: 11716856.
32. Mathur AB, Truskey GA, Reichert WM. Atomic force and total internal reflection fluorescence microscopy for the study of force transmission in endothelial cells. Biophys J 78(4):1725-35, 2000. PMID: 10733955.
33. Mathur AB, Truskey GA, Reichert WM. Total internal reflection microscopy and atomic force microscopy (TIRFM-AFM) to study stress transduction mechanisms in endothelial cells. Crit Rev Biomed Eng 28:197-202, 2000. PMID: 10999387.
34. Anderson JM, Hiltner A, Wiggins MJ, Schubert MA, Collier TO, Kao WJ, Mathur AB. Recent advances in biomedical polyurethane biostability and biodegradation. Polymer International 46(3):163-171, 7/1998.
35. Mathur AB, Collier TO, Kao WJ, Wiggins M, Schubert MA, Hiltner A, Anderson JM. In vivo biocompatibility and biostability of modified polyurethanes. J Biomed Mater Res 36(2):246-57, 8/1997. PMID: 9261687.
36. Mathur AB, Tonelli A, Rathke T, Hudson SM. The dissolution and characterization of Bombyx mori silk fibroin in calcium nitrate-methanol solution and the regeneration of films. Biopolymers 42(1):61-74, 7/1997.

Invited Articles

1. McMahon RE, Wang L, Skoarcki R, Mathur AB. Development of Nanomaterials for Bone Repair and Regeneration. Journal of Biomedical Materials Research: Part B- Applied Biomaterials - JBM.A.3462 2(101):387-97, 2/2013. e-Pub 12/2012.
2. Mathur AB, Gupta V. Silk Fibroin derived nanoparticles for biomedical applications. Nanomedicine (Lond) 5(5):807-820, 7/2010. PMID: 20662650.

Book Chapters

1. Mathur AB. Regenerative Wound Healing via Biomaterials. In: Bioengineering Research of Chronic Wounds: A Multidisciplinary Study Approach. 1, 405-424, 2009.

Last updated: 7/18/2014