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Barry I. Samuels, MD

Present Title & Affiliation

Primary Appointment

Professor, Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Lymphoma and Lymphoproliferative diseases

Education & Training

Degree-Granting Education

1965 University of Michigan Medical School, Ann Arbor, MI, MD, Medicine

Postgraduate Training

1968-1971 Clinical Residency, Radiology, University of California, Los Angeles, CA, Dr. Leo Rigler

Board Certifications

1982 American Board of Radiology Diagnostic Radiology with Special Competence in Nuclear Radiology
1973 American Board of Radiology

Selected Publications

Peer-Reviewed Original Research Articles

1. Poon ML, Fox PS, Samuels BI, O'Brien S, Jabbour E, Hsu Y, Gulbis A, Korbling M, Champlin R, Abruzzo LV, Bassett RL, Khouri IF. Allogeneic stem cell transplantation in chronic lymphocytic leukemia patients with 17p deletion: consult-transplant v consult-no-transplant analysis. Leuk Lymphoma. e-Pub 6/2014. PMID: 24913509.
2. Chakhachiro ZI, Saliba RM, Okoroji GJ, Korbling M, Alousi AM, Betul O, Anderlini P, Ciurea SO, Popat U, Champlin R, Samuels BI, Medeiros LJ, Bueso-Ramos C, Khouri IF. Cytarabine, Ki-67, and SOX11 in patients with mantle cell lymphoma receiving rituximab-containing autologous stem cell transplantation during first remission. Cancer 119(18):3318-25, 9/2013. e-Pub 6/2013. PMID: 23775587.
3. Khouri IF, Saliba RM, Erwin WD, Samuels BI, Korbling M, Medeiros LJ, Valverde R, Alousi AM, Anderlini P, Bashir Q, Ciurea S, Gulbis AM, de Lima M, Hosing C, Kebriaei P, Popat UR, Fowler N, Neelapu SS, Samaniego F, Champlin RE, Macapinlac HA. Nonmyeloablative allogeneic transplantation with or without 90yttrium ibritumomab tiuxetan is potentially curative for relapsed follicular lymphoma: 12-year results. Blood 119(26):6373-8, 6/2012. e-Pub 5/2012. PMID: 22586182.
4. Wang M, Oki Y, Pro B, Romaguera JE, Rodriguez MA, Samaniego F, McLaughlin P, Hagemeister F, Neelapu S, Copeland A, Samuels BI, Loyer EM, Ji Y, Younes A. Phase II study of yttrium-90-ibritumomab tiuxetan in patients with relapsed or refractory mantle cell lymphoma. J Clin Oncol 27(31):5213-8, 2009. e-Pub 9/2009. PMID: 19770379.
5. Alousi AM, Saliba RM, Okoroji GJ, Macapinlac HA, Hosing C, Korbling M, Samuels BI, Popat U, Kebriaei P, Anderlini P, Qazilbash MH, de Lima M, Giralt SA, Champlin RE, Khouri IF. Disease staging with positron emission tomography or gallium scanning and use of rituximab predict outcome for patients with diffuse large B-cell lymphoma treated with autologous stem cell transplantation. Br J Haematol 142(5):786-792, 9/2008. PMID: 18564354.
6. Khouri IF, McLaughlin P, Saliba RM, Hosing C, Korbling M, Lee MS, Medeiros LJ, Fayad L, Samaniego F, Alousi A, Anderlini P, Couriel D, de Lima M, Giralt S, Neelapu SS, Ueno NT, Samuels BI, Hagemeister F, Kwak LW, Champlin RE. 8-year experience with allogeneic stem cell transplantation for relapsed follicular lymphoma after nonmyeloablative conditioning with fludarabine, cyclophosphamide and rituximab. Blood 111(12):5530-5536, 6/2008. PMID: 18411419.
7. Khouri IF, Saliba RM, Admirand J, O'Brien S, Lee MS, Korbling M, Samuels BI, Giralt S, Lima de M, Keating MJ, Champlin RE, Bueso-Ramos C. Graft-versus-leukaemia effect after non-myeloablative haematopoietic transplantation can overcome the unfavourable expression of ZAP-70 in refractory chronic lymphocytic leukaemia. Br J Haematol 137(4):355-363, 5/2007. PMID: 17456058.
8. Dang NH, Pro B, Hagemeister FB, Samaniego F, Jones D, Samuels BI, Rodriguez MA, Goy A, Romaguera JE, McLaughlin P, Tong AT, Turturro F, Walker PL, Fayad L. Phase II trial of denileukin diftitox for relapsed/refractory T-cell non-Hodgkin lymphoma. Br J Haematol 136(3):439-447, 2/2007. PMID: 17233846.
9. Romaguera JE, Fayad L, Rodriguez MA, Broglio KR, Hagemeister FB, Pro B, McLaughlin P, Younes A, Samaniego F, Goy A, Sarris AH, Dang NH, Wang M, Beasley V, Medeiros LJ, Katz RL, Gagneja H, Samuels BI, Smith TL, Cabanillas FF. High rate of durable remissions after treatment of newly diagnosed aggressive mantle-cell lymphoma with rituximab plus hyper-CVAD alternating with rituximab plus high-dose methotrexate and cytarabine. J Clin Oncol 23(28):7013-7023, 10/2005. PMID: 16145068.
10. Goy A, Younes A, McLaughlin P, Pro B, Romaguera JE, Hagemeister F, Fayad L, Dang NH, Samaniego F, Wang M, Broglio K, Samuels BI, Gilles F, Sarris AH, Hart S, Trehu E, Schenkein D, Cabanillas F, Rodriguez AM. Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma. J Clin Oncol 23(4):667-675, 2/2005. PMID: 15613697.
11. Dang NH, Hagemeister FB, Pro B, McLaughlin P, Romaguera JE, Jones D, Samuels BI, Samaniego F, Younes A, Wang M, Goy A, Rodriguez MA, Walker PL, Arredondo Y, Tong AT, Fayad L. Phase II study of denileukin diftitox for relapsed/refractory B-Cell non-Hodgkin's lymphoma. J Clin Oncol 22(20):4095-4102, 10/2004. PMID: 15353540.
12. Dang NH, Hagemeister FB, Duvic M, Romaguera JE, Younes A, Jones D, Samuels B, Fayad LE, Pro B, Samaniego F, Sarris A, Goy A, McLaughlin P, Tong AT, Walker PL, Tiongson LP, Smith TL, Huh YO, Morimoto C, Rodriguez MA. Pentostatin in T-non-Hodgkin's lymphomas: efficacy and effect on CD26+ T lymphocytes. Oncol Rep 10(5):1513-8, Sep-Oct, 9/2003. PMID: 12883733.
13. Sarris AH, Phan A, Duvic M, Romaguera J, McLaughlin P, Mesina O, King K, Medeiros LJ, Rassidakis GZ, Samuels B, Cabanillas F. Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol 20(12):2876-80, 6/2002. PMID: 12065565.
14. Sarris AH, Romaguera J, Hagemeister FB, Rodriguez MA, McLaughlin P, Pro B, Younes A, Mesina O, Cabanillas F, Medeiros LJ, Samuels B. Irinotecan in relapsed or refractory non-Hodgkin's lymphoma. Oncology (Williston Park) 15(7 Suppl 8):53-6, 7/2001. PMID: 11497233.
15. Younes A, Preti HA, Hagemeister FB, McLaughlin P, Romaguera JE, Rodriguez MA, Samuels BI, Palmer JL, Cabanillas F. Paclitaxel plus topotecan treatment for patients with relapsed or refractory aggressive non-Hodgkin's lymphoma. Ann Oncol 12(7):923-927, 7/2001. PMID: 11521796.
16. Sarris AH, Psyrri A, Hagemeister F, Romaguera J, McLaughlin P, Rodriguez MA, Bachier C, Younes A, Mesina O, Oholendt M, Medeiros LJ, Samuels B, Adams LM, Cabanillas F. Infusional vinorelbine in relapsed or refractory lymphomas. Leuk Lymphoma 39(3-4):291-9, 10/2000. PMID: 11342309.
17. Sarris AH, Hagemeister F, Romaguera J, Rodriguez MA, McLaughlin P, Tsimberidou AM, Medeiros LJ, Samuels B, Pate O, Oholendt M, Kantarjian H, Burge C, Cabanillas F. Liposomal vincristine in relapsed non-Hodgkin's lymphomas: early results of an ongoing phase II trial. Ann Oncol 11(1):69-72, 1/2000. PMID: 10690390.
18. Przepiorka D, van Besien K, Khouri I, Hagemeister F, Samuels B, Folloder J, Ueno NT, Molldrem J, Mehra R, Körbling M, Giralt S, Gajewski J, Donato M, Cleary K, Claxton D, Braunschweig I, Andersson B, Anderlini P, Champlin R. Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma. Ann Oncol 10(5):527-32, 5/1999. PMID: 10416001.
19. Oh YK, Ha CS, Samuels BI, Cabanillas F, Hess MA, Cox JD. Stages I-III follicular lymphoma: role of CT of the abdomen and pelvis in follow-up studies. Radiology 210:483-486, 2/1999. PMID: 10207433.
20. Khouri IF, Romaguera J, Kantarjian H, Palmer JL, Pugh WC, Korbling M, Hagemeister F, Samuels B, Rodriguez A, Giralt S, Younes A, Przepiorka D, Claxton D, Cabanillas F, Champlin R. Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma. J Clin Oncol 16(12):3803-9, 12/1998. PMID: 9850025.
21. Ueno NT, Rondon G, Mirza NQ, Geisler DK, Anderlini P, Giralt SA, Andersson BS, Claxton DF, Gajewski JL, Khouri IF, Korbling M, Mehra RC, Przepiorka D, Rahman Z, Samuels BI, van Besien K, Hortobagyi GN, Champlin RE. Allogeneic peripheral-blood progenitor-cell transplantation for poor-risk patients with metastatic breast cancer. J Clin Oncol 16:986-993, 3/1998. PMID: 9508181.
22. Rubenchik I, Sneige N, Edeiken B, Samuels B, Fornage B. In search of specimen adequacy in fine-needle aspirates of nonpalpable breast lesions. Am J Clin Pathol 108(1):13-8, 7/1997. PMID: 9208973.
23. Beech D, Berger D, Han N, Taylor S, Samuels BI, Singletary SE. Follow-up strategies in the post-irradiated breast: techniques involved in the detection of local recurrences following breast conservation therapy. Breast J 2(6):374-379, 4/1996.
24. Samuels BI, Bodey GP, Libshitz HI. Imaging in candidiasis. Semin Roentgenol 31(1):76-82, 1/1996. PMID: 8838947.
25. Varma DG, Richli WR, Charnsangavej C, Samuels BI, Kim EE, Wallace S. MR appearance of the distended iliopsoas bursa. AJR Am J Roentgenol 156:1025-1028, 5/1991. PMID: 2017926.
26. Carson PL, Scherzinger AL, Meyer CR, Jobe W, Samuels B, Adler DD. Lesion detectability in ultrasonic computed tomography of symptomatic breast patients. Invest Radiol 23(6):421-7, 6/1988. PMID: 3042685.
27. Gross MD, Wilton GP, Shapiro B, Cho K, Samuels BI, Bouffard JA, Glazer G, Grekin RJ, Brady T. Functional and scintigraphic evaluation of the silent adrenal mass. J Nucl Med 28(9):1401-1407, 9/1987. PMID: 3625292.
28. Adler DD, Samuels BI, Bowerman RA, Silver TM. Sonographic spectrum of focal splenic lesions. J Diag Med Sonogr 2(6):315-320, 11/1986.
29. Gebarski KS, Gebarski SS, Glazer GM, Samuels BI, Francis IR. The lumbosacral plexus: anatomic-radiologic-pathologic correlation using CT. Radiographics 6(3):401-425, 5/1986. PMID: 2825251.
30. Samuels BI, Freitas JE, Gross MD. A pragmatic view of gallbladder imaging. Magnetic Resonance 6(2):156-171, 1/1985.
31. Schmitt RM, Meyer CR, Carson PL, Samuels BI. Median and spatial low-pass filtering in ultrasonic computed tomography. Med Phys 11(6):767-771, 11/1984. PMID: 6392845.
32. Adler DD, Samuels BI, Blane CE. Sonographic diagnosis of neonatal diaphragmatic inversion. J Clin Ultrasound 12:166-167, 9/1984. PMID: 6423691.
33. Jasinski RW, Samuels BI, Silver TM. Sonographic features of retroperitoneal ganglioneuroma. J Ultrasound Med 3:413-415, 3/1984. PMID: 6384549.
34. Glazer GM, Francis IR, Gebarski K, Samuels BI, Sorensen KW. Dynamic incremental computed tomography in evaluation of the pulmonary hila. J Comput Assist Tomogr 7:59-64, 2/1983. PMID: 6298289.
35. Bowerman RA, Samuels BI, Silver TM. Ultrasonographic features of hepatic adenomas in type I glycogen storage disease. J Ultrasound Med 2:51-54, 2/1983. PMID: 6302304.
36. Wimbish KJ, Sanders MM, Samuels BI, Francis IR. Squamous cell carcinoma of the renal pelvis: case report emphasizing sonographic and CT appearance. Urol Radiol 5:267-269, 1/1983. PMID: 6659208.
37. Sanders MM, Wimbish KJ, Samuels BI, Francis IR. The hyperechoic gallbladder. Med Ultrasound 7:176-177, 1/1983.
38. Schmitt RM, Carford JF, Carson PL, Carlson D, Westrick QJ, Samuels BI. An apparatus for measuring tongue shape and motion during speech. J Ultrasound Med 7:203, 1/1982.
39. Samuels BI, Silver TM. Diagnostic ultrasound in the evaluation of patients with gynecologic cancer. Surg Clin North Am 58(1):3-18, 2/1978. PMID: 347603.
40. Goldstein HM, Zornoza J, Wallace S, Anderson JH, Bree RL, Samuels BI, Lukeman J. Percutaneous fine needle aspiration biopsy of pancreatic and other abdominal masses. Radiology 123:319-322, 5/1977. PMID: 847193.
41. Gold RH, Ehrlich RM, Samuels BI, Dowdy A, Young RT. Scrotal thermography. Radiology 122:129-132, 1/1977. PMID: 830321.
42. Samuels BI, Culbert SJ, Okamura J, Sullivan MP. Early detection of chemotherapy-related pancreatic enlargement in children using abdominal sonography: a preliminary report. Cancer 38:1515-1523, 10/1976. PMID: 991074.
43. Hickey RC, Gallager HS, Dodd GD,Samuels BI, Paulus DD, Jr, Moore DL. The detection and diagnosis of early, occult and minimal breast cancer. Adv Surg 10:287-312, 10/1976. PMID: 185891.
44. Dodd GD, Zermeno A, Samuels BI. Breast thermography section in radiologist's guide to detection of early breast cancer by mammography, thermography, and xeroradiography. American College of Radiology:139-152, 5/1976.
45. Samuels BI, Novy S, Hevezi J, Smith J, Wallace S, Dodd GD. Ultrasound as an aid in the diagnosis and management of ovarian carcinoma: preliminary report. Natl Cancer Inst Monogr 42:87-93, 10/1975. PMID: 1234639.
46. Samuels BI, Novy S, Hevezi J, Smith JL, Wallace S, Dodd GD. Ultrasound in the evaluation and diagnosis of ovarian tumors. Ultrasound in Med 1:219-228, 10/1975.
47. Samuels BI. Usefulness of ultrasound in patients with ovarian cancer. Semin Oncol 2(3):229-233, 9/1975. PMID: 1234802.
48. Samuels BI. The present status of parathyroid thermography. JAMA 233(8):907-908, 8/1975. PMID: 1173908.
49. Samuels BI, Dowdy AH, Lecky JW. Localization of parathyroids by thermography. N Engl J Med 286(4):216-217, 1/1972. PMID: 5007129.
50. Samuels BI. Thermography: a valuable tool in the detection of thyroid disease. Radiology 102(1):59-62, 1/1972. PMID: 5008156.

Invited Articles

1. Kontoyiannis DP, Luna MA, Samuels BI, Bodey GP. Hepatosplenic candidiasis: a manifestation of chronic disseminated candidiasis. Infect Dis Clin North Am 14(3):721-739, 9/2000. PMID: 10987117.
2. Samuels BI, Bodey GP, Libshitz HI. Imaging in candidiasis. Semin Roentgenol 31(1):76-82, 1/1996. PMID: 8838947.

Abstracts

1. Alousi AM, Saliba RM, Okoroji G, Hosing C, Samuels BI, Champlin RE, Khouri J. The influence of PET/Gallium (P/G) status and high-dose rituximab (HDR) in patients (pts) with aggressive, large, B-cell lymphoma (LBCL) receiving autologous stem cell transplants (ASCT). 42nd ASCO American Society of Clinical Oncology 24(18S), 5/2006.
2. Dang NH, Hagemeister FB, Fayad L, Pro B, McLaughlin P, Romaguera JE, Samaniego F, Goy A, Wang M, Walker PL, Samuels BI, Jones D, Rodriguez MA. Analysis of a phase II study of denileukin diftitox (ONTAK (R)) for B and T-cell non-Hodgkin's lymphoma. The Am Soc of Hematol 102(11):303B-303B 4935 Part 2, 12/2003.
3. Pro B, Smith MR, Younes A, Dang NH, Fayad LE, Goy A, Hagemeister F, McLaughlin P, Rodriguez MA, Samuels BI, Arredondo Y, Frankel SR, Zwiebel JA. Genasense (Bcl-2 antisense) plus rituximab is active in patients with relapsed or refractory B-cell non-Hodgkin's lymphoma. The Am Soc of Hematol 102(11):410A-410A 1491 Part 1, 12/2003.
4. Goy A, Hart S, Tiongson LP, Fayad L, Romaguera J, Younes A, Dang N, Pretti A, Samuels BI, Sarris A, Gilles F, Rodriguez MA. Preliminary report of a phase II study of vincristine sulfate liposomes injection (VSLI) in patients with relapsed or refractory Hodgkin's disease. The Am Soc of Hematol 102(11):640A-640A 2362 Part 1, 12/2003.
5. Dryden M, Whitman GJ, Sellin RV, Kushwaha AC, Samuels BI, Stelling CB. Effect of unopposed estrogen on the untreated breast in women with history of breast cancer. Radiological Society of North America 2000 86th Scientific Assembly and Annual Meeting, Radiology 217:447, 11/2000.
6. Khouri J, Romaguera J, Kantarjian H, Pugh W, Przepiorka D, Rodriguez A, Samuels BI, et al. Hyper-CVAD and high dose methotrexate/AR-C (HD MTX-ARA-C) Followed by stem cell transplantation for aggressive mantle cell lymphoma (MCL). The Am Soc of Hematol 7:14, 12/1996.
7. Fornage BD, Samuels BI, Paulus DD, Hortobagyi GN, Singletary SE. The use of sonography in the evaluation of the response to locally advanced breast carcinoma to preoperative chemotherapy. J Ultrasound Med 9(suppl):23, 1/1990.
8. Gross MD, Wilton GP, Shapiro B, Glazer G, Francis IR, Samuels BI. Adrenal scintigraphy in the evaluation of the clinically silent adrenal mass lesion. J Nuc Med 27:908A, 11/1986.
9. Gross MD, Wilton G, Shapiro B, Cho K, Samuels BI, Glazer G, Brady T. Normal adrenal function and asymmetric anatomy: the adrenal goiter. Am Fed Clin Res 33:308A, 1/1985.
10. Chenevert TL, Schmitt RM, Carson PL, Bland PH, Meyer CR, Adler DD, Samuels BI. The potential of ultrasonic CT for breast cancer diagnosis. J Ultrasound Med 3(suppl 9):127, 7/1984.
11. Gebarski KS, Gebarski SS, Glazer GM, Samuels BI, Francis IR. The lumbosacral plexus: radiographic-anatomic-pathologic correlation using computed tomography. Radiology 392:120, 5/1983.
12. Samuels BI, Gold RH, Lecky JW. Re-evaluation of parathyroid thermography. J Nuc Med 15:530, 9/1974.

Book Chapters

1. Samuels BI, Pagani JJ, Libshitz HI. Radiologic features of candida infection. In: Candidiasis: Pathogenesis, Diagnosis, and Treatment, 2. Raven Press: New York, 137-157, 1993.

Letters to the Editor

1. Samuels BI, Freitas JE, Bree RL. Radionuclide hepatobiliary imaging and real-time ultrasound in the detection of acute cholecystitis. Radiology 152:238-239, 4/1984.
2. Carnovale RL, Samuels BI. Letter: Complex ovarian mass on ultrasonography: primary or metastatic tumor? N Engl J Med 294:446-447, 2/1976. PMID: 1246319.
3. Samuels BI, Dowdy AH, Lecky JW. Parathyroid thermography. Radiology 104(3):575-578, 9/1972. PMID: 5051477.

Last updated: 7/29/2014