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Beth M Beadle, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2004 Northwestern University, Chicago, IL, MD, Medicine
2002 Northwestern University, Chicago, IL, PHD, Structural Biology and Biochemistry
1996 Northwestern University, Evanston, IL, BA, Chemistry

Postgraduate Training

7/2005-6/2009 Clinical Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
6/2004-6/2005 Clinical Internship, Surgery, McGaw Medical Center of Northwestern University, Chicago, IL

Honors and Awards

2008 AAWR Eleanor Montague Distinguished Resident Award for Radiation Oncology
2008 AAWR Member-In-Training Outstanding ASTRO Presentation Award
2008 American Radium Society Young Oncologist Essay Award
2008 ASTRO Translational Advances in Radiation Oncology and Cancer Imaging Symposium Travel Grant
2008 MD Anderson Department of Radiation Oncology Eleanor Montague Research Award
2008 RSNA Roentgen Resident/Fellow Research Award
2007 ASTRO Residents/Fellows in Radiation Oncology Research Seed Grant
2007 MD Anderson Department of Radiation Oncology Research Award Honorable Mention
2003 Alpha Omega Alpha Member
2001 Eli Lilly Award for Outstanding Poster at the 15th Symposium of the Protein Society
2001 Finn Wold Travel Grant Award for the 15th Symposium of the Protein Society
1999-2001 NIH Training Grant Awardee T32-GM08382
1998 Drug Discovery Program Symposium Outstanding Poster Award
1997 Northwestern University Medical Student Research Award
1996 Marple-Schweitzer Award for Distinguished Chemistry Undergraduate
1996 Phi Beta Kappa Centennial Prize

Selected Publications

Peer-Reviewed Original Research Articles

1. Takiar V, Gombos DS, Mourtada F, Rechner LA, Lawyer AA, Morrison WH, Garden AS, Beadle BM. Disease control and toxicity outcomes using ruthenium eye plaque brachytherapy in the treatment of uveal melanoma. Pract Radiat Oncol 4(4):e189-e194, Jul-Aug, 7/2014. e-Pub 9/2013. PMID: 25012839.
2. Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially HPV-related malignancies. Head Neck 36(6):819-825, 6/2014. e-Pub 9/2013. PMID: 23720126.
3. Garden AS, Gunn GB, Hessel A, Beadle BM, Ahmed S, El-Naggar AK, Fuller CD, Byers LA, Phan J, Frank SJ, Morrison WH, Kies MS, Rosenthal DI, Sturgis EM. Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer. Cancer. e-Pub 6/2014. PMID: 24898672.
4. Kocak-Uzel E, Gunn GB, Colen RR, Kantor ME, Mohamed AS, Schoultz-Henley S, Mavroidis P, Frank SJ, Garden AS, Beadle BM, Morrison WH, Phan J, Rosenthal DI, Fuller CD. Beam path toxicity in candidate organs-at-risk: Assessment of radiation emetogenesis for patients receiving head and neck intensity modulated radiotherapy. Radiother Oncol 111(2):281-288, 5/2014. e-Pub 4/2014. PMCID: PMC4063998.
5. Yock AD, Rao A, Dong L, Beadle BM, Garden AS, Kudchadker RJ, Court LE. Predicting oropharyngeal tumor volume throughout the course of radiation therapy from pretreatment computed tomography data using general linear models. Med Phys 41(5):051705, 5/2014. PMID: 24784371.
6. Beadle BM, Liao KP, Elting LS, Buchholz TA, Ang KK, Garden AS, Guadagnolo BA. Improved survival using intensity-modulated radiation therapy in head and neck cancers: A SEER-Medicare analysis. Cancer 120(5):702-710, 3/2014. e-Pub 1/2014. PMID: 24421077.
7. Yang J, Beadle BM, Garden AS, Gunn B, Rosenthal D, Ang K, Frank S, Williamson R, Balter P, Court L, Dong L. Auto-segmentation of low-risk clinical target volume for head and neck radiation therapy. Pract Radiat Oncol 4(1):e31-37, Jan-Feb, 1/2014. e-Pub 5/2013. PMID: 24621429.
8. Peterson SK, Shinn EH, Basen-Engquist K, Demark-Wahnefried W, Prokhorov AV, Baru C, Krueger IH, Farcas E, Rios P, Garden AS, Beadle BM, Lin K, Yan Y, Martch SL, Patrick K. Identifying early dehydration risk with home-based sensors during radiation treatment: a feasibility study on patients with head and neck cancer. J Natl Cancer Inst Monogr 2013(47):162-168, 12/2013. PMCID: PMC3881993.
9. Yock AD, Garden AS, Court LE, Beadle BM, Zhang L, Dong L. Anisotropic margin expansions in 6 anatomic directions for oropharyngeal image guided radiation therapy. Int J Radiat Oncol Biol Phys 87(3):596-601, 11/2013. e-Pub 7/2013. PMCID: PMC4063302.
10. Hutcheson KA, Bhayani MK, Beadle BM, Gold KA, Shinn EH, Lai SY, Lewin J. Eat and exercise during radiotherapy or chemoradiotherapy for pharyngeal cancers: Use it or lose it. JAMA Otolaryngol Head Neck Surg 139(11):1127-1134, 11/2013. e-Pub 9/2013. PMCID: PMC3969836.
11. Beadle BM, Liao KP, Chambers MS, Elting LS, Buchholz TA, Kian Ang K, Garden AS, Guadagnolo BA. Evaluating the impact of patient, tumor, and treatment characteristics on the development of jaw complications in patients treated for oral cancers: A SEER-medicare analysis. Head Neck 35(11):1599-1605, 11/2013. e-Pub 11/2012. PMID: 23150453.
12. Beadle BM, William WN, McLemore MS, Sturgis EM, Williams MD. p16 expression in cutaneous squamous carcinomas with neck metastases: A potential pitfall in identifying unknown primaries of the head and neck. Head Neck 35(11):1527-1533, 11/2013. e-Pub 10/2012. PMID: 23108906.
13. Gunn GB, Mendoza TR, Fuller CD, Gning I, Frank SJ, Beadle BM, Hanna EY, Lu C, Cleeland CS, Rosenthal DI. High symptom burden prior to radiation therapy for head and neck cancer: A patient-reported outcomes study. Head Neck 35(10):1490-1498, 10/2013. e-Pub 11/2012. PMCID: PMC3788079.
14. Gunn GB, Debnam JM, Fuller CD, Morrison WH, Frank SJ, Beadle BM, Sturgis EM, Glisson BS, Phan J, Rosenthal DI, Garden AS. The impact of radiographic retropharyngeal adenopathy in oropharyngeal cancer. Cancer 119(17):3162-9, 9/2013. e-Pub 6/2013. PMCID: PMC3775996.
15. Awan M, Kalpathy-Cramer J, Gunn GB, Beadle BM, Garden AS, Phan J, Holliday E, Jones WE, Maani E, Patel A, Choi J, Clyburn V, Tantiwongkosi B, Rosenthal DI, Fuller CD. Prospective assessment of an atlas-based intervention combined with real-time software feedback in contouring lymph node levels and organs-at-risk in the head and neck: Quantitative assessment of conformance to expert delineation. Pract Radiat Oncol 3(3):186-193, 7/2013. PMCID: PMC3706296.
16. Klopp AH, Mourtada F, Yu ZH, Beadle BM, Munsell MF, Jhingran A, Eifel PJ. Pilot study of a computed tomography-compatible shielded intracavitary brachytherapy applicator for treatment of cervical cancer. Pract Radiat Oncol 3(2):115-23, Apr-Jun, 4/2013. e-Pub 5/2012. PMID: 24674314.
17. Garden AS, Dong L, Morrison WH, Stugis EM, Glisson BS, Frank SJ, Beadle BM, Gunn GB, Schwartz DL, Kies MS, Weber RS, Ang KK, Rosenthal DI. Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys 85(4):941-947, 3/2013. e-Pub 9/2012. PMID: 22975604.
18. Garden AS, Kies MS, Morrison WH, Weber RS, Frank SJ, Glisson BS, Gunn GB, Beadle BM, Ang KK, Rosenthal DI, Sturgis EM. Outcomes and patterns of care of patients with locally advanced oropharyngeal carcinoma treated in the early 21st century. Radiat Oncol 8:21, 2013. e-Pub 1/2013. PMCID: PMC3576243.
19. Nasser QJ, Gombos DS, Williams MD, Guadagnolo BA, Morrison WH, Garden AS, Beadle BM, Canseco E, Esmaeli B. Management of radiation-induced severe anophthalmic socket contracture in patients with uveal melanoma. Ophthal Plast Reconstr Surg 28(3):208-212, May-Jun, 5/2012. PMCID: PMC3359825.
20. Chronowski GM, Garden AS, Morrison WH, Frank SJ, Schwartz DL, Shah SJ, Beadle BM, Gunn GB, Kupferman ME, Ang KK, Rosenthal DI. Unilateral radiotherapy for the treatment of tonsil cancer. Int J Radiat Oncol Biol Phys 83(1):204-209, 5/2012. e-Pub 10/2011. PMID: 22019242.
21. Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 18(1):290-300, 1/2012. e-Pub 11/2011. PMCID: PMC3251726.
22. Beadle BM, Jhingran A, Yom SS, Ramirez PT, Eifel PJ. Patterns of regional recurrence after definitive radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys 76(5):1396-1403, 4/2010. e-Pub 7/2009. PMID: 19581056.
23. Beadle BM, Guadagnolo BA, Ballo MT, Lee JE, Gershenwald JE, Cormier JN, Mansfield PF, Ross MI, Zagars GK. Radiation therapy field extent for adjuvant treatment of axillary metastases from malignant melanoma. Int J Radiat Oncol Biol Phys 73(5):1376-1382, 4/2009. e-Pub 9/2008. PMID: 18774657.
24. Beadle BM, Woodward WA, Tucker SL, Outlaw ED, Allen PK, Oh JL, Strom EA, Perkins GH, Tereffe W, Yu TK, Meric-Bernstam F, Litton JK, Buchholz TA. Ten-year recurrence rates in young women with breast cancer by locoregional treatment approach. Int J Radiat Oncol Biol Phys 73(3):734-744, 3/2009. e-Pub 8/2008. PMID: 18707822.
25. Beadle BM, Woodward WA, Middleton LP, Tereffe W, Strom EA, Litton JK, Meric-Bernstam F, Theriault RL, Buchholz TA, Perkins GH. The impact of pregnancy on breast cancer outcomes in women<or=35 years. Cancer 115(6):1174-1184, 3/2009. PMID: 19204903.
26. Beadle BM, Jhingran A, Salehpour M, Sam M, Iyer RB, Eifel PJ. Cervix regression and motion during the course of external beam chemoradiation for cervical cancer. Int J Radiat Oncol Biol Phys 73(1):235-241, 1/2009. e-Pub 5/2008. PMID: 18513882.
27. Chang JY, Moughan J, Johnstone DW, Komaki R, Goldberg M, Langer CJ, Beadle BM, Owen J, Movsas B. Surgical patterns of care in operable lung carcinoma treated with radiation. J Thorac Oncol 1(6):526-531, 7/2006. PMID: 17409912.
28. Beadle BM, Shoichet BK. Structural basis for imipenem inhibition of class C beta-lactamases. Antimicrob Agents Chemother 46(12):3978-3980, 12/2002. PMCID: PMC132770.
29. Beadle BM, Shoichet BK. Structural bases of stability-function tradeoffs in enzymes. J Mol Biol 321(2):285-296, 8/2002. PMID: 12144785.
30. Beadle BM, Trehan I, Focia PJ, Shoichet BK. Structural milestones in the reaction pathway of an amide hydrolase: Substrate, acyl, and product complexes of cephalothin with AmpC beta-lactamase. Structure 10(3):413-424, 3/2002. PMID: 12005439.
31. Trehan I, Beadle BM, Shoichet BK. Inhibition of AmpC beta-lactamase through a destabilizing interaction in the active site. Biochemistry 40(27):7992-7999, 7/2001. PMID: 11434768.
32. Beadle BM, Nicholas RA, Shoichet BK. Interaction energies between beta-lactam antibiotics and E. Coli penicillin-binding protein 5 by reversible thermal denaturation. Protein Sci 10(6):1254-1259, 6/2001. PMCID: PMC2374021.
33. Beadle BM, McGovern SL, Patera A, Shoichet BK. Functional analyses of AmpC beta- lactamase through differential stability. Protein Sci 8(9):1816-1824, 9/1999. PMCID: PMC2144403.
34. Beadle BM, Baase WA, Wilson DB, Gilkes NR, Shoichet BK. Comparing the thermodynamic stabilities of a related thermophilic and mesophilic enzyme. Biochemistry 38(8):2570-2576, 2/1999. PMID: 10029552.
35. Lambert JB, Beadle BM, Kuang K. Phenylsulfonyl as a beta participating group. Journal of Organic Chemistry 64:9241-9246, 1999.

Invited Articles

1. Skinner HD, Holsinger FC, Beadle BM. Current problems in oncology: Oropharynx cancer. Curr Probl Cancer 36(6):334-415, Nov-Dec, 11/2012. e-Pub 9/2012. PMID: 22986060.
2. Beadle BM. Commentary: On Postmastectomy radiation therapy for lymph node negative, locally advanced breast cancer after modified radical mastectomy: Analysis of the NCI Surveillance, Epidemiology, and End Results Database. Breast Diseases: A Year Book Quarterly 20(3). e-Pub 10/2009.
3. Beadle BM. Commentary: On The safety of breast-conserving therapy in patients with breast cancer aged 40 years or younger. Breast Diseases: A Year Book Quarterly 18(4). e-Pub 1/2008.

Book Chapters

1. Garden AS, Beadle BM, Morrison WH. Larynx and hypopharynx cancer. In: Clinical Radiation Oncology. Submitted.

Last updated: 7/29/2014