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Bharat B. Aggarwal, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, The University of Texas Graduate School of Biomedical Sciences, Houston, TX
Professor, Albert B. Alkek Institute of Bioscienes and Technology (IBT), Texas A&M University, Houston, TX

Education & Training

Degree-Granting Education

1977 University of California, Berkeley, CA, PHD, Biochemistry
1972 Banares Hindu University, Varanasi, India, MS, Biochemistry
1970 University of Delhi, Delhi, India, BS, Biochemistry

Postgraduate Training

7/1977-7/1980 Postdoctoral Fellowship, University of California, San Francisco, CA, Professor Harold Papkoff

Experience/Service

Administrative Appointments/Responsibilities

Chief, Cytokine Research Section, Department of Clinical Immunology, Bioimmunotherapy, Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/1989-present

Honors and Awards

2012 2011 James A. Duke Award Excellence in Botanical Literature Award, American Botanical Council
2012 ARTOI Award, Association for Research Integrated Oncology Therapies
2010 World Congress Science Prize, Oxygen Club of California
2008 Excellence in Research Award of McCormick Research Institute, American Association of Nutrition
2006 Outstanding Scientist Award, American Association of Indian Scientists in Cancer Research
2004 Ranbaxy Award for Outstanding Scientist of the Year, Ranbaxy Pharmaceuticals, India
2003 Team Anderson Award, The University of Texas M.D. Anderson Cancer Center
2000 Honored as Most Highly Cited Researcher by the ISI, Institute for Scientific Information

Selected Publications

Peer-Reviewed Original Research Articles
1. Kannappan R, Gupta SC, Kim JH, Aggarwal BB. Tocotrienols fight cancer by targeting multiple cell signaling pathways. Genes Nutr 7(1):43-52, 1/2012. e-Pub 4/9/2011. PMCID: PMC3250528.
2. Aggarwal B, Nesaretnam K. Vitamin E tocotrienols: life beyond tocopherols. Genes Nutr 7(1):1, 1/2012. e-Pub 5/18/2011. PMCID: PMC3250522.
3. Aggarwal BB, Prasad S, Reuter S, Kannappan R, Yadev VR, Park B, Kim JH, Gupta SC, Phromnoi K, Sundaram C, Prasad S, Chaturvedi MM, Sung B. Identification of Novel Anti-inflammatory Agents from Ayurvedic Medicine for Prevention of Chronic Diseases: "Reverse Pharmacology" and "Bedside to Bench" Approach. Curr Drug Targets 12(11):1595-653, 10/2011. e-Pub 5/2011. PMCID: PMC3170500.
4. Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB. Role of nuclear factor-{kappa}B-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Exp Biol Med (Maywood) 236(6):658-71, 6/1/2011. e-Pub 5/12/2011. PMCID: PMC3141285.
5. Reuter S, Gupta SC, Park B, Goel A, Aggarwal BB. Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr 6(2):93-108, 5/2011. e-Pub 4/24/2011. PMCID: PMC3092901.
6. Phromnoi K, Reuter S, Sung B, Prasad S, Kannappan R, Yadav VR, Chanmahasathien W, Limtrakul P, Aggarwal BB. A Novel Pentamethoxyflavone Downregulates Tumor Cell Survival, Proliferative, and Angiogenic Gene Products Through Inhibition of Activation of I{kappa}B Kinase, and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents. Mol Pharmacol 79(2):279-89, 2/2011. e-Pub 10/7/2010. PMCID: PMC3033709.
7. Zhang C, Li B, Zhang X, Hazarika P, Aggarwal BB, Duvic M. Curcumin Selectively Induces Apoptosis in Cutaneous T-Cell Lymphoma Cell Lines and Patients' PBMCs: Potential Role for STAT-3 and NF-kappaB Signaling. J Invest Dermatol 130(8):2110-9, 8/2010. e-Pub 4/15/2010. PMID: 20393484.
8. Kannappan R, Ravindran J, Prasad S, Sung B, Yadav VR, Reuter S, Chaturvedi MM, Aggarwal BB. Gamma-tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptors. Mol Cancer Ther 9(8):2196-207, 8/2010. e-Pub 8/3/2010. PMID: 20682650.
9. Prasad S, Phromnoi K, Yadav VR, Chaturvedi MM, Aggarwal BB. Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer. Planta Med 76(11):1044-63, 8/2010. e-Pub 7/15/2010. PMID: 20635307.
10. Kamat AM, Tharakan ST, Sung B, Aggarwal BB. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 69(23):8958-66, 12/1/2009. e-Pub 11/10/2009. PMID: 19903839.
11. Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Kuzhuvelil HB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. Int J Cancer 125(9):2187-97, 11/1/2009. PMID: 19623659.
12. Aggarwal BB, Danda D, Gupta S, Gehlot P. Models for prevention and treatment of cancer: Problems vs promises. Biochem Pharmacol 78(9):1083-1094, 11/1/2009. e-Pub 5/27/2009. PMCID: PMC2748136.
13. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 30(11):1949-56, 11/2009. e-Pub 9/30/2009. PMCID: PMC2783007.
14. Pervaiz S, Holme AL, Aggarwal BB, Anekonda TS, Baur JA, Gojkovic-Bukarica L, Ragione FD, Kim AL, Pirola L, Saiko P. Resveratrol: its biologic targets and functional activity. Antioxid Redox Signal 11(11):2851-97, 11/2009. PMID: 19432534.
15. Sandur SK, Deorukhkar A, Pandey MK, Pabón AM, Shentu S, Guha S, Aggarwal BB, Krishnan S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int J Radiat Oncol Biol Phys 75(2):534-42, 10/1/2009. PMCID: PMC3090721.
16. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells selectively? AAPS J 11(3):495-510, 9/2009. e-Pub 7/10/2009. PMCID: PMC2758121.
17. Yodkeeree S, Sung B, Limtrakul P, Aggarwal BB. Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species. Cancer Res 69(16):6581-9, 8/15/2009. e-Pub 8/4/2009. PMCID: PMC2741416.
18. Aggarwal BB. Inflammation, a silent killer in cancer is not so silent! Curr Opin Pharmacol 9(4):347-50, 8/2009. e-Pub 8/9/2009. PMID: 19671496.
19. Aggarwal BB, Gehlot P. Inflammation and cancer: how friendly is the relationship for cancer patients? Curr Opin Pharmacol 9(4):351-69, 8/2009. e-Pub 8/6/2009. PMCID: PMC2730981.
20. Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB, Sung B. Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis. Exp Biol Med (Maywood) 234(8):825-49, 8/2009. e-Pub 6/2/2009. PMCID: PMC3141288.
21. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B. Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann N Y Acad Sci 1171(1):59-76, 8/2009. PMCID: PMC3141289.
22. Pang X, Yi Z, Zhang X, Sung B, Qu W, Lian X, Aggarwal BB, Liu M. Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 69(14):5893-900, 7/15/2009. e-Pub 6/30/2009. PMCID: PMC2724674.
23. Aggarwal BB. Response to Kurien and Scofield: Solubility and bioavailability of curcumin. Trends Pharmacol Sci 30(7):335, 7/2009. PMCID: PMC3198920.
24. Mulabagal V, Subbaraju GV, Rao CV, Sivaramakrishna C, Dewitt DL, Holmes D, Sung B, Aggarwal BB, Tsay HS, Nair MG. Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation. Phytother Res 23(7):987-92, 7/2009. PMID: 19152372.
25. Matsuo Y, Campbell PM, Brekken RA, Sung B, Ouellette MM, Fleming JB, Aggarwal BB, Der CJ, Guha S. K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways. Mol Cancer Res 7(6):799-808, 6/2009. e-Pub 6/9/2009. PMID: 19509115.
26. Muralimanoharan SB, Kunnumakkara AB, Shylesh B, Kulkarni KH, Haiyan X, Ming H, Aggarwal BB, Rita G, Kumar AP. Butanol fraction containing berberine or related compound from nexrutine(R) inhibits NFkappaB signaling and induces apoptosis in prostate cancer cells. Prostate 69(5):494-504, 4/1/2009. PMCID: PMC2674392.
27. Sung B, Kunnumakkara AB, Sethi G, Anand P, Guha S, Aggarwal BB. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther 8(4):959-70, 4/2009. PMCID: PMC2694943.
28. Pandey MK, Sung B, Ahn KS, Aggarwal BB. Butein Suppresses Constitutive and Inducible STAT3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1. Mol Pharmacol 75(3):525-33, 3/2009. e-Pub 12/22/2008. PMCID: PMC2684906.
29. Harikumar KB, Kunnumakkara AB, Ahn KS, Anand P, Krishnan S, Guha S, Aggarwal BB. Modification of the cysteine residues in I{kappa}B {alpha} kinase and NF-{kappa}B (p65) by xanthohumol leads to suppression of NF-{kappa}B-regulated gene products and potentiation of apoptosis in leukemia cells. Blood 113(9):2003-13, 2/26/2009. e-Pub 10/24/2008. PMCID: PMC2947354.
30. Reuter S, Schnekenburger M, Cristofanon S, Buck I, Teiten MH, Daubeuf S, Eifes S, Dicato M, Aggarwal BB, Visvikis A, Diederich M. Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1. Biochem Pharmacol 77(3):397-411, 2/1/2009. e-Pub 10/18/2008. PMID: 18996094.
31. Sung B, Murakami A, Oyajobi BO, Aggarwal BB. Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice. Cancer Res 69(4):1477-84, 2/15/2009. e-Pub 2/3/2009. PMID: 19190327.
32. Aggarwal BB, Sung B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 30(2):85-94, 2/2009. e-Pub 12/26/2008. PMID: 19110321.
33. Aggarwal BB, Vijayalekshmi RV, Sung B. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res 15(2):425-30, 1/15/2009. PMID: 19147746.
34. Kunnumakkara AB, Nair AS, Sung B, Pandey MK, Aggarwal BB. Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1. Mol Cancer Res 7(1):118-28, 1/2009. PMCID: PMC2677182.
35. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41(1):40-59, 1/2009. e-Pub 7/9/2008. PMCID: PMC2637808.
36. Shakibaei M, Harikumar KB, Aggarwal BB. Resveratrol addiction: to die or not to die. Mol Nutr Food Res 53(1):115-28, 1/2009. PMID: 19072742.
37. Gupta V, Aseh A, Ríos CN, Aggarwal BB, Mathur AB. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int J Nanomedicine 4:115-22, 2009. e-Pub 4/20/2009. PMCID: PMC2720745.
38. Ralhan R, Pandey MK, Aggarwal BB. Nuclear factor-kappa B links carcinogenic and chemopreventive agents. Front Biosci (Schol Ed) 1(1):45-60, 2009. e-Pub 6/1/2009. PMID: 19482682.
39. Sethi G, Sung B, Kunnumakkara AB, Aggarwal BB. Targeting TNF for Treatment of Cancer and Autoimmunity. Adv Exp Med Biol 647(1):37-51, 2009. PMID: 19760065.
40. Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharmacol 76(11):1590-611, 12/1/2008. e-Pub 8/19/2008. PMID: 18775680.
41. Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 76(11):1340-51, 12/1/2008. e-Pub 8/3/2008. PMID: 18755156.
42. Sethi G, Ahn KS, Sung B, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. SH-5, an AKT inhibitor potentiates apoptosis and inhibits invaion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation. Biochem Pharmacol 76(11):1404-16, 12/1/2008. e-Pub 7/5/2008. PMID: 18606397.
43. Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB. Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis. Cancer Res 68(21):8861-70, 11/1/2008. PMCID: PMC2673720.
44. Sung B, Jhurani S, Ahn KS, Mastuo Y, Yi T, Guha S, Liu M, Aggarwal BB. Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells. Cancer Res 68(21):8938-44, 11/1/2008. PMID: 18974138.
45. Kaur B, Gogia A, Kakar A, Byotra SP, Aggarwal BB. Large gall bladder stone causing mid small bowel obstruction with cholecystoduodenal fistula. J Assoc Physicians India 56(1):914, 11/2008. PMID: 19263696.
46. Shishodia S, Harikumar KB, Dass S, Ramawat KG, Aggarwal BB. The guggul for chronic diseases: ancient medicine, modern targets. Anticancer Res 28(6A):3647-64, Nov-Dec, 11/2008. PMID: 19189646.
47. Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 269(2):199-225, 10/8/2008. e-Pub 5/13/2008. PMID: 18479807.
48. Ahn KS, Sethi G, Chaturvedi MM, Aggarwal BB. Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway. Int J Cancer 123(8):1733-40, 10/15/2008. PMID: 18688862.
49. Aggarwal BB. The past, present and future of multi-targeted cancer treatment "Naturally": Food for thought. Cancer Lett 269(2):187-8, 10/8/2008. e-Pub 5/27/2008. PMID: 18504071.
50. Kunnumakkara AB, Ichikawa H, Anand P, Mohankumar CJ, Hema PS, Nair MS, Aggarwal BB. Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis. Mol Cancer Ther 7(10):3306-17, 10/2008. PMID: 18852134.
51. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P. Potential of Spice-Derived Phytochemicals for Cancer Prevention. Planta Med 74(13):1560-9, 10/2008. e-Pub 7/8/2008. PMID: 18612945.
52. Anand P, Kunnumakkara AB, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB. Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharm Res 25(9):2097-116, 9/2008. e-Pub 7/15/2008. PMCID: PMC2515569.
53. Goel A, Jhurani S, Aggarwal BB. Multi-targeted therapy by curcumin: how spicy is it? Mol Nutr Food Res 52(9):1010-30, 9/2008. PMID: 18384098.
54. Aggarwal BB. Prostate cancer and curcumin: add spice to your life. Cancer Biol Ther 7(9):1436-40, 9/2008. e-Pub 9/21/2008. PMID: 18769126.
55. Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Curcumin and cancer: An "old-age" disease with an "age-old" solution. Cancer Lett 267(1):133-64, 8/18/2008. e-Pub 5/6/2008. PMID: 18462866.
56. Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res 68(15):6100-8, 8/1/2008. PMCID: PMC2714276.
57. Pandey MK, Sung B, Kunnumakkara AB, Sethi G, Chaturvedi MM, Aggarwal BB. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res 68(13):5370-9, 7/1/2008. PMID: 18593939.
58. Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer. Clin Cancer Res 14(14):4491-4499, 7/15/2008. PMID: 18628464.
59. Iyer C, Kosters A, Sethi G, Kunnumakkara AB, Aggarwal BB, Versalovic J. Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling. Cell Microbiol 10(7):1442-52, 7/2008. e-Pub 3/7/2008. PMID: 18331465.
60. Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu M. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 7(7):1789-96, 7/2008. PMCID: PMC2587125.
61. Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Aggarwal BB. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res 68(11):4406-15, 6/1/2008. PMID: 18519703.
62. Sethi G, Ahn KS, Sung B, Aggarwal BB. Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis. Mol Cancer Ther 7(6):1604-14, 6/2008. PMID: 18566231.
63. Sethi G, Ahn KS, Aggarwal BB. Targeting Nuclear Factor-{kappa}B Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis. Mol Cancer Res 6(6):1059-70, 6/2008. PMID: 18567808.
64. Sung B, Pandey MK, Ahn KS, Yi T, Chaturvedi MM, Liu M, Aggarwal BB. Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis. Blood 111(10):4880-91, 5/15/2008. e-Pub 3/18/2008. PMCID: PMC2384122.
65. Takada Y, Sethi G, Sung B, Aggarwal BB. Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. Mol Pharmacol 73(5):1549-57, 5/2008. e-Pub 2/20/2008. PMID: 18287248.
66. Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 14(7):2128-36, 4/1/2008. PMID: 18381954.
67. Harikumar KB, Aggarwal BB. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7(8):1020-35, 4/15/2008. e-Pub 2/15/2008. PMID: 18414053.
68. Verma A, Guha S, Diagaradjane P, Kunnumakkara AB, Sanguino AM, Lopez-Berestein G, Sood AK, Aggarwal BB, Krishnan S, Gelovani JG, Mehta K. Therapeutic significance of elevated tissue transglutaminase expression in pancreatic cancer. Clin Cancer Res 14(8):2476-83, 4/15/2008. PMID: 18413840.
69. Yi T, Yi Z, Cho SG, Luo J, Pandey MK, Aggarwal BB, Liu M. Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling. Cancer Res 68(6):1843-50, 3/15/2008. PMCID: PMC2587446.
70. Herbein G, Varin A, Larbi A, Fortin C, Mahlknecht U, Fulop T, Aggarwal BB. Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages. Curr HIV Res 6(2):117-29, 3/2008. PMID: 18336259.
71. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol 75(4):787-809, 2/15/2008. e-Pub 8/19/2007. PMID: 17900536.
72. Ahn KS, Sethi G, Aggarwal BB. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-kappaB pathway. Biochem Pharmacol 75(4):907-13, 2/15/2008. e-Pub 10/16/2007. PMCID: PMC2757941.
73. Shibata H, Yoshioka Y, Ohkawa A, Minowa K, Mukai Y, Abe Y, Taniai M, Nomura T, Kayamuro H, Nabeshi H, Sugita T, Imai S, Nagano K, Yoshikawa T, Fujita T, Nakagawa S, Yamamoto A, Ohta T, Hayakawa T, Mayumi T, Vandenabeele P, Aggarwal BB, Nakamura T, Yamagata Y, Tsunoda S, Kamada H, Tsutsumi Y. Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist. J Biol Chem 283(2):998-1007, 1/11/2008. e-Pub 11/14/2007. PMID: 18003610.
74. Sung B, Pandey MK, Nakajima Y, Nishida H, Konishi T, Chaturvedi MM, Aggarwal BB. Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB. Mol Cancer Ther 7(1):191-201, 1/2008. PMID: 18202022.
75. Sethi G, Sung B, Aggarwal BB. Nuclear factor-kappaB activation: from bench to bedside. Exp Biol Med (Maywood) 233(1):21-31, 1/2008. PMID: 18156302.
76. Sethi G, Sung B, Aggarwal BB. TNF: a master switch for inflammation to cancer. Front Biosci 13:5094-107, 2008. e-Pub 5/1/2008. PMID: 18508572.
77. Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB. Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha. Oncogene 26(52):7324-32, 11/15/2007. e-Pub 5/28/2007. PMID: 17533369.
78. Pandey MK, Sung B, Ahn KS, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway. Blood 110(10):3517-25, 11/15/2007. e-Pub 8/2/2007. PMCID: PMC2077305.
79. Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs 16(11):1753-73, 11/2007. PMID: 17970636.
80. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807-18, Nov-Dec, 11/2007. e-Pub 11/14/2007. PMID: 17999464.
81. Ahn KS, Sethi G, Aggarwal BB. Nuclear factor-kappa B: from clone to clinic. Curr Mol Med 7(7):619-37, 11/2007. PMID: 18045141.
82. Ahn KS, Gong X, Sethi G, Chaturvedi MM, Jaiswal AK, Aggarwal BB. Deficiency of NRH:quinone oxidoreductase 2 differentially regulates TNF signaling in keratinocytes: up-regulation of apoptosis correlates with down-regulation of cell survival kinases. Cancer Res 67(20):10004-11, 10/15/2007. PMID: 17942934.
83. Takada Y, Sung B, Sethi G, Chaturvedi MM, Aggarwal BB. Evidence that genetic deletion of the TNF receptor p60 or p80 inhibits Fas mediated apoptosis in macrophages. Biochem Pharmacol 74(7):1057-64, 10/1/2007. e-Pub 7/10/2007. PMCID: PMC2702769.
84. Ahn KS, Sethi G, Chao TH, Neuteboom ST, Chaturvedi MM, Palladino MA, Younes A, Aggarwal BB. Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products. Blood 110(7):2286-95, 10/1/2007. e-Pub 7/3/2007. PMCID: PMC1988928.
85. Aggarwal BB, Sethi G, Baladandayuthapani V, Krishnan S, Shishodia S. Targeting cell signaling pathways for drug discovery: an old lock needs a new key. J Cell Biochem 102(3):580-92, 10/15/2007. PMID: 17668425.
86. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res 13(20):6032-9, 10/15/2007. PMID: 17947465.
87. Pathak AK, Bhutani M, Nair AS, Ahn KS, Chakraborty A, Kadara H, Guha S, Sethi G, Aggarwal BB. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol Cancer Res 5(9):943-55, 9/2007. PMID: 17855663.
88. Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic Biol Med 43(4):568-80, 8/15/2007. e-Pub 5/16/2007. PMCID: PMC2754304.
89. Sethi G, Ahn KS, Xia D, Kurie JM, Aggarwal BB. Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products. J Immunol 179(3):1926-33, 8/1/2007. PMID: 17641059.
90. Sandur SK, Pandey MK, Sung B, Ahn KS, Murakami A, Sethi G, Limtrakul P, Badmaev V, Aggarwal BB. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8):1765-73, 8/2007. e-Pub 5/23/2007. PMID: 17522064.
91. Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 72(1):29-39, 7/2007. e-Pub 3/29/2007. PMID: 17395690.
92. Sethi G, Aggarwal BB. Mending the bones with natural products. Chem Biol 14(7):738-40, 7/2007. PMID: 17656310.
93. Shishodia S, Chaturvedi MM, Aggarwal BB. Role of curcumin in cancer therapy. Curr Probl Cancer 31(4):243-305, Jul-Aug, 7/2007. PMID: 17645940.
94. Bover LC, Cardó-Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, Aggarwal BB, Arap W, Pasqualini R. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol 178(12):8183-94, 6/15/2007. PMID: 17548657.
95. Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB. Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue. J Biol Chem 282(24):17340-50, 6/15/2007. e-Pub 4/17/2007. PMID: 17439942.
96. Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. Clin Cancer Res 13(11):3423-30, 6/1/2007. PMID: 17545551.
97. Sawhney M, Rohatgi N, Kaur J, Shishodia S, Sethi G, Gupta SD, Deo SV, Shukla NK, Aggarwal BB, Ralhan R. Expression of NF-kappaB parallels COX-2 expression in oral precancer and cancer: association with smokeless tobacco. Int J Cancer 120(12):2545-56, 6/15/2007. PMID: 17354234.
98. Kunnumakkara AB, Nair AS, Ahn KS, Pandey MK, Yi Z, Liu M, Aggarwal BB. Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1 mediated NF-{kappa}B activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. Blood 109(12):5112-21, 6/15/2007. e-Pub 3/1/2007. PMCID: PMC1890830.
99. Shishodia S, Sethi G, Ahn KS, Aggarwal BB. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem Pharmacol 74(1):118-30, 6/30/2007. e-Pub 3/30/2007. PMCID: PMC2744036.
100. Sung B, Pandey MK, Aggarwal BB. Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation. Mol Pharmacol 71(6):1703-14, 6/2007. e-Pub 3/26/2007. PMID: 17387141.
101. Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 7(3):344-51, 6/2007. e-Pub 5/1/2007. PMID: 17475558.
102. Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway. Mol Cell Biochem 300(1-2):77-87, 6/2007. e-Pub 1/18/2007. PMID: 17235455.
103. Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation. Clin Cancer Res 13(10):3024-32, 5/15/2007. PMID: 17505005.
104. Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-{kappa}B-regulated gene products and TAK1-mediated NF-{kappa}B activation. Blood 109(7):2727-35, 4/1/2007. PMID: 17110449.
105. Aggarwal BB, Banerjee S, Bharadwaj U, Sung B, Shishodia S, Sethi G. Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines. Biochem Pharmacol 73(7):1024-32, 4/1/2007. e-Pub 12/15/2006. PMID: 17240359.
106. Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 67(8):3853-61, 4/15/2007. PMID: 17440100.
107. Manna SK, Aggarwal RS, Sethi G, Aggarwal BB, Ramesh GT. Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis. Clin Cancer Res 13(7):2290-7, 4/1/2007. PMCID: PMC2740379.
108. Izzo JG, Luthra R, Wu TT, Correa AM, Luthra M, Anandasabapathy S, Chao KS, Hung MC, Aggarwal B, Hittelman WN, Ajani JA. Molecular mechanisms in Barrett's metaplasia and its progression. Semin Oncol 34(2 Suppl 1):S2-6, 4/2007. PMID: 17449347.
109. Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene 26(10):1385-97, 3/1/2007. e-Pub 9/4/2006. PMID: 16953224.
110. Bhardwaj A, Sethi G, Vadhan-Raj S, Bueso-Ramos C, Takada Y, Gaur U, Nair AS, Shishodia S, Aggarwal BB. Resveratrol inhibits proliferation, induces apoptosis and overcomes chemoresistance through downregulation of STAT3 and nuclear factor-{kappa}B-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109(6):2293-302, 3/15/2007. e-Pub 12/12/2006. PMID: 17164350.
111. Kamat AM, Sethi G, Aggarwal BB. Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. Mol Cancer Ther 6(3):1022-30, 3/2007. PMID: 17363495.
112. Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 26(8):1201-12, 2/22/2007. e-Pub 8/21/2006. PMID: 16924232.
113. Xia D, Srinivas H, Ahn YH, Sethi G, Sheng X, Yung WK, Xia Q, Chiao PJ, Kim H, Brown PH, Wistuba II, Aggarwal BB, Kurie JM. Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NFkappaB-dependent pathway. J Biol Chem 282(6):3507-19, 2/9/2007. e-Pub 12/11/2006. PMID: 17158870.
114. Ahn KS, Sethi G, Aggarwal BB. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol 178(4):2507-16, 2/15/2007. PMID: 17277159.
115. Aggarwal BB. Nuclear factor-kappaB: a transcription factor for all seasons. Expert Opin Ther Targets 11(2):109-10, 2/2007. PMID: 17227227.
116. Ahn KS, Sethi G, Krishnan K, Aggarwal BB. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282(1):809-20, 1/5/2007. e-Pub 11/17/2006. PMID: 17114179.
117. Ahn KS, Sethi G, Aggarwal BB. Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Mol Pharmacol 71(1):209-19, 1/2007. e-Pub 10/6/2006. PMID: 17028156.
118. Jagetia GC, Aggarwal BB. Spicing up of the immune system by curcumin. J Clin Immunol 27(1):19-35, 1/2007. e-Pub 1/9/2007. PMID: 17211725.
119. Ichikawa H, Nakamura Y, Kashiwada Y, Aggarwal BB. Anticancer drugs designed by mother nature: ancient drugs but modern targets. Curr Pharm Des 13(33):3400-16, 2007. PMID: 18045194.
120. Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian Solid Gold. Adv Exp Med Biol 595(1):1-75, 2007. PMID: 17569205.
121. Izzo JG, Luthra R, Sims-Mourtada J, Chao KS, Lee JH, Wu TT, Correa AM, Luthra M, Aggarwal B, Hung MC, Ajani JA. Emerging molecular targets in esophageal cancers. Gastrointest Cancer Res 1(4 Suppl 2):S3-6, 2007. PMCID: PMC2666833.
122. Garodia P, Ichikawa H, Malani N, Sethi G, Aggarwal BB. From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol 5(1):25-37, 2007. PMID: 17309811.
123. Sandur SK, Ahn KS, Ichikawa H, Sethi G, Shishodia S, Newman RA, Aggarwal BB. Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutr Cancer 57(1):78-87, 2007. PMID: 17516865.

Book Chapters
1. Kunnumakkara AB, Anand P, Harikumar KB, Aggarwal BB. DNA Damage and Cancer Chemoprevention by Polyphenols. In: Chemoprevention of Cancer and DNA Damage by Dietary Factors, First Edition. Ed(s) S Knasmullar, DM DeMarini, IT Johnson, C Gerhauser. WILEY-VCH, Verlag GmbH & Co. Weinheim, 2009.
2. Sethi G, Sung B, Aggarwal BB. Therapeutic potential of VEGI/TL1A in autoimmunity and cancer. In: Adv Exp Med Biol. 647. Landes Bioscience, 207-15, 2009. ISBN: 19760077.
3. Sethi G, Sung B, Kunnumakkara AB, Aggarwal BB. TNF in autoimmunity/cancers. In: Therapeutic Targets of the TNF Superfamily, First Edition. Landes Bioscience, 2009.
4. Jagetia G, Krishnan S, Aggarwal BB. Natural agents that can sensitize tumor cells to chemotherapy and radiation therapy. In: Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, First Edition. Ed(s) B Bonavida: Totowa, NJ, 211-24, 2008.

Grant & Contract Support

Title: Redesign of piperlongumine to fight cancer better
Funding Source: CTT/TI-3D
Role: Co-Principal Investigator
Duration: 11/1/2012 - 10/31/2014
 
Title: Molecular targets of tocotrienol for prevention of colorectal cancer
Funding Source: Malaysian Palm Oil Board
Role: Principal Investigator
Duration: 5/31/2011 - 5/30/2014
 
Title: Targeting inflammation in regulation of symptoms in patients with multiple myeloma
Funding Source: NIH/NCI
Role: Project Leader
Principal Investigator: Dr. Charles Cleeland
Duration: 1/1/2009 - 12/31/2012
 
Title: Caffeic Acid Phenethyl Ester (CAPE)-Based Specific Inhibitor of Inflammatory Pathway
Funding Source: M.D. Anderson Cancer Center
Role: Principal Investigator
Duration: 11/1/2008 - 4/30/2011

Last updated: 12/14/2012