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Bingbing Dai, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Thoracic and Cardiovascular Surgery - Research, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 023
Houston, TX 77030
Room Number: T4.3895

Education & Training

Degree-Granting Education

2003 Shanghai Second Medical University, Shanghai, China, PHD, Biochemistry and Molecular Biology
1998 Shanghai Teachers University, Shanghai, China, BS, Biology

Postgraduate Training

2004-2009 Research Fellowship, Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, Suyun Huang

Honors and Awards

2003 Young Scientist Award, China Nature and Science Foundation

Professional Memberships

American Association Cancer Research
Member, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Liu X, Guo W, Wu S, Wang L, Wang J, Dai B, Kim ES, Heymach JV, Wang M, Girard L, Minna J, Roth JA, Swisher SG, Fang B. Antitumor activity of a novel STAT3 inhibitor and redox modulator in non-small cell lung cancer cells. Biochem Pharmacol 83(10):1456-64, 5/15/2012. e-Pub 2/22/2012. PMID: 22387047.
2. Dai B, Meng J, Peyton M, Girard L, Bornmann WG, Ji L, Minna JD, Fang B, Roth JA. STAT3 mediates resistance to MEK inhibitor through microRNA miR-17. Cancer Res 71(10):3658-68, 5/15/2011. e-Pub 3/28/2011. PMID: 21444672.
3. Dai B, Pieper RO, Li D, Wei P, Liu M, Woo SY, Aldape KD, Sawaya R, Xie K, Huang S. FoxM1B Regulates NEDD4-1 Expression, Leading to Cellular Transformation and Full Malignant Phenotype in Immortalized Human Astrocytes. Cancer Res 70(7):2951-61, 4/2010. e-Pub 3/2010. PMCID: PMC2848915.
4. Zhang P, Ying L, Xu R, Ge S, Mei W, Li F, Dai B, Lu J, Qian G. Tumor-specific, hypoxia-regulated WWOX expression adenovirus inhibits human non-small cell lung cancer growth in vivo. Hum Gene Ther 21(1):27-39, 1/2010. e-Pub 9/2009. PMID: 19737107.
5. Meng J, Dai B, Fang B, Bekele BN, Bornmann WG, Sun D, Peng Z, Herbst RS, Papadimitrakopoulou V, Minna JD, Peyton M, Roth JA. Combination treatment with MEK and AKT inhibitors is more effective than each drug alone in human non-small cell lung cancer in vitro and in vivo. PLoS One 5(11):e14124, 2010. e-Pub 11/2010. PMCID: PMC2993951.
6. Meng J, Peng H, Dai B, Guo W, Wang L, Ji L, Minna JD, Chresta CM, Smith PD, Fang B, Roth JA. High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol Ther 8(21):2073-80, 11/2009. e-Pub 11/2009. PMCID: PMC2835993.
7. Cai R, Xu W, Dai B, Cai X, Xu R, Lu J. SATB1 binds an intronic MAR sequence in human P13kgamma in vitro. Mol Biol Rep, 5/10/2009. e-Pub 5/10/2009. PMID: 19430959.
8. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res 69(8):3501-3509, 4/2009. e-Pub 4/2009. PMID: 19351851.
9. Zhang Y, Zhang N, Dai B, Liu M, Xie K, Sawaya R, Huang S. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res 68(21):8733-8742, 11/1/2008. PMCID: PMC2597644.
10. Dai B, Kang SH, Gong W, Liu M, Aldape KD, Sawaya R, Huang S. Aberrant FoxM1B expression increases matrix metalloproteinase-2 transcription and enhances the invasion of glioma cells. Oncogene 26(42):6212-6219, 9/2007. e-Pub 4/2007. PMID: 17404569.
11. Li K, Cai R, Dai B, Zhang XQ, Wang HJ, Ge SF, Xu WR, Lu J.. SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Biochem Biophys Res Commun 356(1):6-12, 4/27/2007. e-Pub 2/26/2007. PMID: 17343824.

Invited Articles
1. Dai B, Fang B, Roth JA. RNAi-Induced Synthetic Lethality in Cancer Therapy. Cancer Biol Ther 8(23), 12/2009. e-Pub 12/2009. PMID: 19949302.

Book Chapters
1. Dai B, Chen S. Molecular basis of gastric-colorectal cancer. In: Shanghai International Books Publishing Company. Shanghai International Books Publishing Company: Shanghai, China, 2004.
2. Dai B, Chen S. Oncogene and tumor suppressor gene. In: Med Mol Cell Biol, 2nd. Ed(s) S. Chen. Shanghai Science and Technology Publishing Company: Shanghai, China, 2003.

Last updated: 7/3/2012