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Bo Peng, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Research Interests

 

My research focuses on the evolution of complex human diseases and its applications in genetic epidemiology. I have developed methods and programs to simulate the evolution of complex human diseases with applications in the characterization of allele frequencies of disease susceptibility loci (common disease – common variant hypothesis), and in the mapping of complex diseases influenced by multiple interacting genetic and environmental factors. Using lung cancer as a model disease, I am working on the simulation of large datasets with realistic population and individual properties. These datasets will be used to compare and develop statistical methods in the detection and localization of susceptibility loci of diseases that are strongly influenced by environmental factors.

Education & Training

Degree-Granting Education

2006 Rice University, Houston, TX, PHD, Biostatistics
2001 University of Houston, Houston, TX, MA, Applied Mathematics
1996 Shanghai Jiao Tong University, Shanghai, China, BS, Applied Mathematics

Postgraduate Training

5/2006-5/2008 Research Fellowship, Genetic Epidemiology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, Christopher I. Amos

Experience/Service

Academic Appointments

Instructor in Mathematics and Computer Systems Analyst, Shanghai Jiao Tong University, Shanghai, China, 8/1996-7/1999

Honors and Awards

2006-2009 R25 Postdoctoral Fellowship in Cancer Prevention, National Institutes of Health
2004-2006 Predoctoral W. M. Keck Fellowship, W.M. Keck Foundation
2003 R. L. Anderson Student Paper Award, Research Conference on Statistics, SRCOS/ASA

Selected Publications

Peer-Reviewed Original Research Articles
1. Wu CC, Shete S, Chen WV, Peng B, Lee AT, Ma J, Gregersen PK, Amos CI. Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis. Hum Genet. e-Pub 5/2009. PMID: 19415332.
2. Gu X, Frankowski RF, Rosner GL, Relling M, Peng B, Amos CI. A modified forward multiple regression in high-density genome-wide association studies for complex traits. Genet Epidemiol. e-Pub 4/2009. PMID: 19365845.
3. Peng B, Amos CI. Forward-time simulations of non-random mating populations using simuPOP. Bioinformatics 24(11):1408-9, 6/2008. PMID: 18417488.
4. Peng B, Amos CI, Kimmel M. Forward-time simulations of human populations with complex diseases. PLoS Genet 3(3):e47, 3/2007. PMID: 17381243.
5. Peng B, Kimmel M. Simulations provide support for the common disease-common variant hypothesis. Genetics 175(2):763-76, 2/2007. PMID: 17151262.
6. Peng B, Yu RK, Dehoff KL, Amos CI. Normalizing a large number of quantitative traits using empirical normal quantile transformation. BMC Proc 1 Suppl 1:S156, 2007. PMID: 18466501.
7. Peng B, Kimmel M. simuPOP: a forward-time population genetics simulation environment. Bioinformatics 21(18):3686-7, 9/2005. PMID: 16020469.
8. Gorlova O, Peng B, Yankelevitz D, Henschke C, Kimmel M. Estimating the growth rates of primary lung tumours from samples with missing measurements. Stat Med 24(7):1117-34, 4/2005. PMID: 15568189.
9. Pusztai L, Gregory BW, Baggerly KA, Peng B, Koomen J, Kuerer HM, Esteva FJ, Symmans WF, Wagner P, Hortobagyi GN, Laronga C, Semmes OJ, Wright GL, Drake RR, Vlahou A. Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer 100(9):1814-22, 5/2004. PMID: 15112261.

Book Chapters
1. Amos CI, Peng B, Xu Y. Quantitative trait linkage analysis, computational approaches and software. In: Handbook on analyzing human genetic data. Springer. Submitted.
2. Peng B, Kimmel M. Testing the performance of TDT and Linkage methods using simulated virtual populations with polygenic diseases. In: TBD. Submitted.

Grant & Contract Support

Title: Continued Development and Maintenance of a Forward-Time Population Genetics Simulation Environment simuPOP
Funding Source: NIH/NIGMS
Role: Principal Investigator
Duration: 4/1/2010 - 3/30/2015
 
Title: Statistical Methods for Gene Environmnet Interations in Lung Cancer
Funding Source: NIH/NCI
Role: Postdoctoral Fellow
Principal Investigator: Christopher I Amos
Duration: 9/1/2007 - 8/31/2010
 
Title: Positional Gene Identification of Complex Traits
Funding Source: NIH/NCI
Role: Postdoctoral Fellow
Principal Investigator: Christopher I Amos
Duration: 7/1/2002 - 6/30/2007

Last updated: 8/7/2009