Skip to Content

'
Bo Peng, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

My research can generally be described as the methodology development and implementation of large-scale individual-based population genetics simulations, with applications in statistical genetics, genetic epidemiology and public health genomics. Specific research topics include but are not limited to the software development of a general-purpose forward-time population genetics simulation environment simuPOP, evolution of complex human diseases and applications in the development of statistical gene mapping methods, and population health modeling of cancers.

Research Interests

 

My research focuses on the evolution of complex human diseases and its applications in genetic epidemiology. I have developed methods and programs to simulate the evolution of complex human diseases with applications in the characterization of allele frequencies of disease susceptibility loci (common disease – common variant hypothesis), and in the mapping of complex diseases influenced by multiple interacting genetic and environmental factors. Using lung cancer as a model disease, I am working on the simulation of large datasets with realistic population and individual properties. These datasets will be used to compare and develop statistical methods in the detection and localization of susceptibility loci of diseases that are strongly influenced by environmental factors.

Education & Training

Degree-Granting Education

2006 Rice University, Houston, TX, PHD, Biostatistics
2001 University of Houston, Houston, TX, MA, Applied Mathematics
1996 Shanghai Jiao Tong University, Shanghai, China, BS, Applied Mathematics

Postgraduate Training

5/2006-5/2008 Research Fellowship, Genetic Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, Christopher I. Amos

Experience/Service

Academic Appointments

Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 6/2008-8/2011
Research Assistant, Rice University, Houston, TX, 2003-2006
Teaching Assistant, Rice University, Houston, TX, 2001-2003
Teaching Assistant, University of Houston, Houston, TX, 1999-2001
Instructor in Mathematics and Computer Systems Analyst, Shanghai Jiao Tong University, Shanghai, China, 8/1996-7/1999

Honors and Awards

2011 Richard C. Devereaux Outstanding Young Investigator Award in Lung Cancer Prevention, Prevent Cancer Fundation
2006-2009 R25 Postdoctoral Fellowship in Cancer Prevention, National Institutes of Health
2004-2006 Predoctoral W.M. Keck Fellowship, W.M. Keck Foundation
2003 R.L. Anderson Student Paper Award, Research Conference on Statistics, SRCOS/ASA

Selected Publications

Peer-Reviewed Original Research Articles

1. Peng B, Racine B, Chen H.S., Mechanic L.E., Clarke L, Gillanders E. and Feuer E. Genetic Simulation Resources (GSR): A website for the registra-tion and discovery of genetic data simulators. Bioinformatics. e-Pub 2/2013.
2. Vasemägi A, Nilsson J, McGinnity P, Cross T, O’Reilly P, Glebe B, Peng B, Berg PR, Primmer CR. Screen for footprints of selection during domestication/captive breeding of Atlantic salmon. Comparative and Functional Genomics 2012(628204). e-Pub 12/2012.
3. San Lucas FA, Wang G, Scheet P, Peng B. Integrated annotation and analysis of genetic variants from next-generation sequencing studies with variant tools. Bioinformatics 28(3):421-422, 2/2012. e-Pub 12/2011. PMCID: PMC3268240.
4. Swartz MD, Peng B and Shete S. Using ascertainment with two stage genome wide association studies can save resources. Statistics and Its Interface 4:285-294, 2011.
5. Peng B, Li B, Han Y, Amos CI. Power analysis for case-control association studies of samples with known family histories. Hum Genet 127(6):699-704, 6/2010. e-Pub 4/2010. PMID: 20383776.
6. Peng B, Amos CI. Forward-time simulation of realistic samples for genome-wide association studies. BMC Bioinformatics 11:442, 2010. e-Pub 9/2010. PMCID: PMC2939614.
7. Peng B, Liu X. Simulating Sequences of the Human Genome with Rare Variants. Hum Hered 70(4):287-291, 2010. e-Pub 1/2011. PMCID: PMC3164177.
8. Gu X, Frankowski RF, Rosner GL, Relling M, Peng B, Amos CI. A modified forward multiple regression in high-density genome-wide association studies for complex traits. Genet Epidemiol 33(6):518-25, 9/2009. e-Pub 4/2009. PMCID: PMC2732748.
9. Wu CC, Shete S, Chen WV, Peng B, Lee AT, Ma J, Gregersen PK, Amos CI. Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis. Hum Genet 126(2):303-15, 8/2009. e-Pub 5/2009. PMID: 19415332.
10. Peng B, Amos CI. Forward-time simulations of non-random mating populations using simuPOP. Bioinformatics 24(11):1408-9, 6/2008. e-Pub 4/2008. PMCID: PMC2691961.
11. Peng B, Amos CI, Kimmel M. Forward-time simulations of human populations with complex diseases. PLoS Genet 3(3):e47, 3/2007. e-Pub 2/2007. PMCID: PMC1829403.
12. Peng B, Kimmel M. Simulations provide support for the common disease-common variant hypothesis. Genetics 175(2):763-76, 2/2007. PMCID: PMC1800600.
13. Peng B, Yu RK, Dehoff KL, Amos CI. Normalizing a large number of quantitative traits using empirical normal quantile transformation. BMC Proc 1 Suppl 1:S156, 2007. e-Pub 12/2007. PMCID: PMC2367615.
14. Peng B, Kimmel M. simuPOP: a forward-time population genetics simulation environment. Bioinformatics 21(18):3686-7, 9/2005. PMID: 16020469.
15. Gorlova O, Peng B, Yankelevitz D, Henschke C, Kimmel M. Estimating the growth rates of primary lung tumours from samples with missing measurements. Stat Med 24(7):1117-34, 4/2005. PMID: 15568189.
16. Pusztai L, Gregory BW, Baggerly KA, Peng B, Koomen J, Kuerer HM, Esteva FJ, Symmans WF, Wagner P, Hortobagyi GN, Laronga C, Semmes OJ, Wright GL, Drake RR, Vlahou A. Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma. Cancer 100(9):1814-22, 5/2004. PMID: 15112261.

Invited Articles

1. Peng B. Simulating gene-environment interactions in complex human diseases. Genome Med 2(3):1-4, 2010. e-Pub 3/2010. PMCID: PMC2873799.

Books (edited and written)

1. Peng B, Kimmel M and Amos CI. Forward-time population genetics simulations, methods, implementation and applications. Wiley & Sons, 2011. ISBN: 9780470503485.

Grant & Contract Support

Title: Microsimulation of lung cancer risk, progression, and genetic-guided screening
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 12/1/2011 - 12/1/2013
 
Title: Genetic simulation software registration & discovery system
Funding Source: NIH/NCI
Role: Principal Investigator-MDACC
Principal Investigator: Cornerstone Systems Northwest
Duration: 9/1/2011 - 8/31/2013
 
Title: Utility of individual genetic profile in the prevention of lung cancer
Funding Source: Prevent Cancer Foundation
Role: Principal Investigator
Duration: 7/18/2011 - 7/17/2013
 
Title: Microsimulation of lung cancer risk, progression, and genetic-guided screening
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 1/1/2011 - 12/31/2013
 
Title: Cost effectiveness studies of novel cancer prevention strategies
Funding Source: Duncan Family Institute - Seed Funding Research Grant Program
Role: Principal Investigator
Duration: 9/8/2010 - 9/7/2012
 
Title: Continued development and maintenance of a forward-time population genetics simulation environment simuPOP
Funding Source: NIH/NCRR
Role: Principal Investigator
Duration: 4/1/2010 - 3/31/2015
 
Title: Microsimulation of lung cancer risk, progression, and genetic-guided screening
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2010 - 3/31/2012
 
Title: Microsimulation of lung cancer risk, progression, and genetic-guided screening
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 3/1/2010 - 3/1/2013
 
Title: High density association analysis of lung cancer
Funding Source: NIH
Role: Co-Investigator
Principal Investigator: Christopher I. Amos
Duration: 8/1/2009 - 7/31/2012
 
Title: Continued development and maintenance of a forward-time population genetics simulation environment simuPOP
Funding Source: NIH/NCRR
Role: Principal Investigator
Duration: 7/1/2009 - 6/30/2014
 
Title: Statistical methods for gene environment interactions in lung cancer
Funding Source: NIH/NIAMS
Role: Co-Investigator
Principal Investigator: Christopher I. Amos
Duration: 9/30/2007 - 7/31/2011
 
Title: ARRA: High Density Association Analysis of Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Amos
Duration: 7/1/2007 - 9/29/2011
 
Title: Positional gene identification of complex traits
Funding Source: NIH/NCI
Role: Statistician
Principal Investigator: Christopher I Amos
Duration: 7/1/2002 - 6/30/2007

Last updated: 7/24/2013