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Boris Sepesi, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, UT MD Anderson Cancer Center, Houston, TX

Research Interests

Dr. Sepesi’s research interests focus on therapy outcomes and translational research in esophageal and lung cancers.

Clinical Interests

Dr. Sepesi’s clinical focus is on surgical therapies of thoracic and upper gastro-intestinal malignancies, utilizing the full spectrum of endoscopic, minimally invasive, and traditional surgical approaches based on disease specific indications and multidisciplinary plans. To advance therapeutic results he also focuses on enrolling patients in clinical trials, and on participating in multidisciplinary conferences to establish the most optimal personalized treatment plan for every patient.  

Office Address

The University of Texas MD Anderson Cancer Center
Memorial City Regional Care Center
925 Gessner Rd
Unit Number: 2052
Houston, TX 77024
Room Number: Medical Plaza 4 Suite 450
Phone: 713-358-5300
Fax: 713-358-5329

Education & Training

Degree-Granting Education

2004 Jagiellonian University College of Medicine, Krakow, Poland, MD, Cum Laude, Medicine
1999 University of Colorado, Boulder, CO, BA, Psychology

Postgraduate Training

7/2011-6/2013 Clinical Residency, Cardiothoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2009-6/2011 Clinical Residency, General Surgery, University of Rochester Medical Center, Rochester, NY
7/2008-6/2009 Research Fellowship, Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, NY
7/2005-6/2008 Intern and Resident, General Surgery, University of Rochester Medical Center, Rochester, NY
1/2005-6/2005 Intern, General Surgery, University of Colorado, Denver, CO
7/2004-1/2005 Intern, Internal Medicine, University of Colorado, Denver, CO

Board Certifications

6/2014 American Board of Thoracic Surgery
3/2012 Diplomat, American Board of Surgery

Experience/Service

Other Appointments/Responsibilities

Team Member, UT MD Anderson Cancer Center New Patient Access Strategic Planning Team, Houston, TX, 10/2014-present
Committee Member, UT MD Anderson Cancer Center Division of Surgery Promotion and Tenure Committee, Houston, TX, 9/2014-8/2015
Co-Chair of Membership Committee, International Thymic Malignancy Interest Group, Kisco, NY, 1/2014-present
Member, Graduate Medical Education Committee, University of Rochester Medical Center, Rochester, NY, 7/2009-6/2010
Member, Clinical Council, University of Rochester Medical Center, Rochester, NY, 7/2007-6/2008
Class President, Jagiellonian University College of Medicine, Krakow, Poland, 2004

Institutional Committee Activities

Member, Disease Site Liaison Thoracic Oncology, 4/2015-present

Honors and Awards

2010 Ronald Belsey Esophageal Surgery Club, Cologne, Germany
2008 Stuber Scholarship, University of Rochester Medical Center, Rochester, NY

Professional Memberships

Alliance for Clinical Trials in Oncology, Chicago, IL
Member, 8/2013
American College of Surgeons
Resident Member, 2006-present
European Society of Thoracic Surgeons, United Kingdom
Member, 1/2014
Harris County Medical Society, Houston, TX
Member, 1/2014-present
International Association for the Study of Lung Cancer, Aurora, CO
Member, 1/2014-present
International Thymic Malignancy Interest Group
Member, 1/2014-present
Society of Thoracic Surgeons
Member, 2011-present
SWOG (Southwest Oncology Group), Seattle, WA
Member, 5/2014-present
Texas Medical Association, Houston, TX
Member, 1/2014-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett 357(1):179-85, 2/2015. e-Pub 11/2014. PMCID: PMC4301580.
2. Hellmann MD, Chaft JE, William WN, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG, University of Texas MD Anderson Lung Cancer Collaborative Group (Sepesi B). Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol 15(1):e42-50, 1/2014. PMID: 24384493.
3. Sepesi B, Walsh GL. Surgical Therapy of Ground Glass Opacities. Semin Diagn Pathol 31(4):289-92, 2014. PMID: 25239273.
4. Francis AM, Sepesi B, Correa AM, Blum MA, Erasmus JJ, Lee JH, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Welsh JW, Swisher SG, Hofstetter WL, University of Texas MD Anderson Esophageal Cancer Group. The Influence of Histopathologic Tumor Viability on Long-term Survival and Recurrence Rates Following Neoadjuvant Therapy for Esophageal Adenocarcinoma. Ann Surg 258(3):500-7, 9/2013. PMID: 24022442.
5. Wilshire CL, Salvador R, Sepesi B, Niebisch S, Watson TJ, Litle VR, Peyre CG, Jones CE, Peters JH. Reflux-associated oxygen desaturations: usefulness in diagnosing reflux-related respiratory symptoms. J Gastrointest Surg 17(1):30-8, 1/2013. e-Pub 11/2012. PMID: 23143640.
6. Sepesi B, Swisher SG, Walsh GL, Correa A, Mehran RJ, Rice D, Roth J, Vaporciyan A, Hofstetter WL. Omental reinforcement of the thoracic esophagogastric anastomosis: an analysis of leak and reintervention rates in patients undergoing planned and salvage esophagectomy. J Thorac Cardiovasc Surg 144(5):1146-50, 11/2012. e-Pub 8/2012. PMID: 22939861.
7. Sepesi B, Moalem J, Galka E, Salzman P, Schoeniger LO. The influence of staple size on fistula formation following distal pancreatectomy. J Gastrointest Surg 16(2):267-74, 2/2012. e-Pub 10/2011. PMID: 22015618.
8. Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Watson TJ, Swisher SG, M. D. Anderson Esophageal Cancer Group, University of Rochester School of Medicine and Dentistry Foregut Group. Endoscopic esophageal tumor length: a prognostic factor for patients with esophageal cancer. Cancer 117(1):63-9, 1/2011. e-Pub 8/2010. PMID: 20803613.
9. Dubecz A, Sepesi B, Salvador R, Polomsky M, Watson TJ, Raymond DP, Jones CE, Litle VR, Wisnivesky JP, Peters JH. Surgical resection for locoregional esophageal cancer is underutilized in the United States. J Am Coll Surg 211(6):754-61, 12/2010. e-Pub 10/2010. PMID: 20980174.
10. Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Vaporciyan AA, Watson TJ, Swisher SG, Members of the MD Anderson Esophageal Cancer Group and the University of Rochester School of Medicine and Dentistry Foregut Group. A clinical nomogram predicting pathologic lymph node involvement in esophageal cancer patients. Ann Surg 252(4):611-7, 10/2010. PMID: 20881767.
11. Sepesi B, Raymond DP, Peters JH. Esophageal perforation: surgical, endoscopic and medical management strategies. Curr Opin Gastroenterol 26(4):379-83, 7/2010. PMID: 20473156.
12. Polomsky M, Hu R, Sepesi B, O'Connor M, Qui X, Raymond DP, Litle VR, Jones CE, Watson TJ, Peters JH. A population-based analysis of emergent vs. elective hospital admissions for an intrathoracic stomach. Surg Endosc 24(6):1250-5, 6/2010. e-Pub 12/2009. PMID: 20033732.
13. Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg 210(4):418-27, 4/2010. PMID: 20347733.
14. Polomsky M, Jones CE, Sepesi B, O'Connor M, Matousek A, Hu R, Raymond DP, Litle VR, Watson TJ, Peters JH. Should elective repair of intrathoracic stomach be encouraged? J Gastrointest Surg 14(2):203-10, 2/2010. e-Pub 12/2009. PMID: 19957207.
15. Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the value of PET-CT extend beyond pretreatment staging? An analysis of survival in surgical patients with esophageal cancer. J Gastrointest Surg 13(12):2121-7, 12/2009. e-Pub 10/2009. PMID: 19795177.
16. Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci 22(14):6114-20, 7/2002. PMID: 12122072.

Invited Articles

1. Sepesi B, Peters JH. Current Anti-reflux Surgery. Current GERD Reports. 1(4):233-240, 2007.

Abstracts

1. Antonoff MB, Ragalie W, Correa AM, Spicer JD, Sepesi B, Roth JA, Walsh GL, Hofstetter WlL, Swisher SG, Rice DC, Vaporciyan AA, Mehran RJ. Indications For Counseling And Intervention After Pulmonary Resection: Results Of Post-discharge Nursing Telephone Assessments. Western Thoracic Surgical Association Annual Meeting 2015, 6/2015.
2. Sepesi B, Correa AM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Ajani JA, Walsh GL, Swisher SG, Hofstetter WL. Trends and Improving Outcomes in 882 Surgical Patients with Gastro-Esophageal Junction Adenocarcinoma - A Single Institution Experience. The International Society for Diseases of the Esophagus 2014, Vancouver, Canada (#130), 9/2014.
3. Sepesi B, Hofstetter W, Garrett W, Rice D, Mehran R, Vaporciyan A, Roth J, Swisher S. Experience With Primary and Metastatic Adenoid Cystic Carcinoma. Society of Surgical Society 2014 (#1850237), 3/2014.
4. Francis A, Sepesi B, Correa A, Ajani JA, Blum, Swisher SG, Hofstetter WL. Long-Term Survival and Recurrence Rates Following Trimodality Therapy of Esophageal Adenocarcinoma – The Influence of Histologic Tumor Viability. ASA 2013 Annual Meeting (#15), 4/2013.
5. Francis A, Correa A, Betancourt-Cuellar S, Kim J, Sepesi B, Ajani J, etal. Esophageal Tumor Thickness on Computed Tomography as a Predictor of Residual Tumor in Esophageal Adenocarcinoma Following Preoperative Chemoradiation. Academic Surgical Congress 2014 (#61.12), 2/2013.
6. Sepesi B, Correa A, Pataer A, Kalhor N, Bekele NB, Erasmus JJ, Hofstetter WL; Kim E, Komaki R, Mehran RJ, Moran CA, Papadimitrakopoulou V, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, William W, Wistuba I, Swisher SG. The Impact of Histopathologic Response on Pathologic TNM Lung Cancer Staging System (AJCC 7th) Following Neoadjuvant Chemotherapy. STS 49th Annual Meeting, Los Angeles, CA, 2013.
7. Sepesi B, Swisher SG, Walsh G, Correa A, Mehran R, Rice D, Roth J, Vaporciyan A, Hofstetter WL. Omental Reinforcement of the Thoracic Esophagogastric Anastomosis – An Analysis of Leak and Reintervention Rates in Planned and Salvage Esophagectomy Patients. Proc Am Assoc Thorac Surg (#47), 5/2012.
8. Wilshire CL, Salvador R, Sepesi B, Niebisch S, Watson TJ, Litle VR, Peyre CG, Jones CE, Peters JH. Reflux-Associated Oxygen Desaturations: Reliability in Diagnosing Reflux-Related Respiratory Symptoms. Digestive Disease Weekly, 2012.
9. Sepesi B, Moalem J, Galka E, Salzman P, Schoeniger LO. The Influence of Staple Size on Fistula Formation Following Distal Pancreatectomy. J Gastrointest Surg. 2011.
10. Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg 210(4):418-27, 4/2010.
11. Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Ajani JA, Erasmus J, Komaki R, Lee JH, Maru D, Mehran R, Rice DC, et al. A Clinical Nomogram Predicting Pathologic Lymph Node Involvement in Esophageal Cancer Patients. 130th Annual American Surgical Association 252(4):611-7, 2010.
12. Oppong BA, Choi D, Sepesi B, Skinner K. Re-evaluating Lobular Neoplasia and the Risk of Invasive and Intraductal Breast Cancers. The Breast Journal, 2010.
13. Polomsky M, Jones CE, Sepesi B, O'Connor M, Matousek A, Hu R, Raymond DP, Litle VR, Watson TJ, Peters JH. Should elective repair of intrathoracic stomach be encouraged?. J Gastrointest Surg 14(2):203-10, 2010.
14. Dubecz A, Sepesi B, Salvador R, Polomsky M, Watson TJ, Raymond DP, Jones CE, Litle VR, Wisnivesky JP, Peters JH. Surgical resection of locoregional esophageal cancer is underutilized in the United States. J Am College Surg. 211(6):754-61, 2010.
15. Polomsky M, Hu R, Sepesi B, O'Connor M, Qui X, Raymond DP, Litle VR, Jones CE, Watson TJ, Peters JH. A population-based analysis of emergent vs. elective hospital admissions for an intrathoracic stomach. Surg Endosc. 2009.
16. Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the Value of PET-CT Extend Beyond Pretreatment Staging? An Analysis of Survival in Surgical Patients with Esophageal Cancer. Journal of Gastrointestinal Surgery. 13(12):2121-2127, 2009.

Book Chapters

1. Sepesi B, Peters JH. Esophageal Perforation. In: Clinical Decision Making in Gastroenterology and Hepatology, 2012.
2. Sepesi B, Rice D. Mediastinal Lymphadenectomy. In: Mastery of Cardiothoracic Surgery, 2012.
3. Sepesi B. Surgical Approach: Patient Selection and Clinical Outcome. In: Personalized Management of Lung Cancer, 2012.
4. Sepesi B, Raymond DP, Peters JH. The Management of Esophageal Perforation. In: Shackelford’s Surgery of the Alimentary Tract. 7th, 2012.
5. Sepesi B, Hofstetter WL. VATS In Staging and Diagnosis of Lung Cancer. In: Lung Cancer, 2012.
6. Sepesi B, Peters JH. The Management of Barrett’s Esophagus. In: Current Surgical Therapy, 10th, 2010.

Last updated: 5/14/2015