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Boris Sepesi, MD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Thoracic and Cardiovascular Surgery, Division of Surgery, UT MD Anderson Cancer Center, Houston, TX

Research Interests

Dr. Sepesi’s research interests focus on therapy outcomes and translational research in esophageal and lung cancers.

Clinical Interests

Dr. Sepesi’s clinical focus is on surgical therapies of thoracic and upper gastro-intestinal malignancies, utilizing the full spectrum of endoscopic, minimally invasive, and traditional surgical approaches based on disease specific indications and multidisciplinary plans. To advance therapeutic results he also focuses on enrolling patients in clinical trials, and on participating in multidisciplinary conferences to establish the most optimal personalized treatment plan for every patient.  

Office Address

The University of Texas MD Anderson Cancer Center
Memorial City Regional Care Center
925 Gessner Rd
Unit Number: 2052
Houston, TX 77024
Room Number: Medical Plaza 4 Suite 450
Phone: 713-358-5300
Fax: 713-358-5329

Education & Training

Degree-Granting Education

2004 Jagiellonian University College of Medicine, Krakow, Poland, MD, Cum Laude, Medicine
1999 University of Colorado, Boulder, CO, BA, Psychology

Postgraduate Training

7/2011-6/2013 Clinical Residency, Cardiothoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2009-6/2011 Clinical Residency, General Surgery, University of Rochester Medical Center, Rochester, NY
7/2008-6/2009 Research Fellowship, Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester Medical Center, Rochester, NY
7/2005-6/2008 Intern and Resident, General Surgery, University of Rochester Medical Center, Rochester, NY
1/2005-6/2005 Intern, General Surgery, University of Colorado, Denver, CO
7/2004-1/2005 Intern, Internal Medicine, University of Colorado, Denver, CO

Board Certifications

3/2012 Diplomat, American Board of Surgery

Selected Publications

Peer-Reviewed Original Research Articles

1. Francis AM, Sepesi B, Correa AM, Blum MA, Erasmus JJ, Lee JH, Maru DM, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Welsh JW, Swisher SG, Hofstetter WL, University of Texas MD Anderson Esophageal Cancer Group. The Influence of Histopathologic Tumor Viability on Long-term Survival and Recurrence Rates Following Neoadjuvant Therapy for Esophageal Adenocarcinoma. Ann Surg 258(3):500-7, 9/2013. PMID: 24022442.
2. Wilshire CL, Salvador R, Sepesi B, Niebisch S, Watson TJ, Litle VR, Peyre CG, Jones CE, Peters JH. Reflux-associated oxygen desaturations: usefulness in diagnosing reflux-related respiratory symptoms. J Gastrointest Surg 17(1):30-8, 1/2013. e-Pub 11/2012. PMID: 23143640.
3. Sepesi B, Swisher SG, Walsh GL, Correa A, Mehran RJ, Rice D, Roth J, Vaporciyan A, Hofstetter WL. Omental reinforcement of the thoracic esophagogastric anastomosis: an analysis of leak and reintervention rates in patients undergoing planned and salvage esophagectomy. J Thorac Cardiovasc Surg 144(5):1146-50, 11/2012. e-Pub 8/2012. PMID: 22939861.
4. Sepesi B, Moalem J, Galka E, Salzman P, Schoeniger LO. The influence of staple size on fistula formation following distal pancreatectomy. J Gastrointest Surg 16(2):267-74, 2/2012. e-Pub 10/2011. PMID: 22015618.
5. Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Watson TJ, Swisher SG, M. D. Anderson Esophageal Cancer Group, University of Rochester School of Medicine and Dentistry Foregut Group. Endoscopic esophageal tumor length: a prognostic factor for patients with esophageal cancer. Cancer 117(1):63-9, 1/2011. e-Pub 8/2010. PMID: 20803613.
6. Dubecz A, Sepesi B, Salvador R, Polomsky M, Watson TJ, Raymond DP, Jones CE, Litle VR, Wisnivesky JP, Peters JH. Surgical resection for locoregional esophageal cancer is underutilized in the United States. J Am Coll Surg 211(6):754-61, 12/2010. e-Pub 10/2010. PMID: 20980174.
7. Gaur P, Sepesi B, Hofstetter WL, Correa AM, Bhutani MS, Vaporciyan AA, Watson TJ, Swisher SG, Members of the MD Anderson Esophageal Cancer Group and the University of Rochester School of Medicine and Dentistry Foregut Group. A clinical nomogram predicting pathologic lymph node involvement in esophageal cancer patients. Ann Surg 252(4):611-7, 10/2010. PMID: 20881767.
8. Sepesi B, Raymond DP, Peters JH. Esophageal perforation: surgical, endoscopic and medical management strategies. Curr Opin Gastroenterol 26(4):379-83, 7/2010. PMID: 20473156.
9. Polomsky M, Hu R, Sepesi B, O'Connor M, Qui X, Raymond DP, Litle VR, Jones CE, Watson TJ, Peters JH. A population-based analysis of emergent vs. elective hospital admissions for an intrathoracic stomach. Surg Endosc 24(6):1250-5, 6/2010. e-Pub 12/2009. PMID: 20033732.
10. Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg 210(4):418-27, 4/2010. PMID: 20347733.
11. Polomsky M, Jones CE, Sepesi B, O'Connor M, Matousek A, Hu R, Raymond DP, Litle VR, Watson TJ, Peters JH. Should elective repair of intrathoracic stomach be encouraged? J Gastrointest Surg 14(2):203-10, 2/2010. e-Pub 12/2009. PMID: 19957207.
12. Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the value of PET-CT extend beyond pretreatment staging? An analysis of survival in surgical patients with esophageal cancer. J Gastrointest Surg 13(12):2121-7, 12/2009. e-Pub 10/2009. PMID: 19795177.
13. Gemma C, Mesches MH, Sepesi B, Choo K, Holmes DB, Bickford PC. Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proinflammatory cytokines. J Neurosci 22(14):6114-20, 7/2002. PMID: 12122072.

Book Chapters

1. Sepesi B, Peters JH. Esophageal Perforation. In: Clinical Decision Making in Gastroenterology and Hepatology, 2012.
2. Sepesi B, Rice D. Mediastinal Lymphadenectomy. In: Mastery of Cardiothoracic Surgery, 2012.
3. Sepesi B. Surgical Approach: Patient Selection and Clinical Outcome. In: Personalized Management of Lung Cancer, 2012.
4. Sepesi B, Raymond DP, Peters JH. The Management of Esophageal Perforation. In: Shackelford’s Surgery of the Alimentary Tract. 7th, 2012.
5. Sepesi B, Hofstetter WL. VATS In Staging and Diagnosis of Lung Cancer. In: Lung Cancer, 2012.
6. Sepesi B, Peters JH. The Management of Barrett’s Esophagus. In: Current Surgical Therapy, 10th, 2010.

Last updated: 10/7/2014