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Carlos E. Gonzalez-Lepera, MS, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Nuclear Medicine, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX
Director, Cyclotron Radiochemistry Facility, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Cancer Systems Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1881 East Road
Unit Number: 1903
Houston, TX 77054
Room Number: 3SCR1.3908
Phone: 713-792-7320
Fax: 713-792-2358
Email: cegonzalez1@mdanderson.org

Education & Training

Degree-Granting Education

1983 Instituto Balseiro and Centro Atomico Bariloche, Bariloche, Rio Negro, Argentina, PHD, Physics
1979 Instituto Balseiro and Centro Atomico Bariloche, Bariloche, Rio Negro, Argentina, MS, Physics

Postgraduate Training

10/1983-6/1985 Research Fellowship, Physics, University of Tennessee and Oak Ridge National Laboratory, Oak Ridge, TN, Dr. Ivan Sellin

Experience/Service

Academic Appointments

Professor, Experimental Diagnostic Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, 3/2010-5/2013

Institutional Committee Activities

Member, Center for Advanced Biomedical Imaging Steering Committee, 2012-present
Member, Center for Advanced Biomedical Imaging Research Operations Committee, 2012-present

Professional Memberships

American Physical Society (APS), College Park, MD
Member, 1985-present
Society for Molecular Imaging (SMI), Kerrville, TX
Member, 1998-2010
Society of Nuclear Medicine (SNM), Reston, VA
Member, 1991-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Titt U, Paganetti H, Kerr M, Mawlawi O. Feasibility of proton-activated implantable markers for proton range verification using PET. Phys Med Biol 58(21). e-Pub 10/2013. PMID: 24099853.
2. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Min CH, Zhu X, El Fakhri G, Paganetti H, Mawlawi O. Determination of elemental tissue composition following proton treatment using positron emission tomography. Phys Med Biol 58(11). e-Pub 5/2013. PMID: 23681070.
3. Nishii R, Tong W, Wendt R, Soghomonyan S, Mukhopadhyay U, Balatoni J, Mawlawi O, Bidaut L, Tinkey P, Borne A, Alauddin M, Gonzalez-Lepera C, Yang B, Gelovani JG. Pharmacokinetics, Metabolism, Biodistribution, Radiation Dosimetry, and Toxicology of (18)F-Fluoroacetate ( (18)F-FACE) in Non-human Primates. Mol Imaging Biol 14(2):213-24, 4/2012. e-Pub 3/2011. PMID: 21437735.
4. Pal A, Balatoni JA, Mukhopadhyay U, Ogawa K, Gonzalez-Lepera C, Shavrin A, Volgin A, Tong W, Alauddin MM, Gelovani JG. Radiosynthesis and Initial In Vitro Evaluation of [(18)F]F-PEG (6)-IPQA-A Novel PET Radiotracer for Imaging EGFR Expression-Activity in Lung Carcinomas. Mol Imaging Biol 13(5):853-61, 10/2011. PMID: 20859697.
5. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT. Proc Natl Acad Sci U S A 108(4):1603-8, 1/2011. e-Pub 1/2011. PMCID: PMC3029752.
6. Dotti G, Tian M, Savoldo B, Najjar A, cooper LJN, Jackson J, Smith A, Mawlawi O, Uthanmanthil R, Borne A, Brammer D, Paolilo V, Alauddin M, Gonzalez C, Steiner D, Decker WK, Marini F, Kornblau S, Bollard CM Shapall EJ, Gelovani JG. Repetitive Noninvasive Monitoring of HSV1-tk-Expressing T Cells Intravenously Infused into Nonhuman Primates Using Positron Emission Tomography and Computed Tomography with 18F-FEAU. Molecular Imaging 8:230, 2009.
7. Gonzalez-Lepera C, Dembowski B. Production of [18F]Fluoride with a High-Pressure Disposable [18O] Water Target. Applied Radiation and Isotopes 48:613, 1997.
8. Suehiro M, Greenberg J, Shiue C-Y, Gonzalez C, Dembowski B, Reivich M. Radiosynthesis and Biodistribution of the S-[18F]fluoroethyl Analog of McN5652. Nuclear Medicine and Biology 23:407, 1996.
9. Gonzalez-Lepera C. Positron Sources Produced with a Medical Cyclotron: Advantages and Some Applications. Nuclear Instruments and Methods in Physics Research B 99:824, 1995.
10. Gibbons JP, Elston SB, DeSerio R, Breinig M., Biedermann C, Gonzalez Lepera CE, Heil O, Hulskotter HP, Rothard H. Production and Transport of Convoy Electrons in Amorphous Carbon Foils. Nuclear Instruments and Methods in Physics Research B 40:53, 1989.
11. DeSerio R, Gonzalez-Lepera C, Gibbons JP, Burgdörfer J, Sellin IA. Measurements of the hydrogen 2s-2p coherence using the quantum-beat technique. Phys Rev A 37(11):4111-4117, 6/1988. PMID: 9899534.
12. Engar P, Breinig M, DeSerio R, Gonzalez Lepera CE, Sellin IA. Quantitative determination of the fraction of Rydberg electrons in a convoy-electron cusp. Phys Rev A 33(3):2096-2098, 3/1986. PMID: 9896859.
13. Hulskotter HP, Breinig M, Burgdorfer J, DeSerio R, Elston SB, Gonzalez Lepera CE, Kelbch C, Schmidt Bocking H, Sellin IA, Yamazaki Y. Exit Charge-state Dependence of Convoy-election Production in Heavy-ion-Solid Collisions. A Physical Review Rapid Communications 33:2156, 1986.
14. Berry SD, Elston SB, Sellin IA, Breinig M, DeSerio R, Gonzalez Lepera CE, Liljeby L. Observation of High-order Electric Multipoles in Convoy Electron Angular Distributions. Journal of Physics B: Atomic and Molecular Physics 19:L149, 1986.
15. Elston SB, Berry SD, Burgdörfer J, Sellin IA, Breinig M, DeSerio R, Gonzalez Lepera CE, Liljeby L, Groeneveld K, Hofmann D, Koschar P, Nemirovsky IB. Observation of quadruple and hexadecapole moments of the electronic charge cloud produced in electron-loss collisions. Phys Rev Lett 55(21):2281-2284, 11/1985. PMID: 10032100.
16. Focke P, Nemirovsky IB, Gonzalez Lepera E, Meckbach W, Sellin IA, Groeneveld KO. Beam-Foil Convoy Electron Distributions as a Function of Energy and Angle of Emission. Nuclear Instruments and Methods B2:235, 1984.
17. Meckbach W, Vidal R, Focke P, Nemirovsky IB, Gonzalez Lepera E. Double-Differential Distributions Produced by Collisional Electron Loss into the Continuum for the Ho-He System. Physical Review Letters 52:621, 1984.
18. Gonzalez Lepera C.E., Ponce, V.H. Doubly Differential Cross Section for Electron Capture to the Continuum with Molecular Projectiles. Lecture Notes in Physics 213:28, 1984.
19. Elston SB, Berry SD, Breinig M, DeSerio R, Gonzalez Lepera CE, Sellin IA, Groeneveld KO, Hofmann D, Koschar P, Nemirovsky IB, Liljeby LI. Doubly Differential Emission Distributions for Electron Loss to the Continuum from Fast Heavy Projectiles in Gas Targets. Lecture Notes in Physics 213:75, 1984.
20. Ponce VH, Gonzalez Lepera E, Meckbach W, Nemirovsky IB. Molecular Effects in Beam-Foil Electron Transfer to the Continuum. Physical Review Letters 47:572, 1981.

Abstracts

1. Cho J, Ibbott G, Gillin M, Gonzalez-Lepera C, Mawlawi O. TU-A-BRA-03: Obtaining Elemental Tissue Composition of Proton Therapy Patients Using Positron Emission Tomography: A Pilot Study. Med Phys 39(6):3888, 6/2012. PMID: 22756958.
2. Balatoni J, Mukhapadhyay U, Gonzalez-Lepera C, Pal A, Alauddin M, Gelovani JG. Fully Automated Synthesis of [18F]F-PEG6-IPQA, a Novel PET Imaging Agent for Imaging Active Mutant EGFR Expression Using Two Radiosynthesis Modules in Tandem. World Molecular Imaging Congress, Kyoto, Japan, September 2010, 9/2010.
3. Balatoni J, Mukhopadhyay U, Pal A, Ogawa K Gonzalez Lepera C, Tong W, Alauddin M. Gelovani JG. A Novel Radiotracer, [18F]F-PEG6-IPQA, for Imaging the Expression of Active-Mutant EGFR in Tumors: Synthesis and In Vitro Evaluation in Lung Carcinoma Cells Lines. World Molecular Imaging Congress, Nice, France, September 2008, 9/2008.
4. Tian M, Brammer D, Borne A, Uthamanthil R, Nishii R, Mawlawi O, Soghomonyan S, Yang D, Jackson J, Yoas K, Gonzalez Lepera C, Tong W, Gelovani JG. PET/CT with [18F]-Fluoroacetate and [18F] FDG, Serum and Tumor Tissue Biomarkers in Rhesus Macaques with Colon Carcinomas. World Molecular Imaging Congress, Nice, France, September 2008, 9/2008.
5. Tian M, Ogawa K, Yeh HH, Balatoni J, Mukhopadhyay U, Pal A, Jackson J, Mawlawi O, Wendt R, Uthamanthil R, Borne A, Brammer D, Gonzalez Lepera C, Alauddin M, Gelovani JG,. Pharmacokinetics, Biodistribution, Metabolism and Radiation Dosimetry of [18F]F-PEG6-IPQA in Non-Human Primates: A Pre-IND Study. World Molecular Imaging Congress, Nice, France, September 2008, 9/2008.
6. Strangis SR, Gonzalez Lepera C. Production of 61Cu by Deuteron Irradiation on Natural Ni. 18th International Conference on Cyclotrons and Their Applications, Catania, Italy, 9/2007.
7. Strangis SR, Gonzalez Lepera C. Reliable Fluorine-18[18F] Production at High Beam Power. 18th International Conference on Cyclotrons and Their Applications, Catania, Italy, 9/2007.
8. Nishii R, Mushkudiani I, Lim S, Tinkey P, Borne A, Mawlawi O, Wendt R, Alauddin M, Gonzalez C, Tong W, Gelovani J. Biodistribution and Radiation Dosimetry of [18F]-Fluoroacetate in Non-human Primates. The Society of Molecular Imaging August 2006 Annual Meeting, 8/2006.
9. Tong W, Gelovani J, Gonzalez Lepera C. A Simple Automated Radiosynthesis of [18F]Fluoroacetate. The Society for Molecular Imaging August 2006 Annual Meeting, 2006.
10. Gonzalez Lepera C, Jerabek P. Wired Front Foils, a High-Transmission Alternative to Grid Supported Targets for the Production of 18F. 17th International Conference on Applications of Accelerators in Research and Industry, Denton, TX, 11/2002.
11. Clark TW, Gonzalez Lepera C, Haskal ZJ, Chakraborty DP. Producing Radioactive Stents in a Cyclotron: Proton Bombardment of Wallstent and Memotherm Stents. Proceedings Radiological Society of North America December 1998 Meeting, 12/1998.
12. Gonzalez C, Clark TWI, White H, Haskal Z. Cyclotron Activation of Commercially-available Stents Using Proton Beam Irradiation. Proceedings 23rd Annual Meeting Soiety of Cardiovascular & Interventional Radiology, San Francisco, CA, JVIR Supplement 9, 195, 1998.
13. Gonzalez-Lepera C. New O18 Water Target at Penn. Proceedings VIth Workshop on Targetry and Target Chemistry, Vancouver, Canada, 1995.
14. Suehiro M, Greenberg J, Gonzalez-Lepera C, Shiue C-Y, Dembowski B, Shiue GG, Reivich M. Radiosynthesis and Biodistribution of the S-[18F]fluoroethyl Analog of McN5652. Proceedings 42nd Annual Meeting Society of Nuclear Medicine, Minneapolis MN, Journal of Nuclear Medicine 36:151, 1995.
15. Suehiro M, Shiue C-Y, Gonzalez-Lepera C, Dembowski B. Synthesis of [11C] Methanethiol, a Precursor for S-[11C] Methylations. Proceedings XIth International Symposium on Radiopharmaceutical Chemistry, Vancouver, Canada, 1995.
16. Dembowski B, Gonzalez-Lepera C. Control of Radioactive Material Pneumatic Transport System Using and Inexpensive Programmable Logic Controller. Proceedings Fifth International Workshop on Tagetry and Target Chemistry, Brookhaven National Laboratory, Upton NY, 9/1993.
17. Gonzalez-Lepera C, Dembowski B, Staub J. Experiences with a New High-Pressure Water Target for the Production of [13N] Ammonia. Proceedings Fifth International Workshop on Tagetry and Target Chemistry, Brookhaven National Laboratory, Upton, NY, 9/1993.
18. Gonzalez-Lepera C. Production of Long-lived Radioisotopes and its Application to Calibration Sources for PET Cameras. Proceedings Fifth International Workshop on Targetry and Target Chemistry, Brookhaven National Laboratory, Upton, NY, 9/1993.
19. Gonzalez-Lepera C. Status of the Cyclotron Facility at PENN. Proceedings IV International Workshop on Targetry and Target Chemistry, Paul Scherrer Institut, Villigen, Switzerland, 9/1993.
20. Elston SB, Gibbons JP, Gonzalez Lepera CE, DeSerio R, Breinig M, Heil O, Hulskotter HP, Rothard H, Selling IA, Vane CR. Production and Transport of Convoy Electrons in Amorphous Carbon Foils. Proceedings Tenth Conference on the Application of Accelerators in Research and Industry, Denton, TX, 11/1988.
21. Gonzalez Lepera CE, Breinig M, Cederquist H, DeSerio R, Elston SB, Sellin IA. Backward Scattering of Recoil Ions Produced in Swift Ion-Atom Collisions. Proceedings American Physical Society Meeting, Division of Atomic Molecular and Optical Physics, Boston MA, 1987.
22. Elston SB, Gonzalez Lepera CE, Gibbons JP, Breinig M, DeSerio R, Heil O, Hulskotter HP, Sellin IA, Vane CR. Doubly Differential Convoy Electron Emission Distributions in High Velocity Ion-Solid Collisions: Target Thickness Dependence. Proceedings XV International Conference on the Physics of Electronic and Atomic Collisions, Brighton, England, 1987.
23. Gonzalez Lepera CE, Breinig M, Cederquist H, DeSerio R, Elston SB, Gibbons JP, Hulskotter HP, Liljeby L, Vane CR, Sellin IA. Forward and Backward Scattering of Recoil Ions Produced in Swift Ion-Atom Collisions. Proceedings XV International Conference on the Physics of Electronic and Atomic Collisions, Brighton, england, 1987.
24. Elston SB, Gonzalez Lepera CE, Gibbons JP, Breinig M, DeSerio R, Heil O, Hulskotter HP, Sellin IA, Vane CR. Target Thickness Dependence of Doubly Differential Convoy Electron Emission Velocity Distributions. Proceedings American Physical Society Meeting Division of Atomic Molecular and Optical Physics, Boston, MA, 1987.
25. Hulskotter HP, Breinig M, Burgdorfer J, DeSerio R, Elston SB, Gonzalez Lepera CE, Kelbch C, Schmidt Bocking H, Sellin IA, Yamazaki Y. Emergent Charge-state Dependence of Convoy-electron Production in. Proceedings American Physical Society, Division of Electron and Atomic Physics, 6/1986.
26. Berry SD, Elston SB, Sellin IA, Breinig M, DeSerio R, Gonzalez Lepera CE, Liljeby L. High-order Electric Multipoles in Convoy Electron Angular Distributions. Proceedings American Physical Society, Division of Electron and Atomic Physics, 6/1986.
27. Engar P, Breinig M, DeSerio R, Gonzalez Lepera CE, Sellin IA. Rydberg State and Convoy Electron Productin by Fast Oxygen Ions in Foil Targets. Proceedings Eighth Conference on the Application of Accelerators in Research and Industry, Denton, TX, 11/1984.
28. Elston SB, Berry SD, Breining M, DeSerio R, Gonzalez Lepera CE, Sellin IA, Groeneveld KO, Hofmann D, Koschar P, Nemirovsky IB, Liljeby LI. Doubly Differential Emission Distributions for Electron Loss to the Continuum from Fast Heavy Projectiles in Gas Targets. Proceedings Symposium on Forward Electron Ejection in Ion Collisions, University of Aarhus, Denmark, 6/1984.
29. Gonzalez Lepera E, Focke P, Nemirovsky IB, Meckbach W, Sellin IA, Groenveld KO. Beam Foil Convoy Electron Distribution as a Function of Energy and Angle of Emission. Proceedings American Physical Society, Division of Electron and Atomic Physics, Storrs, CT, 5/1984.
30. Vidal R, Meckbach W, Focke P, Nemirovsky IB, Gonzalez Lepera E. A Comparison of Electron Capture and Electron Loss into the Continuum with H+ and Ho Projectiles Interacting with He. Proceedings XIII International Conference on the Physics of Electronic and Atomic Collisions Berlin, Germany, 7/1983.
31. Meckbach W, Vidal R, Focke P, Nemirovsky IB, Gonzalez Lepera E. Beam Foil Electron Distributions as a Function of Energy and Angle of Emission. Proceedings 10th International Conference Atomic Collisions in Solids, Bad Iburg, Germany, 7/1983.
32. Gonzalez Lepera E, Focke P, Nemirovsky IB, Meckbach W, Sellin IA, Groeneveld KO. Beam Foil Electron Transfer to the Continuum with Molecular Dissociatin Fragments. Proceedings 10th International Conference Atomic Collisions in Solids, Bad Iburg, Germany, 7/1983.
33. Meckbach W, Vidal R, Focke P, Nemirovsky IB, Gonzalez Lepera E. Collisional Electron Loss into the Continuum of Protons Using the Ho-He System: A Comparison with Theory. Proceedings XIII International Conference on the Physics of Electronic and Atomic Collisions Berlin Germany, 7/1983.
34. Gonzalez-Lepera CE, Meckbach W, Nemirovsky IB. Cross Section in First Order Born Approximation for Electron Capture to the Continuum with Molecular Projectiles. Proceedings Reunion Nacional de Fisica, La Plata, Argentina, 12/1982.
35. Gonzalez-Lepera DC, Meckbach W, Nemirovsky IB. Electron Capture to the Continuum for H+ and H2+ Incident on Thin Carbon Foils at Energies between 50 and 150 KeV/amu. Proceedings Reunion Nacional de Fisica, Bariloche, Agrentina, 12/1980.

Book Chapters

1. Carlos E. Gonzalez-Lepera. Part 1 Basic Principles - 2 Production of Radioisotopes. In: Clinical PET: Principles and Applications. Ed(s) E. Edmund Kim, et al. Springer-Verlag New York: New York, 2004.

Grant & Contract Support

Title: Labeling, Quality Control and Method Validation of the Novel Radiotracer 111In-FF21101
Funding Source: Boston Strategics
Role: Principal Investigator
Duration: 1/1/2014 - 12/31/2014
 
Title: Labeling, Quality Control and Method Validation of the Novel Immunotherapeutic Drug 90Y FF21101
Funding Source: Boston Strategics
Role: Principal Investigator
Duration: 1/1/2014 - 12/31/2014

Last updated: 1/6/2014