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Chang-Gong Liu, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX
Director, Sequencing & Non-coding RNA Program, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1995 University of Vienna, Vienna, Austria, PHD, Biochemistry-Molecular and Cellular Biology
1989 Shandong University, Jinan, Shandong, China, MS, Developmental Biology
1982 Shandong University, Jinan, Shandong, China, BS, Embryological Biology

Postgraduate Training

5/1998-3/1999 Postdoctoral Associate, Human Cancer Research in Laboratory for Cancer Research, Rutgers University, College of Pharmacy, Piscataway, NJ
11/1995-5/1998 Postdoctoral Associate, Human Neuronal Genetic Disease Studies, Robert Wood Johnson Medical School, Center for Advanced Biotechnology and Medicine, Piscataway, NJ


Academic Appointments

Associate Professor, Ohio State University, Columbus, OH, 11/2004-5/2008
Assistant Professor, Microbiology/Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 7/2002-10/2004
Research Assistant, Biochemistry and Molecular Cell Biology, Human Genetic Disease Studies, University of Vienna, Vienna BioCenter, Vienna, Austria, 7/1991-9/1995
Research Associate/Lecturer, Biology, Shandong University, Jinan, Shandong, China, 7/1982-6/1991

Administrative Appointments/Responsibilities

Director, Microarray Shared Resource, Comprehensive Cancer Center, Ohio State University, Columbus, OH, 11/2004-5/2008
Director, Microarray Core Facility, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 7/2002-10/2004

Other Appointments/Responsibilities

Projects Leader/Senior Scientist, Motorola Life Sciences, Advanced Technologies for SNP and Expression, Northbrook, IL, 1/2002-7/2002
Senior Scientist/Project Leader, Motorola Life Sciences, SNP Genotyping, Northbrook, IL, 8/2000-8/2002
Senior Scientist, Motorola Biochip Systems, Gene Expression Profiling, Northbrook, IL, 4/1999-7/2000

Honors and Awards

2014-present Highly-Cited Researchers, Thomson Reuters
2000-present Guest Professorship, Shandong University
1992-1995 Pre-Doctoral Fellowship, Austria National Science Foundation

Selected Publications

Peer-Reviewed Original Research Articles

1. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett 356(2 Pt B):404-9, 1/28/2015. e-Pub 10/7/2014. PMID: 25304377.
2. Chang HR, Nam S, Kook MC, Kim KT, Liu X, Yao H, Jung HR, Lemos R, Seo HH, Park HS, Gim Y, Hong D, Huh I, Kim YW, Tan D, Liu CG, Powis G, Park T, Liang H, Kim YH. HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer. Gut. e-Pub 11/19/2014. PMCID: PMCN/A.
3. Francis H, McDaniel K, Han Y, Liu X, Kennedy L, Yang F, McCarra J, Zhou T, Glaser S, Venter J, Huang L, Levine P, Lai JM, Liu CG, Alpini G, Meng F. Regulation of the extrinsic apoptotic pathway by microRNA-21 in alcoholic liver injury. J Biol Chem 289(40):27526-39, 10/3/2014. e-Pub 8/12/2014. PMCID: PMC4183793.
4. Zhang L, Ren X, Cheng Y, Liu X, Allen JE, Zhang Y, Yuan Y, Huang SY, Yang W, Berg A, Webb BS, Connor J, Liu CG, Lu Z, El-Deiry WS, Yang JM. The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype. Cancer Biol Ther 15(5). e-Pub 2/20/2014. PMCID: PMC4026083.
5. Drusco A, Nuovo GJ, Zanesi N, Di Leva G, Pichiorri F, Volinia S, Fernandez C, Antenucci A, Costinean S, Bottoni A, Rosito IA, Liu CG, Burch A, Acunzo M, Pekarsky Y, Alder H, Ciardi A, Croce CM. MicroRNA profiles discriminate among colon cancer metastasis. PLoS One 9(6):e96670, 2014. e-Pub 6/12/2014. PMCID: PMC4055753.
6. Zhang Y, Yang WQ, Zhu H, Qian YY, Zhou L, Ren YJ, Ren XC, Zhang L, Liu XP, Liu CG, Ming ZJ, Li B, Chen B, Wang JR, Liu YB, Yang JM. Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. Biochem Pharmacol 87(4). e-Pub 12/2013. PMCID: PMC3926201.
7. Xue X, Cao AT, Cao X, Yao S, Carlson ED, Soong L, Liu CG, Liu X, Liu Z, Duck LW, Elson CO, Cong Y. Downregulation of MicroRNA-107 in intestinal CD11c,(+) myeloid cells in response to microbiota and proinflammatory cytokines increases IL-23p19 expression. Eur J Immunol 44(3). e-Pub 11/2013. PMCID: PMC3959497.
8. Adam L, Wszolek MF, Liu CG, Jing W, Diao L, Zien A, Zhang JD, Jackson D, Dinney CP. Plasma microRNA profiles for bladder cancer detection. Urol Oncol 31(8):1701-8, 11/2013. e-Pub 8/3/2012. PMCID: PMCN/A.
9. Li J, Geng S, Liu X, Liu H, Jin H, Liu CG, Wang B. DNA and protein co-administration induces tolerogenic dendritic cells through DC-SIGN mediated negative signals. Hum Vaccin Immunother 9(10):2237-45, 10/1/2013. e-Pub 6/4/2013. PMCID: PMC3906410.
10. Zhang P, Garnett J, Creighton CJ, Sannaa GA, Igram DR, Lazar A, Liu X, Liu C, Pollock RE. EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis. J Pathol 232(3). e-Pub 10/2013. PMCID: PMC4166508.
11. Zhang L, Ren X, Cheng Y, Huber-Keener K, Liu X, Zhang Y, Yuan YS, Yang JW, Liu CG, Yang JM. Identification of Sirtuin 3, a mitochondrial protein deacetylase, as a new contributor to tamoxifen resistance in breast cancer cells. Biochem Pharmacol 86(6):726-33, 9/15/2013. e-Pub 7/12/2013. PMCID: PMCN/A.
12. Gupta MK, Halley C, Duan ZH, Lappe J, Viterna J, Jana S, Augoff K, Mohan ML, Vasudevan NT, Na J, Sossey-Alaoui K, Liu X, Liu CG, Tang WH, Naga Prasad SV. miRNA-548c: a specific signature in circulating PBMCs from dilated cardiomyopathy patients. J Mol Cell Cardiol 62:131-41, 9/2013. e-Pub 6/2/2013. PMCID: PMC3735826.
13. Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497(7449):383-7, 5/16/2013. e-Pub 5/1/2013. PMCID: PMC3717558.
14. ia Wang, Eagle SH Chu, Xiaoxing Li, Lixia Xu, Joseph JY Sung, Jun Yu, Liu CG, Et al. Inhibits hepatocellular carcinoma metastases in vitro and in mice. Gastroenterology 0016(5085):144, 5/2013.
15. Parker BC, Annala MJ, Cogdell DE, Granberg KJ, Sun Y, Ji P, Li X, Gumin J, Zheng H, Hu L, Yli-Harja O, Haapasalo H, Visakorpi T, Liu X, Liu CG, Sawaya R, Fuller GN, Chen K, Lang FF, Nykter M, Zhang W. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J Clin Invest 123(2):855-65, 2/1/2013. e-Pub 1/9/2013. PMCID: PMC3561838.
16. Moore LM, Kivinen V, Liu Y, Annala M, Cogdell D, Liu X, Liu CG, Sawaya R, Yli-Harja O, Shmulevich I, Fuller GN, Zhang W, Nykter M. Transcriptome and small RNA deep sequencing reveals deregulation of miRNA biogenesis in human glioma. J Pathol 229(3):449-59, 2/2013. PMCID: PMC3857031.
17. Hudson RS, Yi M, Volfovsky N, Prueitt RL, Esposito D, Volinia S, Liu CG, Schetter AJ, Van Roosbroeck K, Stephens RM, Calin GA, Croce CM, Ambs S. Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer 12:13, 2013. e-Pub 2/14/2013. PMCID: PMC3626580.
18. Liang H, Cheung LW, Li J, Ju Z, Yu S, Stemke-Hale K, Dogruluk T, Lu Y, Liu X, Gu C, Guo W, Scherer SE, Carter H, Westin SN, Dyer MD, Verhaak RG, Zhang F, Karchin R, Liu CG, Lu KH, Broaddus RR, Scott KL, Hennessy BT, Mills GB. Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer. Genome Res 22(11):2120-9, 11/2012. e-Pub 10/1/2012. PMCID: PMC3483541.
19. Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G. Epigenetic Regulation of miR-34a Expression in Alcoholic Liver Injury. Am J Pathol 181(3):804-17, 9/2012. e-Pub 7/25/2012. PMCID: PMC3432440.
20. Kim YH, Liang H, Liu X, Lee JS, Cho JY, Cheong JH, Kim H, Li M, Downey TJ, Dyer MD, Sun Y, Sun J, Beasley EM, Chung HC, Noh SH, Weinstein JN, Liu CG, Powis G. AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer. Cancer Res 72(10):2512-21, 5/15/2012. e-Pub 3/20/2012. PMCID: PMC3872998.
21. Meng F, Glaser SS, Francis H, DeMorrow S, Han Y, Passarini JD, Stokes A, Cleary JP, Liu X, Venter J, Kumar P, Priester S, Hubble L, Staloch D, Sharma J, Liu CG, Alpini G. Functional Analysis of microRNAs in Human Hepatocellular Cancer Stem Cells. J Cell Mol Med 16(1):160-173, 1/2012. e-Pub 2/2011. PMCID: PMC3116063.
22. Huber-Keener KJ, Liu X, Wang Z, Wang Y, Freeman W, Wu S, Planas-Silva MD, Ren X, Cheng Y, Zhang Y, Vrana K, Liu CG, Yang JM, Wu R. Differential Gene Expression in Tamoxifen-Resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data. PLoS One 7(7):e41333, 2012. e-Pub 7/23/2012. PMCID: PMC3402532.
23. Katoh H, Qin ZS, Liu R, Wang L, Li W, Li X, Wu L, Du Z, Lyons R, Liu CG, Liu X, Dou Y, Zheng P, Liu Y. FOXP3 Orchestrates H4K16 Acetylation and H3K4 Trimethylation for Activation of Multiple Genes by Recruiting MOF and Causing Displacement of PLU-1. Mol Cell 9(44):770-84, 12/9/2011. PMCID: PMC3243051.
24. Xue X, Feng T, Yao S, Wolf KJ, Liu CG, Liu X, Elson CO, Cong Y. Microbiota Downregulates Dendritic Cell Expression of miR-10a, Which Targets IL-12/IL-23p40. J Immunol 187(11):5879-86, 12/1/2011. e-Pub 11/7/2011. PMCID: PMC3226774.
25. Lenze D, Leoncini L, Hummel M, Volinia S, Liu CG, Amato T, De Falco G, Githanga J, Horn H, Nyagol J, Ott G, Palatini J, Pfreundschuh M, Rogena E, Rosenwald A, Siebert R, Croce CM, Stein H. The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia 25(12):1869-76, 12/2011. e-Pub 6/24/2011. PMCID: PMC3902789.
26. Gocek E, Wang X, Liu X, Liu CG, Studzinski GP. MicroRNA-32 upregulation by 1,25-dihydroxyvitamin D3 in human myeloid leukemia cells leads to Bim targeting and inhibition of AraC-induced apoptosis. Cancer Res 71(19):6230-9, 10/1/2011. e-Pub 8/4/2011. PMCID: PMCN/A.
27. Kim T, Veronese A, Pichiorri F, Lee TJ, Jeon YJ, Volinia S, Pineau P, Marchio A, Palatini J, Suh SS, Alder H, Liu CG, Dejean A, Croce CM. p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2. J Exp Med 208(5):875-83, 5/9/2011. e-Pub 4/25/2011. PMCID: PMC3092351.
28. Sokol L, Caceres G, Volinia S, Alder H, Nuovo GJ, Liu CG, McGraw K, Clark JA, Sigua CA, Chen DT, Moscinski L, Croce CM, List AF. Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes. Br J Haematol 153(1):24-32, 4/2011. e-Pub 2/21/2011. PMCID: PMCN/A.
29. Tili E, Michaille JJ, Liu CG, Alder H, Taccioli C, Volinia S, Calin GA, Croce CM. GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials. Nucleic Acids Res 38(21):7673-88, 11/2010. e-Pub 7/17/2010. PMCID: PMC2995059.
30. Thompson LH, Whiston RA, Rakhimov Y, Taccioli C, Liu CG, Croce C, Metcalfe SM. A LIF/Nanog axis is revealed in T lymphocytes that lack MARCH-7, a RINGv E3 ligase that regulates the LIF-receptor. Cell Cycle 9(20):4213-21, 10/15/2010. e-Pub 10/4/2010. PMCID: PMC3055204.
31. Urdinguio RG, Fernandez AF, Lopez-Nieva P, Rossi S, Huertas D, Kulis M, Liu CG, Croce CM, Calin GA, Esteller M. Disrupted microRNA expression caused by Mecp2 loss in a mouse model of Rett syndrome. Epigenetics 5(7):656-63, 10/1/2010. e-Pub 10/1/2010. PMCID: PMC3052849.
32. Cohn DE, Fabbri M, Valeri N, Alder H, Ivanov I, Liu CG, Croce CM, Resnick KE. Comprehensive miRNA profiling of surgically staged endometrial cancer. Am J Obstet Gynecol 202(6):1-8, 6/2010. e-Pub 4/18/2010. PMID: 20400061.
33. Liu JQ, Joshi PS, Wang C, El-Omrani HY, Xiao Y, Liu X, Hagan JP, Liu CG, Wu LC, Bai XF. Targeting activation-induced cytidine deaminase overcomes tumor evasion of immunotherapy by CTLs. J Immunol 184(10):5435-43, 5/15/2010. e-Pub 4/19/2010. PMCID: PMC2874093.
34. Volinia S, Galasso M, Costinean S, Tagliavini L, Gamberoni G, Drusco A, Marchesini J, Mascellani N, Sana ME, Abu Jarour R, Desponts C, Teitell M, Baffa R, Aqeilan R, Iorio MV, Taccioli C, Garzon R, Di Leva G, Fabbri M, Catozzi M, Previati M, Ambs S, Palumbo T, Garofalo M, Veronese A, Bottoni A, Gasparini P, Harris CC, Visone R, Pekarsky Y, de la Chapelle A, Bloomston M, Dillhoff M, Rassenti LZ, Kipps TJ, Huebner K, Pichiorri F, Lenze D, Cairo S, Buendia MA, Pineau P, Dejean A, Zanesi N, Rossi S, Calin GA, Liu CG, Palatini J, Negrini M, Vecchione A, Rosenberg A, Croce CM. Reprogramming of miRNA networks in cancer and leukemia. Genome Res 20(5):589-99, 5/2010. PMCID: PMC2860161.
35. Ueda T, Volinia S, Okumura H, Shimizu M, Taccioli C, Rossi S, Alder H, Liu CG, Oue N, Yasui W, Yoshida K, Sasaki H, Nomura S, Seto Y, Kaminishi M, Calin GA, Croce CM. Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis. Lancet Oncol 11(2):136-146, 2/2010. e-Pub 12/18/2009. PMID: 20022810.
36. Felli N, Cianetti L, Pelosi E, Carè A, Liu CG, Calin GA, Rossi S, Peschle C, Marziali G, Giuliani A. Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states. BMC Syst Biol 4(85):85, 2010. e-Pub 6/16/2010. PMCID: PMC2904736.
37. Munker R, Liu CG, Taccioli C, Alder H, Heerema N. MicroRNA profiles of drug-resistant myeloma cell lines. Acta Haematol 123(4):201-204, 2010. e-Pub 3/31/2010. PMCID: PMC2881892.
38. Wang X, Zhao Q, Matta R, Meng X, Liu X, Liu CG, Nelin LD, Liu Y. Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. J Biol Chem 284(40):27123-34, 10/2/2009. e-Pub 8/3/2009. PMCID: PMC2785641.
39. Mathé EA, Nguyen GH, Bowman ED, Zhao Y, Budhu A, Schetter AJ, Braun R, Reimers M, Kumamoto K, Hughes D, Altorki NK, Casson AG, Liu CG, Wang XW, Yanaihara N, Hagiwara N, Dannenberg AJ, Miyashita M, Croce CM, Harris CC. MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus: associations with survival. Clin Cancer Res 15(19):6192-200, 10/1/2009. e-Pub 9/29/2009. PMCID: PMC2933109.
40. Naga Prasad SV, Duan ZH, Gupta MK, Surampudi VS, Volinia S, Calin GA, Liu CG, Kotwal A, Moravec CS, Starling RC, Perez DM, Sen S, Wu Q, Plow EF, Croce CM, Karnik S. Unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks. J Biol Chem 284(40):27487-99, 10/2/2009. e-Pub 7/29/2009. PMCID: PMC2785678.
41. Baffa R, Fassan M, Volinia S, O'Hara B, Liu CG, Palazzo JP, Gardiman M, Rugge M, Gomella LG, Croce CM, Rosenberg A. MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 219(2):214-21, 10/2009. PMID: 19593777.
42. Zhu H, Wu H, Liu X, Li B, Chen Y, Ren X, Liu CG, Yang JM. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. Autophagy 5(5):816-23, 8/2009. e-Pub 8/20/2009. PMID: 19535919.
43. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood 113(22):5568-74, 5/28/2009. e-Pub 3/31/2009. PMCID: PMC2689054.
44. Yu J, Ershler M, Yu L, Wei M, Hackanson B, Yokohama A, Mitsui T, Liu C, Mao H, Liu S, Liu Z, Trotta R, Liu CG, Liu X, Huang K, Visser J, Marcucci G, Plass C, Belyavsky AV, Caligiuri MA. TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia. Blood 113(22):5558-67, 5/28/2009. e-Pub 3/27/2009. PMCID: PMC2689053.
45. Sampath D, Calin GA, Puduvalli VK, Gopisetty G, Taccioli C, Liu CG, Ewald B, Liu C, Keating MJ, Plunkett W. Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase, Itch for degradation. Blood 113(16):3744-53, 4/16/2009. e-Pub 12/18/2008. PMCID: PMC2670791.
46. Wang X, Gocek E, Liu CG, Studzinski GP. MicroRNAs181 regulate the expression of p27(Kip1) in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D(3). Cell Cycle 8(5):736-41, 3/1/2009. e-Pub 3/18/2009. PMCID: PMC2804747.
47. Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, Calin GA, Rossi S, Fernandez AF, Carneiro F, Oliveira C, Ferreira B, Liu CG, Villanueva A, Capella G, Schwartz S, Shiekhattar R, Esteller M. A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet 41(3):365-70, 3/2009. e-Pub 2/15/2009. PMID: 19219043.
48. Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM, Fong LY. Zinc Replenishment Reverses Overexpression of the Proinflammatory Mediator S100A8 and Esophageal Preneoplasia in the Rat. Gastroenterology 36(3):953-66, 3/2009. e-Pub 11/24/2008. PMCID: PMC2650087.
49. Fassan M, Baffa R, Palazzo JP, Lloyd J, Crosariol M, Liu CG, Volinia S, Alder H, Rugge M, Croce CM, Rosenberg A. MicroRNA expression profiling of male breast cancer. Breast Cancer Res R58(4):R58, 2009. e-Pub 8/10/2009. PMCID: PMC2750120.
50. Yang N, Kaur S, Volinia S, Greshock J, Lassus H, Hasegawa K, Liang S, Leminen A, Deng S, Smith L, Johnstone CN, Chen XM, Liu CG, Huang Q, Katsaros D, Calin GA, Weber BL, Bützow R, Croce CM, Coukos G, Zhang L. MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancer. Cancer Res 68(24):10307-14, 12/15/2008. PMCID: PMC2762326.
51. Sorrentino A, Liu CG, Addario A, Peschle C, Scambia G, Ferlini C. Role of microRNAs in drug-resistant ovarian cancer cells. Gynecol Oncol 111(3):478-86, 12/2008. e-Pub 9/26/2008. PMID: 18823650.
52. Quaresima B, Romeo F, Faniello MC, Di Sanzo M, Liu CG, Lavecchia A, Taccioli C, Gaudio E, Baudi F, Trapasso F, Croce CM, Cuda G, Costanzo F. BRCA1 5083del19 Mutant Allele Selectively Up-Regulates Periostin Expression In vitro and In vivo. Clin Cancer Res 14(21):6797-803, 11/1/2008. PMID: 18980973.
53. Marcucci G, Maharry K, Radmacher MD, Mrózek K, Vukosavljevic T, Paschka P, Whitman SP, Langer C, Baldus CD, Liu CG, Ruppert AS, Powell BL, Carroll AJ, Caligiuri MA, Kolitz JE, Larson RA, Bloomfield CD. Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B Study. J Clin Oncol 26(31):5078-87, 11/1/2008. e-Pub 9/22/2008. PMCID: PMC2652095.
54. Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM. Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence. J Virol 82(21):10436-43, 11/2008. e-Pub 8/27/2008. PMCID: PMC2573162.
55. Zhu H, Wu H, Liu X, Evans BR, Medina DJ, Liu CG, Yang JM. Role of MicroRNA miR-27a and miR-451 in the regulation of MDR1/P-glycoprotein expression in human cancer cells. Biochem Pharmacol 76(5):582-8, 9/1/2008. e-Pub 6/24/2008. PMCID: PMC2628586.
56. Wang FZ, Weber F, Croce C, Liu CG, Liao X, Pellett PE. Human cytomegalovirus infection alters the expression of cellular microRNA species that affect its replication. J Virol 82(18):9065-74, 9/2008. e-Pub 7/2/2008. PMCID: PMC2546905.
57. Prueitt RL, Yi M, Hudson RS, Wallace TA, Howe TM, Yfantis HG, Lee DH, Stephens RM, Liu CG, Calin GA, Croce CM, Ambs S. Expression of microRNAs and protein-coding genes associated with perineural invasion in prostate cancer. Prostate 68(11):1152-64, 8/1/2008. PMCID: PMC2597330.
58. Ambs S, Prueitt RL, Yi M, Hudson RS, Howe TM, Petrocca F, Wallace TA, Liu CG, Volinia S, Calin GA, Yfantis HG, Stephens RM, Croce CM. Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res 68(15):6162-70, 8/1/2008. PMCID: PMC2597340.
59. Datta J, Kutay H, Nasser MW, Nuovo GJ, Wang B, Majumder S, Liu CG, Volinia S, Croce CM, Schmittgen TD, Ghoshal K, Jacob ST. Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res 68(13):5049-58, 7/1/2008. PMCID: PMC2562630.
60. Langer C, Radmacher MD, Ruppert AS, Whitman SP, Paschka P, Mrózek K, Baldus CD, Vukosavljevic T, Liu CG, Ross ME, Powell BL, de la Chapelle A, Kolitz JE, Larson RA, Marcucci G, Bloomfield CD, Cancer and Leukemia Group B (CALGB). High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. Blood 111(11):5371-9, 6/1/2008. e-Pub 3/31/2008. PMCID: PMC2396728.
61. Garofalo M, Quintavalle C, Di Leva G, Zanca C, Romano G, Taccioli C, Liu CG, Croce CM, Condorelli G. MicroRNA signatures of TRAIL resistance in human non-small cell lung cancer. Oncogene 27(27):3845-55, 6/19/2008. e-Pub 2/4/2008. PMID: 18246122.
62. Marcucci G, Radmacher MD, Maharry K, Mrózek K, Ruppert AS, Paschka P, Vukosavljevic T, Whitman SP, Baldus CD, Langer C, Liu CG, Carroll AJ, Powell BL, Garzon R, Croce CM, Kolitz JE, Caligiuri MA, Larson RA, Bloomfield CD. MicroRNA expression in cytogenetically normal acute myeloid leukemia. N Engl J Med 358(18):1919-28, 5/1/2008. PMID: 18450603.
63. Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu CG, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis VA, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, Bützow R, Rustgi AK, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A 105(19):7004-9, 5/2008. e-Pub 5/2008. PMCID: PMC2383982.
64. Medina R, Zaidi SK, Liu CG, Stein JL, van Wijnen AJ, Croce CM, Stein GS. MicroRNAs 221 and 222 bypass quiescence and compromise cell survival. Cancer Res 68(8):2773-80, 4/15/2008. PMID: 18413744.
65. Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM. MiR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci U S A 105(13):5166-71, 4/1/2008. e-Pub 3/24/2008. PMCID: PMC2278188.
66. Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C, Volinia S, Liu CG, Schnittger S, Haferlach T, Liso A, Diverio D, Mancini M, Meloni G, Foa R, Martelli MF, Mecucci C, Croce CM, Falini B. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci U S A 105(10):3945-50, 3/11/2008. e-Pub 2/28/2008. PMCID: PMC2268779.
67. Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F, Fabbri M, Coombes K, Alder H, Nakamura T, Flomenberg N, Marcucci G, Calin GA, Kornblau SM, Kantarjian H, Bloomfield CD, Andreeff M, Croce CM. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 111(6):3183-9, 3/15/2008. e-Pub 1/10/2008. PMCID: PMC2265455.
68. Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, de Martino I, Iliopoulos D, Pilozzi E, Liu CG, Negrini M, Cavazzini L, Volinia S, Alder H, Ruco LP, Baldassarre G, Croce CM, Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13(3):272-86, 3/2008. PMID: 18328430.
69. Budhu A, Jia HL, Forgues M, Liu CG, Goldstein D, Lam A, Zanetti KA, Ye QH, Qin LX, Croce CM, Tang ZY, Wang XW. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 47(3):897-907, 3/2008. PMID: 18176954.
70. Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, Yuen ST, Chan TL, Kwong DL, Au GK, Liu CG, Calin GA, Croce CM, Harris CC. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 299(4):425-36, 1/30/2008. PMCID: PMC2614237.
71. Blower PE, Chung JH, Verducci JS, Lin S, Park JK, Dai Z, Liu CG, Schmittgen TD, Reinhold WC, Croce CM, Weinstein JN, Sadee W. MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther 7(1):1-9, 1/2008. e-Pub 1/9/2008. PMID: 18187804.
72. Li J, Ran C, Li E, Gordon F, Comstock G, Siddiqui H, Cleghorn W, Chen HZ, Kornacker K, Liu CG, Pandit SK, Khanizadeh M, Weinstein M, Leone G, de Bruin A. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell 14(1):62-75, 1/2008. PMCID: PMC2253677.
73. Rao Y, Lee Y, Jarjoura D, Ruppert AS, Liu CG, Hsu JC, Hagan JP. A comparison of normalization techniques for microRNA microarray data. Stat Appl Genet Mol Biol 7(0):Article22, 2008. e-Pub 7/21/2008. PMID: 18673291.

Invited Articles

1. Liu CG, Spizzo R, Calin GA, Croce CM. Expression profiling of microRNA using oligo DNA arrays. Methods 44(1):22-30, 1/2008. PMCID: PMC3321558.
2. Liu CG, Calin GA, Volinia S, Croce CM. MicroRNA expression profiling using microarrays. Nat Protoc 3(4):563-78, 2008. PMID: 18388938.


1. Smith K, Liu CG, Williams J, Kithcart A, Gienapp I, Shawler T, Song F, Whitacre C. MicroRNAs mediate autoimmune disease pathology. The FASEB Journal 22(669.8), 2008.

Book Chapters

1. Calin GA, Liu CG, Ferracin M, Volinia S, Negrini M, Croce CM. Significance of aberrant expression of miRNAs in cancer cells. In: Bioinformatics in Cancer and Cancer Therapy. Ed(s) Gavin J. Gordon. Humana Press: Totowa, New Jersey, 77-88, 2008. ISBN: 978-1-58829-753-2.

Last updated: 8/18/2015