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Chao-Jen Lai

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX

Research Interests

  • Digital radiography, digital mammography, and cone-beam CT imaging techniques
  • Imaging quality measurement and observer performance

Education & Training

Degree-Granting Education

2000 University of Missouri-Columbia, Columbia, MO, PHD, Nuclear Engineering
1995 University of Missouri-Columbia, Columbia, MO, MS, Health Physics
1986 National Tsing Hua University, Hsin-Chu, Taiwan, BS, Nuclear Engineering

Postgraduate Training

7/2001-6/2004 Research Fellowship, Imaging Physics, The University of Texas M D Anderson Cancer Center, Houston, TX, Dr. Chris Shaw

Experience/Service

Academic Appointments

Instructor, Department of Imaging Physics, Division of Diagnostic Imaging, The University of Texas M D Anderson Cancer Center, Houston, TX, 7/2004-12/2009

Selected Publications

Peer-Reviewed Original Research Articles

1. Rong XJ, Shaw CC, Johnston DA, Lemacks MR, Liu X, Whitman GJ, Dryden MJ, Stephens TW, Thompson SK, Krugh KT, Lai CJ. Microcalcification detectability for four mammographic detectors: flat-panel, CCD, CR, and screen/film. Med Phys 29(9):2052-61, 9/2002. PMID: 12349926.
2. Lai CJ, Shaw CC, Whitman GJ, Johnston DA, Yang WT, Selinko V, Arribas E, Dogan B, Kappadath SC. Visibility of simulated microcalcifications--a hardcopy-based comparison of three mammographic systems. Med Phys 32(1):182-94, 1/2005. PMID: 15719969.
3. Lai CJ, Shaw CC, Whitman GJ, Yang WT, Dempsey PJ, Nguyen V, Ice MF. Receiver operating characteristic analysis for the detection of simulated microcalcifications on mammograms using hardcopy images. Phys Med Biol 51(16):3901-19, 8/2006. PMID: 16885614.
4. Yang WT, Lai CJ, Whitman GJ, Murphy WA, Dryden MJ, Kushwaha AC, Sahin AA, Johnston D, Dempsey PJ, Shaw CC. Comparison of full-field digital mammography and screen-film mammography for detection and characterization of simulated small masses. AJR Am J Roentgenol 187(6):W576-81, 12/2006. PMCID: PMC1892902.
5. Altunbas MC, Shaw CC, Chen L, Lai C, Liu X, Han T, Wang T. A post-reconstruction method to correct cupping artifacts in cone beam breast computed tomography. Med Phys 34(7):3109-18, 7/2007. PMCID: PMC1995653.
6. Lai CJ, Shaw CC, Chen L, Altunbas MC, Liu X, Han T, Wang T, Yang WT, Whitman GJ, Tu SJ. Visibility of microcalcification in cone beam breast CT: effects of X-ray tube voltage and radiation dose. Med Phys 34(7):2995-3004, 7/2007. PMCID: PMC2867610.
7. Yang WT, Carkaci S, Chen L, Lai CJ, Sahin A, Whitman GJ, Shaw CC. Dedicated cone-beam breast CT: feasibility study with surgical mastectomy specimens. AJR Am J Roentgenol 189(6):1312-5, 12/2007. PMCID: PMC2856818.
8. Chen L, Shaw CC, Altunbas MC, Lai CJ, Liu X. Spatial resolution properties in cone beam CT: a simulation study. Med Phys 35(2):724-34, 2/2008. PMCID: PMC2857694.
9. Lai CJ, Shaw CC, Geiser W, Chen L, Arribas E, Stephens T, Davis PL, Ayyar GP, Dogan BE, Nguyen VA, Whitman GJ, Yang WT. Comparison of slot scanning digital mammography system with full-field digital mammography system. Med Phys 35(6):2339-46, 6/2008. PMCID: PMC2809719.
10. Liu X, Shaw CC, Lai CJ, Altunbas MC, Chen L, Han T, Wang T. Scatter rejection and low-contrast performance of a slot-scan digital chest radiography system with electronic aft-collimation: a chest phantom study. Med Phys 35(6):2391-402, 6/2008. PMCID: PMC2809722.
11. Chen L, Shaw CC, Altunbas MC, Lai CJ, Liu X, Han T, Wang, T. Yang WT, Whitman GJ. Feasibility of volume-of-interest (VOI) scanning technique in cone beam breast CT - a preliminary study. Med Phys 35(8):3482-90, 8/2008. PMCID: PMC2809707.
12. Zhang HJ, Yang JJ, Lu JP, Lai CJ, Sheng J, Li YX, Hao Q, Zhang SM, Gupta S. Use of intra-arterial chemotherapy and embolization before limb salvage surgery for osteosarcoma of the lower extremity. Cardiovasc Intervent Radiol 32(4):672-8, 7/2009. PMID: 19296158.
13. Chen L, Shen Y, Lai C, Han T, Zhong Y, Ge S, Liu X, Wang T, Yang WT, Whitman GJ, Shaw CC. Dual resolution cone beam breast CT: a feasibility study. Med Phys 36(9):4007-14, 9/2009. PMCID: PMC2738741.
14. Lai CJ, Chen L, Zhang H, Liu X, Zhong Y, Shen Y, Han T, Ge S, Yi Y, Wang T, Yang WT, Whitman GJ, Shaw CC. Reduction in x-ray scatter and radiation dose for volume-of-interest (VOI) cone beam breast CT: a phantom study. Phys Med Biol 54(21):6691-709, 11/2009. PMCID: PMC2855392.
15. Liu X, Lai CJ, Chen L, Han T, Zhong Y, Shen Y, Wang T, Shaw CC. Scan equalization digital radiography (SEDR) implemented with an amorphous selenium flat-panel detector: initial experience. Phys Med Biol 54(22):6959-78, 11/2009. PMCID: PMC2855213.
16. Liu X, Shaw CC, Lai CJ, Wang T. Comparison of scatter rejection and low-contrast performance of scan equalization digital radiography (SEDR), slot-scan digital radiography, and full-field digital radiography systems for chest phantom imaging. Med Phys 38(1):23-33, 1/2011. PMCID: PMC3017579.
17. Yi Y, Lai CJ, Han T, Zhong Y, Shen Y, Liu X, Ge S, You Z, Wang T, Shaw CC. Radiation doses in cone-beam breast computed tomography: A Monte Carlo simulation study. Med Phys 38(2):589-97, 2/2011. PMCID: PMC3030614.
18. Shen Y, Yi Y, Zhong Y, Lai CJ, Liu X, You Z, Ge S, Wang T, Shaw CC. High resolution dual detector volume-of-interest cone beam breast CT--Demonstration with a bench top system. Med Phys 38(12):6429-42, 12/2011. PMCID: PMC3230641.
19. Liu X, Lai CJ, Whitman GJ, Geiser WR, Shen Y, Yi Y, Shaw CC. Effects of exposure equalization on image signal-to-noise ratios in digital mammography: A simulation study with an anthropomorphic breast phantom. Med Phys 38(12):6489-501, 12/2011. PMCID: PMC3247925.
20. Han T, Lai C-J, Chen L, Zhong Y, Shen Y, Ge S, Yi Y, Liu X, Wang T, Shaw CC. Automatic thresholding of 3D cone beam breast computed tomography for adipose and glandular tissue classification. Journal of Applied Clinical Medical Physics. Submitted.
21. Qu X, Lai C-J, Yi Y, Nakajima Y, Shaw CC. Cupping artifact correction of cone beam breast computed tomography image - A general approach. IEEE Transactions on Medical Imaging. Submitted.

Abstracts

1. Zhong Y, You Z, Liu X, Wang T, Shen Y, Lai C, Shaw C. Comparison of single-view and dual view digital chest tomosynthesis. Medical Physcis 39(6):3608, 6/2012.
2. Shen Y, Zhong Y, Lai C, Wang T, Shaw C. Cone beam breast CT with a high resolution flat panel detector – Improvement of calcification visibility. Medical Physcis 39(6):3915, 6/2012.
3. Lai C, Shen Y, Zhong Y, Whitman G, Yang WT, Wang T, Shaw C. Extraction and insertion of tumor masses in cone beam breast CT images. Medical Physcis 39(6):3915, 6/2012.
4. Shen Y, Zhong Y, Lai C, Liu X, You Z, Ge S, Yi Y, Wang T, Shaw C. Image Quality, Dose Saving and Scatter Reduction in Dual-Resolution Cone Beam CT Breast Imaging Using Two. Medical Physics 38(6):3745-6, 6/2011.
5. Shen Y, Liu X, Lai C, Zhong Y, Ge S, Yi Y, You Z, Wang T, Shaw C. Microcalcifications Visibility in Cone Beam Breast CT with Various Flat Panel Detectors. Medical Physcis 38(6):3744, 6/2011.
6. Liu X, Lai C, Shaw C, Shen Y, Zhong Y, Yi Y, Ge S, You Z. To investigate the effects of exposure equalization on the noise property and visibility of micro-calcifications using simulated SEDM imaging experiments. Medical Physics 38(6):3378, 6/2011.

Book Chapters

1. Whitman GJ, Lai CJ, Liu X, Itani M, Khisty R and Shaw CC. Breast Computed Tomography. In: Digital Mammography: A Practical Approach. Ed(s) GJ Whitman and TM Haygood. Cambridge University Press: Cambridge, United Kingdom, 2012.

Grant & Contract Support

Title: Evaluation of Dedicated Breast CT with Synthetic Abnormal Cases
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2013 - 6/30/2015
 
Title: High Rate Contrast Density Measurement with Dual Orthogonal View Limited Angle CT
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 7/1/2013 - 6/30/2015
 
Title: Three-Dimensional Simulation of Tumor Masses for Cone Beam Breast Computed Tomography
Funding Source: MDACC
Role: Principal Investigator
Duration: 1/1/2013 - 12/31/2013
 
Title: A Novel Strategy To Evaluate Cone Beam Breast CT for Early Detection of Breast Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator
Duration: 12/1/2012 - 11/30/2015
 
Title: A High Resolution Breast CT System for Early Detection of Breast Cancers
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 12/1/2012 - 11/30/2015
 
Title: Observer Performance, Image Quality and Dose in Cone Beam Breast CT
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 9/1/2012 - 8/31/2017
 
Title: Flat-Panel Based Cone Beam CT for 3D Chest Imaging
Funding Source: NIH/NIBIB
Role: Principal Investigator
Duration: 9/1/2012 - 8/31/2014
 
Title: Digital Breast Tomosynthesis with Digitally Addressable X-ray Source
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mark Lucent (Stellaray Inc.)
Duration: 9/1/2012 - 8/31/2014
 
Title: From Chest Radiography to 3D Chest Imaging with Patient Rotation
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 7/1/2012 - 6/30/2017
 
Title: Identification of Digitally Inserted Lesions in Cone Beam Breast CT
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/2012 - 6/30/2016
 
Title: DTS Imaging with a Digitally Addressable X-Ray Sources (DAXS)
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 5/1/2010 - 2/28/2015
 
Title: A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 9/1/2008 - 8/31/2013
 
Title: A Dual Resolution Cone Beam CT System for 3-D Breast Imaging
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 9/1/2007 - 8/31/2008
 
Title: Optimized Digital Mammography with an a-Se FP Imager
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 6/1/2004 - 5/31/2011
 
Title: aSi/Csl FP Digital Chest Imaging with Scatter Rejection and Exposure Equilization
Funding Source: NIH/NIBIB
Role: Co-Investigator
Principal Investigator: Shaw CC
Duration: 6/1/2002 - 3/31/2008

Last updated: 4/29/2013