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Chongjuan Wei, Ph. D

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Co-Director, CCSG Biospecimen Extraction Resource, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1999 Institute of Microbiology Chinese Academy of Sciences (CAS), Beijing, China, PHD, Biochemistry and Molecular Biology
1996 National Laboratory of Enzyme Engineering, Jilin University, Changchun, China, MS, Biochemistry
1993 Department of Biology, Northwest University, Xi'an, China, BS, Biology

Postgraduate Training

11/1999-12/2004 Postdoctoral Fellow, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Assistant-Director, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2009-10/2010
Instructor, Department of Epidemiology, Division of OVP, Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 1/2005-8/2009

Honors and Awards

2002 AACR-AFLAC Scholar-in-Training Award
2000-2002 The Janis Davis Gordon Memorial Fellowship
1999 The First Prize of “Bao Jie” Award, Chinese Academy of Sciences
1999 The First Prize of “Di Ao” Award,, Chinese Academy of Sciences
1999 The First Prize of Jiu Yuan” award, Chinese Academy of Sciences
1999 The First Prize of President Award, Institute of Microbiology
1993 "505" Award for Excellent Undergraduate Student "

Professional Memberships

American Association for Cancer Research
member, 2002-present
American Pancreatic Association
member, 2009-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Walsh KM, Gorlov IP, Hansen HM, Wu X, Spitz MR, Zhang H, Lu E, Wenzlaff AS, Sisson JD, Wei C, Lloyd SM, Chen W, Frazier ML, Seldin MF, Bierut LJ, Bracci PM, Wrensch MR, Schwartz AG, Wiencke JK, Amos CI. Fine-mapping of the 5p15.33, 6p22.1-p21.31 and 15q25.1 regions identifies functional and 2 histology-specific lung cancer susceptibility loci in African-Americans. Cancer Epidemiol Biomarkers Prev. In Press.
2. Chen J, Pande M, Huang YJ, Wei C, Amos CI, Talseth-Palmer BA, Meldrum CJ, Chen WV, Gorlov IP, Lynch PM, Scott RJ, Frazier ML. Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. Carcinogenesis. e-Pub 11/2012. PMID: 23125224.
3. Pande M,Wei C, Chen J, Amos CI, Lynch PM, Lu KH, Lucio LA, Boyd-Rogers SG, Bannon SA, Mork ME, Frazier ML. Cancer spectrum in DNA mismatch repair gene mutation carriers: results from a hospital based Lynch syndrome registry. Fam Cancer. e-Pub 6/2012. PMID: 22714864.
4. Wei C, Bhattaram VK, Igwe JC, Fleming E, Tirnauer JS. The LKB1 Tumor Suppressor Controls Spindle Orientation and Localization of Activated AMPK in Mitotic Epithelial Cells. PLoS One 7(7):e41118, 2012. e-Pub 7/2012. PMCID: PMC3399794.
5. Wei C, Han Y, Spitz MR, Wu X, Chancoco H, Akiva P, Rechavi G, Brand H, Wun I, Frazier ML, Amos CI. A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. Cancer Epidemiol Biomarkers Prev 20(12):2603-9, 12/2011. e-Pub 10/2011. PMID: 22028403.
6. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in caucasians. Mol Carcinog. e-Pub 6/2011. PMID: 21656579.
7. Amos CI, Frazier ML, Wei C, McGarrity TJ. Peutz-Jeghers Syndrome. GeneReviews, 2/2011. PMID: 20301443.
8. Zhu J, Sen S, Wei C, Frazier ML. Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor alpha-mediated transcription. Int J Oncol 36(1):39-48, 1/2010. PMID: 19956831.
9. Wei C, Amos CI, Zhang N, Zhu J, Wang X, Frazier ML. Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model. Cancer Lett 277(2):149-54, 5/2009. e-Pub 1/2009. PMID: 19147279.
10. Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14(4):1167-71, 2/2008. PMID: 18281551.
11. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res 13(10):3100-4, 5/2007. PMCID: PMC2365501.
12. Chen J, Sen S, Amos CI, Wei C, Jones JS, Lynch P, Frazier ML. Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Mol Carcinog 46(4):249-256, 4/2007. e-Pub 2007. PMID: 17219423.
13. Chen J, Zhu J, Pande M, Amos J, Frazier ML,Wei C. Modifiers of expression in mutations of mismatch repair gene carriers in Hereditary Nonpolyposis Colorectal Cancer. Curr. Colorectal Cancer Reports 2:179-184, 2006.
14. Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65(24):11297-11303, 12/2005. PMID: 16357136.
15. Amos CI, Keitheri-Cheteri MB, Sabripour M, Wei C, McGarrity TJ, Seldin MF, Nations L, Lynch PM, Fidder HH, Friedman E, Frazier ML. Genotype-phenotype correlations in Peutz-Jeghers syndrome. J Med Genet 41(5):327-333, 2004. PMID: 15121768.
16. Wei C, Amos CI, Rashid A, Sabripour M, Nations L, McGarrity TJ, Frazier ML. Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome. J Histochem Cytochem 51(12):1665-1672, 12/2003. PMID: 14623934.
17. Wei C, Cheng H, Zhang Y, Yank K. Analysis of the disulfide bonding pattern between domain sequences of recombinant prochymosin solubilized from inclusion bodies. J. Protein Chem 19(4):277-284, 2000.
18. Wei C, Zhang Y, Yang K. Chaperone-mediated refolding of recombinant prochymosin. J. Protein Chem 19(6):449-456, 2000.
19. Wei C, Tang B, Zhang Y, Yang K. Oxidative refolding of recombinant prochymosin. Biochem. J 245:873-879, 1999.

Invited Articles
1. Wei C, Frazier ML. LKB1: a critical mediator in suppressing initiation, differentiation and metastasis in lung cancer. Cell Science Reviews 4(2):40-47, 2007.

Abstracts
1. Wei C, Rashid A, Amos C, Gannon M, Frazier ML. LKB1 Gene Tissue Specific Knockout Mouse Model for Pancreatic Cancer. 36th Annual Meeting of American Pancrease Association, 2005.

Grant & Contract Support

Title: Chemoprevention of Peutz-Jeghers Polyposis in a Mouse Model by Niclosamide
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/15/2011 - 7/31/2013
 
Title: Novel use of niclosamide: Targeting mTOR Signaling in Peutz-Jeghers Syndrome
Funding Source: Duncan Family Institute - Seed Funding Research Program Grant
Role: Principal Investigator
Duration: 7/1/2010 - 8/31/2013
 
Title: Effect from Nicotinic Receptor Variations on Smoking behaviors and Lung Cancer Risk
Funding Source: CPRIT
Role: Co-Investigator
Principal Investigator: Amos
Duration: 5/1/2010 - 4/30/2013
 
Title: Microsimulation of Longitudinal Smoking & Lung Cancer Risk
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Amos
Duration: 8/1/2009 - 7/31/2011
 
Title: Mouse Model of Pancreatic Tumorigenesis with Dysregulation of mTOR
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 6/6/2008 - 5/31/2011
 
Title: Fine Mapping and Sequencing Studies for Lung Cancer Susceptibility
Funding Source: Kleberg Center Project
Role: Co-Investigator
Principal Investigator: Amos
Duration: 6/1/2008 - 12/31/2009
 
Title: Targeting mTOR signaling pathway in pancreatic tumorigenesis
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 4/1/2008 - 3/31/2010
 
Title: ARRA: High Density Association Analysis of Lung Cancer
Funding Source: NIH/NCI
Role: Investigator
Principal Investigator: Christopher Amos
Duration: 7/1/2007 - 9/29/2011
 
Title: Lkb1 lung-specific knockout mouse model for lung adenocarcinomas
Funding Source: University of Texas SPORE in Lung Cancer Investigator Award
Role: Principal Investigator
Duration: 4/2006 - 3/31/2007
 
Title: Mouse Model for Peutz-Jeghers Syndrome
Funding Source: The Janis Davis Gordon Memorial Fellowship
Role: Postdoctoral Fellow
Duration: 4/1/2000 - 12/31/2003
 
Title: Cancer Center Support (Core) Grant
Funding Source: NIH/NCI
Role: Co-Director of Biospecimen Extraction Resource
Principal Investigator: Ronald A. DePinho
Duration: 9/4/1998 - 6/30/2013
 
Title: Molecular Genetics of Hereditary Nonpolyposis Colorectal Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Marsha L. Frazier
Duration: 6/1/1997 - 4/30/2013

Last updated: 11/19/2012