| Christopher I. Amos, PhD |
Present Title & Affiliation
Primary Appointment
Professor, Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, Houston, TX
Dual/Joint/Adjunct Appointment
Professor, Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, University of Texas M. D. Anderson Cancer Center, Houston, TX
Adjunct Professor, Rice University, Houston, TX
Professor, Department of Epidemiology, University of Texas School of Public Health, Houston, TX
Professor, University of Texas Graduate School for Biomedical Sciences, Houston, TX
Bio Statement
Dr. Amos is the deputy ad-interim chair of the Department of Epidemiology and leads the Computational and Genetic Epidemiology Section. He also directs the Human Pedigree Analysis Resource, a core facility of the Cancer Center Support Grant, which supports research for individuals with increased familial risk for developing cancer. His research has ranged from investigating familial factors for prostate, head and neck, lung and colon cancers to study of Peutz-Jeghers syndrome, a rare syndrome predisposing to polyps and multiple cancers. Dr. Amos is leading a study to identify genetic risk factors for lung cancer using a genome-wide association approach. By this method, his team identified a novel locus influencing lung cancer susceptibility in a region of chromosome 15q containing acetyl-cholinergic acid receptors. Dr. Amos has directed the statistical genetics core for the North American Rheumatoid Arthritis Consortium and the Genetic Epidemiology of Lung Cancer Consortium. He also directs the informatics core of Dr. Strong’s P-01 entitled mutational model for childhood cancer and of a grant from Genome
Education & Training
Degree-Granting Education | |
| 1988 | LSU Medical Center, New Orleans, LA, PHD, Biometry |
| 1985 | LSU Medical Center, New Orleans, LA, MS, Biometry |
| 1980 | Reed College, Portland, OR, BA, Mathematics |
Postgraduate Training | |
| 7/1990-12/1993 | Interinstitute Medical Genetics Program, NIH, Bethesda, MD |
| 6/1988-6/1990 | Intramural Research Training Award Fellowship, Family Studies Section, Environmental Epidemiology Branch, Family Studies, Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD |
Board Certifications
| 1993 | American Board of Medical Genetics |
Experience/Service
Academic Appointments
IRTA FEllow, Family Studies Section, EEB, NCI, NIH, Bethesda, MD, 6/1988-6/1990
Graduate Assistant, Department of Medicine, LSU Medical Center, New Orleans, LA, 8/1983-5/1988
Consultantships
Consultant, Howard University Cancer Center, Washington, 1/1988-1/1993
Military or Other Governmental Service
Intramural Research Training Association Fellow, US NCI NIH, 6/1988-6/1990
Selected Publications
Peer-Reviewed Original Research Articles | |
| 1. | Spitz MR, Amos CI, Dong Q, Lin J, Wu X. The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst 100(21). e-Pub 10/2008. PMID: 18957677. |
| 2. | Spitz MR, Etzel CJ, Dong Q, Amos CI, Wei Q, Wu X, Hong WK. An expanded risk prediction model for lung cancer. Cancer Prev Res (Phila Pa) 1(4):250-4, 9/2008. PMCID: PMCNONE. |
| 3. | Liu P, Vikis HG, Wang D, Lu Y, Wang Y, Schwartz AG, Pinney SM, Yang P, de Andrade M, Petersen GM, Wiest JS, Fain PR, Gazdar A, Gaba C, Rothschild H, Mandal D, Coons T, Lee J, Kupert E, Seminara D, Minna J, Bailey-Wilson JE, Wu X, Spitz MR, Eisen T, Houlston RS, Amos CI, Anderson MW, You M. Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. J Natl Cancer Inst 100(18):1326-30, 9/2008. e-Pub 9/2008. PMCID: PMC2538550. |
| 4. | Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 40(5):616-22, 5/2008. e-Pub 4/2/2008. PMID: 18385676. |
| 5. | Gorlov IP, Gorlova OY, Amos CI. Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome. BMC Genomics 9:292, 2008. e-Pub 2008. PMCID: PMC2442617. |
| 6. | Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of peutz-jeghers polyposis by targeting Mammalian target of rapamycin signaling. Clin Cancer Res 14(4):1167-71, 2008. PMCID: PMCNONE. |
| 7. | Amos CI. Successful design and conduct of genome-wide association studies. Hum Mol Genet 16 Spec No. 2:R220-5., 2007. PMID: 17597095. |
Grant & Contract Support
| Title: | International Genome-Wide Association Studies of Lung Cancer |
| Funding Source: | International Agency for Research for Cancer |
| Role: | Principal Investigator-MDACC |
| Principal Investigator: | Paul Brennan |
| Duration: | 12/1/2009 - 11/30/2013 |
| Title: | Genetic Susceptibility for Lung Cancer in African Americans |
| Funding Source: | NIH/NCI |
| Role: | Co-Principal Investigator |
| Duration: | 9/1/2009 - 8/31/2010 |
| Title: | Genomewide Association Studies of Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator-MDACC |
| Duration: | 11/1/2008 - 10/31/2012 |
| Title: | CCSG Human Pedigree Ayalysis Resource (PC13) |
| Funding Source: | NIH/NCI |
| Role: | Core Leader |
| Principal Investigator: | Mendelsohn |
| Duration: | 7/1/2008 - 6/30/2013 |
| Title: | Genome-Wide Association Anaylsis of Bladder Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Xifeng Wu |
| Duration: | 4/1/2008 - 3/31/2013 |
| Title: | Molecular Epidemiology of Head and Neck Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Qingy Wei |
| Duration: | 3/8/2008 - 2/28/2012 |
| Title: | Ecogenetics of Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Margaret R. Spitz, M.D. |
| Duration: | 1/1/2008 - 12/31/2012 |
| Title: | Statistical Methods for Gene Environmental Interactions in Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Duration: | 9/30/2007 - 7/31/2010 |
| Title: | Genetics of Rehumatoid Arthritis - NARAC |
| Funding Source: | NIH/NIAMS |
| Role: | Principal Investigator-MDACC |
| Duration: | 9/20/2007 - 7/31/2012 |
| Title: | High Density Genetic Analysis of Lung Cancer |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Duration: | 7/1/2007 - 5/31/2011 |
| Title: | Epidemiology of PBC: A Genome-Wide Association Study |
| Funding Source: | U C Davis |
| Role: | Co-Investigator |
| Principal Investigator: | E. Gershwin |
| Duration: | 6/6/2007 - 8/31/2009 |
| Title: | International Consortium of Malignant Glioma |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Melissa Bondy |
| Duration: | 12/1/2005 - 7/31/2011 |
| Title: | Cancer Center Support Grant Human Pedigree Analysis Core |
| Funding Source: | NIH/NCI |
| Role: | Core Leader |
| Principal Investigator: | J. Mendelsohn, M.D. |
| Duration: | 7/1/2003 - 6/30/2008 |
| Title: | Genetic Determinants of Human Health and Disease |
| Funding Source: | Genome Ontario |
| Role: | Core Leader |
| Principal Investigator: | K. Siminovitch |
| Duration: | 1/1/2003 - 12/31/2005 |
| Title: | Positional Gene Identification of Complex Traits, No-cost Extension |
| Funding Source: | NIH/NIEHS |
| Role: | Principal Investigator |
| Duration: | 8/1/2002 - 7/31/2007 |
| Title: | Genetics of Rheumatoid Arthritis, No-cost Extension |
| Funding Source: | North Shore/LIJ Research Institute |
| Role: | Principal Investigator-MDACC |
| Principal Investigator: | Peter Gregersen, MD PhD |
| Duration: | 5/1/2002 - 7/31/2009 |
| Title: | SPORE in Genitourinary Cancer, No-cost Extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Colin P. Dinney |
| Duration: | 9/25/2001 - 8/31/2011 |
| Title: | Genetic Influences on Mutagen Sensitvity: A Twin Study, No-cost Extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Xifeng Wu, M.D., Ph.D. |
| Duration: | 5/4/2001 - 4/30/2005 |
| Title: | Mechanism & Prevention of Environmental Disease-Pilot Project, No-cost Extension |
| Funding Source: | NIH/NIEHS |
| Role: | Pilot Project Leader |
| Principal Investigator: | John DiGiovanni |
| Duration: | 4/1/2001 - 3/31/2002 |
| Title: | New Research Registries for the National Institute of Arthritis & Musculoskeletal and Skin Diseases ‘Alopecia Areata Registry’, No-cost Extension |
| Funding Source: | NIH/NIAMS |
| Role: | Consultant |
| Principal Investigator: | Madeline Duvic, M.D |
| Duration: | 9/30/2000 - 9/29/2009 |
| Title: | Pharmacogenetics of Anticancer Agents Research Group, no-cost extension |
| Funding Source: | University of Chicago |
| Role: | Collaborator |
| Principal Investigator: | Gary Rosner |
| Duration: | 1/1/2000 - 6/30/2010 |
| Title: | A Mutational Model for Childhood Cancer, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Core Leader |
| Principal Investigator: | Louise Strong, M.D |
| Duration: | 7/1/1999 - 6/30/2011 |
| Title: | Genetic Epidemiology of Lung Cancer, no-cost extension |
| Funding Source: | University of Cincinnati |
| Role: | Principal Investigator-MDACC |
| Principal Investigator: | M. Anderson, Ph.D. |
| Duration: | 5/1/1999 - 2/28/2011 |
| Title: | Molecular Investigation of Familial Wilms Tumor, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | V. Huff, Ph.D. |
| Duration: | 4/1/1999 - 6/30/2004 |
| Title: | Linkage & Linkage Disequilibrium Methods for Traits, no-cost extension |
| Funding Source: | NIH/NIEHS |
| Role: | Principal Investigator |
| Duration: | 1/1/1999 - 12/31/2001 |
| Title: | Genetic Epidemiology Studies of Peutz-Jeghers Syndrome, no-cost extension |
| Funding Source: | American Cancer Society (ACS) |
| Role: | Principal Investigator |
| Duration: | 1/1/1999 - 12/31/2001 |
| Title: | The Risk/Tox Chip Program, no-cost extension |
| Funding Source: | NIH/NCHGR |
| Role: | Co-Investigator |
| Principal Investigator: | M. Hogan, Ph.D. |
| Duration: | 9/30/1998 - 9/29/2001 |
| Title: | Psychosocial Aspects of Genetic Testing for HNPCC, no-cost extension |
| Funding Source: | NIH/NCHGR |
| Role: | Co-Investigator |
| Principal Investigator: | E. Gritz, Ph.D. |
| Duration: | 8/1/1998 - 7/31/2001 |
| Title: | Texas Cancer Genetics Consortium, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Core Leader |
| Principal Investigator: | L. Strong, M.D. |
| Duration: | 6/1/1998 - 6/3/2012 |
| Title: | Molecular Genetics of HNPCC, no-cost extension |
| Funding Source: | NIH/NIDDK |
| Role: | Co-Investigator |
| Principal Investigator: | M. Frazier, Ph.D. |
| Duration: | 6/1/1997 - 4/30/2012 |
| Title: | Genetic Studies of Rheumatoid Arthritis, no-cost extension |
| Funding Source: | NIH/NIAMS |
| Role: | Principal Investigator |
| Duration: | 1/1/1997 - 12/31/2006 |
| Title: | University of Texas SPORE in Lung Cancer Core C, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Roth |
| Duration: | 9/30/1996 - 4/30/2013 |
| Title: | Ecogenetics of Lung Cancer in Minority Populations, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Margaret R. Spitz, M.D. |
| Duration: | 9/30/1996 - 8/31/2000 |
| Title: | Gliomas: Molecular and Genetic Studies, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | "Melissa Bondy, Ph.D., Principal Investigator of Project 6 ""Genetic Epidemiology of Gliomas""" |
| Duration: | 8/1/1996 - 7/31/2000 |
| Title: | Genetic Basis of Radiation Induced Fibrosis, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Elizabeth Travis, Ph.D. |
| Duration: | 7/1/1996 - 4/30/2005 |
| Title: | Genetic Determinants of High BP in Three Racial Groups, no-cost extension |
| Funding Source: | NIH/NHLBI |
| Role: | Principal Investigator |
| Duration: | 7/1/1996 - 6/30/2000 |
| Title: | Extension of Radiotherapy Research, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | "K. Ang, M.D., Principal Investigator, Mike Weil, Principal Investigator for Project 3: ""Genetic Variation in Radiation Induced Normal Tissue Damage""" |
| Duration: | 4/30/1996 - 2/28/2002 |
| Title: | DNA Repair Gene Expression in Head and Neck Cancer, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Qingyi Wei, Ph.D. |
| Duration: | 4/1/1996 - 3/31/1997 |
| Title: | Familial Studies of Bleomycin Sensitivity, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Duration: | 4/1/1996 - 3/30/1997 |
| Title: | Project 2: Lung Cancer Susceptibility in Former Smokers, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Waun Ki Hong, M.D. |
| Duration: | 7/1/1995 - 6/30/2000 |
| Title: | Environmental and Genetic Determinants of Clinical Prostate Cancer, no-cost extension |
| Funding Source: | NIH/NCI/NIEHS |
| Role: | Co-Investigator |
| Principal Investigator: | Margaret R. Spitz, M.D. |
| Duration: | 7/1/1995 - 6/30/2000 |
| Title: | Familial Aggregation of Prostate Cancer, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Duration: | 7/1/1995 - 12/30/1996 |
| Title: | Linkage Methods for Quantitative and Complex Traits, no-cost extension |
| Funding Source: | NIH/NIGMS |
| Role: | Principal Investigator |
| Duration: | 5/1/1995 - 7/31/2003 |
| Title: | Development of Robust Genetic Linkage Tests, no-cost extension |
| Funding Source: | NIH/NIGMS |
| Role: | Principal Investigator |
| Duration: | 4/1/1995 - 3/31/1998 |
| Title: | Psychosocial Aspects of Genetic Testing for HNPCC, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Ellen Gritz, Ph.D. |
| Duration: | 10/1/1994 - 7/31/2001 |
| Title: | Epidemiologic & Cytogenetic Evaluation of A Cohort of Adult Hodgkin's Disease Patients, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Sara S. Strom, Ph.D. |
| Duration: | 6/1/1994 - 5/31/1996 |
| Title: | Smoking Initiation in African-American Youth, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | Ellen Gritz, Ph.D. |
| Duration: | 7/1/1993 - 6/30/1995 |
| Title: | R25 Supplement in Genetic Epidemiology Education, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | R. Chamberlain, Ph.D. |
| Duration: | 9/15/1992 - 8/31/2007 |
| Title: | Cancer Center Support Grant, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | John Mendelsohn |
| Duration: | 7/1/1978 - 6/30/2008 |
| Title: | Cancer Center Support Grant Supplemental Cancer Prevention Program, no-cost extension |
| Funding Source: | NIH/NCI |
| Role: | Co-Investigator |
| Principal Investigator: | J. Mendelsohn, M.D |
| Duration: | 7/1/1978 - 6/30/2003 |
Last updated: 9/17/2009
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