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Chuan Fen Wu, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1994 Beijing Normal University, Beijing, China, PHD, Molecular and Cellular Biology
1985 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, MS, Cell Biology
1982 Nanchong Teachers College, Nanchong, China, BS, Biology

Postgraduate Training

11/1994-6/1999 Postdoctoral fellow, Dr. Laurence D. Etkin, Department of Molecular Genetics, U T M. D. Anderson Cancer Center, Houston, TX

Experience/Service

Academic Appointments

Instructor, Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 1/2005-2/2007
Research Associate, Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX, 6/1999-12/2004
Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, 1/1988-1/1990
Research Assistant, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China, 1/1985-1/1988

Selected Publications

Peer-Reviewed Original Research Articles

1. Wu CF, Liu S, Lee YC, Wang R, Sun S, Yin F, Bornmann WG, Yu-Lee LY, Gallick GE, Zhang W, Lin SH, Kuang J. RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. e-Pub 5/2013. PMID: 23708659.
2. Wang R, Jung SY, Wu CF, Qin J, Kobayashi R, Gallick GE, Kuang J. Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. Proc Natl Acad Sci U S A 107(46):19885-90, 11/16/2010. e-Pub 11/1/2010. PMCID: PMC2993414.
3. Wu CF, Wang R, Liang Q, Liang J, Li W, Jung SY, Qin J, Lin SH, Kuang J. Dissecting the M phase-specific phosphorylation of serine-proline or threonine-proline motifs. Mol Biol Cell 21(9):1470-81, 5/1/2010. e-Pub 3/10/2010. PMCID: PMC2861607.
4. Traverso EE, Cho MS, Wu CF, Sater AK, Larabell CA, Kloc M, Etkin LD. Disruption of the dynamic sub-cellular localization of the Xenopus tumorhead protein causes embryonic lethality at the early gastrula transition. Differentiation 75(10):521-31, 12/2007. e-Pub 4/25/2007. PMID: 17459085.
5. Feng Z, Wu CF, Zhou X, Kuang J. Alternative polyadenylation produces two major transcripts of Alix. Arch Biochem Biophys 465(2):328-35, 9/15/2007. e-Pub 7/1/2007. PMID: 17673164.
6. Wu CF, Delsert C, Faure S, Traverso EE, Kloc M, Kuang J, Etkin LD, Morin N. Tumorhead Distribution to Cytoplasmic Membrane of Neural Plate Cells is Positively Regulated by Xenopus p21 Activated Kinase1 (X-PAK1). Dev Biol 308(1):169-86, 8/1/2007. e-Pub 5/24/2007. PMID: 17560976.
7. Dejournett RE, Kobayashi R, Pan S, Wu C, Etkin LD, Clark RB, Bögler O, Kuang J. Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins. Biochem J 401(2):521-531, 1/15/2007. PMCID: PMC1820820.
8. Traverso EE, Cho MS, Wu CF, Etkin LD. Identification of TH-B, a new oligomeric variant of the Xenopus morphogenetic factor, tumorhead. Int J Dev Biol 50(4):423-7, 2006. PMID: 16525938.
9. Li JY, Wu CF. New symbiotic hypothesis on the origin of eukaryotic flagella. Naturwissenschaften 92:305-9, 7/2005. PMID: 15905978.
10. Wu CF, Yang P, Traverso EE, Etkin LD, Marcus S. The Xenopus laevis morphogenetic factor, tumorhead, causes defects in polarized growth and cytokinesis in the fission yeast, Schizosaccharomyces pombe. Biochem Biophys Res Commun 325(2):439-44, 12/10/2004. PMID: 15530412.
11. Zearfoss NR, Chan AP, Wu CF, Kloc M, Etkin LD. Hermes is a localized factor regulating cleavage of vegetal blastomeres in Xenopus laevis. Dev Biol 267(1):60-71, 3/1/2004. PMID: 14975717.
12. Li JY, Wu CF. Perspectives on the origin of microfilaments, microtubules, the relevant chaperonin system and cytoskeletal motors--a commentary on the spirochaete origin of flagella. Cell Res 13:219-27, 8/2003. PMID: 12974612.
13. Wu CF, Chan AP, Etkin LD. Difference in the maternal and zygotic contributions of tumorhead on embryogenesis. Dev Biol 255(2):290-302, 3/15/2003. PMID: 12648491.
14. Wu CF, Nakamura H, Chan AP, Zhou YH, Cao T, Kuang J, Gong SG, He G, Etkin LD. Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. Development 128(17):3381-93, 9/2001. PMID: 11546754.
15. Nakamura H, Wu C, Kuang J, Larabell C, Etkin LD. XCS-1, a maternally expressed gene product involved in regulating mitosis in Xenopus. J Cell Sci 113 (Pt 13):2497-505, 7/2000. PMID: 10852828.
16. Che S, El-Hodiri HM, Wu C-F, Nelman-Gonzalez M, Weil MM, Etkin LD, Clark RB, Kuang J. Identification and Cloning of Xp95, a Putative Signal Transduction Protein in Xenopus Oocytes. Journal of Biol. Chem. 274(9):5522-31, 1999.
17. Etkin LD, el-Hodiri HM, Nakamura H, Wu CF, Shou W, Gong SG. Characterization and function of Xnf7 during early development of Xenopus. J Cell Physiol 173(2):144-6, 11/1997. PMID: 9365513.
18. Wu, C-F, Dai, J, Li, J-Y, Wang, Y. The detection of centromere/ kinetochore proteins in Euglena gracilis. Zoological Research 17(4):501-507, 1996.
19. Wu, C-F, Li, J-Y, Wang, Y. The detection of centromere/kinetochore proteins in Tetrahymena thermophila. Zoological Research 17(4):495-499, 1996.
20. Wu, C-F, Li, J-Y, Dai, J, Wang, Y. The detection of centromere/kinetochore proteins in typical dinoflagellate and Oxy. Zoological Research 17(3):307-313,, 1996.
21. Wu, C-F, Li, J-Y, Dai, J, Lu, S, Wang, Y. The responses of archaebacteria to the antibodies against mammalian centromere/ kinetochore proteins. Zoological Research 17(3):323-330, 1996.
22. Wu CF, Lee YC, Wang R, Yin F, Zhang W, Yu-Lee LY, Gallick GE, Lin SH, Kuang J. The signaling kinase RSK catalyzes a conserved activating phosphorylation in human Cdc25A and Cdc25B in mitotic cells. Oncogene. Submitted.

Last updated: 4/2/2014