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Chunlei Zhang, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Dermatology, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Cutaneous T-cell lymphoma, apoptosis, autophagy, epigenetics, biological response modifiers

Education & Training

Degree-Granting Education

1995 Beijing Medical University, Beijing, China, PHD, Dermatology
1987 Inner Mongolia Medical College, Huhehaote, China, MD, Clinical Medicine

Postgraduate Training

1/2000-1/2003 Postdoctoral Research Fellow, Cutaneous T-cell lymphoma, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr.Madeleine Duvic
1/1998-12/1999 Postdoctoral Research Fellow, Cutaneous Oncology, University of Zurich, Zurich, Switzerland, Drs. Udo Dobbeling & Gunter Burg

Honors and Awards

2009 Young Investigator Award, Cutaneous Lymphoma Foundation
2007 Research Grant Award, Ladies Leukemia League, Inc.
2006 Research Grant Award, Dermatology Foundation
2003 Albert M. Kligman Fellowship Award, Society for Investigative Dermatology
1997 Research Career Development Award, The 3rd Hospital of Beijing Medical University
1996 Travel Award, Japanese Dermatological Association
1996 Young Dermatologist Career Award, Chinese Society of Dermatology
1995 Dermatology Research Achievement Award, Beijing Medical University

Selected Publications

Peer-Reviewed Original Research Articles
1. Zhang CL, Li BQ, Gaikwad A, Haridas V, Xu ZX, Gutterman J, Duvic M. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol 128:2728-2735, 2008.
2. Duvic M, Talpur R, Ni X, Zhang CL, Hazarika P, Kelly C, Chiao JH, Reilly JF, Ricker JL, Richon VM, Frankel SR. Phase II trial of oral Vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 109:31-9, 2007.
3. Zhang CL, Toulev A, Kamarashev J, Qin JZ, Dummer R, Dobbeling U. The consequences of p16 tumor suppressor gene inactivation in mycosis fungoides and Sezsary syndrome and the role of the bmi-1 and ras oncogenes in disease progression. Human Pathol 38:995-1002, 2007.
4. Ni X, Zhang CL, Talpur R, Duvic M. Resistance to activation-induced cell death and bystander cytotoxicity via the Fas/Fas ligand pathway are implicated in the pathogenesis of cutaneous T cell lymphomas. J Invest Dermatol 124:741-50, 2005.
5. Zhang CL, Richon V, Ni X, Talpur R, Duvic M. Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. J Invest Dermatol 125:1045-52, 2005.
6. Gaikwad A, Poblenz A, Haridas V, Zhang CL, Duvic M, Gutterman J. Triterpenoid electrophiles (avicins) suppress Hsp70 and XIAP proteins in malignant cells by activation of ubiquitin machinery: implications for pro-apoptotic activity. Clin Cancer Res 11:1953-62, 2005.
7. Zhang CL, Ni X, Konopleva M, Andreeff M, Duvic M. The novel synthetic oleanane triterpenoid CDDO induces apoptosis in mycosis fungoides/Sézary syndrome cells. J Invest Dermatol 123:380-7, 2004.
8. Zhang CL, Kamarashev J, Qin JZ, Dummer R, Burg G, Döbbeling U. Expression of apoptosis regulators in cutaneous T-cell lymphoma cells. J Pathol 200:249-54, 2003.
9. Zhang CL, Hazarika P, Ni X, Weidner DA, Duvic M. Induction of apoptosis by bexarotene in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action. Clin Cancer Res 8:1234-40, 2002.
10. Qin JZ, Kamarashev J, Zhang CL, Dummer R, Burg G, Döbbeling U. Constitutive and IL-7 and IL-15 stimulated DNA-binding of STAT factors and novel factors in cutaneous T cell lymphoma (CTCL) cells. J Invest Dermatol 117:583-9, 2001.
11. Ni X, Hazarika P, Zhang CL, Talpur R, Duvic M. Fas ligand expression by neoplastic T-lymphocytes mediates elimination of CD8+ cytotoxic T lymphocytes in mycosis fungoides: a potential mechanism of tumor immune escape? . Clin Cancer Res 7:2682-92, 2001.
12. Qin JZ, Zhang CL, Dummer R, Burg G, Döbbeling U. IL-7 and IL-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T cell lymphoma (CTCL) cells. Blood 98:2778-83, 2001.
13. Duan XS, Lu J, Zhang CL, Li SY. Study of immunoglobulins and C3 in lesions of exanthematous drug eruption by immunohistochemistry. J Clin Dermatol 30:20-1, 2001.
14. Duan XS, Lu J, Hu XM, Bai YL, Zhang CL, Li SY. Detection of expressed intercellular adhesion molecule-1 and HLA-DR and lymphocyte function assocation antigen-1 in lesions of exanthematous drug eruption by immunohistochemistry. Chin J Derm-Venereol 14:378-80, 2000.
15. Duan XS, Lu J, Zhang CL, Li SY. Detection of lymphocyte type and subtype from patients with eruptive drug dermatitis. Chin J Dermatol 33:358, 2000.
16. Bai YL, Zhang CL, Ying SX, Shen L, Li SY. Expression of oncoprotein rasp21 & mycp62 in cutaneous T cell lymphoma. J Beijing Med Univ 30:24-5, 1998.
17. Bai YL, Zhang CL, Li SY, Zhang B. Immunohistochemical study on ICAM-1/LFA-1 from patients with allergic contact dermatitis. Chin J Dermatol 30:194-5, 1997.
18. Zhang CL, Gong EC, Liu CL, Shen L, Li SY. Molecular diagnosis of lymph nodes from patients with mycosis fungoides/Sezsary syndrome. J Beijing Med Univ 29:48-50, 1997.
19. Zhang CL, Shen L, Zhang BY, Li SY. Study on immunophenotype of cutaneous lymphoma on paraffin-embedded tissue sections. Chin J Derm-Venereol 11:18-9, 1997.
20. Zhang CL, Bai YL, Zhang BY, Zhang B. Study on T-cell subtype from patients with allergic contact dermatitis. J Beijing Med Univ 29:216-7, 1997.
21. Bai YL, Zhang CL, Li SY, Zhang BY, Zhang B. Study on Th-cell subtype in skin biopsy samples from patients with allergic contact dermatitis. Chin J Dermatol 30:251-2, 1997.
22. Lin LH, Zhang CL, Lei PC, Zhang Q, Chen XR. Bullous pemphygoid with ulcer colontitis. J Beijing Med Univ 29:264, 1996.
23. Zhang CL, Gong EC, Liu YS, Shen L, Li SY. Study on clinical application of detecting T-cell receptor gene rearrangements in cutaneous T cell lymphoma. Chin J Dermatol 29:346-8, 1996.
24. Zhang CL, Liu YS, Gong EC, Shen L, Li SY. Study on expression and point mutation of p53 gene in cutaneous T cell lymphoma. Chin J Dermatol 29:439-40, 1996.
25. Zhang CL, Liu YS, Gong EC, Shen L, Li SY. The characteristics of expression of Th1 & Th2 cell-mediated cytokine profile and its significance in mycosis fungoides/Sézary syndrome. J Clin Dermatol 25:193-5, 1996.
26. Lu J, Zhang CL, Li SY. Immunohistochemical study on fixed drug eruption in acute stage. J Clin Dermatol 24:350-2, 1995.

Invited Articles
1. Zhang CL, Duvic M. Benefits of vorinostat in treating advanced cutaneous T-cell lymphomas. US Oncol:27-31, 2009.
2. Duvic M, Zhang CL. Clinical and laboratory experience of vorinostat (suberoylanilide hydroxamic acid) in the treatment of cutaneous T-cell lymphoma. Br J Cancer 95:S13-9, 2006.
3. Zhang CL, Duvic M. Retinoids: Treatment of cutaneous T-cell lymphoma with retinoids. Dermatol Ther 19:264-71, 2006.
4. Zhang CL, Duvic M. Retinoids: therapeutic application and mechanism of action in cutaneous T-cell lymphoma. Dermatol Ther 16:322-30, 2003.
5. Zhang CL, Shen L, Li SY. Advances in immunophenotype of cutaneous lymphoma. Chin J Derm-Venereol 11:39-41, 1997.
6. Zhang CL, Gong EC, Li SY. Study on lymphocyte receptor gene rearrangement analysis in cutaneous lymphoproliferative disorders. Dermatol Rev 22:149-52, 1996.

Book Chapters
1. Zhang CL, Duvic M. Retinoids in cutaneous T-cell lymphoma. In: Retinoids and Carotenoids in Dermatology. Informa Healthcare: New York, USA, 183-96, 2007.
2. Zhang CL, Li SY. Advances in cutaneous lymphoma. In: in Modern Dermatovenereology. Anhui Science & Technology Press: Hefei, China, 397-405, 1997.

Last updated: 11/22/2010