Skip to Content

'
Daniel P. Cahill, III, MD, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Neurosurgery, Division of Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Assistant Professor, Department of Neurosurgery, Division of Surgery, Baylor College of Medicine, Houston, TX

Education & Training

Degree-Granting Education

2001 Johns Hopkins University, Baltimore, MD, MD, Medicine
2001 Johns Hopkins University, Baltimore, MD, PHD, Human Genetics
1994 Yale University, New Haven, CT, BS, Molecular Biophysics & Biochemistry
1994 Yale University, New Haven, CT, MS, Molecular Biophysics & Biochemistry

Postgraduate Training

6/2002-6/2008 Residency, Neurosurgery, Massachusetts General Hospital, Boston, MA
6/2002-6/2008 Research Fellowship, Pathology, Massachusetts General Hospital, Boston, MA
6/2001-6/2002 Internship, General Surgery, Massachusetts General Hospital, Boston, MA

Selected Publications

Peer-Reviewed Original Research Articles
1. Cahill DP, Lengauer C, Yu J, Riggins GJ, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature 392(6673):300-3, 3/1998. PMID: 9521327.
2. Cahill DP, da Costa LT, Carson-Walter EB, Kinzler KW, Vogelstein B, Lengauer C.. Characterization of MAD2B and other mitotic spindle checkpoint genes. Genomics 1;58(2):181-7, 6/1999. PMID: 10366450.
3. Sparks AB, Peterson SN, Bell C, Loftus BJ, Hocking L, Cahill DP, Frassica FJ, Streeten EA, Levine MA, Fraser CM, Adams MD, Broder S, Venter JC, Kinzler KW, Vogelstein B, Ralston SH.. Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma. Calcif Tissue Int 68(3):151-5, 3/2001. PMID: 11351498.
4. Bardelli A, Cahill DP, Lederer G, Speicher MR, Kinzler KW, Vogelstein B, Lengauer C.. Carcinogen-specific induction of genetic instability. Proc Natl Acad Sci U S A 8;98(10):5770-5, 5/2001. e-Pub 4/10/2001. PMCID: PMC33288.
5. Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, Karess R, Kinzler KW, Vogelstein B, Velculescu VE, Lengauer C.. Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 1;64(9):2998-3001, 5/2004. PMID: 15126332.
6. Hunter C, Smith R, Cahill DP, Stephens P, Stevens C, Teague J, Greenman C, Edkins S, Bignell G, Davies H, O'Meara S, Parker A, Avis T, Barthorpe S, Brackenbury L, Buck G, Butler A, Clements J, Cole J, Dicks E, Forbes S, Gorton M, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Kosmidou V, Laman R, Lugg R, Menzies A, Perry J, Petty R, Raine K, Richardson D, Shepherd R, Small A, Solomon H, Tofts C, Varian J, West S, Widaa S, Yates A, Easton DF, Riggins G, Roy JE, Levine KK, Mueller W, Batchelor TT, Louis DN, Stratton MR, Futreal PA, Wooster R.. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res 15;66(8):3987-91, 4/2006. PMID: 16618716.
7. Nagurney JT, Feldman D, Cahill DP, Gatha NM, Koroshetz WJ.. Unusual visual symptoms in a patient with bilateral vertebral artery dissection: a case report. J Emerg Med 31(2):169-71, 8/2006. PMID: 17044579.
8. Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 11(1):83-95, 1/2007. PMID: 17222792.
9. Greenman C, Stephens P, Smith R, Dalgliesh G, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O’Meara S, Avis T, Barthorpe S, Bhamra S, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew Y, deFazio A, Greaves MF, Green AR, Easton DF, Chenevix-Trench G, Khoo SK, Tan M, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR.. Patterns of somatic mutation in human cancer genomes. Nature 8;446(7132):153-8, 3/2007. PMID: 17344846.
10. Cahill DP, Levine KK, Betensky RA, Codd PJ, Romany CA, Reavie LB, Batchelor TT, Futreal PA, Stratton MR, Curry WT, Iafrate AJ, Louis DN.. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin Cancer Res 1;13(7):2038-45, 4/2007. PMID: 17404084.
11. Cahill DP, Codd PJ, Batchelor TT, Curry WT, Louis DN. MSH6 inactivation and emergent temozolomide resistance in human glioblastomas. Clin Neurosurg 55:165-71, 2008. PMID: 19248684.
12. Yip S, Miao J, Cahill DP, Iafrate AJ, Aldape K, Nutt CL, Louis DN. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin Cancer Res 15(14):4622-9, 7/2009. PMID: 19584161.

Grant & Contract Support

Title: Translational Molecular Genetic Analysis of Chemotherapeutic Resistance in Human Brain Tumors
Funding Source: Burroughs-Wellcome Career Award in Medical Sciences
Role: Principal Investigator
Duration: 2008 - present
 
Title: Investigation of Mismatch Repair Pathway Inactivation in Chemoresistant Glioblastomas
Funding Source: Brain Tumor Society
Role: Co-Investigator
Principal Investigator: Louis
Duration: 2006 - 2008
 
Title: Investigation of Mismatch Repair Pathway Inactivation in Chemoresistant Glioblastomas
Funding Source: National Brain Tumor Foundation
Role: Principal Investigator
Duration: 2006 - 2008
 
Title: Molecular Immunology and Tumor Biology
Funding Source: NIH/NCI
Role: Postdoctoral Fellow
Principal Investigator: D. Louis
Duration: 2005 - 2007
 
Title: Analysis of Oligodendroglioma Gene Expression Profiles.
Funding Source: American Association of Neurological Surgery Neurosurgery Research and Education Foundation
Role: Principal Investigator
Duration: 2005 - 2007

Last updated: 9/3/2009