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David L. Mitchell, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Carcinogenesis, Science Park – Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX

Education & Training

Degree-Granting Education

1988 The University of Texas at Austin, Austin, TX, PHD, Molecular Biology
1980 The University of Texas Health Science Center at Houston, Houston, TX, MS, Molecular Biology
1975 The University of Texas at Austin, Austin, TX, BS, Zoology

Postgraduate Training

1/1988-1/1990 Alexander Hollaender Postdoctoral Fellow, University of California, San Francisco, CA

Selected Publications

Peer-Reviewed Original Research Articles
1. Lange SS, Mitchell DL, Vasquez KM. High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage. Proc Natl Acad Sci U S A 105(30):10320-5, 7/2008. PMCID: PMC2492475.
2. Mitchell D, Paniker L, Sanchez G, Bellla Z, Garaczi E, Szell M, Hamid Q, Kemeny L, Koreck A. Molecular response of nasal mucosa to therapeutic exposure to broad-band ultraviolet radiation. J Cell Mol Med 12(5):1-10, 7/2008. PMID: 18671762.
3. Nijhof JG, van Pelt C, Mulder AA, Mitchell DL, Mullenders LH, de Gruijl FR. Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency. Carcinogenesis 28(4):792-800, 4/2007. PMID: 17127714.
4. Hansen AJ, Mitchell DL, Wiuf C, Paniker L, Brand TB, Binladen J, Gilichinsky DA, Ronn R, Willerslev E. Crosslinks rather than strand breaks determine access to ancient DNA sequences from frozen sediments. Genetics 173(2):1175-9, 6/2006. PMCID: PMC1526502.
5. Mitchell DL, Byrom M, Chiarello S, Lowery MG. Effects of chronic exposure to ultraviolet B radiation on DNA repair in the dermis and epidermis of the hairless mouse. J Invest Dermatol 116(2):209-15, 2/2001. PMID: 11179995.
6. Mitchell DL, Greinert R, de Gruijl FR, Guikers KL, Breitbart EW, Byrom M, Gallmeier MM, Lowery MG, Volkmer B. Effects of chronic low-dose ultraviolet B radiation on DNA damage and repair in mouse skin. Cancer Res 59(12):2875-84, 6/1999. PMID: 10383149.
7. Britt AB, Chen JJ, Wykoff D, Mitchell D. A UV-sensitive mutant of Arabidopsis defective in the repair of pyrimidine-pyrimidinone(6-4) dimers. Science 261(5128):1571-4, 9/1993. PMID: 8372351.
8. Karentz D, Cleaver JE, Mitchell DL. Cell survival characteristics and molecular responses of antarctic phytoplankton to UV radiation. J Phycol 27(3):326-41, 6/1991.
9. Mitchell DL, Nguyen TD, Cleaver JE. Nonrandom induction of pyrimidine-pyrimidone (6-4) photoproducts in ultraviolet-irradiated human chromatin. J Biol Chem 265(10):5353-6, 4/1990. PMID: 2318816.
10. Mitchell DL, Clarkson JM. The development of a radioimmunoassay for the detection of photoproducts in mammalian cell DNA. Biochim Biophys Acta 655(1):54-60, 8/1981. PMID: 7260090.

Invited Articles
1. Mitchell DL, Karentz D. Molecular and biological responses of Antarctic phytoplankton to ultraviolet radiation. Antarctic J of the U.S. 25:174-5, 1990.
2. Mitchell DL, Nairn RS. The biology of the (6-4) photoproduct. Photochem Photobiol 49(6):805-19, 6/1989. PMID: 2672059.
Other Articles
1. Mitchell D. Revisiting the photochemistry of solar UVA in human skin. Proc Nat Acad Sci USA 103(37):13567-8, 9/2006. PMCID: PMC1564261.

Book Chapters
1. Mitchell DL, Ghosh R. Oxidative DNA damage and promoter function. In: Oxidative Damage to Nucleic Acids. Molecular Biology Intelligence Unit, Chapter 7. Ed(s) Evans MD, Cooke MS. Landes Bioscience: Leicester, UK, 2007.
2. Cleaver JE, Mitchell DL. Ultraviolet radiation carcinogenesis. In: Holland Frei Cancer Medicine. Chapter 17, 7. Ed(s) Kufe DW, Frei III E, Holland JV, Weichselbaum RR, Pollock RE, Bast Jr RC, Hong WK, Hait WN. BC Decker, Inc. Columbia, 2006.
3. Mitchell DL. DNA Damage Induced by Ultraviolet Radiation. In: Encyclopedia of Molecular Biology and Molecular Medicine, Second Edition. 3. Ed(s) Meyers RA. Chernow: New York, 1-34, 2004.
4. Mitchell DL. DNA damage and repair. In: CRC Handbook of Organic Photochemistry and Photobiology, 2. Ed(s) Horspool WM, Lenci F. CRC Press: London, 140.1-140.15, 2003.
5. Mitchell DL. Ultraviolet radiation. In: Encyclopedia of Molecular Biology: and Molecular Medicine. Chernow Publishers, In press, 2000.
6. Mitchell DL. DNA damage and repair. In: A Handbook of Organic Photochemistry and Photobiology. Ed(s) Horspool W, Song PS. CRC Press: London, 1310-5, 1995.
7. Mitchell DL. Ultraviolet radiation damage to DNA. In: Molecular Biology and Biotechnology: A Comprehensive Desk Reference. Ed(s) Meyers RA. VCH Publishers: New York, 939-43, 1995.
8. Mitchell DL, Karentz D. The induction and repair of DNA photodamage in the environment. In: Environmental UV Photobiology. Ed(s) Young AR, Bjorn LO, Moan J, Nultsch W. Plenum Press, 345-77, 1993.

Last updated: 9/21/2009