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Dean Tang, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Carcinogenesis, Science Park -Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX

Dual/Joint/Adjunct Appointment

Adjunct Associate Professor, School of Pharmacy, The University of Texas at Austin, Austin, TX

Research Interests

cancer stem cells; prostate cancer; apoptosis

Education & Training

Degree-Granting Education

1994 Wayne State University Medical School, Detroit, MI, PHD, Cancer Biology
1989 Wuhan University School of Medicine, Wuhan, China, MS, Molecular Oncology

Selected Publications

Peer-Reviewed Original Research Articles
1. Jeter CR, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, Calhoun-Davis T, Zaehres H, Daley GQ, Tang DG. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 27(5):993-1005, 5/2009. PMID: 19415763.
2. Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward S, Tang DG. Critical and distinct roles of p16 and telomerase in regulating the proliferative lifespan of normal human prostate epithelial progenitor cells. J Biol Chem 283(41):27957-72, 10/2008. PMCID: PMC2562067.
3. Li H, Chen X, Calhoun-Davis T, Claypool K, Tang DG. PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells. Cancer Res 68(6):1820-5, 3/2008. PMID: 18339862.
4. Patrawala L, Calhoun-Davis T, Schneider-Broussard R, Tang DG. Hierarchical organization of prostate cancer cells in xenograft tumors: the CD44+alpha2beta1+ cell population is enriched in tumor-initiating cells. Cancer Res 67(14):6796-805, 7/2007. PMID: 17638891.
5. Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell 125(7):1333-46, 6/2006. PMID: 16814719.
6. Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, Coghlan L, Tang DG. Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 25(12):1696-708, 3/2006. PMID: 16449977.
7. Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Cancer Res 65(14):6207-19, 7/2005. PMID: 16024622.
8. Bhatia B, Tang S, Yang P, Doll A, Aumueller G, Newman RA, Tang DG. Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells. Oncogene 24(22):3583-95, 5/2005. PMID: 15750631.
9. Tang DG, Tokumoto YM, Apperly JA, Lloyd AC, Raff MC. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 291(5505):868-71, 2/2001. PMID: 11157165.

Last updated: 10/19/2009