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Dimpy Koul, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 1002
Houston, TX 77030
Room Number: BSRB, Rm S5.8336C
Email: dkoul@mdanderson.org

Education & Training

Degree-Granting Education

1996 Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, PHD, Immunopathology
1989 Kashmir University, Srinagar, India, MS, Biochemistry
1987 Kashmir University, Srinagar, India, BS, Biology

Postgraduate Training

1999 Postdoctoral Fellow, Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
1998 Research Fellowship, Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
1997 Senior Demonstrator, Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Experience/Service

Academic Appointments

Associate Professor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2010-present

Honors and Awards

2000 Young Investigator Award, American Association of Indian Scientists in Cancer Research
1999 M. D. Anderson Cancer Center Amgen Award for Excellence in Basic Research, The University of Texas M. D. Anderson Cancer Center
1996 Fogarty Fellowship, NIH
1995 International Union of Immunological Society Fellowship (IUI), International Union of Immunological Society
1994 National Medal for the Best Young Scientist, Indian Immunology Society
1994 Outstanding Merit Fellowship for Graduate Studies, Post Graduate Institute of Medical Education and Research (PGIMER)
1989 University Gold Medal and Honor of Distinction, Kashmir University, India
1986 University Outstanding Merit Fellowship in M.S. studies for merit in BS, Kashmir University, India

Professional Memberships

American Association for the Advancement of Science (AAAS), Washington, DC
Member
American Association of Cancer Research (AACR), Pittsburgh, PA
Member, present
Indian Immunology Society (IIS), New Delhi, India
Life Member, present
Society of Biological Chemists (SBC), Bangalore, Karnataka, India
Member

Selected Publications

Peer-Reviewed Original Research Articles

1. Koul D, Fu J, Shen R, LaFortune TA, Wang S, Tiao N, Kim YW, Liu JL, Ramnarian D, Yuan Y, Garcia-Echevrria C, Maira SM, Yung WK. Antitumor activity of NVP-BKM120- a selective pan class 1 PI3 Kinase inhibitor showed differential forms of cell death based on P53 status of glioma cells. Clin Cancer Res 18(1):184-95, 1/2012. e-Pub 11/2011. PMID: 22065080.
2. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell 20(3):384-99, 9/2011. PMCID: PMC3172881.
3. Guan S, Shen R, Lafortune T, Tiao N, Houghton P, Yung WK, Koul D. Establishment and characterization of clinically relevant models of ependymoma: a true challenge for targeted therapy. Neuro Oncol 13(7):748-58, 7/2011. e-Pub 6/2011. PMCID: PMC3129270.
4. Kim YW, Liu TJ, Koul D, Tiao N, Feroze AH, Wang J, Powis G, Yung WK. Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM. Neuro Oncol 13(4):367-75, 4/2011. PMCID: PMC3064700.
5. Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. Int J Cancer 128(4):787-96, 2/2011. PMCID: PMC2990813.
6. Koul D, Shen R, Kim YW, Kondo Y, Lu Y, Bankson J, Ronen SM, Kirkpatrick DL, Powis G, Yung WK. Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro Oncol 12(6):559-69, 6/2010. e-Pub 2/2010. PMCID: PMC2940638.
7. Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM, Garcia-Echevrria C, Yung WKA. NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol Cancer Ther 8(8):2204-10, 8/2009. e-Pub 8/2009. PMID: 19671762.
8. Verma A, Guha S, Wang H, Fok JY, Koul D, Abbruzzese J, Mehta K. Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res 14(7):1997-2005, 4/2008. PMID: 18381937.
9. Freire P, Yung WK, Aldape KD, Bogler O, Koul D, Coombes K, Mills GB, Vasconcelos AT, Almeida JS. Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS Biol 3(12):e4076, 2008. e-Pub 12/2008. PMCID: PMC2605252.
10. Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway. Mol Cell Biochem 300(1-2):77-87, 1/2007. PMID: 17235455.
11. Koul D, Takada Y, Shen R, Aggarwal BB, Yung WK. PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells. Biochem Biophys Res Commun 350(2):463-71, 11/2006. e-Pub 9/2006. PMCID: PMC2703012.
12. Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. Mol Cancer Ther 5(3):637-44, 3/2006. PMID: 16546978.
13. Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther 4(11):1681-8, 11/2005. PMID: 16275989.
14. Nigro JM, Misra A, Zhang L, Smirnov I, Colman H, Griffin C, Ozburn N, Chen M, Pan E, Koul D, Yung WK, Feuerstein BG, Aldape KD. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res 65(5):1678-86, 3/2005. PMID: 15753362.
15. Unni E, Koul D, Yung WK, Sinha R. Se-methylselenocysteine inhibits phosphatidylinositol 3-kinase activity of mouse mammary epithelial tumor cells in vitro. Breast Cancer Res 7(5):R699-707, 2005. PMCID: PMC1242134.
16. Mehta K, Fok J, Miller FR, Koul D, Sahin AA. Prognostic significance of tissue transglutaminase in drug resistant and metastatic breast cancer. Clin Cancer Res 10(23):8068-76, 12/2004. PMID: 15585642.
17. Hazarika P, McCarty MF, Prieto VG, George S, Babu D, Koul D, Bar-Eli M, Duvic M. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res 64(20):7361-9, 10/2004. PMID: 15492257.
18. Shishodia S, Koul D, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 173(3):2011-22, 8/2004. PMID: 15265936.
19. Cerrato JA, Khan T, Koul D, Lang FF, Conrad CA, Yung WK, Liu TJ. Differential activation of the Fas/CD95 pathway by Ad-p53 in human gliomas. Int J Oncol 24(2):409-17, 2/2004. PMID: 14719118.
20. Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem 278(41):40057-66, 10/2003. e-Pub 7/2003. PMID: 12869565.
21. Koul D, Shen R, Garyali A, Ke LD, Liu TJ, Yung WK. MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer. Int J Oncol 21(3):469-75, 9/2002. PMID: 12168088.
22. Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK. Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene 21(15):2357-64, 4/2002. PMID: 11948419.
23. Sheng X, Koul D, Liu JL, Liu TJ, Yung WK. Promoter analysis of tumor suppressor gene PTEN: identification of minimum promoter region. Biochem Biophys Res Commun 292(2):422-6, 3/2002. PMID: 11906179.
24. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN. Oncogene 20(46):6669-78, 10/2001. PMID: 11709701.
25. Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res 61(18):6693-7, 9/2001. PMID: 11559537.
26. Koul D, Yao Y, Abbruzzese JL, Yung WK, Reddy SA. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem 276(14):11402-8, 4/2001. PMID: 11278366.
27. Tanaka M, Koul D, Davies MA, Liebert M, Steck PA, Grossman HB. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene 19(47):5406-12, 11/2000. PMID: 11103942.
28. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59(11):2551-6, 6/1999. PMID: 10363971.
29. Sano T, Lin H, Chen X, Langford LA, Koul D, Bondy ML, Hess KR, Myers JN, Hong YK, Yung WK, Steck PA. Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis. Cancer Res 59(8):1820-4, 4/1999. PMID: 10213484.
30. Steck PA, Lin H, Langford LA, Jasser SA, Koul D, Yung WK, Pershouse MA. Functional and molecular analyses of 10q deletions in human gliomas. Genes, Chromosomes and Cancer 24(2):135-43, 2/1999. PMID: 9885980.
31. Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res 58(23):5285-90, 12/1998. PMID: 9850049.
32. Koul D, Obeyesekere NU, Gutterman JU, Mills GB, Choubey D. p202 self-associates through a sequence conserved among the members of the 200-family proteins. FEBS Lett 438(1-2):21-4, 10/1998. PMID: 9821952.
33. Koul D, Lapushin R, Xu HJ, Mills GB, Gutterman JU, Choubey D. p202 prevents apoptosis in murine AKR-2B fibroblasts. Biochem Biophys Res Commun 247(2):379-82, 6/1998. PMID: 9642135.
34. Sehgal S, Koul D, Verma S. Effect of immunization with human SP-10 in male rodents. Am J Reprod Immunol 36(3):167-74, 9/1996. PMID: 8874713.
35. Siddiqui M, Kumar R, Koul D, Spiegelhalder B, Preussmann R. Salivary nitrate and nitrite concentrations from sample population of children and adults in high risk area of esophageal and gastric cancers in Kashmir, India. Cancer Lett 64(2):133-6, 1992.

Invited Articles

1. Koul D. PTEN signaling pathways in glioblastoma. Cancer Biol Ther 7(9):1321-1325, 2008. e-Pub 9/2008. PMID: 18836294.

Abstracts

1. Fu J, Koul D, Yao J, Wang S, Gumin J, Shen R, Vaillant B, Colman H, Lang F, Aldape K, Yung WK. Molecular and lineage analysis of glioblastoma stem cells identifies clinically relevant models of glioblatoma. 102nd Annual Meeting of the American Association for Cancer Research, Orlando, Florida. April 2-6, 2011, 4/2011.
2. Koul D, Shen R, LaFortune T, and Yung WK. NVP-BKM120: a selective pan-PI3 Kinase inhibitor induces G2/M arrest in glioma cell lines via FOXO3a and GADD45a loop. 101st Annual Meeting of the American Association for Cancer Research, Washington, DC, April 17-21, 2010, 4/2010.
3. Guan S, Yung WKA, Koul D. Methionine aminopeptidase-2 interferes with VHL to regulate VEGF transcription through HIF-1 alpha: role for angiogenesis inhibition in glioma. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; (#4080), 2009.
4. Kim YW, Koul D, Kim SH, Almeida JS, Bogler O, Aldape K, Yung WKA. Novel gene set identification and pathway specific survival patterns using gene expression profiling of human glioblastoma: A study based on TCGA data analysis. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; (#2427), 2009.
5. Koul D, Shen R, Edge J, Henry V, Webb D, Bankson J, Ronen S, Powis G, Kirkpatrick DL, Yung WKA. Cellular and in vivo activity of a new PI3K inhibitor-PX866 for treatment of human glioblastoma. 99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA (#3731), 4/2008.
6. Kim YW, Tiao N, Lafortune T, Liu T-J, Powis G, Yung WKA, Koul D. Identification of novel synergistic targets RACK-1 and galectin-1 for rational drug combinations with PI3 Kinase inhibitors using siRNA synthetic lethality screening. 99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA (#2761), 4/2008.
7. Verma A, Guha S, Koul D, Wang H, Mehta K. Regulation of tumor suppressor protein PTEN by tissue transglutaminase: prognostic significance in pancreatic cancer. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA (#LB-29), 2007.
8. Koul D, Shen R, Edge J, Iwado E, Kondo Y, Liu TJ, Powis G, Kirkpatrick DL, Yung WK. Targeting Phosphatidylinositol 3-Kinase (P13K) Pathway in Human Glioblastoma with PX866: a small molecule P13K inhibitor. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA (#278), 2007.
9. Koul D, Shen R, Edge J, Iwado E, Knondo Y, Liu TJ, Powis G, Kirkpatrick L, Yung WK. Phosphatidylinositol 3-Kinase (P13K) pathway- a therapeutic target for human glioblastoma. Neuro-oncol 8(4):414 (#ET-20), 10/2006.
10. Koul D, Bergh S, Shen R, Yung WKA. Targeting integrin linked kinase (ILK) pathway in human glioblastoma. Neuro-oncol 6(4):332 (#ET-10), 10/2004.
11. Koul D, Shen R, Bergh S, Yung WKA. Characterization of PTEN associated proteins. Proc Amer Assoc Cancer Res 45:815 (#3533), 3/2004.
12. Koul D, Bergh S, Shen R, Yung WKA. Targeting ILK Pathway in Human Glioblastoma. Proc Amer Assoc Cancer Res 45:1200 (#5205), 3/2004.
13. Koul D, Shen R, Bergh S, Yung WKA. Characterization of PTEN associated proteins. Neuro-oncol 5(4):279-360 (#CB-11), 11/2003.
14. Koul D, Bergh S, Shen R, Yung WKA. Targeting PTEN/PI3K pathway in human glioblastoma. Neuro-oncol 5(4):290-291 (#CB-12), 10/2003.
15. Liu JL, Sheng X, Koul D, Yung WKA. Cell cycle-dependent subcellular localization of PTEN/MMAC tumor suppressor is regulated by PI3k signaling cascades. Neuro-oncol 4(4):315 (#28), 10/2002.
16. Koul D, Parthasarathy R, Shen R, Liu TJ, Yung WKA. PTEN tumor suppressor gene inhibits matrix metalloproteinase-2 gene expression and invasion in human glioma cells. Neuro-oncol 4(4):338 (#114), 10/2002.
17. Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK. MMAC/PTEN tumor suppressor gene inhibits matrix metalloproteinase-2 gene expression and invasion in human glioma cells. 93rd Annual meeting of American Association for Cancer Research, San Fransisco, CA, 4/2002.
18. Koul D, Yao Y, Abbruzzese JL, Yung WKA, Reddy SA. MMAC/PTEN tumor suppressor inhibits cytokine-induced NFkB activation–Evidence for a novel mechanism. 92nd Annual meeting of American Association for Cancer Research, New Orleans, LA, 3/2001.
19. Gomez-Manzano C, Mitilianga P, Koul D, Yung WKA. E2F transcriptionally upregulates BCL- 2. Neuro-oncol 2(4):265 (#80), 10/2000.
20. Gomez-Manzano C, Fueyo J, Glass T, Koul D, Lee HY, Shi YX, Liu TJ, Yung WKA. MMAC/PTEN downregulates VEGF in gliomas. Neuro-oncol 2(4):265 (#81), 10/2000.
21. Koul D, Yao Y, Reddy SAG, Abbruzzese JL, Yung WKA. Regulation of NFkB and Ap-1 activation through MMAC/PTEN. Neuro-oncol 2(4):275 (#122), 10/2000.
22. Koul D, Jasser SA, Davies MA, Liu JL, Lu Y, Reddy SAG, Mills GB, Yung WKA, Steck PA. Motif analysis of Tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and signal transduction and reveals alternative mechanisms of Akt phosphorylation. 91st AACR Annual Meeting-- Apr 14-18, 2000; San Francisco, CA, 4/2000.
23. Koul D, Steck PA. Functional roles of MMAC/PTEN. 90th AACR Annual Meeting-- Apr 10-14, 1999; Philadelphia, PA (Invited Speaker), 10/1999.
24. Koul D. Regulatory functions of MMAC/PTEN tumor suppressor gene. Fourth Annual Meeting of Society for Neuro-Oncology; Scottsdale, AZ, 1999.
25. Koul D, Sehgal S, Verma S. Anti SP-10 antibodies do not interfere with spermatogenesis. Ninth International Congress of Immunology; San Fransisco, CA, 7/1995.
26. Koul D, Sehgal S, Verma S. Effect of immunization with human SP-10 in male rodents. Sixth International Congress of Reproductive Immunology, Washington, DC, 7/1995.
27. Koul D, Verma S, Sehgal S. Effect of immunization with human SP-10 in male rodents. Indian Immunology Society; Chandigarh, India, 1994.
28. Sehgal S, Koul D, Vasishta K, Herr J. Serum antibodies to recombinant human intra-acrosomal antigen SP-10 in infertile couples. Fourteenth Annual Meeting of the American Society for Reproductive Immunology (ASRI); Philadelphia, PA, 1994.
29. Koul D. Status of human SP-10 as a candidate contraceptive vaccine. Indian Immunology Society; Chandigarh, India, 1994.
30. Koul D, Vasishta K, Sehgal S. Identification and characterization of a 26 Kd immunodominant antigen of human sperm membrane. Indian Immunology Society; Bhopal, India, 12/1993.
31. Sehgal S, Koul D, Singh G, Wright RM, Herr J. Cross-reactivity of SP-10 with bull spermatozoa. International Congress of Reproductive Immunology; Rome, Italy, 8/1992.
32. Sehgal S, Sinha R, Koul D, Khullar N. Diagnostic Assay for Kalazar. 8th International Congress of Immunology; Budapest, Hungary, 1992.
33. Sehgal S, Koul D, Gupta SK, Gupta R, Singh G, Dhall K. Comparative evaluation of antisperm antibodies in infertile couples. Indian Immunology Society; Delhi, India, 1991.
34. Sehgal S, Singh G, Koul D, Malhotra S. Use of flowcytometry in evaluation of sperm bound antibodies. Indian Immunology Society; Delhi, India, 1991.

Book Chapters

1. Koul D, Davies MA, Steck PA, Yung WK. MMAC/PTEN: The Progression Tumor Suppressor Gene. In: Recent Research Developments in Cancer. 2, Part II. Ed(s) S.G. Pandalai. Transworld research network: Trivandrum, India, 271-281, 2000. ISBN: 81-86846-68-9.

Books (edited and written)

1. Steck PA, Yung WK, Davies MA, Koul D, Jasser, S. Functional identification and characterization of MMAC/PTEN: Involvement in malignant progression. Current Options for the Human Genome Project, 2000.

Grant & Contract Support

Title: Targeting the Ependymoma with Signaling Inhibitors and Rational Combinations Using Synthetic Lethality Screen
Funding Source: Children's Brain Tumor Foundation (CBTF)
Role: Principal Investigator
Duration: 11/1/2009 - 11/30/2012
 
Title: Collaborative Medical Research, LLC
Funding Source: Collaborative Ependymoma Research Network (CERN)
Role: Co-Investigator
Principal Investigator: Dr. W.K. Alfred Yung
Duration: 7/20/2007 - 7/19/2013
 
Title: Deciphering Synergistic Combinatorial Targets in Glioma
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: W. K. Alfred Yung, M.D.
Duration: 7/1/2006 - 6/30/2012

Last updated: 8/5/2013