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Dingzhi Wang, PhD

Present Title & Affiliation

Primary Appointment

Professor, Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Dr. Wang's research is focused on understanding the molecular and genetic basis for colorectal cancer.  

He has several projects underway to understand the molecular mechanisms by which prostaglandins and other 

inflammatory mediators affect epithelial biology, carcinogenesis and inflammatory bowel disease.

Education & Training

Degree-Granting Education

1985 Shanghai Institute of Materia Medica, Chinese - Academy of Sciences, Shanghai, China, PHD, PhD
1978 Yunnan University, Yunnan, China, BS, Bachelor of Science

Postgraduate Training

1992-1997 Post-Doctorial, Biomedical, Vanderbilt University, Nashville, TN, Mark Boothby

Experience/Service

Academic Appointments

Research Associate Professor, Department of Gastrointestinal (GI) Medical Oncology, Vanderbilt University, Nashville, TN, 2002-2009
Research Assistant Professor, Department of Cancer Biology, Vanderbilt University, Nashville, TN, 2001-2002
Research Assistant Professor, Cell Biology, Vanderbilt University, Nashville, TN, 2000-2001
Research Instructor, Cell Biology, Vanderbilt University, Nashville, TN, 1997-2000

Honors and Awards

2008 Aspen Cancer Conference Fellow Award, 23rd Aspen Cancer Conference in Aspen, CO
2001 Travel Award, International Cytokine Meeting in Maui, Hawaii

Professional Memberships

American Association for Cancer Research
Member, 2008-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Xia D, Wang D, Kim SH, Katoh H, Dubois RN. Prostaglandin E(2) promotes intestinal tumor growth via DNA methylation. Nat Med 18(2):224-6, 2012. e-Pub 1/2012. PMCID: PMC3274627.
2. Kim SH, Park YY, Kim SW, Lee JS, Wang D, Dubois RN. ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression. Cancer Res 71(22):7010-20, 11/2011. e-Pub 9/2011. PMCID: PMC3217078.
3. Wang D, Ning W, Xie D, Guo L, Dubois RN. Peroxisome proliferator-activated receptor d confers resistance to peroxisome proliferator-activated receptor ?-induced apoptosis in colorectal cancer cells. Oncogene. e-Pub 7/2011. PMID: 21765467.
4. Xia D, Holla VR, Wang D, Menter DG, DuBois RN. Prostaglandin E2 Induces Human Enhancer of Filamentation 1 to Promote Proliferation of Colorectal Carcinoma Cells. Cancer Res 70:824-31, 2009.
5. Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 68(15):6468-76, 8/2008. PMCID: PMC2561258.
6. Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimlulates cancer progression. Proc Natl Acad Sci U S A 103(50):19069-74, 12/2006. e-Pub 12/2006. PMCID: PMC1748178.
7. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK, DuBois RN. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203(4):941-51, 4/2006. e-Pub 3/2006. PMCID: PMC2118273.
8. Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res 65(9):3735-44, 5/2005. PMCID: PMC2584020.
9. Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res 65(5):1822-9, 3/2005. PMID: 15753380.
10. Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN. Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem 280(1):476-83, 1/2005. e-Pub 11/2004. PMID: 15520008.
11. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95, 9/2004. PMID: 15380519.
12. Gupta RA, Wang D, Katkuri S, Wang H, Dey SK, DuBois RN. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat Med 10(3):245-7, 3/2004. e-Pub 2/2004. PMID: 14758356.
13. Wang D, DuBois RN. Cyclooxygenase 2-derived prostaglandin E2 regulates the angiogenic switch. Proc Natl Acad Sci U S A 101(2):415-6, 1/2004. e-Pub 1/2004. PMCID: PMC327160.
14. Ma, G.E., Chen, J.Q., Wang, D.Z., Huang, H.Z. Studies on the alkaloies of Cephalotaxus-isolation of 7-deoxycephalofortuneine, a new alkaloid. Acta Botanica Sinica(31):137-140, 1989.
Other Articles
1. Wang D, Dubois RN. Associations Between Obesity and Cancer: The Role of Fatty Acid Synthase. J Natl Cancer Inst 104(5):343-5, 3/7/2012. e-Pub 2/6/2012. PMCID: PMC3295747.
2. Wang D, Dubois RN. Epoxyeicosatrienoic acids: a double-edged sword in cardiovascular diseases and cancer. J Clin Invest 122(1):19-22, 1/2012. e-Pub 12/2011. PMCID: PMC3248310.
3. Wang D, DuBois RN. Therapeutic potential of peroxisome proliferator-activated receptors in chronic inflammation and colorectal cancer. Gastroenterol Clin North Am 39(39):697-707, 9/2010. PMCID: PMC2957674.
4. Wang D, Dubois RN. Eicosanoids and cancer. Nat Rev Cancer 10(3):181-93, 3/2010. e-Pub 2/2010. PMCID: PMC2898136.
5. Wang D, Dubois RN. The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 29(6):781-8, 2/2010. e-Pub 11/2009. PMID: 19946329.
6. Wang D, Dubois RN, Richmond A. The role of chemokines in intestinal inflammation and cancer. Curr Opin Pharmacol 9(6):688-96, 12/2009. e-Pub 9/2009. PMCID: PMC2787713.
7. Wang D, Dubois RN. Prostaglandins and cancer. Gut 55(1):115-22, 1/2006.
8. Wang D, Mann JR, DuBois RN. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology 128(5):1445-61, 5/2005. PMID: 15887126.
9. Wang D, Mann JR, DuBois RN. WNT and cyclooxygenase-2 cross-talk accelerates adenoma growth. Cell Cycle 3(12):1512-5, 12/2004.
10. Wang D, Dubois RN. Cyclooxygenase-2: a potential target in breast cancer. Semin Oncol 31(1 Suppl 3):64-73, 2/2004. PMID: 15052544.

Grant & Contract Support

Title: Prostaglandins and Inflammation in Colorectal Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Principal Investigator
Principal Investigator: Raymond DuBois
Duration: 4/1/2010 - 4/1/2013
 
Title: Mechanisms for Chemoprevention of Cancer
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Duration: 6/22/2004 - 4/30/2010
 
Title: Nuclear Hormone Receptors and Intestinal Epithelial Biology
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 7/1/2002 - 6/30/2011
 
Title: Role of Eicosanoids in Intestinal Epithelial Growth and Function
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 8/20/1994 - 7/31/2013

Last updated: 7/27/2012