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Dingzhi Wang, PhD

Present Title & Affiliation

N/A

Research Interests

Dr. Wang's research is focused on understanding the molecular and genetic basis for colorectal cancer.  

He has several projects underway to understand the molecular mechanisms by which prostaglandins and other 

inflammatory mediators affect epithelial biology, carcinogenesis and inflammatory bowel disease.

Education & Training

Degree-Granting Education

1985 Shanghai Institute of Materia Medica, Chinese - Academy of Sciences, Shanghai, China, PHD, PhD
1978 Yunnan University, Yunnan, China, BS, Bachelor of Science

Postgraduate Training

1992-1997 Research Fellowship, Biomedical, Vanderbilt University, Nashville, TN, Mark Boothby

Experience/Service

Academic Appointments

Professor, Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2009-present

Honors and Awards

2008 Aspen Cancer Conference Fellow Award, 23rd Aspen Cancer Conference in Aspen, CO
2001 Travel Award, International Cytokine Meeting in Maui, Hawaii

Selected Publications

Peer-Reviewed Original Research Articles
1. Wang D, Wang H, Ning W, Backlund MG, Dey SK, DuBois RN. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res 68(15):6468-76, 8/2008. PMCID: PMC2561258.
2. Pedchenko TV, Gonzalez AL, Wang D, DuBois RN, Massion PP. Peroxisome proliferator-activated receptor beta/delta expression and activation in lung cancer. Am J Respir Cell Mol Biol 39(6). e-Pub 6/2008. PMID: 18566335.
3. Wang D, DuBois RN. Pro-inflammatory prostaglandins and progression of colorectal cancer. Cancer Lett 267(2). e-Pub 4/2008. PMCID: PMC2553688.
4. Wang D, Dubois RN. Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res 2008:931074, 2008. PMCID: PMC2422873.
5. Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, DuBois RN, Dey SK. Stage-specific integration of maternal and embryonic peroxisome proliferator-activated receptor delta signaling is critical to pregnancy success. J Biol Chem 282(52):37770-82, 12/2007. e-Pub 10/2007. PMID: 17965409.
6. Wang D, DuBois RN. Inflammatory mediators and nuclear receptor signaling in colorectal cancer. Cell Cycle 6(6). e-Pub 3/2007. PMID: 17374999.
7. Wang D, DuBois RN. Measurement of eicosanoids in cancer tissues. Methods Enzymol 433:27-50, 2007. PMID: 17954227.
8. Wang D, Wang H, Guo Y, Ning W, Katkuri S, Wahli W, Desvergne B, Dey SK, DuBois RN. Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 103(50):19069-74, 12/2006. e-Pub 12/2006. PMCID: PMC1748178.
9. Wang D, Wang H, Brown J, Daikoku T, Ning W, Shi Q, Richmond A, Strieter R, Dey SK, DuBois RN. CXCL1 induced by prostaglandin E2 promotes angiogenesis in colorectal cancer. J Exp Med 203(4):941-51, 4/2006. e-Pub 3/2006. PMCID: PMC2118273.
10. Wang D, Dubois RN. Prostaglandins and cancer. Gut 55(1):115-22, 1/2006. e-Pub 8/2005. PMCID: PMC1856377.
11. Musiek ES, Gao L, Milne GL, Han W, Everhart MB, Wang D, Backlund MG, DuBois RN, Zanoni G, Vidari G, Blackwell TS, Morrow JD. Cyclopentenone isoprostanes inhibit the inflammatory response in macrophages. J Biol Chem 280(42):35562-70, 10/2005. e-Pub 8/2005. PMID: 16100121.
12. Daikoku T, Wang D, Tranguch S, Morrow JD, Orsulic S, DuBois RN, Dey SK. Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res 65(9):3735-44, 5/2005. PMCID: PMC2584020.
13. Wang D, Mann JR, DuBois RN. The role of prostaglandins and other eicosanoids in the gastrointestinal tract. Gastroenterology 128(5):1445-61, 5/2005. PMID: 15887126.
14. Wang D, Buchanan FG, Wang H, Dey SK, DuBois RN. Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res 65(5):1822-9, 3/2005. PMID: 15753380.
15. Holla VR, Wang D, Brown JR, Mann JR, Katkuri S, DuBois RN. Prostaglandin E2 regulates the complement inhibitor CD55/decay-accelerating factor in colorectal cancer. J Biol Chem 280(1):476-83, 1/2005. e-Pub 11/2004. PMID: 15520008.
16. Wang H, Guo Y, Wang D, Kingsley PJ, Marnett LJ, Das SK, DuBois RN, Dey SK. Aberrant cannabinoid signaling impairs oviductal transport of embryos. Nat Med 10(10):1074-80, 10/2004. e-Pub 9/2004. PMID: 15378054.
17. Wang D, Wang H, Shi Q, Katkuri S, Walhi W, Desvergne B, Das SK, Dey SK, DuBois RN. Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 6(3):285-95, 9/2004. PMID: 15380519.

Grant & Contract Support

Title: Nuclear Hormone Receptors and Intestinal Epithelial Biology
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 2007 - 2012
 
Title: Mechanisms for Chemoprevention of Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 2004 - present
 
Title: Role of Eicosanoids in Intestinal Epithelial Growth and Function
Funding Source: NIH/NCI
Role: Co-Investigator
Duration: 1994 - 2008

Last updated: 8/20/2009