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Donghui Li, PhD

Present Title & Affiliation

Primary Appointment

Professor, Department of Gastrointestinal (GI) Medical Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1988 University of Texas, School of Public Health, Houston, TX, PHD, Environmental Science (Toxicology)
1986 University of Texas, School of Public Health, Houston, TX, MS, Environmental Science (Toxicology)
1978 Beijing Medical University, School of Public Health, Beijing, China, BS, Public Health

Experience/Service

Institutional Committee Activities

Member, Institutional Biosafety Committee, 2004-present
Member, Molecular Carcinogenesis Steering Committee, 2004-2005
Member, Division of Cancer Medicine Research Subcommittee, 2000-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Chen Y, Lu J, Huang Y, Bi Y, Xu M, Xu Y, Wang T, Li M, Li D, Ning G. History of Schistosome Infection, Metabolic Profiles and Risk of Diabetic Mellitus: A cross sectional study in rural China. J Clin Endoc Met. In Press.
2. Dong X, Li Y, Chang P, Hess KR, Abbruzzese JL, Li D. DNA mismatch repair network gene polymorphism as a susceptibility factor for pancreatic cancer. Mol Carcinog 51(6):491-9, 6/2012. e-Pub 6/2011. PMCID: PMC3179809.
3. Sahin IH, Shama MA, Tanaka M, Abbruzzese JL, Curley SA, Hassan M, Li D. Association of diabetes and perineural invasion in pancreatic cancer. Cancer Science 1(3):357-362, 2012.
4. Li D. Metformin as an Antitumor Agent in Cancer Prevention and Treatment. J Diabetes 3(4):320-7, 12/2011. e-Pub 2/2011. PMID: 21631893.
5. Tang H, Dong X, Hassan M, Abbruzzese JL, Li D. Body Mass Index and Obesity- and Diabetes-associated Genes and Risk for Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev 20(5):779-92, 5/2011. e-Pub 2/2011. PMCID: PMC3089680.
6. Chang P, Li Y, Li D. Micronuclei Levels in Peripheral Blood Lymphocytes as a Potential Biomarker for Pancreatic Cancer Risk. Carcinogenesis 32(2):210-5, 2/2011. e-Pub 11/2010. PMCID: PMC3026847.
7. Tanaka M, Javle M, Dong X, Eng C, Abbruzzese JL, Li D. Gemcitabine Metabolic and Transporter Gene Polymorphisms Are Associated with Drug Toxicity and Efficacy in Patients with Locally Advanced Pancreatic Cancer. Cancer 116(22):5325-35, 11/2010. e-Pub 7/2010. PMCID: PMC2966859.
8. Dong X, Javle M, Hess KR, Shroff R, Abbruzzese JL, Li D. Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. Gastroenterology 139(2):464-73, 473.e1-3, 8/2010. e-Pub 4/2010. PMCID: PMC2910789.
9. Tang H, Dong X, Day RS, Hassan MM, Li D. Antioxidant Genes, Diabetes and Dietary Antioxidants in Association with Risk of Pancreatic Cancer. Carcinogenesis 31(4):607-13, 4/2010. e-Pub 1/2010. PMCID: PMC2847085.
10. Hassan MM, Curley SA, Li D, Kaseb A, Davila M, Abdalla EK, Javle M, Moghazy DM, Lozano RD, Abbruzzese JL, Vauthey JN. Association of diabetes duration and diabetes treatment with the risk of hepatocellular carcinoma. Cancer 116(8):1938-46, 4/2010. e-Pub 2/2010. PMID: 20166205.
11. Petersen GM, Amundadottir L, Fuchs CS, Kraft P, Stolzenberg-Solomon RZ, Jacobs KB, Arslan AA, Bueno-de-Mesquita HB, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, Klein AP, LaCroix A, Li D, Mandelson MT, Olson SH, Risch HA, Zheng W, Albanes D, Bamlet WR, Berg CD, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hankinson SE, Hassan M, Howard B, Hunter DJ, Hutchinson A, Jenab M, Kaaks R, Kooperberg C, Krogh V, Kurtz RC, Lynch SM, McWilliams RR, Mendelsohn JB, Michaud DS, Parikh H, Patel AV, Peeters PH, Rajkovic A, Riboli E, Rodriguez L, Seminara D, Shu XO, Thomas G, Tj°nneland A, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wang Z, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Fraumeni JF, Hoover RN, Hartge P, Chanock SJ. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 42(3):224-8, 3/2010. e-Pub 1/2010. PMCID: PMC2853179.
12. Okazaki T, Javle M, Tanaka M, Abbruzzese JL, Li D. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Clin Cancer Res 16(1):320-9, 1/2010. e-Pub 12/2009. PMCID: PMC2802655.
13. Bracci PM, Wang F, Hassan MM, Gupta S, Li D, Holly EA. Pancreatitis and pancreatic cancer in two large pooled case-control studies. Cancer Causes Control 20(9):1723-1731, 11/2009. PMCID: PMC2767517.
14. Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, LaCroix A, Zheng W, Albanes D, Bamlet W, Berg CD, Berrino F, Bingham S, Buring JE, Bracci PM, Canzian F, Clavel-Chapelon F, Clipp S, Cotterchio M, de Andrade M, Duell EJ, Fox JW, Gallinger S, Gaziano JM, Giovannucci EL, Goggins M, Gonzßlez CA, Hallmans G, Hankinson SE, Hassan M, Holly EA, Hunter DJ, Hutchinson A, Jackson R, Jacobs KB, Jenab M, Kaaks R, Klein AP, Kooperberg C, Kurtz RC, Li D, Lynch SM, Mandelson M, McWilliams RR, Mendelsohn JB, Michaud DS, Olson SH, Overvad K, Patel AV, Peeters PH, Rajkovic A, Riboli E, Risch HA, Shu XO, Thomas G, Tobias GS, Trichopoulos D, Van Den Eeden SK, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hartge P, Hoover RN. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 41(9):986-90, 9/2009. e-Pub 8/2/2009. PMID: 19648918.
15. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood Based Biomarkers of Disease. Cancer Prev Res (Phila Pa) 2(9):807-13, 9/2009. e-Pub 9/2009. PMID: 19723895.
16. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology 137(2):482-8, 8/2009. e-Pub 4/16/2009. PMCID: PMC2735093.
17. Cotton RT, Li D, Scherer SE, Muzny DM, Hodges SE, Catania RL, Witkiewicz AK, Brody JR, Kennedy EP, Yeo CJ, Brunicardi FC, Gibbs RA, Gingras MC, Fisher WE. Single nucleotide polymorphism in RECQL and survival in resectable pancreatic adenocarcinoma. HPB (Oxford) 11(5):435-444, 8/2009. e-Pub 7/2009. PMCID: PMC2742614.
18. Eng-Wong J, Perkins SN, Bondy M, Li D, Eva Singletary S, N˙˝ez N, Hursting S, Chang S. Premenopausal breast cancer; estrogen receptor status and insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and leptin. Breast J 15(4):426-8, Jul-Aug, 7/2009. PMID: 19601950.
19. Li D, Morris JS, Liu J, Hassan MM, Day RS, Bondy ML, Abbruzzese JL. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. JAMA 301(24):2553-62, 6/24/2009. PMCID: PMC2760963.
20. Hassan MM, Kaseb A, Li D, Patt YZ, Vauthey JN, Thomas MB, Curley SA, Spitz MR, Sherman SI, Abdalla EK, Davila M, Lozano RD, Hassan DM, Chan W, Brown TD, Abbruzzese JL. Association between hypothyroidism and hepatocellular carcinoma: a case-control study in the United States. Hepatology 49(5):1563-70, 5/2009. PMID: 19399911.
21. Dong X, Jiao L, Li Y, Evans DB, Wang H, Hess KR, Abbruzzese JL, Li D. Significant associations of mismatch repair gene polymorphisms with clinical outcome of pancreatic cancer. J Clin Oncol 27(10):1592-9, 4/1/2009. e-Pub 2/23/2009. PMCID: PMC2668967.
22. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol 16(2):431-9, 2/2009. e-Pub 11/20/2008. PMID: 19020940.
23. Hassan MM, Spitz MR, Thomas MB, Curley SA, Patt YZ, Vauthey JN, Glover KY, Kaseb A, Lozano RD, El-Deeb AS, Nguyen NT, Wei SH, Chan W, Abbruzzese JL, Li D. The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States. J Hepatol 50(2):334-41, 2/2009. e-Pub 10/16/2008. PMCID: PMC2658718.
24. Li D, Suzuki H, Liu B, Morris J, Liu J, Okazaki T, Li Y, Chang P, Abbruzzese JL. DNA Repair Gene Polymorphisms and Risk of Pancreatic Cancer. Clin Cancer Res 15(2):740-6, 1/15/2009. PMCID: PMC2629144.
25. Suzuki H, Li Y, Dong X, Hassan MM, Abbruzzese JL, Li D. Effect of insulin-like growth factor gene polymorphisms alone or in interaction with diabetes on the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 17(12):3467-73, 12/2008. PMCID: PMC2600618.
26. Hassan MM, Li D, El-Deeb AS, Wolff RA, Bondy ML, Davila M, Abbruzzese JL. Association between hepatitis B virus and pancreatic cancer. J Clin Oncol 26(28):4557-62, 10/1/2008. PMCID: PMC2562875.
27. Hassan MM, Spitz MR, Thomas MB, El-Deeb AS, Glover KY, Nguyen NT, Chan W, Kaseb A, Curley SA, Vauthey J-N, Ellis LM, Abdalla E, Lozano RD, Patt YZ, Brown TD, Abbruzzeze JL, Li D. Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: Case-control study. Int J Cancer 123(8):1883-1891, 10/15/2008. PMCID: PMC2673571.
28. Hassan M, Phan A, Dagohoy C, Li D, Yao J.. Risk Factors Associated with Neuroendocrine Tumors: A U.S.-Based Case-Control Study. Int J Cancer 123(4):867-73, 8/15/2008. PMID: 18491401.
29. Zhao H, Wang LE, Li D, Chamberlain RM, Sturgis EM, Wei Q. Genotypes and haplotypes of ERCC1 and ERCC2/XPD genes predict levels of benzo[a]pyrene diol epoxide-induced DNA adducts in cultured primary lymphocytes from healthy individuals: a genotype-phenotype correlation analysis. Carcinogenesis 29(8):1560-6, 8/2008. e-Pub 7/16/2008. PMCID: PMC2516484.
30. Suzuki H, Jiao L, Li Y, Doll MA, Hein DW, Hassan MM, Day RS, Bondy ML, Abbruzzese JL and Li D.. Interaction of the Cytochrome P4501A2, SULT1A1 and NAT gene Polymorphisms with Smoking and Dietary Mutagen Intake in Modification of the Risk of Pancreatic Cancer. Carcinogenesis 29(6):1184-1191, 6/2008. e-Pub 5/21/2008. PMCID: PMC2443278.
31. Okazaki T, Jiao L, Chang P, Evans DB, Abbruzzese JL, Li D. Single Nucleotide Polymorphisms of DNA Damage Response Genes Are Associated with Overall Survival in Patients with Pancreatic Cancer. Clin Cancer Res 14(7):2042-8, 4/1/2008. PMCID: PMC2423806.
32. Hassan MM, Phan A, Li D, Dagohoy CG, Leary C, Yao JC. Family history of cancer and associated risk of developing neuroendocrine tumors: a case-control study. Cancer Epidemiol Biomarkers Prev 17(4):959-65, 4/2008. PMID: 18398037.
33. White DL, Li D, Nurgalieva Z, El-Serag HB. Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis. Am J Epidemiol 167(4):377-89, 2/15/2008. e-Pub 12/7/2007. PMID: 18065725.
34. Hu Y, Li G, Xue X, Zhou Z, Li X, Fu J, Cohen B, Roy N, Li D, Sun J, Nan P, Tang MS, Qu Q.. PAH-DNA adducts in a Chinese population: Relationship to PAH exposure, smoking, and polymorphisms of metabolic and DNA repair genes. Biomarkers 13(1):27-40, 2/2008. PMID: 17896209.
35. Jiao L, Hassan MM, Bondy ML, Wolff RA, Evans DB, Abbruzzese JL, Li D. XRCC2 and XRCC3 Gene Polymorphism and Risk of Pancreatic Cancer. Am J Gastroenterol 103(2):360-7, 2/2008. e-Pub 11/6/2007. PMCID: PMC2268638.
36. Hassan MM, Bondy ML, Wolff RA, Abbruzzese JL, Vauthey JN, Pisters PW, Evans DB, Khan R, Chou TH, Lenzi R, Jiao L, Li D. Risk factors for pancreatic cancer: case-control study. Am J Gastroenterol 102(12):2696-707, 12/2007. e-Pub 8/31/2007. PMCID: PMC2423805.
37. Jiao L, Doll MA, Hein DW, Bondy ML, Hassan MM, Hixson JE, Abbruzzese JL and Li D. Haplotype of N-acetyltransferase 1 and 2 and Risk of Pancreatic Cancer. Cancer Epidemiol Biomarkers Prev 16(11):2379-2386, 11/2007. PMCID: PMC2215308.
38. Kawamoto T, Krishnamurthy S, Tarco E, Trivedi S, Wistuba II, Li D, Roa I, Roa JC, Thomas MB. HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer. Gastrointest Cancer Res 1(6):221-7, 11/2007. PMCID: PMC2631213.
39. Lin EH, Hassan M, Li Y, Zhao H, Nooka A, Sorenson E, Xie K, Champlin R, Wu X, Li D. Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence. Cancer 110(3):534-42, 8/1/2007. PMID: 17594720.
40. Li D, Wang LE, Chang P, el-Naggar AK, Sturgis EM, Wei Q. In Vitro Benzo[a]pyrene Diol Epoxide-Induced DNA Adducts and Risk of Squamous Cell Carcinoma of Head and Neck. Cancer Res 67(12):5628-5634, 6/15/2007. PMID: 17575128.
41. Hassan MM, Abbruzzese JL, Bondy ML, Wolff RA, Vauthey JN, Pisters PW, Evans DB, Khan R, Lenzi R, Jiao L, Li D. Passive smoking and the use of noncigarette tobacco products in association with risk for pancreatic cancer: a case-control study. Cancer 109(12):2547-56, 6/15/2007. PMCID: PMC2215306.
42. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 Polymorphisms Contribute to an Earlier Age at Diagnosis of Pancreatic Cancer in Caucasians. Clin Cancer Res 13(10):3100-3104, 5/15/2007. PMCID: PMC2365501.
43. Li D, Liu H, Jiao L, Chang DZ, Beinart G, Wolff RA, Evans DB, Hassan MM, Abbruzzese JL. Effects of Base Excision Repair Gene Polymorphisms on Pancreatic Cancer Survival. Int J Cancer 120(8):1748-54, 4/15/2007. PMCID: PMC1892183.
44. Li D, Day RS, Bondy ML, Sinha R, Nguyen NT, Evans DB, Abbruzzese JL, Hassan MM. Dietary mutagen exposure and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 16(4):655-61, 4/2007. PMCID: PMC1892159.
45. Jiao L, Bondy ML, Hassan MM, Chang DZ, Abbruzzese JL, Evans DB, Smolensky MH, Li D. Glutathione S-transferase gene polymorphisms and risk and survival of pancreatic cancer. Cancer 109(5):840-8, 3/1/2007. PMCID: PMC1892189.
46. Jiao L, Chang P, Pervez PF, Lai D, Abbruzzese JL, Li D. Polymorphisms of phase II xenobiotic-metabolizing and DNA repair genes and in vitro N-ethyl-N-nitrosourea-induced O6-ethylguanine levels in human lymphocytes. Mutat Res 627(2):146-57, 3/5/2007. e-Pub 12/8/2006. PMCID: PMC1828113.
47. Paracchini V, Raimondi S, Gram IT, Kang D, Kocabas NA, Kristensen VN, Li D, Parl FF, Rylander-Rudqvist T, Soucek P, Zheng W, Wedren S, Taioli E. Meta- and pooled analyses of the cytochrome P-450 1B1 Val432Leu polymorphism and breast cancer: a HuGE-GSEC review. Am J Epidemiol 165(2):115-25, 1/15/2007. e-Pub 10/19/2006. PMID: 17053044.
48. Jiao L, Hassan MM, Bondy ML, Abbruzzese JL, Evans DB, Li D.. The XPD Asp312Asn and Lys751Gln polymorphisms, corresponding haplotype and pancreatic cancer risk. Cancer Lett 245(1-2):61-8, 1/8/2007. e-Pub 2/3/2006. PMCID: PMC1741855.
49. Jiao L, Zhu J, Hassan MM, Evans DB, Abbruzzese JL, Li D. K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking. Pancreas 34(1):55-62, 1/2007. PMCID: PMC1905887.
50. Lu J, Wei Q, Bondy ML, Yu TK, Li D, Brewster A, Shete S, Sahin A, Meric-Bernstam F, Wang LE. Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non-Hispanic white women age younger than 55 years. Cancer 107(9):2245-53, 11/1/2006. PMID: 17063466.
51. Lu J, Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. Carcinogenesis 27(11):2209-16, 11/2006. e-Pub 5/19/2006. PMID: 16714331.
52. Zhu J, Rashid A, Cleary K, Abbruzzese JL, Friess H, Takahashi S, Shirai T, Li D. Detection of 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP)-DNA adducts in human pancreatic tissues. Biomarkers 11:319-28, 7/2006. PMID: 16908439.
53. Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, Abbruzzese JL. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol 24(11):1720-8, 4/10/2006. e-Pub 3/6/2006. PMCID: PMC1435378.
54. Person MD, Shen J, Traner A, Hensley SC, Lo HH, Abbruzzese JL, Li D. Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. J Biomol Tech 17(2):145-56, 4/2006. PMCID: PMC2291776.
55. Li D, Liu H, Jiao L, Chang DZ, Beinart G, Wolff RA, Evans DB, Hassan MM, Abbruzzese JL. Significant effect of homologous recombination DNA repair gene polymorphisms on pancreatic cancer survival. Cancer Res 66(6):3323-30, 3/15/2006. PMCID: PMC1462866.
56. Li D, Jiao L, Li Y, Doll MA, Hein DW, Bondy ML, Evans DB, Wolff RA, Lenzi R, Pisters PW, Abbruzzese JL, Hassan MM. Polymorphisms of cytochrome P4501A2 and N-acetyltransferase genes, smoking, and risk of pancreatic cancer. Carcinogenesis 27(1):103-11, 1/2006. e-Pub 6/29/2005. PMCID: PMC1350610.
57. Beger RD, Schnackenberg LK, Holland RD, Li D and Dragan Y. Metabolomic Models of Human Pancreatic Cancer Using 1D Proton NMR Spectra of Lipids in Plasma. Metabolomics 2:125-34, 2006.
58. Jiao L, Bondy ML, Hassan MM, Wolff RA, Evans DB, Abbruzzese JL, Li D. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Cancer Detect Prev 30(3):284-91, 2006. e-Pub 7/17/2006. PMCID: PMC1857309.
59. Yokoi K, Shih LC, Kobayashi R, Koomen J, Hawke D, Li D, Hamilton SR, Abbruzzese JL, Coombes KR, Fidler IJ. Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer. Int J Oncol 27(5):1361-9, 11/2005. PMID: 16211233.
60. Li D, Ahmed M, Li Y, Jiao L, Chou TH, Wolff RA, Lenzi R, Evans DB, Bondy ML, Pisters PW, Abbruzzese JL, Hassan MM. 5,10-Methylenetetrahydrofolate reductase polymorphisms and the risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 14(6):1470-6, 6/2005. PMID: 15941958.
61. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The rapamycin analog CCI-779 is a potent inhibitor of pancreatic cancer cell proliferation. Biochem Biophys Res Commun 331(1):295-302, 5/27/2005. PMID: 15845392.
62. Zhu J, Abbruzzese JL, Izzo J, Hittelman WN, Li D. AURKA amplification, chromosome instability, and centrosome abnormality in human pancreatic carcinoma cells. Cancer Genet Cytogenet 159(1):10-7, 5/2005. PMID: 15860351.
63. Koomen JM, Li D, Xiao LC, Liu TC, Coombes KR, Abbruzzese J, Kobayashi R. Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. J Proteome Res 4(3):972-81, May-Jun, 5/2005. PMID: 15952745.
64. Koomen JM, Shih LN, Coombes KR, Li D, Xiao LC, Fidler IJ, Abbruzzese JL, Kobayashi R. Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. Clin Cancer Res 11(3):1110-8, 2/1/2005. PMID: 15709178.
65. Koomen JM, Zhao H, Li D, Nasser W, Hawke DH, Abbruzzese JL, Baggerly KA, Kobayashi R. Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting. Rapid Commun Mass Spectrom 19(12):1624-36, 2005. PMID: 15915451.
66. Touillaud MS, Pillow PC, Jakovljevic J, Bondy ML, Singletary SE, Li D, Chang S. Effect of dietary intake of phytoestrogens on estrogen receptor status in premenopausal women with breast cancer. Nutr Cancer 51(2):162-9, 2005. PMID: 15860438.
67. Ebrahimi B, Tucker SL, Li D, Abbruzzese JL, Kurzrock R. Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer 101(12):2727-36, 12/15/2004. PMID: 15526319.
68. Shen J, Person MD, Zhu J, Abbruzzese JL, Li D. Protein expression profiles in pancreatic adenocarcinoma compared with normal pancreatic tissue and tissue affected by pancreatitis as detected by two-dimensional gel electrophoresis and mass spectrometry. Cancer Res 64(24):9018-26, 12/2004. PMID: 15604267.
69. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells. Oncogene 23(53):8571-80, 11/11/2004. PMID: 15467756.
70. Soliman AS, Vulimiri SV, Kleiner HE, Shen J, Eissa S, Morad M, Taha H, Lukmanji F, Li D, Johnston DA, Lo H, Lau S, Digiovanni J, Bondy ML. High levels of oxidative DNA damage in lymphocyte DNA of premenopausal breast cancer patients from Egypt. Int J Environ Health Res 14(2):121-134, 4/2004. PMID: 15203457.
71. Koomen JM, Zhao H, Li D, Abbruzzese J, Baggerly K, Kobayashi R. Diagnostic protein discovery using proteolytic peptide targeting and identification. Rapid Commun Mass Spectrom 18(21):2537-48, 2004. PMID: 15468157.
72. Zhu J, Chang P, Bondy ML, Sahin AA, Singletary SE, Takahashi S, Shirai T, Li D. Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 12(9):830-7, 9/2003. PMID: 14504191.
73. Li D, Zhu J, Firozi PF, Abbruzzese JL, Evans DB, Cleary K, Friess H, Sen S. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res 9(3):991-7, 3/2003. PMID: 12631597.
74. Habib SL, Phan ML, Patel SK, Li D, Monks TJ, Lau S. Reduced constitutive 8-oxoguanine-DNA glycosylase expression and impaired induction following oxidative DNA damage in the tuberin deficient Eker rat. Carcinogenesis 24(3):573-582, 3/2003. PMID: 12663520.
75. Silva EG, Mistry D, Li D, Kuerer HM, Atkinson EN, Lopez AN, Shannon R, Hortobagyi GN. Elevated luteinizing hormone in serum, breast cancer tissue, and normal breast tissue from breast cancer patients. Breast Cancer Res Treat 76(2):125-30, 11/2002. PMID: 12452449.
76. Hassan MM, Hwang LY, Hatten CJ, Swaim M, Li D, Abbruzzese JL, Beasley P, Patt YZ. Risk factors for hepatocellular carcinoma: synergism of alcohol with viral hepatitis and diabetes mellitus. Hepatology 36(5):1206-13, 11/2002. PMID: 12395331.
77. Li D, Walcott FL, Chang P, Zhang W, Zhu J, Petrulis E, Singletary SE, Sahin AA, Bondy ML. Genetic and environmental determinants on tissue response to in vitro carcinogen exposure and risk of breast cancer. Cancer Res 62(16):4566-70, 8/15/2002. PMID: 12183407.
78. Firozi PF, Bondy ML, Sahin AA, Chang P, Lukmanji F, Singletary ES, Hassan MM, Li D. Aromatic DNA adducts and polymorphisms of CYP1A1, NAT2, and GSTM1 in breast cancer. Carcinogenesis 23(2):301-6, 2/2002. PMID: 11872636.
79. Li D, Firozi PF, Zhang W, Shen J, DiGiovanni J, Lau S, Evans D, Friess H, Hassan M, Abbruzzese JL. DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer. Mutat Res 513(1-2):37-48, 1/15/2002. PMID: 11719088.
80. Li D, Wang M, Firozi PF, Chang P, Zhang W, Baer-Dubowska W, Moorthy B, Vulimiri SV, Goth-Goldstein R, Weyand EH, DiGiovanni J. Characterization of a major aromatic DNA adduct detected in human breast tissues. Environ Mol Mutagen 39(2-3):193-200, 2002. PMID: 11921189.

Invited Articles

1. Li D, Xie K, Wolff R, Abbruzzese JL. Pancreatic Cancer. Lancet 363(9414):1049-57, 3/27/2004. PMID: 15051286.
2. Li D, Jiao L. Molecular epidemiology of pancreatic cancer. Int J Gastrointest Cancer 33(1):3-14, 2003. PMID: 12909734.
Other Articles
1. Li D and Hassan MM. Letter of response to comments on the article entitled "Passive Smoking and Use of Noncigarette Tobacco Products and Risk for Pancreatic Cancer. Cancer 112(3):672, 2008.

Abstracts

1. Li D, Moughan J, Chang P, Hoffman JP, Regine WF, Abrams RA, Safran H, Freedman GM, Guha C, Abbruzzese JL. RecQ1 A159C Polymorphism is associated with overall survival of patients with resected pancreatic cancer: a replication study in RTOG 9704. GI ASCO, 2011.
2. Fogelman DR, Wang XS, Hassan M, Li D, Javle MM, Varadhachary GR, Shroff RT, Overman MJ, Wolff RA, Abbruzzese JL. Serum cytokines may outweigh clinical factors in predicting weight loss in advanced pancreatic cancer. GI ASCO, 2011.
3. Li D, Morris J, Liu J, Hassan MM, Day RS, Bondy ML, Evans DB, Abbruzzese JL. Association of Body Mass Index with Risk, Age of Onset and Survival of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 49, 2009.
4. Li D, Dong X, Jiao L, Li Y, Evans DB, Wang H, Hess KR, Abbruzzese JL. Effects of DNA Mismatch Repair Gene Polymorphisms on Clinical Outcome of Pancreatic Cancer. GI ASCO, 2009.
5. Shroff RT, Javle MM, Dong X, Kumar SV, Krishnan S, Wolff RA, Abbruzzese JL, Li D. Prognostic Value of Polymorphisms in the Insulin-Like Growth Factor Receptor (IGFR) Pathway in Patients with Locally Advanced Pancreatic Cancer (LAPC). JCO, 2009.
6. Li D, Suzuki H, Dong X, Okazaki T, Hassan MM, Abbruzzese JL, Li D. Insulin-like growth factor gene polymorphisms and risk of pancreatic cancer. Proc. Am. Assoc. Cancer Res. 2008.
7. Javle MM, Okazaki T, Evans DB, Crane C, Abbruzzese JL, Li D. Polymorphisms of Genes Involved in Gemcitabine Metabolism Correlate with Prognosis in Patients Receiving Neoadjuvant Therapy for Pancreatic Cancer. J Clin Oncol 26 (#4501), 2008.
8. Dong X, Li Y, Jiao L, Evans DB, Abbruzzese JL, Li D. Significant Effects of Mismatch Repair Gene Polymorphisms on Pancreatic Cancer Survival. Proc. Am. Assoc. Cancer Res. 48, 2008.
9. Li D, Okazaki T, Suzuki H, Javle M, Jiao L, Evans DB, Abbruzzese JL. Genetic Variations in Drug Metabolism and DNA Damage Response and Repair as Predictors for Clinical Outcomes of Pancreatic Adenocarcinoma. 15th SPORE Investigator's Workshop, 7/2007.
10. Li D, Hassan MM, Khan R, Bondy ML, Abbruzzese JL, and Day RS. Dietary Micronutrient Intakes and Risk of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 47, 2007.
11. Li D, Okazaki T, Suzuki H, Javle M, Jiao L, Evans D, Abbruzzese JL. Genetic Variations in Drug Metabolism and DNA Repair as Predictors for Clinical Outcomes of Pancreatic Adenocarcinoma. Keyston Symposium: GI Cancer, 2007.
12. Nooka AK, Chang DZ, Abbruzzese JL, Evans DB, Wolff RA, Hassan MM, Li D. Impact of NAT1 Polymorphism on Survival of Pancreatic Cancer. GI ASCO, 2007.
13. Hassan MM, Okazaki T, Jiao L, Steven C, Thomas M, Brown T, Vauthey N, Abdalla E, Patt YZ, Abbruzzese JL, Li D. Polymorphisms of manganese superoxide dismutase gene and susceptibility to hepatocellular carcinoma. Proc. Am. Assoc. Cancer Res. 47, 2007.
14. Okazaki T, Jiao L, Evans DB, Abbruzzese JL, Li D. Single nucleotide polymorphism of ATM and CHEK-1 genes are associated with survival of pancreatic cancer. Proc. Am. Assoc. Cancer Res. 47, 2007.
15. Jiao L, Hassan MM, Chang DZ, Abbruzzese JL, Li D. Association of GSTP1, GSTM1, and GSTT1 Polymorphisms with Risk and Overall Survival of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 46, 2006.
16. Lu J, Wei Q, Bondy ML, Li D, Brewster A, Yu TK, Sahin A, Meric-Bernstam F, Hung KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1 gene associated with risk of sporadic breast cancer in young women: A case-control study. Proc. Am. Assoc. Cancer Res. 46, 2006.
17. Li D, Evans DB, Hess K, Frazier M, Crane C, Abbruzzese JL. Polymorphisms of RecQ1, RAD54L, ATM and XRCC1 Genes and Prognosis of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 46, 2006.
18. Eng-Wong J, Chang S, Husting S, Perkins SN, Nunuz N, Bondy ML, Li D, Singletary SE. Premenopausal breast cancer and the association between estrogen receptor status, insulin-like growth factor-I (IGF-I), insulin-like growth factor binding protein-3 (IGFBP-3) and leptin. ASCO, 2006.
19. Lin E, Li Y, Trent J, Burgess M, Patel R, Benjamin R, Li D, Chen L. Real Time Quantitative RT-PCR of CD133 mRNA: A Potential Angiogenic Surrogate Marker of Response for Patient With Metastatic Sarcoma. ASCO, 2006.
20. Busaidy NL, Yazbeck CF, Shah P, Evans DB, Li D, Geraci JM, Weiser MA. Resectable pancreatic cancer patients with diabetes have shorter survival than nondiabetics. ASCO, 2006.
21. Hassan MM, Khan R, Mestry K, Bondy ML, Abbruzzese JL, Evans DB, Wolff RA, Chou TH, Ho L, Xiong HQ, Lenzi R, Vauthey N, Pisters PW and Li D. Risk Factors of Pancreatic Cancer in The United States: Case-Control Study. Proc. Am. Assoc. Cancer Res. 46, 2006.
22. Li Y, Zhu JJ, Abbruzzese JL, Li D. RNA Mediated TM2 (beta) Gene Silencing Alters Neoplastic Phenotypes of Human Pancreatic Cancer Cell Lines. Proc. Am. Assoc. Cancer Res. 46, 2006.
23. Li D, Liu H, Evans DB, Abbruzzese JL, Chen J and Frazier M. Genetic Polymorphisms as Significant Predictive Factors for Patients with Pancreatic Adenocarcinoma. The 13th SPORE Investigator Workshop, 7/2005.
24. Li D, Hassan MM, Jiao L, Frazier M, Evans DB, Abbruzzese JL. DNA Repair Gene Polymorphisms and Risk of Pancreatic Cancer. Proc Am Assoc Cancer Res 45 (#A4089), 2005.
25. Hassan MM, Li Y, Mestry K, Imam M. Bondy ML, Abbruzzese JL, Evans DB, Wolff RA, Chou TH, Ho L, Xiong HQ, Lenzi R, Pisters PW, Li D. Genetic variations in MnSOD and CAT genes and the risk of pancreatic cancer. Proc Am Assoc Cancer Res 45:A4921, 2005.
26. Jiao L, Hassan MM, Evans DB, Abbruzzese JL, Li D. Genotype and Hyplotype of XRCC2, XRCC3 and Rad54L Genes and Risk of Pancreatic Cancer. Proc Am Assoc Cancer Res 45:A4090, 2005.
27. Zhu J, Shen J, Person M, Abbruzzese JL, Li D. Protein expression profiles in pancreatic adenocarcinoma cell lines and pancreatic adenocarcinomas tissues detected by Western blot and immunohistochemistry. Proc Am Assoc Cancer Res 45:A3104, 2005.
28. Chang P, Hassan M, Abbruzzese JL, Evans DB, Wolff R, Lenzi R, Pisters PW, Nooka A, Li D. Background and H2O2-induced micronuclei in peripheral blood lymphocytes as a risk factor for pancreatic cancer. Proc. Am. Assoc. Cancer Res. 45:A485, 2004.
29. Zhu JJ, Evans DB, Abbruzzese JL, Cleary K, Li D. Detection of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA Adducts in Pancreas Tissues and the Risk of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 45:A1917, 2004.
30. Li D, Stuff J, Bondy M, Day S, Abbruzzese JL, Evans DB, Wolff R, Chou TH, Lenzi R, Pisters PW, Nooka A, Hassan M. Dietary exposure to heterocyclic aromatic amines and risk of pancreatic cancer. Proc. Am. Assoc. Cancer Res. 45:A484, 2004.
31. Li Y, Ahmed M, Hassan M, Abbruzzese JL, Nooka A, Wolff R, Lenzi R, Evans DB, Pisters PW, Li D. Folate level, Methylenetetrahydrofolate Reductase Polymorphisms, and Risk of Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 45:A486, 2004.
32. Jiao L, Hassan M, Abbruzzese JL, Evans DB, Wolff RA, Lenzi R, Chou TH, Pisters PW, Nooka A, Li D. Genetic and epigenetic changes in plasma DNA of pancreatic cancer patients - association with tobacco smoking and implication for early diagnosis. Proc. Am. Assoc. Cancer Res. 45:A893, 2004.
33. Hassan M, Nooka A, Zhang W, Ahmed M, Thomas M, Brown T, Curley SA, Ellis ML, Vauthey N, Patt YZ, Li D. Polymorphisms of transforming growth factor-b1 (TFGFb1) gene and susceptibility to hepatocellular carcinoma. Proc. Am. Assoc. Cancer Res. 45:A269, 2004.
34. Shen H, Person MD, Zhu J, Abbruzzese JL, Li D. Protein expression profiles in normal pancreatic tissues, pancreatitis, and pancreatic adenocarcinomas as detected by proteomics. Proc. Am. Assoc. Cancer Res. 45:A3539, 2004.
35. Zhu J, Abbruzzese JL, Izzo J, Hittelman WN, Li D. Aurora2 amplification and chromosome instability in human pancreatic cancer cell lines. Proc. Am. Assoc. Cancer Res 44:A1200, 2003.
36. Hassan M, Zhang WQ, Nooka A, Patt YZ, Ahmed M, Thomas M, Brown T, Curley SA, Vauthey JN, Ellis LM, Li D. C262T polymorphism of the catalase gene and susceptibility to hepatocellular carcinoma. Proc. Am. Assoc. Cancer Res. 44:A2605, 2003.
37. Chang P, Hassan M, Abbruzzese JL, Evans DB, Wolff RA, Lenzi R, Pisters PW, Nooka A, Li D. In vitro carcinogen-induced DNA adducts as a risk factor for pancreatic cancer. Proc. Am. Assoc. Cancer Res. 44:A4515, 2003.
38. Jiao L, Zhu J, Hassan M, Connor T, Issa JP, Abbruzzese JL, Wolff R, Lenzi R, Evans DB, Pisters PW, Li D. Is aberrant promoter hypermethylation of p16 and ppENK genes in pancreatic cancer related to environmental exposure? . Proc. Am. Assoc. Cancer Res. 44:A2198, 2003.
39. Jiao L, Hassan M, Firozi PF, Abbruzzese JL, Evans DB, Wolff RA, Lenzi R, Pisters PW, Nooka A, Li D. Tobacco smoking, phase II drug metabolizing genes, and pancreatic cancer risk in Caucasians. Proc. Am. Assoc. Cancer Res. 44:A2616, 2003.
40. Josyula S, Zhang W, Li D, Thompson PA. Apparent lack of random mutations in the replication control region of mitochondrial (mt) DNA in human breast tumors. Proc. Am. Assoc. Cancer Res. 43:A212, 2002.
41. Zhu J, Chang P, Bondy ML, Sahin A, Singletary ES, Takahashi S, Shirai T, Li D. Detection of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP)-DNA adducts in normal breast tissues by immunohistochemistry and risk of breast cancer. Proc. Am. Assoc. Cancer Res. 43:A5044, 2002.
42. Zhang W, Josyula S, Thompson PA, Li D. DNA mutations in the DLP6 control region of the mitochondrial (mt) genome in breast tissues from women with or without cancer. Proc. Am. Assoc. Cancer Res. 43:A4080, 2002.
43. Xiong P, Bondy M, Li D, Shen H, Wang LE, Singletary E, Spitz MR, Wei Q. G2 sensitivity to gamma radiation and modification by the p53 codon 72 polymorphism in a Breast Cancer Case-Control Study. Proc. Am. Assoc. Cancer Res. 43:A2850, 2002.
44. Hassan M, Zhang W, Zhu J, Patt YZ, Swaim M, Schwartz M, Ghalib R, Gudena V, Abbruzzese JL, Li D. Glutathione Peroxidase and GSH/GSSG in Hepatocellular Carcinoma and Cirrhosis in Relation to HCV and Alcohol. Proc. Am. Assoc. Cancer Res. 43:A4299, 2002.
45. Bedeir AS, Soliman AS, El-Ghawalby N, Rashid A, E-Ghawalby A, Bassiouni N, Bondy M, Li D, Levin B, Abbruzzese JL, Hamilton SR. High Proportion of G-to-T Transversion in Codon 12 of the K-ras Proto-oncogene in Egyptian Pancreatic Cancer. Proc. Am. Assoc. Cancer Res. 43:A1972, 2002.
46. Li D, Lukmanji F, Chang P, Zhang W, Zhu J, Petrulis E, Singletary SE, Sahin A, Bondy M. In vitro carcinogen-induced DNA adducts in breast tissues and lymphocytes as a susceptibility marker for breast cancer. Proc. Am. Assoc. Cancer Res. 43:A5042, 2002.
47. Li D, Hassan M, Chang P, Zhu J, Schwartz M, Ghalib R, Gudena V, Abbruzzese JL, Patt YZ. Increased oxidative DNA damage in HCV and alcohol-related liver cirrhosis and hepatocellular carcinoma2002. Proc. Am. Assoc. Cancer Res. 43:A2841, 2002.
48. Jiao L, Hassan M, Gudena V, Connor TH, Abbruzzese JL, Li D. Susceptibility to Pancreatic Cancer and Genetic Polymorphisms of Cytochrome P450 2E1 and O6-Alkylguanine DNA Alkyltransferase gene. Proc. Am. Assoc. Cancer Res. 43:A2849, 2002.
49. Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The PI 3-kinase Pathway is Constitutively Activated in Pancreatic Cancer ľ Role of Tumor Suppressor MMAC/PTEN. Proc. Am. Assoc. Cancer Res. 43:A1788, 2002.
50. Soliman AS, Bondy M, El-Ghawalby N, E-Ghawalby A, Bassiouni N, Li D, Bedeir AS, Hamilton SR, Levin B, Abbruzzese JL. Unusually high rate of young-onset pancreatic cancer in the East Nile Delta region of Egypt. Proc. Am. Assoc. Cancer Res. 43:A2850, 2002.

Book Chapters

1. Li D. Obesity and Pacreatic Cancer. In: Energy Balance and Cancer. Ed(s) Markowitz S, Berger NA. Springer: New York. In Press.
2. Jiao L, Li D. Epidemiology: World Overview, Risk Factors, and Prospects for Prevention. In: Pancreatic Cancer. Ed(s) Neoptolemos, Buchler, Abbruzzese, Raul Urrutia. Springer: New York, 2009.
3. Wolff RA, Crane CH, Li D, Abbruzzese JL, Evans DB. Neoplasma of the Exocrine Pancreas. In: Cancer Medicine, 7. Ed(s) Holland, Frei, Bast, Kufe, Pollock, Weichselbaum. BC Decker, Shelton, 1331-58, 2006.
4. Li D, Jiao L. Epidemiology. In: Pancreatic Cancer. Jones Bartlett Publishers, 103-12, 2005.
5. Li D. Epidemiology and Molecular Epidemiology of Pancreatic Cancer. In: Gastrointestinal Oncology. Oxford University Press, 329-335, 2004.

Last updated: 7/1/2013