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Dos D. Sarbassov, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Molecular and Cellular Oncology, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Faculty, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Unit Number: 108
Houston, TX 77030
Room Number: Y7.6083
Phone: 713-792-3357
Fax: 713-794-3270

Education & Training

Degree-Granting Education

1997 University of Arkansas for Medical Sciences, Little Rock, AR, PHD, Biochemistry and Molecular Biology
1991 National Kazakh State University, Almaty, Kazakhstan, Kazakhstan, BS, Biology

Postgraduate Training

1/1999-9/2004 Postdoctoral Fellowship, Whitehead Institute for Biomedical Research, Cambridge, MA, Dr. David M. Sabatini
6/1997-8/1998 Visiting Fellowship, Cornell University Medical College, New York, NY, Dr. Selina Chen-Kiang


Academic Appointments

Faculty, Cancer Biology Program, Graduate School of Biomedical Science, The University of Texas Health Science Center and MD Anderson Cancer Center, Houston, TX, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Zeng Z, Sarbassov dos D, Samudio IJ, Yee KW, Munsell MF, Ellen Jackson C, Giles FJ, Sabatini DM, Andreeff M, Konopleva M. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 109(8):3509-12, 4/2007. e-Pub 12/2006. PMCID: PMC1852241.
2. Sarbassov D.D., Ali S.M., Sengupta S., Sheen J-H., Hsu P., Bagley A.F., Markhard A.L., and Sabatini D.M.. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 22(2):159-168, 2006. e-Pub 4/2006. PMID: 16603397.
3. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex. Science 307(5712):1098-1101, 2/18/2005. PMID: 15718470.
4. Sarbassov D.D. and Sabatini D.M.. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem 280(47):39505-9, 2005. e-Pub 9/2005. PMID: 16183647.
5. Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Current Biology 14(14):1296-302, 7/2004. PMID: 15268862.
6. Kim D-H, Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., Sabatini D.M. mTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110:163-175, 2002.

Last updated: 4/23/2015