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Dragan Mirkovic, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd.
Unit Number: 94
Houston, TX 77030
Room Number: Y2.5609
Phone: 713-563-2643
Fax: 713-563-2545

Education & Training

Degree-Granting Education

1993 State University of New York at Stony Brook, Stony Brook, NY, PHD, Applied Mathematics
1990 University of Zagreb, Zagreb, Croatia, MS, Nuclear Engineering
1983 University of Zagreb, Zagreb, Croatia, BS, Nuclear Engineering

Honors and Awards

1990-1993 Research Fellowship (Selective), State University of New York Stony Brook
1989-1990 IAEA Fellowship, Brookhaven National Laboratory

Selected Publications

Peer-Reviewed Original Research Articles

1. Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Kornguth D, Mohan R, Newhauser WD. Stray radiation dose and second cancer risk for a pediatric patient receiving craniospinal irradiation with proton beams. Phys Med Biol 54(8):2259-2275, 4/21/2009. e-Pub 3/20/2009. PMID: 19305045.
2. Newhauser WD, Fontenot JD, Mahajan A, Kornguth D, Stovall M, Zheng Y, Taddei PJ, Mirkovic D, Mohan R, Cox JD, Woo S,. The risk of developing a second cancer after receiving craniospinal proton irradiation. Phys Med Biol 54(8):2277-2291, 4/2009.
3. Newhauser WD, Fontenot JD, Taddei PJ, Mirkovic D, Giebeler A, Zhang R, Mahajan A, Kornguth D, Stovall M, Yepes P, Woo S, Mohan R. Contemporary Proton Therapy Systems Adequately Protect Patients from Exposure to Stray Radiation. AIP Conference Proceedings CAARI 2008: 20th International Conference on the Application of Accelerators in Research and Industry 1099:450-455, 3/2009.
4. Taddei PJ , Krishnan S, Mirkovic D, Yepes P, Newhauser WD. Effective Dose from Stray Radiation for a Patient Receiving Proton Therapy for Liver Cancer. AIP Conference Proceedings of CAARI 2008: 20th International Conference on the Application of Accelerators in Research and Industry 1099:445-449, 3/2009.
5. Ezhil M, Vedam S, Balter P, Choi B, Mirkovic D, Starkschall G, Chang JY. Determination of patient-specific internal gross tumor volumes for lung cancer using four-dimensional computed tomography. Radiat Oncol 4:4, 2009. PMCID: PMC2645420.
6. Sawakuchi GO, Titt U, Mirkovic D, Mohan R. Density heterogeneities and the influence of multiple Coulomb and nuclear scatterings on the Bragg peak distal edge of proton therapy beams. Phys Med Biol 53(17):4605-19, 9/2008. e-Pub 8/2008. PMID: 18678928.
7. Kurzak J, Mirkovic D, Pettitt BM, Johnsson SL. Automatic Generation of FFT for Translations of Multipole Expansions in Spherical Harmonics. International Journal of High Performance Computing Applications 22:219-230, May 01, 2008, 5/2008.
8. Newhauser WD, Giebeler A, Langen KM, Mirkovic D, Mohan R. Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants? Phys Med Biol 53(9):2327-44, 5/2008. PMID: 18421122.
9. Taddei PJ, Fontenot JD, Zheng Y, Mirkovic D, Lee AK, Titt U, Newhauser WD. Reducing stray radiation dose to patients receiving passively scattered proton radiotherapy for prostate cancer. Phys Med Biol 53(8):2131-47, 4/2008. e-Pub 3/2008. PMID: 18369278.
10. Fontenot J, Taddei P, Zheng Y, Mirkovic D, Jordan T, Newhauser W. Equivalent dose and effective dose from stray radiation during passively scattered proton radiotherapy for prostate cancer. Phys Med Biol 53(6):1677-88, 3/2008. e-Pub 2/2008. PMID: 18367796.
11. Zheng Y, Fontenot J, Taddei P, Mirkovic D, Newhauser W. Monte Carlo simulations of neutron spectral fluence, radiation weighting factor and ambient dose equivalent for a passively scattered proton therapy unit. Phys Med Biol 53(1):187-201, 1/2008. e-Pub 12/2007. PMID: 18182696.
12. Canic S, Tambaca J, Mikelic A, Hartley CJ, Mirkovic D, Chavez J, Rosenstrauch D. Blood flow through axially symmetric sections of compliant vessels: new effective closed models. Conf Proc IEEE Eng Med Biol Soc 5:3696-3699, 2007. PMID: 17271096.
13. Yang XF, Mirkovic D, Zhang S, Zhang QE, Yan Y, Xiong Z, Yang F, Chen IH, Li L, Wang H. Processing sites are different in the generation of HLA-A2.1-restricted, T cell reactive tumor antigen epitopes and viral epitopes. International Journal Immunopathology Pharmacology 19/4:853-70, 10/2006. PMID: 17166407.
14. Yang Y, Yang F, Xiong Z, Yan Y, Wang X, Nishino M, Mirkovic D, Nguyen J, Wang H, Yang X. An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene 24:4778-4788, 2005.
15. Canic S, Ravi-Chandar K, Krajcer Z, Mirkovic D, Lapin S. Mathematical Model analysis of Wallstent and Aneurx: dynamic responses of bare-metal endoprosthesis compared with those of stent-graft. Texas Heart Institute Journal 32/4:502-6, 2005.
16. Mirkovic D, Johnson SL. Automatic performance tuning for fast fourier transforms. International Journal of High Performance Computing Applications 18/1:47-64, 2004.
17. Mirkovic D, Johnson SL. CODELAB: A developers' tool for efficient code generation and optimization. Lecture Notes in Computer Science 2657/4:729-738, 2003.
18. Canic S, Mirkovic D. A hyperbolic system of conservation laws arising in modeling endovascular treatment of abdominal aortic aneurysm. Hyperbolic Problems: Theory, numerics, applications 141:227-236, 2001.
19. Mirkovic D, Johnsson SL. Automatic Performance Tuning in UHFFT Library. Lecture Notes in Computer Science 2073/1:71-80, 2001.
20. Canic S, Mirkovic D. Numericdal study of riemann problems for the two-dimensional unsteady transonic small disturbance equation. SIAM Journal on Applied Mathematics 58:1365-1393, 1998.
21. Mirkovic D, Diamond DJ. Effect of flusing of boron during a boiling water reactor anticipated transsient without scram. Nuclear Technology 95:162-174, 1991.
22. Mirkovic D, Diamond DJ, Hsu CJ, Fitzpatrick R. The potential for catastrophic fuel damage during beyond-design-basis over pressurization accidents in a boiling water reactor. Nuclear Technology 93:158-165, 1991.
23. Mirkovic D, Diamond DJ. Boron Flusing during BWR ATWS. Trans of American Nuclear Society 61:222-223, 1990.
24. Diamond DJ, Hsu C-J, Fitzpatrick, R, Mirkovic D. Reactivity accidents with the potential for catastrophic fuel damage. Nuclear Safety 31:311-317, 1990.

Editorials

1. Rumbaut RE, Mirkovic D. Magnetic therapy for edema in inflammation: a physiological assessment. Am J Physiol Heart Circ Physiol 294(1):19-20, 11/2007. PMID: 18032520.

Abstracts

1. Mirkovic D, Titt U, Sawakuchi GO, Zhang X, Li Y, Mohan R. Monte Carlo computation of the effective dose in scanning beam proton therapy. Med. Phys. 36(6):2612, 6/2009.
2. Harvey MC, Taddei PJ, Mirkovic D, Newhauser WD. Nuclear Model Evaluation of Uncertainties in Therapeutic Absorbed Dose and Secondary Neutron Production in Proton Radiotherapy using MCNPX. Medical Physics 36(6):2702, 6/2009.
3. Peng Y, Balter P, mirkovic D, Vedam S. Real-time characterization of respiratory motion regularity during radiation therapy. Med. Phys. 36(6):2503, 6/2009.
4. Yepes P, Newhauser WD, Randeniya S, Taddei PJ, mirkovic D. Reducing the Simulation Time of a Prostate Cancer Clinical Setup by Two Orders of Magnitude. Med. Phys 36(6):2622, 6/2009.
5. Taddei PJ, Mirkovic D, Fontenot JD, Zheng Y, Kornguth D, Mohan R, Newhauser WD. Second cancer risk from secondary neutrons for a boy who received proton craniospinal irradiation. Med. Phys. 36(6):2628, 6/2009.
6. Titt U, Zhang X, Li Y, Mirkovic D, Sawakuchi G, Mohan R. Monte Carlo Study of Distal Edge Degradation in Proton Therapy Due to Heterogeneities. Proof of Principle with a Case Study. Medical Physics 35(6), 6/2008.
7. Taddei PJ, Mirkovic D, Fontenot JD, Giebeler A, Zheng Y, Titt U, Woo S, Newhauser WD. Reducing Stray Radiation Dose for a Pediatric Patient Receiving Craniospinal Irradiation with Protons. Medical Physics 35(6), 6/2008.
8. Mirkovic D, Vedam S, Chang JY. Volumetric Analysis of Moving Structures in Radiation Treatment Planning. Medical Physics 35(6), 6/2008.
9. Newhauser W, Fontenot J, Zheng Y, Taddei P, Mirkovic D, Titt U, Zhu X, Sahoo N, Schaffner B, Langenegger A, Koch N, Zhang X, Mohan R. A Monte-Carlo Based Dose Engine for Proton Radiotherapy Treatment Planning. Medical Physics 34(6):2406, 6/2007.
10. Taddei P, Fontenot J, Zheng Y, Mirkovic D, Titt U, Newhauser W. Monte Carlo Investigation of Local Shielding to Reduce Stray Radiation Doses to Patients Receiving Proton Therapy. Medical Physics 34(6):2471, 6/2007.
11. Kang Y, Mirkovic D, Dong L. Sensitivity of Proton and Photon Plans to the Intra- and Inter-Fractional Changes in Patient's Anatomy. Medical Physics 34(6):2390, 6/2007.
 

Other

1. Nuclear Regulatory Comission Report. Mirkovic D, Diamond, DJ (1990) Boron Flushing During BWR Anticipated Transient Without Scram, Technical report, U.S. Nuclear Regulatory Commission, NUREG/CR-5573.
2. Conference proceedings.

Mirkovic D. N-Dimensional Finite Element Package. Proceedings of the High Performance Computing Conference, April 1996, New Orleans, LA, pp. 324-329, 1996.

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3. Conference proceedings. Mirkovic D, Mahasoom R, Johnsson SL. An Adaptive Software Library for Fast Fourier Transforms. Proceedings of the 2000 International Conference on Supercomputing, Santa Fe, NM , pp. 215-224, 2000.
4. Conference proceedings.

Mirkovic D, Johnsson SL. Automatic Performance Tuning in UHFFT Library. In proceedings of the 2001 International Conference on Computational Science, ICCS 2001, May 2001, San Francisco, Lecture Notes in Computer Science 2073, Vol. 1, pp. 71-80, 2001.

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5. Conference proceedings.

Canic S, Tambaca J, Mikelic A, Hartley C J, Mirkovic D, Chavez J, Rosenstrauch D. Blood flow through axially symmetric sections of compliant vessels: new effective closed models, Proceedings of the 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, September 1-5, 2004.

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6. Conference proceedings.

Ali A, Johnsson L, Mirkovic D. Empirical Auto-tuning Code Generator for FFT and Trignometric Transforms ODES: 5th Workshop on Optimizations for DSP and Embedded Systems, in conjunction with International Symposium on Code Generation and Optimization (CGO), 2007.

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Grant & Contract Support

Title: Moving proton therapy towards its full potential by using fast Monte Carlo techniquies
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Principal Investigator-MDACC
Principal Investigator: Yepes
Duration: 3/1/2015 - 2/28/2018
 
Title: Intensity Modulated Particle Therapy
Funding Source: Sister Institution Network Fund
Role: Co-Investigator
Duration: 2/1/2012 - 9/30/2014
 
Title: In-Situ PET Imaging for Adaptive Proton Therapy
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Collaborator
Principal Investigator: Yiping Shao
Duration: 11/2/2011 - 11/2/2014
 
Title: Optimizing Proton Therapy - Core B: Clinical and Computational Support
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014
 
Title: Optimizing Proton Therapy - Core C: Statistics, Data Exchange, Management and Support
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Thomas DeLaney
Duration: 9/25/2008 - 7/31/2014

Last updated: 7/30/2014