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Dr. Edward T.H. Yeh received his bachelor's degree in biochemistry with honors from the University of California, Berkeley, and his medical degree from the University of California, Davis.   Following medical residency, he completed a post-doctoral fellowship in Immunology at Harvard Medical School.  In 1987, he was appointed Assistant Professor of Medicine at the Massachusetts General Hospital and Harvard Medical School.  In 1992, Dr. Yeh joined the faculty of The University of Texas Health Science Center at Houston. In 2000, he founded the Department of Cardiology at The University of Texas MD Anderson Cancer Center. 

Dr. Yeh established a new field called Onco-cardiology that specializes in providing comprehensive cardiac care to cancer patients. His laboratory made the seminal discovery that Topoisomerase 2b (Top2b) mediates anthracycline-induced cardiotoxicity. This finding heralds in a new age of personalized cardio-protection for patient undergoing chemotherapy.  In 1996, Dr. Yeh’s laboratory discovered Sentrin/SUMO, which has revolutionized our understanding of heart disease, cancer, and neuro-degenerative diseases. His laboratory was the first to discover NEDD8, a ubiquitin-like protein modifier that has broad clinical applications. His research on GPI anchor biosynthesis laid the foundation for finding the cause of paroxysmal nocturnal hemoglobinuria. His laboratory also made major contributions in the use of adult stem cells to treat patients who suffer from heart attack and heart failure.  Dr. Yeh received grants from the National Institute of Health, Cancer Prevention Research Institute of Texas, and Department of Defense. He was a Massachusetts General Hospital/Upjohn Scholar, Arthritis Investigator of Arthritis Foundation, and Established Investigator of the American Heart Association. He has written over 200 scientific papers and book chapters, many of which are landmark contributions to science and medicine.

Dr. Yeh was elected to memberships in Academia Sinica, the Association of American Physicians, and the American Society for Clinical Investigation. He was selected as the Distinguished Alumnus of the University of California, Davis Medical School and has served for ten years as Associate Editor of Circulation. Dr. Yeh is a current member of the Editorial Board of Circulation, Texas Heart Institute Journal, and Journal of Biological Chemistry. He has held prominent positions as the President of the Houston Cardiology Society, President of the Board of American Heart Association, Houston Chapter, and Board Member of the American Heart Association, Texas Affiliate and South Central Affiliate. He was the medical honoree of the American Heart Association Heart Ball in Houston 2011. He has been named America’s Top Cardiologist and Best Doctors in America.

Molecular basis of anthracycline cardiotoxicity

Adult stem cells in the treatment of heart disease

Pathophysiology of SUMOylation and De-SUMOylation

Last updated: 5/22/2013