| Edward T. Yeh, M.D. |
Present Title & Affiliation
Primary Appointment
Bio Statement
After earning his bachelor's degree in biochemistry with honors from the
Research Interests
SUMOylation
NEDDylation
Stem cell transplant for congestive heart failure
Cardiac complications of anti-cancer therapy
The role of inflammation in the development of coronary artery disease
Clinical Interests
Congestive Heart Failure
Education & Training
Degree-Granting Education | |
| 1980 | University of California, Davis, CA, MD, Medicine |
| 1976 | University of California, Berkeley, CA, AB, (Honor), Biochemistry |
Postgraduate Training | |
| 1/1992-1/1995 | Clinical Fellow in Cardiology, Cardiology, The University of Texas - Houston Health Science Center, Houston, TX, James T. Willerson |
| 1/1986-1/1987 | Clinical Fellow in Rheumatology, Rheumatology, Massachusetts General Hospital, Boston, MA, Stephen M. Krane |
| 1/1983-1/1986 | Research Fellowship, Immunology, Harvard Medical School, Boston, MA, Baruj Benacerraf |
Board Certifications
| 1/1999 | Nuclear Cardiology |
| 1/1995 | Cardiovascular Diseases |
| 1993 | Rheumatology |
| 1/1983 | Internal Medicine |
Honors and Awards
| 2008-2009 | McNair Scholar, Texas Heart Institute |
| 2007 | America's Top Cardiologists |
| 2007 | Best Doctors, Elected to Best Doctors in America |
| 2006 | Academician, Academia Sinica, Republic of China |
| 2005 | Outstanding Advocate Award, American Heart Association-Houston |
| 2001 | Distinguished Alumnus Award, U. C. Davis Medical School |
| 2000 | Association of American Physicians |
| 1993 | American Society of Clinical Investigation |
| 1992-1999 | Established Investigator, American Heart Association |
| 1987-1990 | Investigator Award, Arthritis Foundation |
| 1987-1990 | Upjohn/Massachusetts General Hospital Scholar Award |
| 1973-1974 | Kraft Prize for Undergraduates, U.C. Berkeley |
Selected Publications
Peer-Reviewed Original Research Articles | |
| 1. | Yeh, E.T., Bickford, C.. Cardiovascular Complications of Cancer Therapy: Incidence, Pathogenesis, Diagnosis and Management. J Am Coll Cardiol 53(53):2231-47, 6/2009. PMID: 19520246. |
| 2. | Yeh ETH. SUMOylation and De-SUMOylation: Wrestling with Life's Processes. J Biol Chem 284(13):8223-8227, 2009. e-Pub 11/13/2008. PMCID: PMC2659178. |
| 3. | Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131(3):584-95, 11/2/2007. PMCID: PMC2128732. |
| 4. | Zhang S, Shpall E, Willerson JT, Yeh ETH. Fusion of Human Hematopoietic Progenitor Cells and Murine Cardiomyocytes Is Mediated by α4 β1/Vascular Cell Adhesion Molecule-1 Interaction. Circ Res 100/5:693-702, 3/2007. PMID: 17303762. |
| 5. | Gao F, Cheng J, Shi T, Yeh ET. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol 8(10):1171-7, 10/2006. e-Pub 9/24/2006. PMID: 16998474. |
| 6. | Calabro P, Willerson JT, Yeh ETH. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108:1930-2, 10/2003. PMID: 14530191. |
| 7. | Yeh ETH, Zhang S, Wu HD, Korbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 108:2070-3, 10/2003. PMID: 14568894. |
| 8. | Pasceri V, Cheng JS, Willerson JT, Yeh ETH. Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation 103:2531-4, 5/2001. PMID: 11382718. |
| 9. | Pasceri V, Willerson JT, Yeh ETH. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102:2165-8, 10/2000. PMID: 11056086. |
| 10. | DeGasperi R, Thomas L, Sugiyama E, Chang HM, Beck PJ, Orlean P, Albright C, Waneck G, Sambrook J, Warren C, Yeh ETH. Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene. Science 250(4983):988-991, 1990. PMID: 1978413. |
| 11. | Yeh ETH, Reiser H, Bamezai A, Rock KL. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor. Cell 52(5):665-74, 3/1988. PMID: 2894252. |
Grant & Contract Support
| Title: | De-SUMOylation and the Hypoxic Response |
| Funding Source: | NIH/NCI |
| Role: | Principal Investigator |
| Duration: | 3/1/2009 - 1/31/2014 |
| Title: | Molecular Imaging of Stem Cell Transplantation in the Heart |
| Funding Source: | NIH/NHLBI |
| Role: | Co-Principal Investigator |
| Principal Investigator: | Dr. Juri G. Gelovani |
| Duration: | 8/15/2007 - 4/30/2011 |
Last updated: 11/19/2009
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