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Edward T. Yeh, M.D.

Present Title & Affiliation

Primary Appointment

Professor and Chairman, Department of Cardiology, Division of Internal Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX
A Conversation with a Living Legend Professor, Department of Cardiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Bio Statement

After earning his bachelor's degree in biochemistry with honors from the University of California, Berkeley, and his Medical degree from the University of California, Davis, Dr. Yeh trained as an immunologist under Nobel laureate Dr. Baruj Benacerraf at Harvard Medical School, Boston. In 1987, he was appointed Assistant Professor of Medicine at the Massachusetts General Hospital and Harvard Medical School. He is board-certified in Internal Medicine, Cardiovascular Diseases, and Nuclear Cardiology. In 1992, Dr. Yeh joined the faculty of The University of Texas Health Science Center at Houston. His laboratory has discovered three novel biochemical pathways (SUMOylation, Neddylation, and GPI anchor biosynthesis) that have revolutionized our understanding of cell cycle progression, cell signaling, and the pathogenesis of leukemia. His laboratory is also at the forefront in deciphering the role of inflammation in the development of atherosclerosis and in the study of using stem cells to repair damaged heart muscles. He has received grants from the National Institute of Health and support from the Massachusetts General Hospital/Upjohn Scholarship, Arthritis Investigator Award from the Arthritis Foundation, and the Established Investigator Award from the American Heart Association. Dr. Yeh has mentored a large number of physician/scientists and basic scientists, who have become independent investigators. He has written over 100 scientific papers, many of which are landmark contributions to science and medicine. He is the founding Chairman of the Department of Cardiology at the University of Texas M. D. Anderson Cancer Center. Among his many honors, Dr. Yeh was elected to memberships in Academia Sinica, the Association of American Physicians, and the American Society for Clinical Investigation. He was selected as the Distinguished Alumnus of the University of California, Davis Medical School and has served for ten years as Associate Editor of Circulation. Dr. Yeh is a member of the Texas Heart Institute and currently serves as a board member of the American Heart Association, Southwestern Affiliate. He has held prominent positions as the President of the Houston Cardiology Society and President of the board of American Heart Association, Houston Chapter.

Research Interests

SUMOylation

NEDDylation

Stem cell transplant for congestive heart failure

Cardiac complications of anti-cancer therapy

The role of inflammation in the development of coronary artery disease

Clinical Interests

Congestive Heart Failure

Education & Training

Degree-Granting Education

1980 University of California, Davis, CA, MD, Medicine
1976 University of California, Berkeley, CA, AB, (Honor), Biochemistry

Postgraduate Training

1/1992-1/1995 Clinical Fellow in Cardiology, Cardiology, The University of Texas - Houston Health Science Center, Houston, TX, James T. Willerson
1/1986-1/1987 Clinical Fellow in Rheumatology, Rheumatology, Massachusetts General Hospital, Boston, MA, Stephen M. Krane
1/1983-1/1986 Research Fellowship, Immunology, Harvard Medical School, Boston, MA, Baruj Benacerraf

Board Certifications

1/1999 Nuclear Cardiology
1/1995 Cardiovascular Diseases
1993 Rheumatology
1/1983 Internal Medicine

Honors and Awards

2008-2009 McNair Scholar, Texas Heart Institute
2007 America's Top Cardiologists
2007 Best Doctors, Elected to Best Doctors in America
2006 Academician, Academia Sinica, Republic of China
2005 Outstanding Advocate Award, American Heart Association-Houston
2001 Distinguished Alumnus Award, U. C. Davis Medical School
2000 Association of American Physicians
1993 American Society of Clinical Investigation
1992-1999 Established Investigator, American Heart Association
1987-1990 Investigator Award, Arthritis Foundation
1987-1990 Upjohn/Massachusetts General Hospital Scholar Award
1973-1974 Kraft Prize for Undergraduates, U.C. Berkeley

Selected Publications

Peer-Reviewed Original Research Articles

1. Yeh, E.T., Bickford, C.. Cardiovascular Complications of Cancer Therapy: Incidence, Pathogenesis, Diagnosis and Management. J Am Coll Cardiol 53(53):2231-47, 6/2009. PMID: 19520246.
2. Yeh ETH. SUMOylation and De-SUMOylation: Wrestling with Life's Processes. J Biol Chem 284(13):8223-8227, 2009. e-Pub 11/13/2008. PMCID: PMC2659178.
3. Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell 131(3):584-95, 11/2/2007. PMCID: PMC2128732.
4. Zhang S, Shpall E, Willerson JT, Yeh ETH. Fusion of Human Hematopoietic Progenitor Cells and Murine Cardiomyocytes Is Mediated by α4 β1/Vascular Cell Adhesion Molecule-1 Interaction. Circ Res 100/5:693-702, 3/2007. PMID: 17303762.
5. Gao F, Cheng J, Shi T, Yeh ET. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol 8(10):1171-7, 10/2006. e-Pub 9/24/2006. PMID: 16998474.
6. Calabro P, Willerson JT, Yeh ETH. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108:1930-2, 10/2003. PMID: 14530191.
7. Yeh ETH, Zhang S, Wu HD, Korbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation 108:2070-3, 10/2003. PMID: 14568894.
8. Pasceri V, Cheng JS, Willerson JT, Yeh ETH. Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation 103:2531-4, 5/2001. PMID: 11382718.
9. Pasceri V, Willerson JT, Yeh ETH. Direct proinflammatory effect of C-reactive protein on human endothelial cells. Circulation 102:2165-8, 10/2000. PMID: 11056086.
10. DeGasperi R, Thomas L, Sugiyama E, Chang HM, Beck PJ, Orlean P, Albright C, Waneck G, Sambrook J, Warren C, Yeh ETH. Correction of a defect in mammalian GPI anchor biosynthesis by a transfected yeast gene. Science 250(4983):988-991, 1990. PMID: 1978413.
11. Yeh ETH, Reiser H, Bamezai A, Rock KL. TAP transcription and phosphatidylinositol linkage mutants are defective in activation through the T cell receptor. Cell 52(5):665-74, 3/1988. PMID: 2894252.

Grant & Contract Support

Title: De-SUMOylation and the Hypoxic Response
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 3/1/2009 - 1/31/2014
 
Title: Molecular Imaging of Stem Cell Transplantation in the Heart
Funding Source: NIH/NHLBI
Role: Co-Principal Investigator
Principal Investigator: Dr. Juri G. Gelovani
Duration: 8/15/2007 - 4/30/2011

Last updated: 11/19/2009