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Emil J Freireich

Present Title & Affiliation

Primary Appointment

Ruth Harriet Ainsworth Chair, Developmental Therapeutics, Developmental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1949 University of Illinois College of Medicine, Chicago, MD, (with honors), Medicine
1947 University of Illinois College of Medicine, Chicago, IL, BS, Medicine

Honors and Awards

2010 10th Edward H. Ahrens Jr. Award, SCTS/ACRT/APOR
2009 Castle Connolly National Physician of the Year Lifetime Achievement Award, Castle Connolly Medical Ltd.
2008 Paul Ehrlich Magic-Bullet Lifetime Achievement Award
2006 Honorary First Fellow Award, 40th Anniversary of the Medical Oncology Fellowship Program
2005 Founding Member, The University of Texas Academy of Health Science Education
2005 Gerald P. Bodey Sr., M.D. Distinguished Award
2003 Pollin Prize for Pediatric Research, Columbia University College of Physicians and Surgeons
2001 9th Cino del Duca Award, 11th International Congress on Anti-Cancer Treatment
2000 Charles A. LeMaistre, M.D. Outstanding Achievement Award in Cancer
2000 Faculty Achievement Award for Education, M. D. Anderson Cancer Center
2000 Signator of The Treaty of Paris Against Cancer
2000 The President's Award, M. D. Anderson Cancer Center
2000 University of Illinois Alumni Achievement Award
1999 50th Anniversary Commemorative Award, Leukemia Society of America
1999 Nagib Taleb Award, 4th Middle East Oncology Congress
1999 Partners in Courage Achievement Award, American Cancer Society
1997 Dr. Emil J Freireich Day
1997 Festschrift Symposium in Honor of 70th Birthday
1996 Medical Oncology Fellows Outstanding Teacher Award, The University of Texas M. D. Anderson Cancer Center
1996 Medicus Hippocraticus Award, First International Medical Olympiad
1996 Member, The University of Texas System Faculty Advisory Council
1996 Return of the Child Award, Leukemia Society of America
1995 Distinguished Service to Graduate Medical Education, The Accreditation Council for Graduate Medical Education
1994 1st Dr. Arlan J. Gottlieb Memorial Award, Leukemia Society of America, Central NY Chapter
1994 C. Edwin Cohn-C.G.P. de Laval Award, World Apheresis Association
1994 Dean's Excellence Award, Graduate School of Biomedical Sciences
1993 Chairman, Faculty Senate, The University of Texas M. D. Anderson Cancer Center
1993 Listed in The Best Doctors in America
1992 Gold Medal of the Faculty of Medicine of Masaryck
1992 Silver Medal of the Faculty of Pediatrics of the Charles University
1991 First Allen Latham, Jr. Award for Scientific Contribution to the Development of Apheresis of the European Society of Haemapheresis
1990 Recipient of the First National Institutes of Health Distinguished Alumni Award
1989 Outstanding Achievement Award in Recognition of Notable Contributions in Cancer, 24th Annual Meeting American Society of Contemporary Medicine and Surgery
1988 Henry M. and Lillian Stratton Lecture, XXII Congress of the International Society of Hematology
1987 Biomedicine and Pharmacotherapy Prize, International Society of Medical Ethics, Philosophy, Methodology and Economy
1985 Outstanding Investigator Award, National Cancer Institute
1984 First Harold Lupiloff Award in Oncology, Wayne State University
1983 Alpha Epsilon Delta, The Prehealth Honor Society
1983 Charles F. Kettering Prize, General Motors Cancer Research Foundation
1982 Fourteenth Annual Danely Slaughter Lecturer, St. Francis Hospital
1982 Honorary Degree of Doctor of Science, University of Illinois Medical School Centennial Celebration
1981 Fortieth Anniversary Commemorative Medical of Achievement in Clinical Science, The University of Texas M. D. Anderson Cancer Center
1981 Sixth Annual Jeffrey A. Gottlieb Memorial Award for Outstanding Achievement in Cancer Therapeutic Research, The University of Texas M. D. Anderson Cancer Center
1980 Gifford-Hill Visiting Professor of Medicine, The University of Texas Southwestern Medical School in Dallas
1980 Leukemia Society of America Award for Outstanding Service to Mankind
1980 Ruth Harriet Ainsworth Professor of Developmental Therapeutics
1979 Fifteenth Annual Guest Lecturer, Leukemia Research Fund, Great Britain
1979 Robert Roesler de Villiers Award, Leukemia Society of America
1979 Who's Who in America
1978 Fourth Annual Myron Karon Memorial Award, Childrens' Hospital of Los Angeles
1977 Fourth Annual John Hoover Moon Memorial Lectureship, Medical College of Virginia
1977 Third Annual Distinguished Leukemia Lectureship, Alabama Chapter of the Leukemia
1976 Seventh Annual David A. Karnofsky Award and Lecture, American Society of Clinical Oncology
1974 Alumnus of the Year for Service to Education or Research, University of Illinois Medical School Alumnus Association
1972 Albert Lasker Medical Research Award
1970 President's Award for Outstanding Service, Leukemia Society of America
1947 Alpha Omega Alpha

Selected Publications

Peer-Reviewed Original Research Articles

1. Holland JF, Freireich EJ. Emil Frei III, 1924-2013. J Clin Oncol 31(30):3727-30, 10/2013. e-Pub 9/2013. PMID: 24019548.
2. Freireich EJ. Leukocyte Transfusion and the Development of the Continuous-Flow Blood Cell Separator. Transfus Med Rev 25(4):344-50, 10/2011. e-Pub 5/31/2011. PMID: 21632206.
3. Freireich EJ. Origins of Platelet Transfusion Therapy. Transfus Med Rev 25(3):252-6, 7/2011. e-Pub 3/2/2011. PMID: 21371858.
4. Körbling M, Freireich EJ. 25 years of peripheral blood stem cell transplantation. Blood 117(24):6411-6, 6/16/2011. e-Pub 4/1/2011. PMID: 21460243.
5. Gehan EA, Freireich EJ. The 6-MP versus placebo clinical trial in acute leukemia. Clin Trials 8(3):288-97, 6/2011. PMID: 21730077.
6. Duzkale H, Schweighofer CD, Coombes KR, Barron LL, Ferrajoli A, O'Brien S, Wierda WG, Pfeifer J, Majewski T, Czerniak BA, Jorgensen JL, Medeiros LJ, Freireich EJ, Keating MJ, Abruzzo LV. LDOC1 mRNA is differentially expressed in chronic lymphocytic leukemia and predicts over-all survival in untreated patients. Blood 117(15):4076-84, 4/14/2011. e-Pub 2/10/2011. PMCID: PMC3087532.
7. Kantarjian H, Ravandi F, O'Brien S, Cortes J, Faderl S, Garcia-Manero G, Jabbour E, Wierda W, Kadia T, Pierce S, Shan J, Keating M, Freireich EJ. Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia. Blood 116(22):4422-9, 11/2010. e-Pub 7/2010. PMID: 20668231.
8. Golemovic M, Quintás-Cardama A, Manshouri T, Orsolic N, Duzkale H, Johansen M, Freireich EJ, Kantarjian H, Zingaro RA, Verstovsek S. MER1, a novel organic arsenic derivative, has potent PML-RARalpha- independent cytotoxic activity against leukemia cells. Invest New Drugs 28(4):402-12, 8/2010. e-Pub 5/26/2009. PMID: 19468689.
9. Verma D, Kantarjian H, Faderl S, O'Brien S, Pierce S, Vu K, Freireich E, Keating M, Cortes J, Ravandi F. Late relapses in acute myeloid leukemia: analysis of characteristics and outcome. Leuk Lymphoma 51(5):778-82, 5/2010. e-Pub 3/2010. PMID: 20196624.
10. Santos FP, Faderl S, Garcia-Manero G, Koller C, Beran M, O'Brien S, Pierce S, Freireich EJ, Huang X, Borthakur G, Bueso-Ramos C, de Lima M, Keating M, Cortes J, Kantarjian H, Ravandi F. Adult acute erythroleukemia: an analysis of 91 patients treated at a single institution. Leukemia 23(12):2275-80, 12/2009. e-Pub 9/10/2009. PMID: 19741728.
11. Freireich EJ, Kantarjian H, Keating MJ. Leukemia research, 2008. Clin Lymphoma Myeloma 9 Suppl 3:S178, 2009. PMID: 19778837.
12. Maruyama F, Yang P, Stass SA, Cork A, Freireich EJ, Lee MS, Chang KS. Detection of the AML1/ETO fusion transcript in the t(8;21) masked translocation in acute myelogenous leukemia. Cancer Res 53(19):4449-51, 10/1993. PMID: 8402610.
13. Giralt S, Escudier S, Kantarjian H, Deisseroth A, Freireich EJ, Andersson BS, O'Brien S, Andreeff M, Fisher H, Cork A, et al. Preliminary results of treatment with filgrastim for relapse of leukemia and myelodysplasia after allogeneic bone marrow transplantation. N Engl J Med 329(11):757-61, 9/1993. PMID: 7688862.
14. Frei E III, Freireich EJ. The clinical cancer researcher - still an embattled species. J Clin Oncol 11(9):1639-51, 9/1993. PMID: 8355033.
15. Dimopoulos MA, Kantarjian H, Estey E, O'Brien S, Delasalle K, Keating MJ, Freireich EJ, Alexanian R. Treatment of Waldenstrom macroglobulinemia with 2-chlorodeoxyadenosine. Ann Intern Med 118(3):195-8, 2/1993. PMID: 8093333.
16. Freireich EJ. White cell transfusions born again. Leuk Lymphoma 11 Suppl 2:161-5, 1993. PMID: 7510195.
17. Freireich EJ, Cork A, Stass SA, McCredie KB, Keating MJ, Estey EH, Kantarjian HM, Trujillo JM. Cytogenetics for detection of minimal residual disease in acute myeloblastic leukemia. Leukemia 6(6):500-6, 6/1992. PMID: 1602788.
18. Chang KS, Wang G, Freireich EJ, Daly M, Naylor SL, Trujillo JM, Stass SA. Specific expression of the annexin VIII gene in acute promyelocytic leukemia. Blood 79(7):1802-10, 4/1992. PMID: 1313714.
19. Estey EJ, Kurzrock R, Kantarjian HM, O'Brien, SM, McCredie, KB, Beran, M, Koller, C, Keating, MJ, Hirsch-Ginsberg C, Huh YO, Stass S, Freireich EJ. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA). Blood 79:882-887, 1992.
20. Freireich EJ. A study of the status of clinical cancer research in the United States (1990). J Natl Cancer Inst 83(12):829-37, 6/1991. PMID: 2061942.
21. Chang KS, Trujillo JM, Ogura T, Castiglione CM, Kidd KK, Zhao SR, Freireich EJ, Stass SA. Rearrangement of the retinoic acid receptor gene in acute promyelocytic leukemia. Leukemia 5(3):200-4, 3/1991. PMID: 1849600.
22. Keating MJ, Kantarjian H, O'Brien S, Koller C, Talpaz M, Schachner J, Childs CC, Freireich EJ, McCredie KB. Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia. J Clin Oncol 9(1):44-9, 1991. PMID: 1702145.
23. Kantarjian, HM, Walters, RS, Keating, MJ, Smith, TL, O'Brien, S, Estey, EH, Huh, YO, Spinolo, J, Dicke, K, Barlogie, B, McCredie, KB, Freireich, EJ. Results of the vincristine, doxorubicin, and dexamethasone regimen in adults with standard- and high-risk acute lymphocytic leukemia. J. Clin. Oncol. 8:994-1004, 1990.
24. Keating MJ, Kantarjian H, Talpaz M, Redman J, Koller C, Barlogie B, Velasquez W, Plunkett W, Freireich EJ, McCredie KB. Fludarabine: a new agent with major activity against chronic lymphocytic leukemia. Blood 74(1):19-25, 7/1989. PMID: 2473795.
25. Lee MS, Chang KS, Freireich EJ, Kantarjian HM, Talpaz M, Trujillo JM, Stass SA. Detection of minimal residual bcr/abl transcripts by a modified polymerase chain reaction. Blood 72(3):893-7, 9/1988. PMID: 2458151.
26. Lee MS, Chang KS, Cabanillas F, Freireich EJ, Trujillo JM, Stass SA. Detection of minimal residual cells carrying the t(14;18) by DNA sequence amplification. Science 237(4811):175-8, 7/1987. PMID: 3110950.
27. Keating MJ, Gehan EA, Smith TL, Estey EH, Walters RS, Kantarjian HM, McCredie KB, Freireich EJ. A strategy for evaluation of new treatments in untreated patients: application to a clinical trial of AMSA for acute leukemia. J Clin Oncol 5(5):710-21, 5/1987. PMID: 3553435.
28. Kantarjian HM, Keating MJ, Walters RS, Smith TL, McCredie KB, Freireich EJ. Role of maintenance chemotherapy in acute promyelocytic leukemia. Cancer 59(7):1258-63, 4/1987. PMID: 3469011.
29. Estey EH, Keating MJ, Dixon DO, Trujillo JM, McCredie KB, Freireich EJ. Karyotype is prognostically more important than the FAB system's distinction between myelodysplastic syndrome and acute myelogenous leukemia. Hematol Pathol 1(4):203-8, 1987. PMID: 3504436.
30. Keating MJ, Cork A, Broach Y, Smith T, Walters RS, McCredie KB, Trujillo J, Freireich EJ. Toward a clinically relevant cytogenetic classification of acute myelogenous leukemia. Leuk Res 11(2):119-33, 1987. PMID: 3469482.
31. Holmes R, Keating MJ, Cork A, Broach Y, Trujillo J, Dalton WT, Jr, McCredie KB, Freireich EJ. A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). Blood 65(5):1071-8, 5/1985. PMID: 3857943.
32. Keating MJ, McCredie KB, Bodey GP, Smith TL, Gehan E, Freireich EJ. Improved prospects for long-term survival in adults with acute myelogenous leukemia. Jama 248(19):2481-6, 11/1982. PMID: 6957624.
33. Keating MJ, Smith TL, Gehan EA, McCredie KB, Bodey GP, Freireich EJ. A prognostic factor analysis for use in development of predictive models for response in adult acute leukemia. Cancer 50(3):457-65, 8/1982. PMID: 7093887.
34. Estey EH, Keating MJ, McCredie KB, Bodey GP, Freireich EJ. Causes of initial remission induction failure in acute myelogenous leukemia. Blood 60(2):309-15, 8/1982. PMID: 6953982.
35. Smith TL, Gehan EA, Keating MJ, Freireich EJ. Prediction of remission in adult acute leukemia: development and testing of predictive models. Cancer 50(3):466-72, 8/1982. PMID: 7093888.
36. Legha SS, Benjamin RS, Mackay B, Ewer M, Wallace S, Valdivieso M, Rasmussen SL, Blumenschein GR, Freireich EJ. Reduction of doxorubicin cardiotoxicity by prolonged continuous intravenous infusion. Ann Intern Med 96(2):133-9, 2/1982. PMID: 7059060.
37. Keating MJ, Smith TL, McCredie KB, Bodey GP, Hersh EM, Gutterman JU, Gehan E, Freireich EJ. A four-year experience with anthracycline, cytosine arabinoside, vincristine and prednisone combination chemotherapy in 325 adults with acute leukemia. Cancer 47(12):2779-88, 6/1981. PMID: 6942906.
38. Mavlight GM, Stuckey SE, Cabanillas FF, Keating MJ, Tourtellotte WW, Schold SC, Freireich EJ. Diagnosis of leukemia or lymphoma in the central nervous system by beta 2-microglobulin determination. N Engl J Med 303(13):718-22, 9/1980. PMID: 6157089.
39. Keating MJ, Smith TL, Gehan EA, McCredie KB, Bodey GP, Spitzer G, Hersh E, Gutterman J, Freireich EJ. Factors related to length of complete remission in adult acute leukemia. Cancer 45(8):2017-29, 4/1980. PMID: 6989483.
40. Buzdar AU, Blumenschein GR, Gutterman JU, Tashima CK, Hortobagyi GN, Smith TL, Campos LT, Wheeler WL, Hersh EM, Freireich EJ, Gehan EA. Postoperative adjuvant chemotherapy with fluorouracil, doxorubicin, cyclophosphamide, and BCG vaccine. A follow-up report. Jama 242(14):1509-13, 10/1979. PMID: 470088.
41. Bottino J, McCredie KB, Ho DW, Freireich EJ, Buckles R, Herbst S, Lawson M. Continuous intravenous arabinosyl cytosine infusions delivered by a new portable infusion system. Cancer 43(6):2197-201, 6/1979. PMID: 455216.
42. Buzdar AU, Gutterman JU, Blumenschein GR, Hortobagyi GN, Tashima CK, Smith TL, Hersh EM, Freireich EJ, Gehan EA. Intensive postoperative chemoimmunotherapy for patients with stage II and stage III breast cancer. Cancer 41(3):1064-75, 3/1978. PMID: 638948.
43. Rodriguez V, Cabanillas F, Burgess MA, McKelvey EM, Valdivieso M, Bodey GP, Freireich EJ. Combination chemotherapy ("CHOP-Bleo") in advanced (non-Hodgkin) malignant lymphoma. Blood 49(3):325-33, 3/1977. PMID: 65189.
44. Freireich EJ, Bodey GP, McCredie KB, Hersh EM, Gehan EA, Hart J, Gutterman JU, Rodriguez V, Smith T, Hester JP. Developmental therapy in adult acute leukemia. Arch Intern Med 136(12):1417-21, 12/1976. PMID: 793554.
45. Gehan EA, Smith TL, Freireich EJ, Bodey G, Rodriquez V, Speer J, McCredie K. Prognostic factors in acute leukemia. Semin Oncol 3(3):271-82, 9/1976. PMID: 1068529.
46. Hester JP, McCredie KB, Freireich EJ. Granulocyte transfusions: analysis of donor, procedure, recipient variables. Blut 32(4):253-6, 4/1976. PMID: 1260142.
47. Bodey GP, Freireich EJ, Gehan E, McCredie KB, Rodriguez V, Gutterman J, Burgess MA. Late intensification therapy for acute leukemia in remission. Chemotherapy and immunotherapy. Jama 235(10):1021-5, 3/1976. PMID: 946184.
48. McCredie KB, Freireich EJ, Hester JP, Vallejos C. Increased granulocyte collection with the blood cell separator and the addition of etiocholanolone and hydroxyethyl starch. Transfusion 14(4):357-64, 7/1974. PMID: 4843243.
49. Trujillo JM, Cork A, Hart JS, George SL, Freireich EJ. Clinical implications of aneuploid cytogenetic profiles in adult acute leukemia. Cancer 33(3):824-34, 3/1974. PMID: 4521889.
50. Bickers JN, Gehan EA, Freireich EJ, Coltman CA, Jr, Wilson HE, Hewlett JS, Stuckey WJ, Van Slyck EJ. Cytarabine for acute leukemia in adults. Effect of schedule on therapeutic response. Arch Intern Med 133(2):251-9, 2/1974. PMID: 4521467.
51. Gehan EA, Freireich EJ. Non-randomized controls in cancer clinical trials. N Engl J Med 290(4):198-203, 1/1974. PMID: 4587632.
52. Rodriguez V, Hart JS, Freireich EJ, Bodey GP, McCredie KB, Whitecar JP Jr, Coltman CA Jr. POMP combination chemotherapy of adult acute leukemia. Cancer 32(1):69-75, 7/1973. PMID: 4515259.
53. Whitecar JP Jr, Bodey GP, Freireich EJ, McCredie KB, Hart JS. Cyclophosphamide (NSC-26271), vincristine (NSC-67574), cytosine arabinoside (NSC-63878), and prednisone (NSC-10023) (COAP) combination chemotherapy for acute leukemia in adults. Cancer Chemother Rep 56(4):543-50, 8/1972. PMID: 5081596.
54. Hersh EM, Whitecar JP Jr, McCredie KB, Bodey GP Sr, Freireich EJ. Chemotherapy, immunocompetence, immunosuppression and prognosis in acute leukemia. N Engl J Med 285(22):1211-6, 11/1971. PMID: 5286519.
55. Hart JS, Trujillo JM, Freireich EJ, George SL, Frei E III. Cytogenetic studies and their clinical correlates in adults with acute leukemia. Ann Intern Med 75(3):353-60, 9/1971. PMID: 5284907.
56. McCredie KB, Hersh EM, Freireich EJ. Cells capable of colony formation in the peripheral blood of man. Science 171(968):293-4, 1/1971. PMID: 5538844.
57. Curtis JE, Hersh EM, Freireich EJ. Antigen-specific immunity in recipients of leukocyte transfusions from immune donors. Cancer Res 30(12):2921-9, 12/1970. PMID: 5494577.
58. Harris J, Freireich EJ. In vitro growth of myeloid colonies from bone marrow of patients with acute leukemia in remission. Blood 35(1):61-3, 1970. PMID: 5263120.
59. Freireich EJ, Bodey GP, Harris JE, Hart JS. Therapy for acute granulocytic leukemia. Cancer Res 27(12):2573-7, 12/1967. PMID: 5237353.
60. Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep 50(4):219-44, 5/1966. PMID: 4957125.
61. Karon M, Freireich EJ, Frei E III, Taylor R, Wolman IJ, Djerassi I, Lee SL, Sawitsky A, Hananian J, Selawry O, James D, Jr, George P, Patterson RB, Burgert O, Jr, Haurani FI, Oberfield RA, Macy CT, Hoogstraten B, Blom J. The role of vincristine in the treatment of childhood acute leukemia. Clin Pharmacol Ther 7(3):332-9, 5/1966. PMID: 5327856.
62. Bodey GP, Buckley M, Sathe YS, Freireich EJ. Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64(2):328-40, 2/1966. PMID: 5216294.
63. Morse EE, Carbone PP, Freireich EJ, Bronson W, Kliman A. Repeated leukapheresis of patients with chronic myelocytic leukemia. Transfusion 6:175-182, 1966.
64. Morse EE, Freireich EJ, Carbone PP, Bronson W, Frei E III. The transfusion of leukocytes from donors with chronic myelocytic leukemia to patients with leukopenia. Transfusion 6:183-192, 1966.
65. Levin RH, Whang J, Carbone PP, Freireich EJ. Erythroid homograft following leukocyte transfusion in a patient with acute leukemia. I. Clinical studies and implications. Blood 26(5):587-96, 11/1965. PMID: 5321110.
66. Freireich EJ, Judson G, Levin RH. Separation and collection of leukocytes. Cancer Res 25(9):1516-20, 10/1965. PMID: 5861076.
67. Hersh EM, Carbone PP, Wong VG, Freireich EJ. Inhibition of the primary immune response in man by anti-metabolites. Cancer Res 25(7):997-1001, 8/1965. PMID: 5843275.
68. Hersh EM, Bodey GP, Nies BA, Freireich EJ. Causes of Death in Acute Leukemia: a Ten-Year Study of 414 Patients from 1954-1963. Jama 193:105-9, 7/1965. PMID: 14304351.
69. Kliman A, Carbone PP, Gaydos LA, Freireich EJ. Effects of Intensive Plasmapheresis on Normal Blood Donors. Blood 23:647-56, 5/1964. PMID: 14142503.
70. Freireich EJ, Levin RH, Whang J, Carbone PP, Bronson W, Morse EE. The Function and Fate of Transfused Leukocytes from Donors with Chronic Myelocytic Leukemia in Leukopenic Recipients. Ann N Y Acad Sci 113:1081-9, 2/1964. PMID: 14120509.
71. Levin RH, Whang J, Tjio JH, Carbone PP, Frei E III, Freireich EJ. Persistent Mitosis of Transfused Homologous Leukocytes in Children Receiving Antileukemic Therapy. Science 142:1305-11, 12/1963. PMID: 14074844.
72. Freireich EJ, Kliman A, Gaydos LA, Mantel N, Frei E III. Response to Repeated Platelet Transfusion from the Same Donor. Ann Intern Med 59:277-87, 9/1963. PMID: 14065945.
73. Freireich EJ, Gehan EA, Frei E III, Schroeder LR, Wolman, IJ, Anbari, R, Burgert, EO, Mills, SD, Pinkel, D, Selawry, OS, Moon, JH, Gendel, BR, Spurr, CL, Storrs R, Haurani F, Hoogstraten B, Lee S. The effect of 6-mercaptopurine on the duration of steroid-induced remissions in acute leukemia: A model for evaluation of other potentially useful therapy. Blood 21:699-716, 1963.
74. Gaydos LA, Freireich EJ, Mantel N. The quantitative relation between platelet count and hemorrhage in patients with acute leukemia. N Engl J Med 266:905-9, 5/1962. PMID: 13897369.
75. Freireich EJ, Frei E III, Karon M. Methylglyoxal bis (guanylhydrazone): a new agent active against acute myelocytic leukemia. Cancer Chemother Rep 16:183-6, 2/1962. PMID: 13894981.
76. Rieselbach RE, Morse EE, Rall DP, Frei E III, Freireich EJ. Treatment of meningeal leukemia with intrathecal aminopterin. Cancer Chemother Rep 16:191-6, 2/1962. PMID: 14492194.
77. Karon MR, Freireich EJ, Frei E. A preliminary report of vincristine sulphate - A new active agent for the treatment of acute leukemia. Pediatrics 30:791-796, 1962.
78. Freireich EJ, Gehan EA, Sulman D, Boggs DR, Frei E. The effect of chemotherapy on acute leukemia in the human. J Chronic Dis 14:593-608, 12/1961. PMID: 13894982.
79. Kliman A, Gaydos LA, Schroeder LR, Freireich EJ. Repeated plasmapheresis of blood donors as a source of platelets. Blood 18:303-9, 9/1961. PMID: 14456944.
80. Freireich EJ, Frei E, Holland JF, Pinkel D, Selawry O, Rothberg H, Haurani F, Taylor R, Gehan EA. Evaluation of a new chemotherapeutic agent in patients with 'advanced refractory' acute leukemia. Studies of 6-azauracil. Blood 16:1268-78, 9/1960. PMID: 13701706.
81. Moore EW, Thomas LB, Shaw RK, Freireich EJ. The central nervous system in acute leukemia: a postmortem study of 117 consecutive cases, with particular reference to hemorrhages, leukemic infiltrations, and the syndrome of meningeal leukemia. Arch Intern Med 105:451-68, 3/1960. PMID: 14423837.
82. Freireich EJ, Thomas LB, Frei E, Fritz RD, Forkner CE. A distinctive type of intracerebral hemorrhage associated with "blastic crisis" in patients with leukemia. Cancer 13:146-54, Jan-Feb, 1960. PMID: 13824827.
83. Freireich EJ, Schmidt PJ, Schneiderman MA, Frei E. A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia. N Engl J Med 260(1):6-11, 6/1959. PMID: 13613493.
84. Freireich EJ, Miller A, Emerson CP, Ross JF. The effect of inflammation on the utilization of erythrocyte and transferrin bound radioiron for red cell production. Blood 12(11):972-83, 11/1957. PMID: 13471662.
85. Freireich EJ, Ross JF, Bayles TB, Emerson CP, Finch SC. Radioactive iron metabolism and erythrocyte survival studies of the mechanism of the anemia associated with rheumatoid arthritis. J Clin Invest 36(7):1043-58, 7/1957. PMID: 13449157.

Book Chapters

1. Freireich EJ. Acute Myeloid Leukemia. In: 60 Years of Survival Outcomes at The University of Texas MD Anderson Cancer Center. Ed(s) MA Rodriguez, TW Burke, RS Walters. Springer, 205-209, 2013.
2. Freireich EJ. Biomedicine & Pharmacotherapy. In: Clinial research today and tomorrow. 55, 572-573, 2001.
3. Karon M, Bodey GP, Freireich EJ. The chemotherapy of acute leukemia. A therapeutic model for the treatment of childhood tumors. In: Neoplasia in Childhood. Year Book Medical Publishers, 241-258, 2000.
4. Wiernik P, Goldman J, Dutcher J, Kyle R. Historical Prospectives on Actue Leukemia. In: Neoplastic Diseases of the Blood. Submitted.

Letters to the Editor

1. Mattiuzzi G, Martinez F, Lichtiger B, et al. Safety and efficacy of unirradiated white cell transfusions. Blood, 11/2010.

Last updated: 6/17/2014