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Eric L. Chang, M.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Director, Central Nervous System Stereotactic Radiation Program, Department of Radiation Oncology, Division of Radiation of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1994 Harvard Medical School, Boston, MA, MD, Medicine
1990 Massachusetts Institute of Technology, Cambridge, MA, BS, Biology

Postgraduate Training

4/2009 Training, Gamma Knife Perfexion Upgrade Training Course, Cleveland Clinic Health System Gamma Knife Center, Cleveland, OH, Dr. Gene H. Barnett, Dr. John Suh
4/2009 Leadership Academy Training, Junior Heart of Leadership, The University of Texas MD Anderson Cancer Center, Houston, TX
2/2009 Training, Leksell Gamma Knife Perfexion Application Introductory Training, Stockholm, Sweden, Mr. Peter Froberg
7/1997-6/1998 Research, Boston Children's Hospital, Boston, MA, Dr. Bruce Zetter
7/1995-6/1999 Clinical Residency, Harvard Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA, Dr. Jay Harris
6/1994-6/1995 Clinical Internship, California Pacific Medical Center, University of California, San Francisco, CA, Dr. Allan Pont

Board Certifications

1999 American Board of Radiology

Honors and Awards

2002-2003 Named in Strathmore’s Who’s Who
2001 The American Society for Therapeutic Radiology and Oncology (ASTRO), Travel Grant to attend ESTRO and visit Institute Gustave-Roussy, Villejuif, France
1997 American Society for Clinical Oncology (ASCO) Award, Methods in Clinical Cancer Research Workshop, Vail, Colorado
1997 The American College of Radiation Oncology (ACRO), Howard H. Wong Fellowship in Radiation Oncology
1993 Howard Hughes Medical Institute Research Fellowship Winner
1990 Sigma Xi Research Society

Selected Publications

Peer-Reviewed Original Research Articles
1. Nguyen QN, Chang EL. Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep 10(4):338, 7/2009. e-Pub 7/2008. PMID: 18778560.
2. Torres MA, Chang EL, Mahajan A, Lege DG, Riley BA, Zhai X, Lii M-F, Kornguth DG, Pelloski CE, Woo Sy. Optimal treatment planning for skull base chordoma: Photon, Protons, or a Combination of Both. Int J Radiat Oncol Biol Phys 74:1033-9, 2009.
3. Wang H, Shiu A, Wang C, O'Daniel J, Mahajan A, Woo S, Liengsawangwong P, Mohan R, Chang EL. Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys 71(4):1261-71, 7/15/2008. e-Pub 5/15/2008. PMID: 18485614.
4. Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P. Multimodality Treatment of Osteosarcoma: Radiation in a High-risk cohort. Pediatr Blood Cancer 50(5):976-82, 5/2008. PMID: 18213710.
5. Clarke JW, Chang EL, Levin VA, Mayr NA, Hong E, Cavaliere R, Lo SS. Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients. Expert Rev Anticancer Ther 8(5):733-41, 5/2008. PMID: 18471046.
6. S S Lo,A Fakiris, R Abdulrahman, M Henderson, E Chang, J Suh, R Timmerman. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in pediatric brain tumors. Expert Rev. Neurotherapeutics 8(5):864, 1/2008.
7. Hadziahmetovic M, Clarke JW, Cavaliere R, Mayr NA, Montebello JF, Grecula JC, Newton HB, Chang EL, Lo SS. CNS germinomas: what is the best treatment strategy? Expert rev of neurother 8:1527-36, 2008.
8. Wang C, Shiu A, Lii M, Woo S, Chang EL. Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine. Technol Cancer Res Treat 6(3):187-196, 2007. PMID: 17535027.
9. Chang EL, Akyurek S, Avalos T, Rebueno N, Spicer C, Garcia J, Famiglietti R, Allen PK, Chao KS, Mahajan A, Woo SY, Maor MH. Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys 68(1):144-150, 2007. e-Pub 2/15/2007. PMID: 17306935.
10. Yom SS, Frija EK, Mahajan A, Chang E, Klein K, Shiu A, Ohrt J, Woo S. Field-in-field technique with intrafractionally modulated junction shifts for craniospinal irradiation. Int J Radiat Oncol Biol Phys 69(4):1193-1198, 2007. PMID: 17967308.
11. Hermanto U, Frija EK, Lii MJ, Chang EL, Mahajan A, Woo SY. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: Does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys 67:1135-1144, 2007. PMID: 17208388.
12. Chang EL, Wefel JS, Maor MH, Hassenbusch SJ 3rd, Mahajan A, Lang FF, Woo SY, Mathews L, Allen P, Shiu AS, Meyers C. Neurocognitive Function in Patients with 1 to 3 New Brain Metases Initially Treated with Stereotactic Radiosurgery Alone. Neurosurgery 60:285-292, 2007.
13. Chang EL, Shiu AS, Mendel E, Matthews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiation therapy for spinal metastasis and its pattern of failure. J Neurosurg 7:151-60, 2007.
14. Olch AJ, Geurts M, Thomadsen B, Famiglietti R, Chang EL. Portal imaging practice patterns of children's oncology group institutions: Dosimetric assessment and recommendations for minimizing unnecessary exposure. Int J Radiat Oncol Biol Phys 67:594-600, 2007. PMID: 17236976.
15. Lo SS, Chang EL, Yamada Y, Sloan AE, Suh JH, Mendel E. Stereotactic radiosurgery and radiation therapy for spinal tumors. Expert Rev Neurother 7(1):85-93, 2007. PMID: 17187488.
16. Akyurek S, Chang EL, Mahajan A, Hassenbusch SJ, Allen PK, Mathews LA, Shiu AS, Maor MH, Woo SY. Stereotactic Radiosurgical Treatment of Cerebral Metastases Arising from Breast Cancer. Am J Clin Oncol 3(3):310-314, 2007. PMID: 17551311.
17. Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer 107:2228-2236, 2006. PMID: 17019739.
18. Hu C, Chang EL, Hassenbusch SJ 3rd, Allen PK, Woo SY, Mahajan A, Komaki R, Liao Z. Nonsmall cell lung cancer presenting with symchronous solitary brain metastasis. Cancer 106(9):1998-2004, 2006.
19. Suh JH, Stea B, Nabid A, Kresl JJ, Fortin A, Mercier JP, Senzer N, Chang EL, Boyd AP, Cagnoni PJ, Shaw E. Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol 24(1):106-114, 2006. PMID: 16314619.
20. Rogers LR, Rock JP, Sills AK, Vogelbaum MA, Suh JH, Ellis TL, Stieber VW, Asher AL, Fraser RW, Billingsley JS, Lewis P, Schlellingerhout D, Shaw EG,. Results of a phase II trial of the GliaSite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases. J Neurosurg 105:375-384, 2006.
21. Lo SS, Chang EL, Sloan AE. Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy in the management of intracranial ependymoma. Expert Review of Neurotherapeutics 6(4):501-507, 2006.
22. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY. Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol 80(2):177-183, 2006. PMID: 16648988.
23. Mahajan A, McCutcheon IE, Suki D, Chang EL, Hassenbusch SJ, Weinberg JS, Shiu A, Maor MH, Woo SY. Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme. J Neurosurg 103(2):210-217, 2005. PMID: 16175848.
24. Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem 38(6):558-571, 2005. PMID: 15885237.
25. Chang EL, Selek U, Hassenbusch SJ, 3rd, Maor MH, Allen PK, Mahajan A, Sawaya R, Woo SY. Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery. Neurosurgery 56(5):936-45; discussion 936-45, 2005. PMID: 15854241.
26. Lo SS, Chang EL, Suh JH. Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases. Expert Rev Neurother 5(4):487-495, 2005. PMID: 16026232.
27. Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Woo SY, Cox JD, Smith AR. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys 63(2):262-272, 2005. PMID: 16168831.
28. Hutchinson LM, Chang EL, Becker CM, Shih MC, Brice M, DeWolf WC, Gaston SM, Zetter BR. Use of thymosin beta15 as a urinary biomarker in human prostate cancer. Prostate 64(2):116-127, 2005. PMID: 15666387.
29. Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M, Colman H, Yang H, Ledoux A, Blair H, Passe S, Jenkins RB, Aldape KD. YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res 11(9):3326-3334, 2005. PMID: 15867231.
30. Kudchadker RJ, Chang EL, Bryan F, Maor MH, Famiglietti R. An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy. Int J Radiat Oncol Biol Phys 59(4):1229-1235, 2004. PMID: 15234060.
31. Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH. Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer 100:1491-1497, 2004. PMID: 15042684.
32. Chang EL, Shiu AS, Lii MF, Rhines LD, Mendel E, Mahajan A, Weinberg JS, Mathews LA, Brown BW, Maor MH, Cox JD. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys 59(5):1288-1294, 2004. PMID: 15275711.
33. Soyuer S, Chang EL, Selek U, Shi W, Maor MH, DeMonte F. Radiotherapy after surgery for benign cerebral meningioma. Radiother Oncol 71(1):85-90, 2004. PMID: 15066300.
34. Selek U, Chang EL, Hassenbusch SJ, 3rd, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys 59(4):1097-1106, 2004. PMID: 15234044.
35. Manon R, Hui S, Chinnaiyan P, Suh J, Chang E, Timmerman R, Phan S, Das R, Mehta M. The impact of mid-treatment MRI on defining boost volumes in the radiation treatment of glioblastoma multiforme. Technol Cancer Res Treat 3:303-307, 2004. PMID: 15161323.

Invited Articles
1. Nguyen Q-N, Chang EL. Emerging role of proton beam radion therapy for chordoma and chondrosarcoma of the skull base. Curr oncol Reports 10(4):338-43, 2008.
2. Suki D, Lang FF, Maldaun MVC, Abouassi H, Chang EL, de Aguiar PHP, Sawaya R:. Complications of stereotactic radiosurgery in patients with brain metastses: considerations for deep and functional brain tumor locations. Neurosurg Quarterly 17(2):81-91, 2007.
3. Lo S, Chang EL, Dropcho E. Temozloamide and Radiation Therapy: Is the combination the standard of treatment for patients with glioblastoma multiforme? Am J Oncol Rev 4(9):1-5, 2005.
4. Lo S, Kish K, Chang E, Levin K, Keole S, Sloan A, Fontanesi J. Juvenile Pilocytic Astrocytoma. eMedicine Journal 3(12):1-13, 2004.
Other Articles
1. Hadziahmetovic, Mersiha M. CNS germinomas: what is the best treatment strategy? Expert review of neurotherapeutics 8(10):1527, 10/2008.

Abstracts
1. Chang Eric, Shiu Almon, Grossman Patricia, Allen Pamela, Wang Xin Shelley, Mahajan Anita, Kornguth David, Mendoza Tito, Cleeland Charles, Rhines Laurence. Prospective Study of Cancer Control and Patient Reported Outcomes for Spinal Metastases Treated with Stereotactic Body Radiosurgery. American Association of Neurological Surgeons, San Diego, CA, 5/2009.
2. Chang EL. Phase III Randomized Clinical Trial of Stereotactic Radiosurgery with or without Whole Brain Irradiation for Patients Newly Diagnosed with 1-3 Brain Metastases. 50th Annual Meeting of American Society for Therapeutic Radiology and Oncology, Boston, MA (Late-breaking abstract in Plenary Session.), 9/2008.
3. Nguyen Q-N, Mahajan A, Chang EL, Woo SY. The evaluation of bone marrow toxicities associated with electron, photon, or proton craniospinal irradiation in peadiataric patients. International Society of Pediatric Neuro-Oncology, 6/2008.
4. Settle SH, Chang EL, Brooks BV, Nguyen Q-N, Gombos DS, Levin VA, Mahajan A, Kornguth DG, Pelloski CE, Woo SY. A Lacrimal-Sparing IMRT Technique for Definitive. American Radium Society Proceeding in Oncology22 22(4):S1:32, 5/2008.
5. Nguyen Q-N, Chang EL, Shiu AS, Mahajan A, Allen PK, Woo SY, Rhines LD. Aggressive management of spinal oligometastases using stereotactic body radiation therapy. American Radium Society Proceeding in Oncology 22(4):S1:31, 5/2008.
6. Lang FF, Suki D, Maor M, Chang E, Hess K, Graham S, Hentschel S, Sawaya R,. Conventional Surgery versus Sterotactic Radiosurgey in the Treatment of Single Brain Metastases: A Prospective Trial with both Radomized and Nonrandomized Arms. Plenary Session I at 2008 Annual Meeting of American Association of Neurological Surgeons,, 5/2008.
7. Sejpal SV, Bluett J, Kornguth D, Levy LB, Mahajan A, Pelloski C, Chang EL, Woo SH. Dose changes to the cribiform plate (CP) and Lens (L) with Head Hyper-Extension (HE) or Flexion (F) in a medullbolastoma (MB) patient treated in the supine position with proton beam therapy (PBT). American Radium Society Proceeding in Oncology 22(4):S1:33, 5/2008.
8. Chang EL,Nguyen Q-N, Shiu AS, Mahajan A, Allen PK,Wang X-S, Woo SY, Rhines LD. Metastatic renal cell carcinoma involving the spine treated with stereotactic body radiation therapy. American Radium Society 22(4):S1-3, 5/2008.
9. J Lee, S Taylor, B N Bekele, M Debnam, E Chang, P K Allen , D D Karp, D J Stewart, Y Oh, Yonsei University Medical School, Houston, Texas, M. D. Anderson Cancer Center. Local therapy of primary disease improves survival in non-small cell lung cancer metastatic to a brain and other single organ sites. ASCO American Society of Clinical Oncology. e-Pub 1/2008.
10. Witgert ME, Lang, Suki D, Chang EL, Wefel J. Baseline cognitive impairment inpatients with single brain metastasis. Annual Meeting of the Society for Neuro-Oncology (poster presentation), 11/2007.
11. Wang HC, Shiu A, Wang C, Mahajan A, Chang EL,. Cumulative Dose Distribution Analysis for CT Image-Guided Sterotactic Radiation Therapy for Spine Metastases Patients. Radiation Oncology Biology Physics 69:S242, 10/2007.
12. Shiu A, Wang CH, Ye J, Cotrutz C, Meier R, Mehta V, Vermeulen S, Chang EL. Dose Distribution Comparison for the IGRT Treatment Using CyberKnife Verus LINAC IMRT Sterotactic Body Radiotherapy. Radiation Oncology Biology Physics 69:S689, 10/2007.
13. Torres MA, Woo SY, Riley BA, Lege DG, Zhai X, Lii M, Kornguth G, Pelloski CE, Mahajan A, Chang EL. Optimal Treatment Planning for Skull Base Chordomas: Photons, Protons or a Combination of Both?. Radiation Oncology Biology Physics 69:s168, 10/2007.
14. Congjun Wang, Shiu A, He Wang and Chang EL. Image-Guided Sterotactic Body Radiotherapy Using Cone-Beam Computer Tomography for Treatment of Spinal Tumor. AAPM (poster presentation) Minneapolis, MN, 7/2007.
15. Gombos D, Chang EL. Asymmetric Administration of adjuvant external beam radiotherapy (EBRT) following systemic & Periocular chemotherapy in a patient with bilateral group d (R-E Vb) retinoblastoma. ISOO Meeting 2007 International Society of Ocular Oncology, 6/2007.
16. Shiu A, Wang C, Ye J, Cotrutz C, Meier R, Mehta V, Vermeulen S, Chang EL. Dose distribution comparison for the treatment of spinal metastases using cyberknife versus IMRT stereotactic body radiotherapy. 8th International Stereotactic Radiosurgery Society Congress, San Francisco, CA, June 23-27, 2007:200, 6/2007.
17. Wang H, Wang C, Mahajan A, Woo S, Chang EL,. Dosimetric effect of isocenter shift and patient rotation errors in image-guided sterotactic radiotherapy for metastatic spine. 8th International Stereotactic Radiosurgery Society Congress, San Francisco, CA, June 23-27 2007 2007:199 (OS 7-7-2), 6/2007.
18. Chang EL, Shiu A, Mendel E, Mathews L, Mahajan A, Allen P, Weinberg J, Brown B, Wang X, Woo S, Rhine L. Phase I/II study of sterotactic spine radiation therapy for spinal metastasis and its pattern of failure. 8th International Stereotactic Radiosurgery Society Congress, San Francisco, CA, June 23-27,2007:135(PL 3-3), 6/2007.
19. Jackson EF, Mahajnkali S, Wefel JS, Chang EL. Evaluation of Functional Magnetic Resonance Imaging, Relative Cerebral Blood Volume, and Neuropsychological Testing in Patients with 1-3 Brain Metastases treated with Stereotactic Radiosurgery +/- Whole Brain Radiation. 35th Annual Meeting International Neuropsychological Society, 2/2007.
20. Lang F, McPherson C, Suki D, Chang EL, Maor M, Sawaya R, Mahajan A. Adjuvant Radiotherapy after surgical resection of single brain metastases: An analysis of 358 patients by primary tumor site. Neuro-Oncology 9:588, 1/2007.
21. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutceheon I, Mahajan A, Maor M, Woo SY,. Spinal Myxopapillary Ependymoma Outcomes in Patients Treated with Surgery and Radiotherapy at M.D. Anderson Cancer Center. American Society of Clinical Oncology. American Society of Clinical Oncology 2006 ASCO Annual Meeting, Georgia World Congress Center, Atlanta, GA (Poster presentation #1547), 6/2006.
22. Chang EL, Shiu AS, Mendel E, Mathews LA, Wang S, Woo S, Mahajan A, Weinberg J, Rhines L. Interim Results of a Phase I/II Evaluation of Stereotactic Radiation for Spinal Metastases. American Association of Neurological Surgeons Annual Meeting, San Francisco, CA (Oral presentation Scientific Session #617), 4/2006.
23. Kornguth D, Mahajan A, Frija E, Chang E, Pelloski C, Woo S. Comparison of LINACs Either Equipped with On-Board Imaging/Core Beam CT or CT-on-Rails for IGRT. Medical Physics 33(6):2018, 2006.
24. Suh JH, Mehta MP, Dagnault A, Chabot P, Chang EL, Fortin MA, Grecula JC, Nabid A, Souhami L, Renschler MF. Motexafin Gadolinium-based treatment planning MRI identifies occult brain metastases amendable to stereotactic radiosurgery: imaging results of a phase II trial of Motexfin Gadolinum and whole brain radiotherapy with stereotactic radiosurgery (Abstract #1110). Int J Radiat Oncol Biol Phys 66 (S193), 2006.
25. Kornguth D, Mahajan A, Frija E, Chang E, Pelloski, Woo S. Shape of variability of craniopharyngioma as measured on CT-on-rails during radiotherapy treatment (Abstract #2091). Int J Radiat Oncol Biol Phys 66(3):643, 2006.
26. Akyurek S, Chang EL, Mahajan A, Hassenbusch SJ, Allen PK, Mathews L, Shiu AS, Woo SY. Stereotactic radiosurgical treatment of brain metastases arising from breast cancer (Abstract #2086). Int J Radiat Oncol Biol Phys 66:S257, 2006.
27. Chang EL, Shiu AS, Mendel E, Mathews LA, Wang S, Woo s, Mahajan A, Weinberg J, Rhines L. Interim Results of a Phase I/II Evaluation of Stereotactic Body Radiotherapy for Spinal Metastases. 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO (Oral presentation, Scientific Session #113), 10/2005.
28. Hu C-S, Chang EL. Outcome Variation in Non-small Cell Lung Cancer Patients with Solirary Brain Metastasis. 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO (Poster presentation #2273), 10/2005.
29. Nguyen Q-N, Chang EL. Pattern of Failure from Evolving Radiation Therapy Target Volumes Used in the Treatment of Intracranial Geminoma. 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO (Poster presentation #2046), 10/2005.
30. Suki D, Lang FF, Maldaun M, Chang E, Sawaya R. Complications of Stereotactic Radiosurgery in Patients with Brain Metastases: Consideration for Deep and Functional Brain Tumor Locations. Society of Neuro Oncology Annual Meeting a World Federation of Neuro-Oncology hosted by the EANO, Edinburgh, United Kingdom, 5/2005.
31. Oh YW, Taylor S, Bekele N, Huang YT, Merriman K, Chang E, Suki D, Karp DD. Number of Metastatic sites is a strong predictor of survival in non small cell lung cancer (NSCLC). ASCO Annual Meeting, Orange County Convention Center, Orlando, FL, 5/2005.
32. Li XN, Shu Q, Munshi A, Xia YF, Chang E, Woo SY, Meyn RE, Lau CC. Enhancement of Radiation Sensitivity of Human Medulloblastoma Cells by Histone Deacetylase Inhibitors Valproic Acid is Associated with the Activation of P21 and Down-Regulation of C-MYC and Surviving Genes. (AACR) 96th Annual Meeting 2005, Anaheim, CA, 4/2005.
33. Mahajan A, Chang EL, Weinberg JS, Hassenbusch SJ, Maor MH, Woo SY. The Evolution of Magnetic Resonance Imaging Changes Over Time After Stereotactic Radiosurgery for Intracranial Metastasis. (ARS) 87th Annual Meeting, Hotel Arts Barcelona, Spain, 4/2005.
34. Suh J, Stea B, Nabid A, Kresl J, Fortin A, Mercier JP, Senzer N, Chang E, Holz JB, Shaw E. Standard Whole Brain Radiation Therapy (WBRT) plus Supplemental Oxygen (O2) with or without efaproxiral (EFAPROXYN™) in Patients with Brain Metastases: Updated Survival Results of the Randomized REACH (RT-009) Study. European Society of Hematology Medical Oncology, 2005.
35. Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Smith AR. Treatment Planning with Protons for Pediatric Retinoblastoma, Medulloblastoma, and Pelvic Sarcomas: How do Protons Compare with Other Conformal Techniques? . Radiological Society of North America, 11/2004.
36. Pelloski CE, Maor MH, Chang EL, Mahajan A, Colman H, Yang H, Ledoux A, Aldape KD. YKL-40 Expression Correlates with Poor Radiation Response and Decreased Overall Survival in Glioblastoma: A Clinicopathologic Study of 279 Patients. Neuro-Oncology 6:PA-19, 11/2004.
37. Chang EL, Shiu AS, Lii M-F, Mendel E, Mahajan A, Weinberg JS, Woo SY, Rhines L. Phase I Clinical Evaluation of Near-Simultaneous Computed Tomographic Image-Guided Stereotactic Radiotherapy for Spinal Metastases (Oral presentation). American Association of Neurological Surgeons and Congress of Neurological Surgeons Section on Tumors 6th Biennial Satellite Symposium, Palace Hotel, San Francisco, CA, 10/2004.
38. Adamus AT, Chang EL, Mathews LA, Franzini L, Swint JM. Preference elicitation using the time trade-off method in patient with 1 to 3 newly diagnosed brain metastases in a prospective randomized clinical trial comparing radiosurgery with and without whole brain radiation (Poster). 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Atlanta, GA, 10/2004.
39. Suh JH, Stea B, Nabid A, Kresl J, Fortin A, Mercier JP, Senzer N, Chang E, Boyd A, Shaw E, Cagnoni PJ. Prognostic Factors for Survival in Patients with Brain Metastases: Results of a Worldwide Phase 3 Randomized Trial in 538 Patients (Study RSR13 RT-009). 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Atlanta, GA, 10/2004.
40. Chang EL, Wefel JS, Meyers CA, Mahajan A, Mathews LA, Smythe L, Allen PK, Hassenbusch SJ, Maor MH. Prospective Neurocognitive Evaluation of Patients with 1 to 3 Newly Diagnosed Brain Metastases Treated with Stereotactic Radiosurgery Alone (Oral presentation). 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Atlanta, GA, 10/2004.
41. Shiu AS, Chang EL, Lii M-F. Retrospective study of positioning accuracy and planned versus delivered dose for CT image-guided stereotactic spinal radiotherapy. 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Atlanta, GA, 10/2004.
42. Pelloski CE, Maor MH, Chang EL, Mahajan A, Colman H, Yang H, Ozburn N, Aldape K. YKL-40 Expression Correlates With Decreased Radiation Response and Overall Survival in Young Patients With Subtotally Resected Glioblastoma (Post discussion). 46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Atlanta GA, 10/2004.
43. Shiu A, Chang E, Court L, Wang C, Lii M-F. Evaluation of positioning accuracy and planned versus delivered dose distributions for CT image-guided stereotactic spinal radiotherapy. American Association of Physics in Medicine, 46th Annual Meeting. Pittsburgh, PA, 7/2004.
44. Soyuer S, Chang EL, Shi W, Maor M, Demonte F. Operable benign meningioma patients appear to have expected survival that is equivalent to a normal United States population. 2004 ASCO Annual Meeting, New Orleans, LA (Poster presentation). 2004 ASCO Annual Meeting, New Orleans, LA, 6/2004.
45. Suh J, Stea B, Nabid A, Kresl J, Fortin A, Mercier J, Senzer N, Chang EL, Holz J-B, Shaw E. Standard whole brain radiation therapy (WBRT) with supplemental oxygen (O2), with or without RSR13 (efproxiral) in patients with brain metastases: Results of the randomized REACH (RT-009) study. ASCO Annual Meeting, New Orleans, LA. (Poster Presentation), 6/2004.
46. Chang EL. Outcome May Differ By Histology Among So-Called “Radioresistant” Brain Metastases Treated with Stereotactic Radiosurgery (Oral presentation). 86th Annual Meeting of the American Radium Society, Napa Valley, CA, 5/2004.
47. Mahajan A, McCutcheon IE, Chang EL, Maor MH. Stereotactic Radiosurgery for Recurrent Glioblastoma. 86th Annual Meeting of the American Radium Society, Napa Valley, CA. The Cancer Journal 10(1 Suppl):49, 5/2004.
48. Pelloski CE, Maor MH, Chang EL, Mahajan A, Colman H, Yang H, Ozburn N, Aldape KA. The Correlation of YKL-40 Expression With Radiation Response and Overall Survival in Patients With Subtotally Resected Glioblastoma (Oral presentation). 86th Annual Meeting of the American Radium Society, Napa Valley, CA, 5/2004.
49. Suh J, Stea B, Nabid A, Kresl J, Fortin A, Mercier JP, Senzer N, Chang E, Holz JB, Shaw E. Standard whole brain radiation therapy (WBRTTM) plus supplemental oxygen (O2) with or without efaproxiral (EFAPROXYNTM) in patients with brain metastases: updated survival results of the randomized REACH (RT-009) study. European Society for Medical Oncology, 2004.

Book Chapters
1. Lo SS. Chang EL. Clinical spinal cord tolerance to radiosurgery. In: Spine Radiosurgery. Ed(s) Gerszten P, Ryu S: Thieme, New York, 23-34, 2009.
2. Lo SS, Suh JH, Chang EL. Radiobiology and radiation therapy of skull base tumors. In: Comprehensive Management of Tumors of the Skull Base (2008). Ed(s) Hanna EY, Demonte F. New York, 159-174, 2008.
3. Chang EL, Shiu AS. Spinal Tumors—Fractionated Radiation Therapy Perspective. In: Principles and Practice of Stereotactic Radiosurgery. Ed(s) Chin LS, Regine UF. Springer-Verlag: Berlin-Heidelberg-New York, 455-458, 2008.
4. Janjan NA, Mahajan A, Chang EL. Emergencies in palliative medicine. In: Textbook of Palliative Medicine. Ed(s) Bruera E, 817-834, 2006.
5. Mahajan A Chang E. Concepts and Clinical Applications. In: Part III. Central Nervous System, Skull Base and Paraspinal Tumors. IMRT Handbook: Foundations and Clinical Applications. Ed(s) Bartfield T, Wazes D. Springer-Verlag: Berlin-Heidelberg-New York, 345-358, 2005.
6. Chan K, Petropoulos D, Chang EL, Rytting ME. Hodgkin lymphoma and non-Hodgkin lymphoma. In: Pediatric Oncology. Ed(s) Chan KW, Rarey RB. Springer Science and Business Media, Inc. New York City, NY, 18-29, 2005.
7. Selek U ,Chang EL. Skull Base and Posterior Fossa. In: Intensity Modulated Radiation Therapy for Head and Neck Cancer. Ed(s) K.S. Clifford Chao, Gokhan Ozyigit. Lippincott Williams & Wilkins: Philadelphia, PA, 82-104, 2005.
8. Lang FF, Chang EL, Abi-Said D, Wildrick DM, Sawaya R. Metastatic Brain Tumors. In: Youmans Neurological Surgery. Ed(s) Winn HR. W.B. Saunders Co. Philadelphia, PA, 1077-1097, 2004.
9. Komaki R Chang EL. Whole Brain Radiation. In: Intracranial Metastases: Current Management Strategies. Ed(s) Sawaya R. Futura Publishing Co. Malden, Massachusetts, 126-138, 2004.

Last updated: 3/3/2010