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Eric S. Yvon, PhD

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX
Associate Technical Director, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2008 EPHE, University of Paris, La Sorbonne, Paris, France, PHD, Summa cum laude, Immunology
1999 EPHE, University of Paris, La Sorbonne, Paris, France, MSc, Summa cum laude, Immunology
1987 ESBB, University of Paris, Paris, France, BS, Cum laude, Biology and Biochemistry

Experience/Service

Academic Appointments

Senior Research Scientist, Department of Stem Cell Transplantation - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012-2013
Instructor, Baylor College of Medicine, Center for Cell and Gene Therapy, Houston, TX, 2010-2012
Research Associate, Baylor College of Medicine Center for Cell and Gene Therapy, Houston, TX, 2000-2010
Research Associate, Necker-EM Hospital, Cell and Gene Therapy Laboratory, Paris, France, 1999-2000
Research Assistant, Necker-EM Hospital, Immunology and Hematology Laboratory, Paris, France, 1990-1999

Selected Publications

Peer-Reviewed Original Research Articles

1. Hegde M, Corder A, Chow KKh, Mukherjee M, Ashoori A, Kew Y, Zhang YJ, Baskin DS, Merchant FA, Brawley VS, Byrd TT, Krebs S, Wu MF, Liu H, Heslop HE, Gottachalk S, Yvon E, Ahmed N. Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in Glioblastoma. Mol Ther 21(11):2087-101, 11/2013. e-Pub 8/13/2013. PMID: 23939024.
2. Louis CU, Savoldo B, Dotti G, Pule M, Yvon E, Myers GD, Rossig C, Russell HV, Diouf O, Liu E, Liu H, Wu MF, Gee AP, Mei Z, Rooney CM, Heslop HE, Brenner MK. Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma. Blood 118(23):6050-6, 12/1/2011. e-Pub 10/7/2011. PMCID: PMC3234664.
3. Huye LE, Nakazawa Y, Patel MP, Yvon E, Sun J, Savoldo B, Wilson MH, Dotti G, Rooney CM. Combining mTor inhibitors with rapamycin-resistant T cells: a two-pronged approach to tumor elimination. Mol Ther 19(12):2239-48, 12/2011. e-Pub 8/30/2011. PMCID: PMC3242659.
4. Ramos CA, Asgari Z, Liu E, Yvon E, Heslop HE, Rooney CM, Brenner MK, Dotti G. An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies. Stem Cells 28(6):1107-15, 6/2010. PMCID: PMC3290395.
5. Ahmed N, Salsman VS, Yvon E, Louis CU, Perlaky L, Wels WS, Dishop MK, Kleinerman EE, Pule M, Rooney CM, Heslop HE, Gottschalk S. Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol Ther 17(10):1779-87, 10/2009. e-Pub 6/16/2009. PMCID: PMC2835000.
6. Yvon E, Del Vecchio M, Savoldo B, Hoyos V, Dutour A, Anichini A, Dotti G, Brenner MK. Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells. Clin Cancer Res 15(18):5852-60, 9/15/2009. e-Pub 9/8/2009. PMCID: PMC2745508.
7. Russell HV, Strother D, Mei Z, Rill D, Popek E, Biagi E, Yvon E, Brenner M, Rousseau R. A phase 1/2 study of autologous neuroblastoma tumor cells genetically modified to secrete IL-2 in patients with high-risk neuroblastoma. J Immunother 31(9):812-9, Nov-Dec, 11/2008. PMID: 18833006.
8. Pule MA, Savoldo B, Myers GD, Rossig C, Russell HV, Dotti G, Huls MH, Liu E, Gee AP, Mei Z, Yvon E, Weiss HL, Liu H, Rooney CM, Heslop HE, Brenner MK. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med 14(11):1264-70, 11/2008. e-Pub 11/2/2008. PMCID: PMC2749734.
9. Russell HV, Strother D, Mei Z, Rill D, Popek E, Biagi E, Yvon E, Brenner M, Rousseau R. Phase I trial of vaccination with autologous neuroblastoma tumor cells genetically modified to secrete IL-2 and lymphotactin. J Immunother 30(2):227-33, Feb-Mar, 2/2007. PMID: 17471169.
10. Biagi E, Rousseau R, Yvon E, Schwartz M, Dotti G, Foster A, Havlik-Cooper D, Grilley B, Gee A, Baker K, Carrum G, Rice L, Andreeff M, Popat U, Brenner M. Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. Clin Cancer Res 11(19 Pt 1):6916-23, 10/1/2005. PMID: 16203783.
11. Vigouroux S, Yvon E, Biagi E, Brenner MK. Antigen-induced regulatory T cells. Blood 104(1):26-33, 7/1/2004. e-Pub 3/16/2004. PMID: 15026316.
12. Yvon ES, Vigouroux S, Rousseau RF, Biagi E, Amrolia P, Dotti G, Wagner HJ, Brenner MK. Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. Blood 102(10):3815-21, 11/15/2003. e-Pub 7/3/2003. PMID: 12842995.
13. Vigouroux S, Yvon E, Wagner HJ, Biagi E, Dotti G, Sili U, Lira C, Rooney CM, Brenner MK. Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes. J Virol 77(20):10872-80, 10/2003. PMCID: PMC224961.
14. Biagi E, Yvon E, Dotti G, Amrolia PJ, Takahashi S, Popat U, Marini F, Andreeff M, Brenner MK, Rousseau RF. Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells. Hum Gene Ther 14(6):545-59, 4/10/2003. PMID: 12718765.
15. Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P, Selz F, Hue C, Certain S, Casanova JL, Bousso P, Deist FL, Fischer A. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 288(5466):669-72, 4/28/2000. PMID: 10784449.

Grant & Contract Support

Title: Regulation and Targeting of GD2+ Breast Cancer Stem-Like Cells
Funding Source: MD Anderson Institutional Support
Role: Investigator
Principal Investigator: Andreeff
Duration: 11/1/2013 - 10/31/2016
 
Title: Blanton-Davis Ovarian Cancer Research Program
Funding Source: Sprint for Life Research Awards
Role: Co-Investigator
Duration: 2013 - 2014
 
Title: Cellular Therapy of Cancer
Funding Source: Cancer Prevention & Research Institute of Texas (CPRIT)
Role: Co-Investigator
Principal Investigator: Brenner
Duration: 7/1/2011 - 6/30/2016
 
Title: Improving Cord Blood Transplantation
Funding Source: NIH/NCI
Role: Collaborator
Principal Investigator: Shpall/Bollard
Duration: 2011 - 2016

Last updated: 11/11/2013