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Erik P Sulman, M.D., Ph.D

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2003 Temple University School of Medicine, Philadelphia, PA, MD, Medicine
2003 Temple University School of Medicine, Philadelphia, PA, PHD, Molecular Biology and Cancer Genetics
1993 The University of Pennsylvania, Philadelphia, PA, BA, Biochemistry

Postgraduate Training

2/2006-6/2008 Research Fellowship, Brain Tumor Center, The University of Texas M. D. Anderson Cancer Center, Houston, TX, Kenneth Aldape, M. D.
7/2004-6/2008 Clinical Residency, Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, Thomas Buchholz, M.D.
7/2003-6/2004 Clinical Internship, Internal Medicine, Albert Einstein Medical Center, Philadelphia, PA, Glenn Eiger, M.D.

Honors and Awards

2008 ASTRO Translational Research in Radiation Oncology and Radiology Symposium Travel Award, ASTRO
2007 ASTRO Translational Research in Radiation Oncology and Radiology Symposium Travel Award, ASTRO
2007 Eleanor Montague Prize, The University of Texas M. D. Anderson Cancer Center
2007 Scholar-in-Training Award, American Association for Cancer Research
2007 Young Oncologist Essay Award, American Radium Society
2004-2008 B. Leonard Holman Research Pathway, American Board of Radiology
2003 Intern of the Year, Albert Einstein Medical Center
2000 Scholar-in-Training Award, American Assoication for Cancer Research-Genetech

Selected Publications

Peer-Reviewed Original Research Articles
1. Caro MS, Lim WK, Alvarez MJ, Bollo RJ, Zaho X, Snyder EY, Sulman EP, Anne S, Doetsch F, Colman H, Lasorella A, Aldape K, Califano A, Iavarone A. A transcriptional module initiates and maintains mesenchymal transformation in brain tumors. Nature. In Press.
2. Colman H, Zhang L, Sulman EP, McDonald JM, Shooshtari NL, Rivera A, Popoff S, Nutt CL, Louis DN, Cairncross JG, Gilbert MR, Phillips HS, Mehta MP, Chakravarti A, Pelloski CE, Bhat K, Feuerstein BG, Jenkins RB, Aldape K. A multigene predictor of outcome in glioblastoma. Neuro Oncol 12(1):49-57, 1/2010. e-Pub 10/20/2009. PMID: 20150367.
3. Sulman, EP, Komaki, R, Klopp, AH, Cox, JD, Chang, JY. Exclusion of Elective Nodal Irradiation is Associated with Minimal Elective Nodal Failure in Non-Small Cell Lung Cancer. Radiat Oncol 4:5, 2009. e-Pub 1/2009. PMCID: PMC2651897.
4. Sulman EP, Schwartz DL, Le TT, Ang KK, Morrison WH, Rosenthal DI, Ahamad A, Kies M, Glisson B, Weber R, Garden AS. Imrt Reirradiation of Head and Neck Cancer-Disease Control and Morbidity Outcomes. Int J Radiat Oncol Biol Phys 73(2):399-409, 6/2008. e-Pub 6/2008. PMID: 18556144.
5. Klopp AH, Chang JY, Tucker SL, Sulman EP, Balter PA, Liu HH, Bucci MK, Macapinlac HA, Komaki R, Cox JD. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys 69(5):1409-16, 12/1/2007. e-Pub 9/27/2007. PMID: 17904303.
6. Pelloski CE, Ballman KV, Furth AF, Zhang L, Lin E, Sulman EP, Bhat K, McDonald JM, Yung WK, Colman H, Woo SY, Heimberger AB, Suki D, Prados MD, Chang SM, Barker FG, Buckner JC, James CD, Aldape K. Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol 25(16):2288-94, 6/1/2007. PMID: 17538175.
7. Sulman EP, White PS, Brodeur GM. Genomic annotation of the meningioma tumor suppressor locus on chromosome 1p34. Oncogene 23(4):1014-20, 1/2004. PMID: 14749765.
8. Matise TC, Porter CJ, Buyske S, Cuttichia AJ, Sulman EP, White PS. Systematic evaluation of map quality: human chromosome 22. Am J Hum Genet 70(6):1398-410, 6/2002. PMID: 11992248.
9. White PS, Thompson PM, Seifried BA, Sulman EP, Jensen SJ, Guo C, Maris JM, Hogarty MD, Allen C, Biegel JA, Matise TC, Gregory SG, Reynolds CP, Brodeur GM. Detailed molecular analysis of 1p36 in neuroblastoma. Med Pediatr Oncol 36(1):37-41, 1/2001. PMID: 11464901.
10. Hogarty MD, Liu X, Thompson PM, White PS, Sulman EP, Maris JM, Brodeur GM. BIN1 inhibits colony formation and induces apoptosis in neuroblastoma cell lines with MYCN amplification. Med Pediatr Oncol 35(6):559-62, 12/2000. PMID: 11107117.
11. Hogarty MD, Liu X, Guo C, Thompson PM, Weiss MJ, White PS, Sulman EP, Brodeur GM, Maris JM. Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas. Med Pediatr Oncol 35(6):512-5, 12/2000. PMID: 11107105.
12. Maris JM, Weiss MJ, Guo C, Gerbing RB, Stram DO, White PS, Hogarty MD, Sulman EP, Thompson PM, Lukens JN, Matthay KK, Seeger RC, Brodeur GM. Loss of heterozygosity at 1p36 independently predicts for disease progression but not decreased overall survival probability in neuroblastoma patients: a Children's Cancer Group study. J Clin Oncol 18(9):1888-99, 5/2000. PMID: 10784629.
13. White PS, Sulman EP, Porter CJ, Matise TC. A comprehensive view of human chromosome 1. Genome Res 9(10):978-88, 10/1999. PMID: 10523526.
14. Hogarty MD, White PS, Sulman EP, Brodeur GM. Mononucleotide repeat instability is infrequent in neuroblastoma. Cancer Genet Cytogenet 106(2):140-3, 10/15/1998. PMID: 9797779.
15. Sulman EP, Dumanski JP, White PS, Zhao H, Maris JM, Mathiesen T, Bruder C, Cnaan A, Brodeur GM. Identification of a consistent region of allelic loss on 1p32 in meningiomas: correlation with increased morbidity. Cancer Res 58(15):3226-30, 8/1998. PMID: 9699646.
16. White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. Cytogenet Cell Genet 81(1):60-4, 1998. PMID: 9691177.
17. Maris JM, Jensen J, Sulman EP, Beltinger CP, Allen C, Biegel JA, Brodeur GM, White PS. Human Krüppel-related 3 (HKR3): a candidate for the 1p36 neuroblastoma tumour suppressor gene? Eur J Cancer 33(12):1991-6, 10/1997. PMID: 9516840.
18. White PS, Maris JM, Sulman EP, Jensen SJ, Kyemba SM, Beltinger CP, Allen C, Kramer DL, Biegel JA, Brodeur GM. Molecular analysis of the region of distal 1p commonly deleted in neuroblastoma. Eur J Cancer 33(12):1957-61, 10/1997. PMID: 9516832.
19. Maris JM, Kyemba SM, Rebbeck TR, White PS, Sulman EP, Jensen SJ, Allen C, Biegel JA, Brodeur GM. Molecular genetic analysis of familial neuroblastoma. Eur J Cancer 33(12):1923-8, 10/1997. PMID: 9516825.
20. Jensen SJ, Sulman EP, Maris JM, Matise TC, Vojta PJ, Barrett JC, Brodeur GM, White PS. An integrated transcript map of human chromosome 1p35-p36. Genomics 42(1):126-36, 5/15/1997. PMID: 9177782.
21. Reddy UR, Phatak S, Allen C, Nycum LM, Sulman EP, White PS, Biegel JA. Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. Genomics 41(2):283-5, 4/15/1997. PMID: 9143508.
22. Sulman EP, Tang XX, Allen C, Biegel JA, Pleasure DE, Brodeur GM, Ikegaki N. ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers. Genomics 40(2):371-4, 3/1997. PMID: 9119409.
23. Kuroda H, White PS, Sulman EP, Manohar CF, Reiter JL, Cohn SL, Brodeur GM. Physical mapping of the DDX1 gene to 340 kb 5' of MYCN. Oncogene 13(7):1561-5, 10/3/1996. PMID: 8875996.
24. Maris JM, Kyemba SM, Rebbeck TR, White PS, Sulman EP, Jensen SJ, Allen C, Biegel JA, Yanofsky RA, Feldman GL, Brodeur GM. Familial predisposition to neuroblastoma does not map to chromosome band 1p36. Cancer Res 56(15):3421-5, 8/1/1996. PMID: 8758905.
25. Maris JM, Jensen SJ, Sulman EP, Beltinger CP, Gates K, Allen C, Biegel JA, Brodeur GM, White PS. Cloning, chromosomal localization, physical mapping, and genomic characterization of HKR3. Genomics 35(2):289-98, 7/15/1996. PMID: 8661141.
26. Beltinger CP, White PS, Maris JM, Sulman EP, Jensen SJ, LePaslier D, Stallard BJ, Goeddel DV, de Sauvage FJ, Brodeur GM. Physical mapping and genomic structure of the human TNFR2 gene. Genomics 35(1):94-100, 7/1/1996. PMID: 8661109.
27. Ikegaki N, Tang XX, Liu XG, Biegel JA, Allen C, Yoshioka A, Sulman EP, Brodeur GM, Pleasure DE. Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family. Hum Mol Genet 4(11):2033-45, 11/1995. PMID: 8589679.
28. Maris JM, White PS, Beltinger CP, Sulman EP, Castleberry RP, Shuster JJ, Look AT, Brodeur GM. Significance of chromosome 1p loss of heterozygosity in neuroblastoma. Cancer Res 55(20):4664-9, 10/15/1995. PMID: 7553646.
29. White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C. A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3. Proc Natl Acad Sci U S A 92(12):5520-4, 6/6/1995. PMID: 7777541.
30. Beltinger CP, White PS, Sulman EP, Maris JM, Brodeur GM. No CDKN2 mutations in neuroblastomas. Cancer Res 55(10):2053-5, 5/15/1995. PMID: 7743501.

Invited Articles
1. Sulman EP, Guerrero M, Aldape K. Beyond grade: molecular pathology of malignant gliomas. Semin Radiat Oncol 19(3):142-9, 7/2009. PMID: 19464628.
2. Woodward WA, Sulman EP. Cancer stem cells: markers or biomarkers? Cancer Metastasis Rev 27(3):459-70, 9/2008. PMID: 18437295.
3. Sulman E, Aldape K, Colman H. Brain tumor stem cells. Curr Probl Cancer 32(3):124-42, May-Jun, 5/2008. PMID: 18501775.
4. Rivera AL, Pelloski CE, Sulman E, Aldape K. Prognostic and predictive markers in glioma and other neuroepithelial tumors. Curr Probl Cancer 32(3):97-123, May-Jun, 5/2008. PMID: 18501774.

Abstracts
1. Goodman LD, Le TT, Love P, Gumin J, Lang FF, Colman H, Aldape K, Sulman EP. Glioma cancer stem cells expressing podoplanin exhibit a unique gene expression signature, even in the absence of CD133 (#7315), 4/2009.
2. Sulman, E.P., Goodman, L.D., Le, T.T., Gumin, J., Lang, F.F., Colman, H., Aldape, K.D. Radioresistant glioma stem cells express high-levels of the transmembrane protein podoplanin, a prognostic marker for survival in patients with malignant astrocytomas. Presented at: International Conference on Translational Research and Pre-Clinical Strategies in Radiation Oncology, Geneva, Switzerland. 3/2009.
3. Sulman, E.P., Bonato, V., De La Garza, M., Broom, B.M., Do, K.A., Aldape, K.D. A Prognostic Mesenchymal Gene Signature Identified from Analysis of Multiple Intentional Expression Profiling Datasets Suggests a Sampling Bias in the Cancer Genome Atlas Glioblastoma Cohort. Presented at: American Association for Cancer Research Translation of the Cancer Genome, Boston, MA, 2/2009.
4. Sulman, E.P., Goodman, L.D., Le, T.T., Gumin, J., Lang, F.F., Colman, H., Aldape, K.D. A Novel Biomarker of Glioma Stem Cells, Patient Outcome, and Radiation Resistance Presented at: American Association for Cancer Research Translational Cancer Medicine, Jerusalem, Isreal, 11/2008.
5. Sulman, E.P, Goodman , L.D., Le, T.T., Gumin, J., Lang, F.F., Colman, H. Aldape, K.D. Podoplanin is a novel marker of glioma stem cells that is independent of CD133. Presented at: 2008 ASTRO Translational Advances in Radiation Oncology and Cancer Imaging Symposium, Arlington, VA, 10/2008.
6. Sulman, E.P., Pelloski, C.E., Aldape, K.D. Analysis of patients receiving histone deacetylase inhibiting antiepileptic agents during radiation treatment of glioblastoma. Presented at: 50th Annual Meeting of the American Society for Therapeutic Radiation Oncology, Boston, MA, 9/2008.
7. Sulman, E.P, Goodman, L.D., Le, T.T., Pelloski, C.E., Bhat, K., Gumin, J., Lang, F.F., Colman, H., Aldape, K.D. Podoplanin is a novel marker of glioma stem cells that is independent of CD133. Presented at: 54th Annual Meeting of the Radiation Research Society, Boston, MA, 9/2008.
8. Sulman, E.P., Goodman, L.D., Le, T.T., Pelloski, C.P., Bhat, K., Gumin, J., Lang, F.F., Colman, H., Aldape, K.D. A novel marker of glioma stem cells that is prognostic for treatment response and patient outcome. Presented at: American Association for Cancer Research Annual Meeting 2008, San Diego, CA, 4/2008.
9. Mirvish, E., Sulman, E, Misra, A., Nigro, J., Smirnov, I., Kapp, L, McDonald, J.M., Long, L., Popoff, S., Colman, H., Berens, M., Aldape, K., Feuerstein, B. AQP1 is associated with GBM survival, and may mediate aggressiveness through increased cell motility. Presented at: Society for Neuro-Oncology Annual Meeting 12th Annual Meeting, Dallas, TX, 11/2007.
10. Sulman, E.P., Colman, H., Pelloski, C.E., Aldape, K.D. Podoplanin is an independent prognostic marker of survival in malignant gliomas and is co-expressed with CD133 on tumor-derived stem cells. Presented at: Society for Neuro-Oncology Annual Meeting 12th Annual Meeting, Dallas, TX, 11/2007.
11. Sulman, E.P., Colman, H., Le, T.T., Pelloski, C.E., Aldape, K.D. Podoplanin expression in gliomas: association with patient survival, radioresistance, and tumor-derived stem cells. Submitted to: American Society for Therapeutic Radiation Oncology and Radiology Translational Research in Radiation Oncology and Radiology, San Francisco, CA, 9/2007.
12. Sulman, E.P., Pelloski, C.E., McDonald, J.M., Long, L., McGovern, S.L., De La Cruz, C., Aldape, K.D. Long-term survivors of malignant gliomas identified by podoplanin expression analysis. Presented at: 89th Annual Meeting of the American Radium Society, Amsterdam, The Netherlands, 5/2007.
13. Sulman EP, McDonald JM, Long L, Popoff SL, Colman H, Aldape KD. Aquaporin-1 is decreased in long-term survivors of glioblastoma. Presented at: American Association for Cancer Research Annual Meeting 2007, Los Angeles, CA, 4/2007.
14. Sulman, E.P., Pelloski, C.E., McDonald, J.M., De La Cruz, C., Long, L., Popoff, S.C., McGovern, S.L., Colman, H., Aldape, K.D. Podoplanin expression identifies long-term survivors of low-grade and malignant astrocytomas. Presented at: American Association for Cancer Research Annual Meeting 2007, Los Angeles, CA, 4/2007.
15. Sulman, E.P., Schwartz, D.L., Morrison, W.H., Rosenthal, D.I., Chao, K.S., Ahamad, A., Ang, K.K., Garden, A.S. IMRT re-irradiation for locoregionally recurrent or in-field second primary head and neck cancer. Presented at: 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, PA, 11/2006.
16. Sulman, E.P., Krishnan, S., Vadhan-Raj, S., Allen, P.K., Crane, C.H., Janjan, N.A. Impact of anemia on the outcome of patients treated with preoperative chemoradiation for rectal cancer. Presented at: 88th Annual Meeting of the American Radium Society, Maui, HI, 5/2006.
17. Sulman, E.P., Guerrero, T.M., Harvey, M.C., Balter, P.A., Komaki, R. Dynamic and static ventilation derived from radiotherapy planning CT images. Presented at: The European Cancer Conference 13, Paris, France, 10/2005.
18. Sulman, E.P., Chang, J.Y., Liao, Z., Guerrero, T.M., Jeter, M., Stevens, C.W., Cox, J.D., Komaki, R. Exclusion of elective nodal irradiation does not decrease local regional control of non-small cell lung cancer. Presented at: 47th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO, Oct 16-20, 2005. Int. J. of Radiat. Oncol. Biol. Phys. 63 (Supplement 1), 2005. (Abstr#1133), 10/2005.
19. Sulman, E.P., Guerrero, T.M., Sanders, K.E., Balter, P.A., Komaki, R. Significant differences are observed between dynamic versus static ventilation derived from radiotherapy planning CT images. Presented at: 6th International Lung Cancer Congress, Kauai, HI,, 6/2005.
20. Woodward, W.A., Sulman, E.P., Cox, J.D., Buchholz, T.A. Adjectives used in letters of recommendation to radiation oncology residency differ by applicant gender. Proceedings of the 87th Annual Meeting of the American Radium Society, Barcelona, Spain. 5/2005.
21. Sulman, E.P, Kung, B., Rappaport. Annotation of the meningioma tumor suppressor locus on 1p33-p34 and analysis of PTCH2 as a canadate suppressor gene. Proceedings of the 94th Annual Meeting of the American Association for Cancer Research, Washington, D.C. 7/2003.

Book Chapters
1. Sulman, E.P., Guererro, M., Aldape, K. In: Transcriptional Profiling: Tumor Biology and treatment stratification, in CNS Cancer, Models, Prognostic Factors and Targets, Van Meir, E, Ed., Humana Press, 2008.

Last updated: 2/26/2010