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Francois-Xavier Claret, Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Systems Biology, Division of Basic Science Research, University of Texas, MD Anderson Cancer Center, Houston, TX
Assistant Professor, Molecular Therapeutics (now Department of Systems Biology), Division of Cancer Medicine, University of Texas, M.D. Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Graduate School of Biomedical Sciences (GSBS), University of Texas Medical School (UTMS) and Health Science Center (HSC). Program affiliation in Cancer Biology, Houston, TX
Associate Professor, Graduate School of Biomedical Sciences (GSBS), University of Texas Medical School (UTMS) and Health Science Center (HSC), Houston, TX, U.S. Program affiliation in Experimental Therapeutics Academic Program, Houston, TX
Assistant Professor, Graduate School of Biomedical Sciences (GSBS), University of Texas Medical School (UTMS) and Health Science Center (HSC). Programs affiliation in Cancer Biology, Houston, TX

Research Interests

    •   Translational oncology

    •  Cell signaling and Cell Cycle Control

    •           MicroRNAs in drug resistance 
    •           Animal models of cancer

    My translational oncology research focus is on understanding the molecular basis of cancer, especially identifying the cell signaling that leads to oncogene activation and cell cycle dysregulation. The long-term goal of our research is to identify novel targets that can be translated into new therapeutic approaches for cancer patients. Our lab is dedicated to the identification and characterization of cell cycle regulatory pathways and identification of over-activate signaling pathways that play a role in the transition from normal to malignant cells. I have conducted pioneering research on cell signaling and cell cycle control, in particular, research on the relationship between oncogenes and therapeutic resistance. My laboratory discovered Jab1/Csn5 (COPS5) oncogene, a negative regulator of the cell cycle inhibitors p27 and p57, and provided the first evidence of its role in promoting cell proliferation and tumorigenesis and its association with poor outcome in invasive breast cancer, hepatocellular carcinoma, and other tumor types. We further demonstrated the intriguing roles of Jab1 in regulating genomic instability and DNA repair. We recently identified Src/Stat3 pathways as an upstream activator of Jab1 and reported how microRNAs regulate this process.

         We apply multiple approaches to integrate information from across different data platforms, e.g., cancer genomics (The Cancer Genome Atlas), epigenomics (microRNA profiling), molecular biology, and proteomics (RPPA), using new bioinformatic tools. We integrate functional and clinical data in order to identify major signaling pathways that are disturbed in individual cancers and define specific interventional points/nodes for targeted therapies/drugs that could be the basis for individualized treatment strategies.

         My current research focuses on the molecular determinants of therapeutic resistance to Her2-targeted therapies for breast cancer, the development of new therapeutic strategies involving microRNAs to combat drug resistance, the characterization of predictive markers and signatures for treatment response, and the development of genetically engineered mouse models to explore mechanistic and novel targeted therapeutic approaches.

    Office Address

    The University of Texas MD Anderson Cancer Center
    6565 MD Anderson Blvd
    Unit Number: 1058
    Houston, TX 77030
    Phone: 713-563-4204
    Fax: 713-563-6351

    Education & Training

    Degree-Granting Education

    1993 University of Lausanne, Lausanne, Switzerland, Ph.D., Molecular Biology

    Postgraduate Training

    1993-1997 Research Fellowship, Cell Signaling, University of California San Diego (UCSD), School of Medicine, La Jolla, CA, (Dr. Michael Karin)


    Institutional Committee Activities

    Member, Program Reviewer for Experimental Therapeutics (ETAP), 2011-present
    Executive Committee Member, Experimental Therapeutics Academic Program (ETAP), 2010-present
    Member, Institutional Research Grants Program (Basic Science), 2009-present
    Reviewer, Internal Review for CPRIT (Cancer Prevention and Research Institute of Texas) Applications, 2009
    Ad Hoc Reviewer, The Center for Targeted Therapeutics (CTT) Research Fund,, 2008
    Member, TRIUMPH Postdoctoral Program in translational research, 2007-present
    Committee Member, Alfred G. Knudson Outstanding Dissertation Award, 2005
    Member, Faculty Advisory Board, Altana Pharma Award, 2002-2007
    Member, Faculty Advisory Board, Odyssey Scholars and Fellows Program, 1999-2007
    Steering Committee, Aim for Excellence, 1999-2000
    Representative, Faculty Senate Representative, 1999-2000
    Member, Cancer Biology Program, 1998-present

    Honors and Awards

    2014 Associate Editor Frontiers in Oncology, Section Molecular Cancer Therapeutics
    2014 Editorial Board PLOS ONE
    2012 Individual Investigator Award, Cancer Prevention & Research Institute of Texas
    2010-present Executive Committee Member of the Experimental Therapeutics Academic Program
    2009-present Board Member - Scientific Committee & Keynote Speaker, Hellenic Association for Molecular Cancer Research, Athens, Greece
    2008 Best Boss Award Nominee, MD Anderson Cancer Center
    2006-2007 1st Annual Faculty Recognition & Award of Excellence in Translational Research Nominee, MD Anderson Cancer Center
    2003 The Leading BioScientists of the Next Decade, ROCHE
    2002 Bristol-Myers Squibb Oncology Scholar in Cancer Research, AACR
    1997 French University Professorship, French National Educational Center (CNU)
    1997 Post-doctoral Research Fellowship, Swiss League Against Cancer
    1996-1997 Advanced Post-doctoral Research Fellowship Recipient, French Cancer League (La Ligue)
    1996 Postdoctoral Research Fellowship, Swiss Cancer League
    1996 Travel Award, University of California San Diego
    1995 Advanced Post-doctoral Research Fellowship, Swiss National Science Foundation
    1993 Long term fellowship, Human Frontiers Science Program Fellowship
    1992 Doctoral Research Fellowship, Lausanne University
    1992 Doctoral Research Scholarship Awards, Swiss Cancer League
    1992 Swiss Doctoral Research Fellowship, Vaud Academic Society (SAV)
    1992 Travel Award, Swiss National League Against Cancer
    1990 Doctoral Research Fellowship Award, Vaud State Cancer League (Switzerland)
    1990 Doctoral Research Scholarship Awards, Swiss Cancer League
    1986-1987 Doctoral Research Scholarship, French Ministry for Foreign Affairs, (France)

    Selected Publications

    Peer-Reviewed Original Research Articles

    1. Wang S, Pan Y, Zhang R, Xu T, Wu W, Wang C, Huang H, Calin GA, Yang H, Claret FX. Hsa-miR-24-3p Increases Nasopharyngeal Carcinoma Radiosensitivity by Targeting Both the 3’UTR and 5’UTR of Jab1/Csn5. Oncogene. In Press. PMID: 27157611.
    2. Pan Y, Wang S, Su B, Zhou F, Zhang R, Xu T, Zhang R, Leventaki V, Drakos E, Liu W, Claret FX.. Stat3 Contributes to Cancer Progression by Regulating Jab1/Csn5 Expression. Oncogene. In Press. PMID: 27524414.
    3. Guo H, Jing L, Cheng Y, Atsaves V, Lv Y, Wu T, Su R, Zhang Y, Zhang R, Liu W, Rassidakis GZ, Wei Y, Nan K, Claret FX. Downregulation of the Cyclin-Dependent Kinase Inhibitor p57 Is Mediated by Jab1/Csn5 in Hepatocarcinogenesis. Hepatology 63:898-913, 3/2016. PMID: 26606000.
    4. Xu T, Su B, Wang C, Wang S, Huang H, Pan Y, Wang D, Wei W, Claret, FX*, Yang H*. Molecular markers to assess short-term disease local recurrence in nasopharyngeal carcinoma. Oncology Reports 33(3):1418-1426, 2016. PMID: 25607111.
    5. Hua WF, Zhong Q, Xia TL, Xiao Y, Zhang MY, Zhou AJ, Tu ZW, Qu C, Li MZ, Xia YF, Wang HY, Xie D, Claret FX, Song EW, Zeng MS.. RBM24 suppresses cancer progression by upregulating miR-25 to target MALAT1 in nasopharyngeal carcinoma. Cell Death & Disease 7(9):e2352, 2016. PMCID: PMCpending.
    6. Atsaves V, Zhang R, Ruder D, Pan Y, Leventaki V, Rassidakis GZ, Claret FX. Constitutive control of AKT-1 expression by JUNB/CJUN in ALK+ Anaplastic large cell lymphoma: a novel crosstalk mechanism. Leukemia 29(11), leu.2015.127. Epub. e-Pub 11/2015. PMCID: PMC4633353.
    7. Xu T, Huang Z, Deng Y, Wang S, Su B, Wei W, Jiang J, Li A, Zhang G, Yang H*, Claret FX*, Hu W*. (*) Co-corresponding authors. Clinical implications of hepatitis B viral infection in Epstein–Barr virus-associated nasopharyngeal carcinoma. Journal of Clinical Virology 64:64-71, 3/2015. PMCID: PMC25987255.
    8. Wang S, Zhang R, Claret FX*, Yang H* (*) Co-corresponding authors. Involvement of microRNA-24 and DNA Methylation in Resistance of Nasopharyngeal Carcinoma to Ionizing Radiation. Mol Cancer Ther 13(12):3163-74, 12/2014. PMCID: PMC4258432.
    9. Atsaves V, Lekakis L, Drakos E, Leventaki V, Ghaderi M, Baltatzis GE, Chioureas D, Jones D, Feretzaki M, Liakou C, Panayiotidis P, Gorgoulis V, Patsouris E, Medeiros LJ, Claret FX, Rassidakis GZ. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK+ anaplastic large cell lymphoma. Br J Haematol 167(4):514-23, 11/2014. e-Pub 8/22/2014. PMID: 25145835.
    10. Zhou F, Meng S, Claret FX. Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention. Blood Reviews 27:261-67, 9/2013. PMID: 24054128.
    11. Zhou F, Shen Q, Claret FX.. Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia. Journal of Leukocyte Biology 94(3):423-9, 9/2013. PMID: 23715741.
    12. Pan Y, Wang M, Bu X, Zuo Y, Wang S, Wang D, Liu Q, Xu T, Wang C, Claret FX, Yang H. Curcumin analogue T83 exhibits potent antitumor activity and induces radiosensitivity through inactivation of Jab1 in nasopharyngeal carcinoma. BMC cancer 13(1):323, 7/2013. PMID: 23815987.
    13. Pan Y, Zhang Q, Atsaves V, Yang H, Claret FX. Suppression of Jab1/CSN5 induces radio- and chemo-sensitivity in nasopharyngeal carcinoma through changes to the DNA damage and repair pathways. Oncogene 32(22):2756-66, 5/2013. PMCID: PMC3566273.
    14. Echalier A*, Pan Y*, Birol M, Tavernier N, Pintard L, Hoh F, Ebel C, Galophe N, Claret FX, Dumas C. (*) Equal contribution. Insights into the regulation of the human Cop9 signalosome catalytic subunit, CSN5/Jab1. Proceedings of the National Academy of Sciences U S A (PNAS) 110(4):1273-8, 1/2013. PMID: 23288897.
    15. Pan Y, Zhou F, Zhang R, Claret FX. Stat3 inhibitor Stattic exhibits potent antitumor activity and induces chemo- and radio-sensitivity in nasopharyngeal carcinoma. PLOS ONE 8(1):e54565, January 29, 2013. PMCID: PMCPMC3558509.
    16. Vu T and Claret FX. Trastuzumab: updated mechanisms of action and resistance in breast cancer. Frontiers in Cancer Molecular Targets and Therapeutics. 2(62), 6/2012. PMCID: PMC3376449.
    17. Pan Y, Zhang Q, Tian L, Wang X, Fan X, Zhang H, Claret FX*, Yang H* (*) Co-corresponding authors. Jab1/CSN5 negatively regulates p27 and plays a role in the pathogenesis of nasopharyngeal carcinoma. Cancer Research 72(7):1890-1900, 4/2012. PMCID: PMC3460549.
    18. Zhang Q, Claret FX. Phosphatases: the new brakes for cancer development? Enzyme Research 2012(659649), 2012. e-Pub 10/2011. PMCID: PMC3206369.
    19. Shackleford TJ, Zhang Q, Tian L, Vu TT, Korapati AL, Baumgartner A, Le XF, Liao WS, Claret FX.. STAT3 and CCAAT/Enhancer Binding Protein beta (C/EBP-β) regulate Jab1/CSN5 expression in mammary carcinoma cells. Breast Cancer Research 13(3):R65, 6/2011. PMCID: PMC3218954.
    20. Drakos E, Rassidakis G, Schlette E, Li J, Singh RJ, Vega F, Claret FX, Ford J, Medeiros LJ.. Activation of p53 Pathway by MDM2 Inhibitor Nutlin-3a Overcomes BCL2 Overexpression in a Preclinical Model of Diffuse Large B-cell Lymphoma Associated with t(14;18)(q32;q21). Leukemia (Nature Publishing Group) 5(25):856-867, 2011. PMCID: PMC3094765.
    21. Drakos E, Leventaki V, Atsaves V, Schlette EJ, Lin P, Vega F, Claret FX, Medeiros JL, Rassidakis GZ.. Expression of Serine 194-phosphorylated FADD strongly correlates with proliferation in B-cell Non-Hodgkin lymphomas. Human Pathology 42(8):1117-24, 2011. PMID: 21315423.
    22. Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC Jr.. The Role of p27Kip1 in Dasatinib-Enhanced Paclitaxel Cytotoxicity in Human Ovarian Cancer Cells. Journal of the National Cancer Institute (JNCI) 103(18):1403-22, 2011. PMCID: PMC3176777.
    23. Tian L, Peng G, Parant JM, Leventaki V, Drakos I, Zhang Q, Parker-Thornburg J, Shackleford T, Dai H, Lin, S-Y. Lozano G, Rassidakis, GZ, Claret FX.. Essential Roles of Jab1 in Cell Survival, Spontaneous DNA Damage, and DNA Repair. Oncogene (Nature Publishing Group) 29(46):6125-6137, 2010. PMCID: PMC3495558.
    24. Shackleford T, Claret FX. JAB1: a new player in cell cycle control and cancer. Cell Division 5(1):1-14, 2010. PMCID: PMC2976740.
    25. Vivas-Mejia P, Benito JM, Fernandez A, Han HD, Mangala L, Rodriguez-Aguayo C, Chavez-Reyes A, Lin YG, Carey MS, Nick AM, Stone RL, Kim HS, Claret FX, Bornmann W, Hennessy BT, Sanguino A, Peng Z, Sood AK, Lopez-Berestein G. JNK-1 Inhibition Leads to Antitumor Activity in Ovarian Cancer. Clinical Cancer Research 1(16):184-94, 2010. PMID: 20028751.
    26. Shin S, Asano T, Yao Y, Krishnan K, Korc M, Sabapathy K, Menter DG, Claret FX, Abbruzzese JL and Reddy SA.. Activator Protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel AKT-mediated mechanism. Molecular Cancer Research 7(5):745-54, 2009. PMID: 19435822.
    27. Estrella VC, Eder AM, Liu S, Pustilnik TB, Tabassam FH, Claret FX, Gallick GE, Mills GB, Wiener JR. Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway. International Journal of Oncology 31(2):441-9, 2007. PMID: 17611702.
    28. Leventaki V, Drakos E, Medeiros LJ, Lim MS, Elenitoba-Johnson KS, Claret FX and Rassidakis GZ.. NPM-ALK oncogenic kinase promotes cell cycle progression through activation of JNK/c-Jun signalling in anaplastic large cell lymphoma. Blood 110(5):6589-89, 2007. PMID: 17416736.
    29. Vega F, Medeiros JF, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Cancer Research 66(13):6589-97, 2006. PMID: 16818631.
    30. Kim HJ, Chakravarti N, Oridate N, Choe C, Claret FX, Lotan R. N-(4-hydroxyphenyl)retinamide-induced apoptosis triggered by reactive oxygen species is mediated by activation of MAPKs in head and neck squamous carcinoma cells. Oncogene 25(19):2785-94, 2006. PMCID: PMC1458365.
    31. Kouvaraki MA, Korapati AL, Rassidakis GZ, Tian L, Zhang Q, Chiao P, Ho L, Evans DB, Claret FX. Potential Role of Jun Activation Domain-Binding Protein 1 as a Negative Regulator of p27kip1 in Pancreatic Adenocarcinoma. Cancer Research 66(17):8581-9, 2006. PMCID: PMC1780177.
    32. Zhang Q, Tian L, Mansouri A, Korapati AL, Johnson TJ, Claret FX. Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells. FEBS Letters 579(18):3932-40, 2005. PMCID: PMC1366489.
    33. Rassidakis GZ, Feretzaki M, Atwell C, Grammatikakis I, Lin Q, Lai R, Claret FX, Medeiros LJ, Amin HM. Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma. Blood 105(2):827-9, 2005. PMCID: PMC1382060.
    34. Rassidakis GZ, Thomaides A, Atwell C, Ford R, Jones D, Claret FX, Medeiros LJ. JunB expression is a common feature of CD30+ lymphomas and lymphomatoid papulosis. Modern Pathology 18(10):1365-70, 2005. PMCID: PMC1382062.
    35. Fang X, Yu S, Bast RC, Liu S, Xu HJ, Hu SX, LaPushin R, Claret FX, Aggarwal BB, Lu Y, Mills GB. Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. Journal of Biological Chemistry 279(10):9653-61, 2004. PMID: 14670967.
    36. Kouvaraki MA, Rassidakis GZ, Tian L, Kumar R, Kittas C, Claret FX. Jun activation domain-binding protein 1 (JAB1) expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Cancer Res 63(11):2977-81, 6/2003. PMID: 12782606.
    37. Mansouri A, Zhang Q, Ridgway LD, Tian L, Claret FX. Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation. Oncology Research 13(6-10):399-404, 2003. PMID: 12725530.
    38. Rassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ, Medeiros LJ. Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clinical Cancer Research 9(3):1121-8, 2003. PMID: 12631617.
    39. Esteva FJ, Sahin AA, Rassidakis GZ, Yuan LX, Smith TL, Yang Y, Gilcrease MZ, Cristofanilli M, Nahta R, Pusztai L, Claret FX. Jun activation domain binding protein 1 expression is associated with low p27(Kip1)levels in node-negative breast cancer. Clinical Cancer Research 9(15):5652-9, 2003. PMID: 14654548.
    40. Pyle ME, Korbonits M, Gueorguiev M, Jordan S, Kola B, Morris DG, Meinhardt A, Powell MP, Claret FX, Zhang Q, Metz C, Bucala R, Grossman AB. Macrophage migration inhibitory factor expression is increased in pituitary adenoma cell nuclei. Journal of Endocrinology 176(1):103-10, 2003. PMID: 12525254.
    41. Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. Journal of Biological Chemistry 278(21):19245-56, 2003. PMID: 12637505.
    42. Le XF, Claret FX, Lammayot A, Tian L, Deshpande D, LaPushin R, Tari AM, Bast RC, Jr. The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition. Journal of Biological Chemistry 278(26):23441-50, 2003. e-Pub 4/2003. PMID: 12700233.
    43. Korbonits M, Chahal HS, Kaltsas G, Jordan S, Urmanova Y, Khalimova Z, Harris PE, Farrell WE, Claret FX, Grossman AB. Expression of phosphorylated p27(Kip1) protein and Jun activation domain-binding protein 1 in human pituitary tumors. Journal of Clinical Endocrinology & Metabolism 87(6):2635-43, 2002. PMID: 12050228.
    44. Aytac U, Claret FX, Ho L, Sato K, Ohnuma K, Mills GB, Cabanillas F, Morimoto C, Dang NH. Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint. Cancer Research 61(19):7204-10, 10/2001. PMID: 11585756.
    45. Deng L, Lin-Lee YC, Claret FX, Kuo MT. 2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. Journal of Biological Chemistry 276(1):413-20, 2001. PMID: 11020383.
    46. Lee HY, Sueoka N, Hong WK, Mangelsdorf DJ, Claret FX, Kurie JM. All-trans-retinoic acid inhibits Jun N-terminal kinase by increasing dual-specificity phosphatase activity. Molecular and Cellular Biology 19(3):1973-80, 1999. PMCID: PMC83990.
    47. Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Molecular and Cellular Biology 19(1):751-63, 1999. PMCID: PMC83932.
    48. *Herdegen T, *Claret FX, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M (*) Equal contribution. Lasting N-terminal phosphorylation of c-Jun and activation of c-Jun N-terminal kinases after neuronal injury. Journal of Neuroscience 18(14):5124-35, 1998. PMID: 9651196.
    49. Lee HY, Dawson MI, Claret FX, Chen JD, Walsh GL, Hong WK, Kurie JM. Evidence of a retinoid signaling alteration involving the activator protein 1 complex in tumorigenic human bronchial epithelial cells and non-small cell lung cancer cells. Cell Growth & Differentiation 8(3):283-91, 1997. PMID: 9056670.
    50. Claret FX, Hibi M, Dhut S, Toda T, Karin M. Jun activation-domain binding proteins (JAB1): a new group of conserved coactivators that increase the specificity of AP-1 factors. Nature 383(6599):453-457, 10/3/1996. PMID: 8837781.
    51. Claret FX, Antakly T, Karin M, Saatcioglu F. A shift in the ligand responsiveness of thyroid hormone receptor alpha induced by heterodimerization with retinoid X receptor alpha. Molecular and Cellular Biologyl 16(1):219-27, 1996. PMCID: PMC230995.
    52. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268(5208):286-90, 1995. PMID: 7716521.
    53. Cavigelli M, Dolfi F, Claret FX, Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. EMBO Journal 14(23):5957-64, 1995. PMCID: PMC394715.
    54. Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81(7):1147-57, 1995. PMID: 7600582.
    55. Saatcioglu F, Claret FX, Karin M. Negative transcriptional regulation by nuclear receptors. Seminars in Cancer Biology 5(5):347-59, 10/1994. PMID: 7849263.
    56. Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370(6486):226-9, 1994. PMID: 8028671.
    57. Claret FX, Chapel S, Garces J, Tsai-Pflugfelder M, Bertholet C, Shapiro DJ, Wittek R, Wahli W. Two functional forms of the Xenopus laevis estrogen receptor translated from a single mRNA species. Journal of Biological Chemistry 269(19):14047-55, 1994. PMID: 8188685.
    58. Schild C, Claret FX, Wahli W, Wolffe AP. A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro. EMBO Journal 12(2):423-33, 1993. PMCID: PMC413225.
    59. *Corthesy B, *Claret FX, Wahli W (*) Equal contribution. Estrogen receptor level determines sex-specific in vitro transcription from the Xenopus vitellogenin promoter. Proceedings of the National Academy of Sciences U S A (PNAS) 87(20):7878-82, 1990. PMCID: PMC54854.
    60. Corthesy B, Cardinaux JR, Claret FX, Wahli W. A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter. Molecular and Cellular Biology 9(12):5548-62, 1989. PMCID: PMC363725.
    61. Heggler-Bordier B, Claret FX, Wahli W. Immuno-electron microscopic identification of human estrogen receptor-DNA complexes at the estrogen-responsive element and in the first intron of a Xenopus vitellogenin gene. Journal of Molecular Biology 204(1):217-20, 1988. PMID: 3216393.

    Invited Articles

    1. Claret FX, Shackleford T.. JNK Signaling in Diseases. Chapter: Encyclopedia of Cancer Therapeutic Targets; Georgetown Lombardi; Springer Science & Business Media Publishing, Ed. John L. Marshall. New York, NY, USA, 2/2016. e-Pub 2/2016.
    2. Pan Y, Yang H, Claret FX. Emerging Roles of Jab1/Csn5 in DNA Damage Response, DNA Repair and Cancer. Cancer Biol Ther 15(3):256-62, 3/1/2014. e-Pub 2/4/2014. PMCID: PMC3974825.
    3. Vu TT, Sliwkowski MX, Claret FX. Personalized drug combinations to overcome trastuzumab resistance in HER2-positive breast cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846(2):353-365, 2014. PMID: 25065528.
    4. Zhou F, Meng S, Song H, Claret FX.. Dickkopf-1 is a key regulator of myeloma bone disease: Opportunities and challenges for therapeutic intervention. Blood Reviews 27(6):261–267, 9/2013. PMID: 24054128.
    5. Zhou F, Shen Q, Claret FX.. Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia. Journal of Leukocyte Biology 94(3):423-9, 9/2013. PMID: 23715741.
    6. Vu T, Claret FX. Trastuzumab: updated mechanisms of action and resistance in breast cancer. Frontiers in Cancer Molecular Targets and Therapeutics. 2(62), 6/2012. PMCID: PMC3376449.
    7. Pan Y, Claret FX. Targeting Jab1/CSN5 in nasopharyngeal carcinoma. Cancer Letters 2(326):155-60, 2012. PMCID: PMC3474602.
    8. Zhang Q, Claret FX.. Phosphatases: The New Brakes for Cancer Development? Enzyme Research 2012(659649). e-Pub 2011. PMCID: PMC3206369.
    9. Mansouri, A, Ridgway, LD Claret, F-X.. Activation of the JNK/SAPK and p38 mitogen-activated protein kinase signaling pathways sensitize tumor cells to cisplatin-induced apoptosis. TheScientificWorldJOURNAL 1 (1 Suppl)(3):35-36, 2001. PMID: 10.1100.
    10. Saatcioglu F, Claret FX, Karin M.. Negative transcriptional regulation by nuclear receptors. Seminars in Cancer Biology 5:347-359, 1994. PMID: 7849263.

    Last updated: 9/2/2016