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Gary L. Johanning, PHD, MS, BS

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Veterinary Sciences, Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas M. D. Anderson Cancer Center, Bastrop, TX
Postdoctoral Research Associate, Biochemistry, University of Missouri, Columbia, MO

Dual/Joint/Adjunct Appointment

Associate Professor, Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Smithville, TX

Office Address

Department of Veterinary Sciences, Michale E. Keeling Center for Comparative Medicine and Research, The University of Texas M. D. Anderson Cancer Center
650 Cool Water Drive
Unit Number: 119
Bastrop, TX 78602
Room Number: BRE1.2014
Phone: 512-321-3991
Fax: 512-332-7375
Email: gljohann@mdanderson.org

Education & Training

Degree-Granting Education

1978 University of Missouri, Columbia, MO, PHD, Degree in Biochemistry
1976 University of Missouri, Columbia, MO, MS, Degree in Biochemistry
1973 University of Missouri, Columbia, MO, BS, Chemistry/Biochemistry

Postgraduate Training

1989-1993 Postdoctoral Fellow, Molecular Biology, Case Western Reserve University, Cleveland, OH

Experience/Service

Academic Appointments

Member, NIH Funded Center for Research on Environmental Diseases, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 12/2004-present
Regular Member of the Graduate Faculty, The University of Texas Health Science Center at Houston, Houston, TX, 6/2004-present
Member, The University of Texas Health Science Center at Houston Graduate School of Biomedical Sciences, Houston, TX, 2/2004-present
Associate Professor, Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL, 2002-2004
Associate Scientist, Clinical Nutrition Research Center, The University of Alabama at Birmingham, Birmingham, AL, 2000-2004
Associate Scientist, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 1998-2004
Member, Cell Adhesion and Matrix Research Center, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, AL, 1996-2004
Associate Member, Cell Adhesion and Matrix Research Center, The University of Alabama at Birmingham, Birmingham, AL, 1996-2004
Associate Scientist, Cell Adhesion and Matrix Research Center, The University of Alabama at Birmingham, Birmingham, AL, 1995-2004
Assistant Professor, Department of Nutrition Science, The University of Alabama at Birmingham, Birmingham, AL, 1993-2002
Postdoctoral Research Associate, Biochemistry, University of Missouri, Columbia, MO, 1986-1989
Assistant Professor, Department of Chemistry, Armstrong Atlantic State University, Savannah, GA, 1981-1986

Administrative Appointments/Responsibilities

Member, Faculty Senate Academic Planning Committee, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2007-present
Member, Faculty Senate Education Committee, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2007-present
Member, Faculty Senate, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 9/2006-present
On-site Graduate School of Biomedical Sciences (GSBS) Advisor, Department of Veterinary Sciences, The University of Texas M. D. Anderson Cancer Center, Bastrop, TX, 2006-present

Other Appointments/Responsibilities

Member, Advisory Committee of the Cancer Prevention and Control Training Program, The University of Alabama at Birmingham, Birmingham, AL, 2001-2004
Member, Grant Review, University of Alabama at Birmingham, Birmingham, AL, 2000-2001
Member, Campaign for The University of Alabama at Birmingham, Birmingham, AL, 1999-2000
Member, Radiation Safety Committee, The University of Alabama at Birmingham, Birmingham, AL, 1998-2004
Member, PHD Committee, The University of Alabama at Birmingham, Birmingham, AL, 1997-2004
Member, Seminar Committee, The University of Alabama at Birmingham, Birmingham, AL, 1997-1998
Member, Strategic Planning Focus Group, The University of Alabama at Birmingham, Birmingham, AL, 1997
Member, Ad Hoc Faculty Evaluation Committee, The University of Alabama at Birmingham, Birmingham, AL, 1995-1996
Member, Research Design Service Course Subcommittee, The University of Alabama at Birmingham, Birmingham, AL, 1995-1996
Chairman, Nutrition Diagnostic Laboratory Quality Assurance Committee, The University of Alabama at Birmingham, Birmingham, AL, 1994-2004
Member, Faculty Affairs Committee, The University of Alabama at Birmingham, Birmingham, AL, 1994-1999
Member, Research Advisory Committee, The University of Alabama at Birmingham, Birmingham, AL, 1994-1996
Member, Cultural Diversity Faculty Focus Group, The University of Alabama at Birmingham, Birmingham, AL, 1994-1995

Institutional Committee Activities

Member, MDACC Committee preparing for visit of Southern Association of Colleges and Schools (SACS), 2009
Chair, Department of Veterinary Sciences Subscriptions/Library Journals Committee, 2008-present
Chair, Developed Graduate School of Biomedical Sciences (GSBS) Course entitled "Application of Animal Models to Translational Research", 8/2007
Chair, Non-Tenure Track Progress Review Committee for Virginia Scofield, PHD, 4/2007
Member, Bastrop Facility Strategic Planning Committee for Basic Research & Education Building, 2006-2007
Member, MDACC Committee preparing for visit of Southern Association of Colleges and Schools (SACS), 2005
Member, Safety Committee, Department of Veterinary Sciences, 2004-present

Honors and Awards

1991-1993 Postdoctoral Fellow, National Institutes of Health, Metabolism Training Grant (AM 07319)
1989-1991 Pew Postdoctoral Fellow, Pew Foundation

Professional Memberships

American Association for Cancer Research
Member, 4/2002-present
American Association for the Advancement of Science
Member, 5/1989-present
American Society of Nutrition Science
Full Member, 1/1990-present
Sigma Xi
Member, 7/1987-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Wang-Johanning F, Radvanyi L, Rycaj K, Plummer JB, Yan P, Sastry KJ, Piyathilake CJ, Hunt KK, Johanning GL. Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients. Cancer Res 68(14):5869-77, 7/2008. PMID: 18632641.
2. Wang-Johanning F, Huang M, Liu J, Rycaj K, Plummer JB, Barnhart KF, Satterfield WC, Johanning GL. Sheep stromal-epithelial cell interactions and ovarian tumor progression. Int J Cancer 121(10):2346-2354, 11/2007. PMID: 17657741.
3. Piyathilake CJ, Johanning GL. Environmental Influences on DNA Methylation. Progress in DNA Methylation Research, 1/2007. PMID: 1-60021-722-2.
4. Johanning GL, Wang-Johanning F. Efficacy of a medical nutriment in the treatment of cancer. Altern Ther Health Med 13(3)(2):56-63, Mar-Apr, 2007. PMID: 17405680.
5. Wang-Johanning F, Liu J, Rycaj K, Huang M, Tsai K, Rosen DG, Chen DT, Lu DW, Barnhart KF, Johanning GL. Expression of multiple human endogenous retrovirus surface envelope proteins in ovarian cancer. Int J Cancer 120(1):81-90, 2007. PMID: 17013901.
6. Piyathilake CJ, Azrad M, Macaluso M, Johanning GL, Cornwell PE, Partridge EE, Heimburger DC. Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status. Nutrition 23(3):229-235, 2007. PMID: 17303386.
7. Whiteside MA, Piyathilake CJ, Bushell TM, Johanning GL. Intrinsic cisplatin resistance in lung and ovarian cancer cells propagating in medium acutely depleted of folate. Nutr Cancer 54(2):274-284, 2006. PMID: 16898872.
8. Henao OL, Piyathilake CJ, Waterbor JW, Funkhouser E, Johanning GL, Heimburger DC, Partridge EE. Women with polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are less likely to have cervical intraepithelial neoplasia (CIN) 2 or 3. Int J Cancer 113(6):991-997, 3/2005. PMID: 15514969.
9. Wang-Johanning F, Johanning GL. Viral Detection. Methods in Molecular Biology 292:3-14, 1/2005. PMID: 15507697.
10. Whiteside MA, Heimburger DC, Johanning GL. Micronutrients and cancer therapy. Nutr Rev 62(4):142-147, 4/2004. PMID: 15141429.
11. Whiteside MA, Chen DT, Desmond RA, Abdulkadir SA, Johanning GL. A novel time-course cDNA microarray analysis method identifies genes associated with the development of cisplatin resistance. Oncogene 23(3):744-752, 1/2004. PMID: 14737109.
12. Johanning GL, Piyathilake CJ. Retinoids and epigenetic silencing in cancer. Nutr Rev 61(8):284-289, 8/2003. PMID: 13677591.
13. Wang-Johanning F, Frost AR, Jian B, Azerou R, Lu DW, Chen DT, Johanning GL. Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma. Cancer 98(1):187-197, 7/2003. PMID: 12833471.
14. Wang-Johanning F, Frost AR, Jian B, Epp L, Lu DW, Johanning GL. Quantitation of HERV-K env gene expression and splicing in human breast cancer. Oncogene 22(10):1528-1535, 3/2003. PMID: 12629516.
15. Piyathilake CJ, Henao O, Frost AR, Macaluso M, Bell WC, Johanning GL, Heimburger DC, Niveleau A, Grizzle WE. Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States). Cancer Causes Control 14:37-42, 2/2003. PMID: 12708723.
16. Johanning GL, Heimburger DC, Piyathilake CJ. DNA methylation and diet in cancer. J Nutr 132(12):3814S-3818S, 12/2002. PMID: 12468630.
17. Powell CS, Blaylock ML, Wang R, Hunter HL, Johanning GL, Nagy TR. Effects of energy expenditure and Ucp1 on photoperiod-induced weight gain in collared lemmings. Obes Res 10(6):541-550, 6/2002. PMID: 12075603.
18. Johanning GL, Wenstrom KD, Tamura T. Changes in frequencies of heterozygous thermolabile 5,10-methylenetetrahydrofolate reductase gene in fetuses with neural tube defects. J Med Genet 39:366-367, 5/2002. PMID: 12011159.
19. Wang-Johanning F, Lu DW, Wang Y, Johnson MR, Johanning GL. Quantitation of human papillomavirus 16 E6 and E7 DNA and RNA in residual material from ThinPrep papanicolaou tests using real-time polymerase chain reaction analysis. Cancer 94(8):2199-210, 4/2002. PMID: 12001118.
20. Piyathilake CJ, Johanning GL. Cellular vitamins, DNA methylation and cancer risk. J Nutr 132(8 Suppl):2340S-2344S, 2002. PMID: 12163689.
21. Rodríguez-Burford C, Steele VE, Anderson AS, Stockard CR, Weiss HL, Eto I, Johanning GL, Grizzle WE, Grubbs CJ. Effects of body weight gain reduction resulting from chemopreventive agent treatment on mammary gland morphology. Nutr Cancer 43(1):67-75, 2002. PMID: 12467137.
22. Wang-Johanning F, Lu D, Wang Y, Johnson MR, Johanning GL. Modified assays for evaluation of HPV 16 E6 and E7 mRNA expression. Cancer 24:2199-2210, 2002.
23. Wang Y, Hu L, Yao R, Wang M, Crist KA, Grubbs CJ, Johanning GL, Lubet RA, You M. Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor. Oncogene 20:7710-7721, 11/2001. PMID: 11753649.
24. Piyathilake CJ, Frost AR, Bell WC, Oelschlager D, Weiss H, Johanning GL, Niveleau A, Heimburger DC, Grizzle WE. Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression. Hum Pathol 32:856-862, 8/2001. PMID: 11521231.
25. Wang-Johanning F, Frost AR, Johanning GL, Khazaeli MB, LoBuglio AF, Shaw DR, Strong TV. Expression of human endogenous retrovirus K envelope transcripts in human breast cancer. Clin Cancer Res 7:1553-1560, 6/2001. PMID: 11410490.
26. Moore NG, Wang-Johanning F, Chang PL, Johanning GL. Omega-3 fatty acids decrease protein kinase expression in human breast cancer cells. Breast Cancer Res Treat 67:279-283, 6/2001. PMID: 11561774.
27. Johanning GL, Cope MB, Wilborn T, Grubbs CJ, Lubet RA. Effect of high retinoid doses on RAR-Beta mRNA expression in female B6D2F1 mice. Anticancer Res 21:1691-1695, 5/2001. PMID: 11497248.
28. Wenstrom KD, Johanning GL, Johnston KE, DuBard M. Association of the C677T methylenetetrahydrofolate reductase mutation and elevated homocysteine levels with congenital cardiac malformations. Am J Obstet 184:806-812; discussion 812-817, 4/2001. PMID: 11303187.
29. Johanning GL, Tamura T, Johnston KE, Wenstrom KD. Comorbidity of 5,10-methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms and risk for neural tube defects. J Med Genet 37:949-951, 12/2000. PMID: 11186937.
30. Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE, Heimburger DC, Niveleau A. Immunohistochemical evaluation of global DNA methylation: comparison with in vitro radiolabeled methyl incorporation assay. Biotech Histochem 75:251-258, 11/2000. PMID: 11131565.
31. Piyathilake CJ, Bell WC, Johanning GL, Cornwell PE, Heimburger DC, Grizzle WE. The accumulation of ascorbic acid by squamous cell carcinomas of the lung and larynx prevents global DNA hypomethylation. Cancer 89:171-176, 7/2000. PMID: 10897014.
32. Piyathilake CJ, Macaluso M, Johanning GL, Whiteside M, Heimburger DC, Giuliano A. Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia and cancer. Anticancer Res 20:1751-1758, 5/2000. PMID: 10928104.
33. Wenstrom KD, Johanning GL, Owen J, Johnston KE, Acton S, Cliver S, Tamura T. Amniotic fluid homocysteine levels, 5, 10-methylenetetrahydrafolate reductase genotypes, and neural tube closure sites. Am J Med Genet 90:6-11, 1/2000. PMID: 10602110.
34. Wenstrom KD, Johanning GL, Owen J, Johnston KE, Acton S, Tamura T. Role of amniotic fluid homocysteine level and of fetal 5, 10-methylenetetrahydrafolate reductase genotype in the etiology of neural tube defects. Am J Med Genet 90:12-16, 1/2000. PMID: 10602111.
35. Piyathilake CJ, Johanning GL, Macaluso M, Whiteside M, Oelschlager DK, Heimburger DC, Grizzle WE. Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation. Nutr Cancer 37:99-107, 2000. PMID: 10965526.
36. Baggott JE, Johanning GL. 10-formyl-dihydrofolic acid is bioactive in human leukemia cells. J Nutr 129:1315-1318, 7/1999. PMID: 10395592.
37. Zinn KR, Chaudhuri TR, Mountz JM, Vandenberg GJ, Gordon DT, Johanning GL. 59Fe is retained from an elemental 59Fe powder supplement without effects on 65 zinc, 47 calcium and 67 copper in young pigs. J Nutr 129:181-187, 1999.
38. Zinn KR, Chaudhuri T, Mountz JM, Smyth C, Wu Q, Gordon D, Johanning GL. Effect of dietary iron and zinc on retentions of Fe-59 powder: simultaneous in vivo measurements of Fe-59, Zn-65, Ca-47, and Cu-67 in the young pig. J Nutr 129:181-187, 1999.
39. Baggott JE, Robinson CB, Eto I, Johanning GL, Cornwell PE. Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid. J Inorg Biochem 71:181-187, 9/1998. PMID: 9833324.
40. German NS, Johanning GL. Eicosapentaenoic acid and epidermal growth factor modulation of human breast cancer cell adhesion. Cancer Lett 118:95-100, 9/1997. PMID: 9310265.
41. Johnson M, Yang HS, Johanning GL, Patel MS. Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: Genomic structure, promoter sequence, and chromosomal localization. Genomics 41:320-326, 5/1997. PMID: 9169128.
42. Johanning GL. Modulation of breast cancer cell adhesion by unsaturated fatty acids. Nutrition 12:810-816, 11/1996. PMID: 8974109.
43. Tamura T, Johanning GL, Goldenberg RL, Johnston KE, DuBard MB. Effect of angiotensin-converting enzyme gene polymorphism on pregnancy outcome, enzyme activity, and zinc concentration. Obstet Gynecol 88:497-502, 10/1996. PMID: 8841206.
44. Baggott JE, Johanning GL, Branham KE, Prince CW, Morgan SL, Eto I, Vaughn WH. Cofactor role for 10-formyl-dihydrofolic acid. Biochem J 308:1031-1036, 6/1995. PMID: 8948466.
45. Johanning GL, Johnston KE, Tamura T, Goldenberg RL. Ethnic differences in angiotensin converting enzyme gene polymorphism. J Hypertens 13:710-711, 6/1995. PMID: 7594431.
46. Johanning GL, Lin TY. Unsaturated fatty acid effects on human breast cancer cell adhesion. Nutr Cancer 24:57-66, 1995. PMID: 7491298.
47. Bobilya DJ, Johanning GL, Veum TL, O'Dell BL. Chronological loss of bone zinc during dietary zinc deprivation in neonatal pigs. Am J Clin Nutr 59:649-653, 3/1994. PMID: 8116543.
48. Patel MS, Vadlamudi S, Johanning GL. Artificial rearing of rat pups: implications for nutrition research. Annu Rev Nutr 14:21-40, 1994. PMID: 7946518.
49. Hiremagalur BK, Vadlamudi S, Johanning GL, Patel MS. Long-term effects of feeding high carbohydrate diet in pre-weaning period by gastrostomy: a new rat model for obesity. Int J Obes Relat Metab Disord 17:495-502, 9/1993. PMID: 8220651.
50. Chang M, Naik S, Johanning GL, Ho L, Patel MS. Multiple protein-binding sites in the promoter-regulatory region of the alpha subunit of the human poruvate dehydrogenase gene. Biochemistry 32:4263-4269, 4/1993. PMID: 8476854.
51. Patel MS, Vadlamudi SP, Johanning GL. Overview of pup in a cup model: hepatic lipogenesis in rats artificially reared on a high-carbohydrate formula. J Nutr 123(2):373-377, 2/1993. PMID: 8429388.
52. Johanning GL, Morris JI, Madhusudhan KT, Samols D, Patel MS. Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene. Proc Natl Acad Sci U S A 89:10964-10968, 11/1992. PMID: 1332063.
53. Hiremagalur BK, Johanning GL, Kalhan SC, Patel MS. Alterations in hepatic lipogenic capacity in rat pups artificially reared on a milk-substitute formula high in carbohydrate or medium-chain triglycerides. J Nutr Biochem 3:474-480, 1992.
54. Johanning GL, Browning JD, Bobilya DJ, Veum TL, O'Dell BL. Effect of zinc deficiency on enzyme activities in rat and pig erythrocyte membranes. Proc Soc Exp Biol Med 195:224-229, 11/1990. PMID: 2172996.
55. Johanning, GL, Browning JD, Bobilya DJ, Veum TL, O'Dell BL. Effect of zinc deficiency and food restriction on erythrocyte fragility and plasma membrane composition. Nutr Res 10:1463-1471, 1990.
56. Johanning GL, O'Dell BL. Effect of zinc deficiency and food restriction in rats on erythrocyte membrane zinc, phospholipid and protein content. J Nutr 119:1654-1660, 11/1989. PMID: 2600670.
57. Huang HM, Johanning GL, O'Dell BL. Phenolic acid content of food plants and possible nutritional implications. J Agric Food 34:48-51, 1986.
58. Johanning GL, Barr DF, Iannotti EL, O'Dell BL. Effect of dietary fiber on a guinea pig intestinal anaerobe, bacteroides ovatus. J Nutr 114:354-360, 2/1984. PMID: 6319647.
59. Knehans AW, Johanning GL, O'Dell BL. Relationship between fiber rich foods and serum sterols in guinea pigs. Nutr Rep Int 24:1075-1085, 1981.

Abstracts
1. Wang-Johanning F, Rycaj K, Huang M, Plummer JB, Marks JW, Johanning GL, Rosenblum MG. Anti-HERV-K antibody 6H5 and 6H5/rGel inhibit cell growth and induce apoptosis in breast and ovarian cancer cells. Proc Annu Meet Am Assoc Cancer Res, 4/2007.
2. Okegbile EO, Jones A, Johanning G, Grubbs C. Chemopreventive effect of antioxidants on SK-OV-3 tumor-forming ovarian epithelial cancer cells. Proc Annu Meet Am Assoc Cancer Res, 4/2007.
3. Rycaj K, Wang-Johanning F, Johanning G, Lu M. In vivo antitumor effects of HERV-K env antigen on mammary tumors expressing the HERV-K gene. Proc Annu Meet Am Assoc Cancer Res, 4/2007.
4. Okegbile EO, Johanning G, Grubbs C. Down regulation of nitric oxide release by antioxidants in ovarian cancer cell proliferation. Proc Annu Meet Am Assoc Cancer Res 47 (#4804), 2006.
5. Huang M, Liu J, Johanning GL, Wang-Johanning F. Stromal-epithelial cell interactions and ovarian tumor progression. Proc Annu Meet Am Assoc Cancer Res 47 (#1678), 2006.
6. Piyathilake CJ, Henao O, Azrad M, Macalus M, Johanning G, Cornwell P, Partridge E, Heimburger D. Protective effect of MTHFR polymorphism on cervical intrapithelial neoplasia (CIN) is modified by riboflavin status. FASEB J 19:A1499-A1499, 3/2005.
7. Wang-Johanning F, Nehete PN, Rycaj K, Treit J, Johanning GL, Sastry KJ. Antigenic and immunogenic properties of envelope gene products of human endogenous retrovirus type K from breast cancer. Proc Annu Meet Am Assoc Cancer Res 46 (#5127), 2005.
8. Okegbile E, Johanning G, Grubbs C. Preliminary studies on the regulation of extracellular interlukin-8 by vitamin E during ovarian cancer progression. FASEB J 18:C109-C110 Suppl. S, 5/2004.
9. Okegbile E, Johanning GL, Grubbs CJ. Preliminary studies on chemoprevention of ovarian cancer progression by vitamin C. Proc Annu Meet Am Assoc Cancer Res 45 (#1385), 2004.
10. Henao OL, Piyathilake CJ, Waterbor J. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) polymorphisms are associated with a decreased risk of cervical dysplasia. FASEB J 17:A373-A373 Part 1, 2003.
11. Wang-Johanning F, Teng L, Chen DT, Lu DW, Johanning GL. Microarray analysis of differential gene expression profiles in ovarian cancer. Proc Annu Meet Am Assoc Cancer Res 2nd ED 44 (#6009), 2003.
12. Piyathilake CJ, Cerfolio RJ, Whiteside MA, Meleth S, Johanning GL, Heimburger DC, Grizzle WE. Alterations in global DNA methylation in buccal mucosal cells reflect changes in tissues at risk of developing non-small cell lung cancer. Proc Annu Meet Am Assoc Cancer Res (#5155), 2002.
13. Piyathilake CJ, Oelschlager DK, Cerfolio RJ. Associations among folate, vitamin C, vitamin B-12, and global DNA methylation in adenocarcinomas of the lung. FASEB J 16:A268-A268 Part 1, 2002.
14. Piyathilake CJ, Heimburger DC, Meleth S. Gene-nutrient interactions and global DNA methylation in peripheral leukocytes. FASEB J 16:A264-A264 Part 1, 2002.
15. Wang-Johanning F, Lu D, Epp L, Johanning G. Construction and functional evaluation of a single-chain antibody against HPV16 E6 and comparison with anti-E7 scFv. Proc Annu Meet Am Assoc Cancer Res 42, 2001.
16. Johanning GL, Lu D, Wang-Johanning F. Modified assays for evaluation of HPV 16 E6 and E7 mRNA expression in cervical tissues. Proc Annu Meet Am Assoc Cancer Res 42, 2001.
17. Piyathilake CJ, Whiteside MA, Johanning GL, Henao O, Macaluso M, Heimburger DC. Modulation of cancer risk by genetic polymorphism of methylene tetrahydrofolate reductase (MTHFR) and methionine synthase (MS) may depend on the racial distribution of study subjects. FASEB J 15:A618-A618, 2001.
18. Piyathilake CJ, Henso O, Macaluso M, Frost AR, Johanning GL, Belt WC, Heimburger DC, Niveleau A, Grizzle WE. Race and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung. FASEB J 15:A618-A618, 2001.
19. Piyathilake CJ, Oelschlager D, Bell WC, Whiteside MA, Johanning GL, Heimburger DC, Grizzle WE. Variations of vitamin concentrations and DNA methylation in squamous cell cancers of the oral cavity, larynx and lung. FASEB J 15:A619-A619, 2001.
20. Blaylock ML, Powell CS, Johanning GL, Nagy TR. Downregulation of UCP1 is related to a reduction in resting energy expenditure. FASEB J 14:A756-A756, 2000.
21. Johanning GL, Wilborn TW, Cope MB, Grubbs CJ, Steele VE, Kelloff GJ, Lubet RA. Effect of high doses of retinoids on RAR-b mRNA expression in female mice. Proc Annu Meet Am Assoc Cancer Res 41:54, 2000.
22. Piyathilake CJ, Johanning GL, Frost AR, Whiteside MA, Manne U, Grizzle WE, Heimburger DC, Niveleau A. Immunohistochemical evaluation of global DNA methylation: comparison with in vitro ratio-labeled methyl incorporation assay. Proc Annu Meet Am Assoc Cancer Res 41:497-498, 2000.
23. Piyathilake CJ, Johanning GL, Macaluso M, Whiteside MA, Oelschlager DK, Heimburger DC, Grizzle WE. Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation. FASEB J 14:A473-A473, 2000.
24. Moore NG, Wang-Johanning F, Johanning GL. Omega-3 polyunsaturated fatty acids decrease PKARIa subunit expression and adherence of MDA-MB-231 human breast cancer cells. Proc Annu Meet Am Assoc Cancer Res 41:54, 2000.
25. Wang-Johanning F, Johnson MR, Frost AR, Johanning GL, Wang K, Shaw DR, LoBuglio AF. Quantitation of HERV-K10 mRNA expression by real time RT-PCR in human breast cancer cells microdissected by laser capture. Proc Annu Meet Am Assoc Cancer Res 41:315, 2000.
26. Piyathilake CJ, Bell WC, Johanning GL, Cornwell PE, Heimburger DC, Grizzle WE. The accumulation of ascorbic acid by squamous cell cancers of the lung and larynx enhances global methylation of DNA. Proc Annu Meet Am Assoc Cancer Res 41:497, 2000.
27. Wenstrom KD, DuBard M, Owen J, Johanning G, Tamura T. The relationship of amniotic fluid homocysteine and the 677C®T MTHFR mutation to spontaneous pregnancy loss in women with a history of NTD. Am J Obstet Gynecol 182:S190, 2000.

Grant & Contract Support

Title: Human Endogenous Retrovirus Type K as a Biomarker of Early Breast Cancer
Funding Source: National Breast Cancer Foundation
Role: Principal Investigator
Duration: 11/1/2009 - 11/1/2011
 
Title: Viral Antigens as Melanoma Specific Markers and Targets for Detection, Diagnosis, and Immunotherapy Against Melanoma
Funding Source: Melanoma Research Foundation
Role: Co-Investigator
Principal Investigator: Wang-Johanning
Duration: 1/1/2009 - 12/31/2010
 
Title: The Impact of Gestational and Postnatal Exposure on Metabolic Programming and Breast Cancer Risk
Funding Source: Department of the Army/USAMRRA
Role: Co-Investigator
Principal Investigator: Fuchs-Young
Duration: 3/1/2008 - 2/28/2009
 
Title: Obesity and breast cancer in a mouse model
Funding Source: The University of Texas M. D. Anderson Cancer Center Cattlemen for Cancer Research Internal Funding Allocation
Role: Principal Investigator
Duration: 1/18/2008 - 1/17/2010
 
Title: Breast Cancer Screening by Assessing Human Endogenous Retrovirus-K (HERV-K) Antibodies and RNA
Funding Source: Avon Foundation
Role: Principal Investigator
Duration: 1/1/2008 - 12/31/2009
 
Title: Obesity and Breast Cancer in a Mouse Model
Funding Source: The University of Texas M. D. Anderson Cancer Center, Cattlemen for Cancer Research Internal Funding Allocation
Role: Principal Investigator
Duration: 10/1/2007 - 9/30/2008
 
Title: Folic Acid and Antigen-Specific Cellular Immunity
Funding Source: The University of Texas M. D. Anderson Cancer Center, Cattlemen for Cancer Research Internal Funding Allocation
Role: Principal Investigator
Duration: 6/1/2006 - 5/31/2008
 
Title: Acyl Co-A Binding Protein Expression in Cancer
Funding Source: The University of Texas M. D. Anderson Cancer Center, Cattlemen for Cancer Research Internal Funding Allocation
Role: Principal Investigator
Duration: 10/1/2004 - 10/31/2009
 
Title: Cancer CAM Vitamins and Cancer Chemotherapy Resistance
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2003 - 8/31/2008
 
Title: Vitamins and Prevention of Cancer Progression
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 9/1/2003 - 8/31/2007
 
Title: The Role(s) of Human Endogenous Retrovirus Expression in Ovarian Cancer
Funding Source: The University of Texas M. D. Anderson Cancer Center
Role: Investigator
Principal Investigator: Wang-Johanning
Duration: 1/1/2002 - 12/13/2002
 
Title: Polyphenols & Nutrients: Genes, Proteins and Cancer Risk
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Barnes
Duration: 9/28/2001 - 3/27/2002
 
Title: Epigenetic Changes and Vitamin Status in Breast Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 8/1/2000 - 7/31/2003
 
Title: HERV-K10 as a Target of Immunotherapy for Breast Cancer
Funding Source: Department of Defense (DOD)
Role: Principal Investigator
Duration: 7/10/2000 - 12/31/2003
 
Title: Genetic and Epigenetic Differences in Susceptibility for Lung Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Piyathilake
Duration: 7/1/1999 - 6/30/2001
 
Title: Study of Chemopreventive Agents in Animal Models
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Grubbs
Duration: 7/1/1999 - 9/30/2000
 
Title: HPV Oncoprotein Expression in Cervical Cancer
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 1/1/1999 - 12/31/2001
 
Title: HPV Oncoprotein Ablation via Single-Chain Antibodies
Funding Source: NIH/NCI
Role: Principal Investigator
Duration: 7/1/1998 - 6/30/2000
 
Title: Regulation of Energy Partitioning During Weight Change
Funding Source: NIH/NDDK
Role: Co-Investigator
Principal Investigator: Nagy
Duration: 6/1/1998 - 5/31/2003
 
Title: Faculty Research Initiatives Grant
Funding Source: The University of Alabama at Birmingham, School of Health-Related Professions (SHRP)
Role: Principal Investigator
Duration: 10/1/1996 - 9/30/1998
 
Title: Faculty Research Initiatives
Funding Source: The University of Alabama at Birmingham, School of Health-Related Professions (SHRP)
Role: Principal Investigator
Duration: 10/1/1994 - 9/30/1995
 
Title: Core Clinical Nutrition Research Center
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Krumdieck
Duration: 8/1/1993 - 5/31/1995
 
Title: Human Endogenous Retrovirus-K as a Serum Biomarker for Early Detection of Lung Cancer
Funding Source: Lung Cancer Research Program 2009 Concept Award
Role: Principal Investigator
 
Title: Human Endogenous Retroviruses as Biomarkers of Early Breast Cancer
Funding Source: NIH/NCI
Role: Principal Investigator

Last updated: 9/22/2009