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Gilbert J. Cote, B.S., Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Endocrine Neoplasia and Hormonal Disorders - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Education & Training

Degree-Granting Education

1987 University of Vermont, Burlington, VT, PHD, Biochemistry
1980 University of New Hampshire, Durham, NH, BS, Biochemistry (cum laude)

Postgraduate Training

7/1985-8/1987 Postdoctoral Fellowship, Molecular Endocrinology, Baylor College of Medicine, Houston, TX, Robert F. Gagel, M.D.

Honors and Awards

2012 F1000 Faculty Member of the Year, F1000

Selected Publications

Peer-Reviewed Original Research Articles

1. Kouvaraki MA, Shapiro SE, Perrier ND, Cote GJ, Gagel RF, Hoff AO, Sherman SI, Lee JE, Evans DB. RET proto-oncogene: a review and update of genotype-phenotype correlations in hereditary medullary thyroid cancer and associated endocrine tumors. Thyroid 15(6):531-44, 6/2005. PMID: 16029119.
2. Kouvaraki MA, Shapiro SE, Cote GJ, Lee JE, Yao JC, Waguespack SG, Gagel RF, Evans DB, Perrier ND. Management of pancreatic endocrine tumors in multiple endocrine neoplasia type 1. World J Surg 30(5):643-53, 5/2006. PMID: 16680581.
3. Cheung HC, Corley LJ, Fuller GN, McCutcheon IE, Cote GJ. Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. Mod Pathol 19(8):1034-41, 5/2006. PMID: 16729017.
4. Jiménez C, Cote G, Arnold A, Gagel RF. Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes? J Clin Endocrinol Metab 91(8):2851-8, 2006. PMID: 16735498.
5. Evans DB, Rich TA, Cote GJ. Surgical Management of Familial Hyperparathyroidism. Ann Surg Oncol 14(5):1525-1527, 2/2007. PMID: 17285397.
6. Grubbs EG, Rich TA, Li G, Sturgis EM, Younes MN, Myers JN, Edeiken-Monroe B, Fornage BD, Monroe DP, Staerkel GA, Williams MD, Waguespack SG, Hu MI, Cote G, Gagel RF, Cohen J, Weber RS, Anaya DA, Holsinger FC, Perrier ND, Clayman GL, Evans DB. Recent advances in thyroid cancer. Curr Probl Surg 45(3):156-250, 3/2008. PMID: 18346477.
7. Ye L, Santarpia L, Cote GJ, El-Naggar AK, Gagel RF. High Resolution Array-Comparative Genomic Hybridization Profiling Reveals DNA Copy Number Alterations associated with Medullary Thyroid Carcinoma. J Clin Endocrinol Metab 93(11):4367-72, 9/2008. e-Pub 9/2/2008. PMID: 18765511.
8. Habra MA, Jimenez C, Huang SC, Cote GJ, Murphy WA, Gagel RF, Hoff AO. Expression analysis of fibroblast growth factor-23, matrix extracellular phosphoglycoprotein, secreted frizzled-related protein-4, and fibroblast growth factor-7: identification of fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein as major factors involved in tumor-induced osteomalacia. Endocr Pract 14(9):1108-14, 12/2008. PMID: 19158050.
9. Cheung HC, Baggerly KA, Tsavachidis S, Bachinski LL, Neubauer VL, Nixon TJ, Aldape KD, Cote GJ, Krahe R. Global Analysis of Aberrant RNA Splicing in Glioblastoma. BMC Genomics 9:216, 2008. PMID: 18474104.
10. Santarpia L, El-Naggar AK, Cote GJ, Myers JN, Sherman SI. Phosphatidylinositol 3-kinase/akt and ras/raf-mitogen-activated protein kinase pathway mutations in anaplastic thyroid cancer. J Clin Endocrinol Metab 93(1):278-284, 2008. e-Pub 11/2007. PMID: 17989125.
11. Hu J, He X, Cote GJ, Krahe R. Singular Value Decomposition-based Alternative Splicing Detection. Journal of the American Statistical Association 104:944-53, 9/2009.
12. Gao Y, Fotovati A, Lee C, Wang M, Cote G, Guns E, Toyota B, Faury D, Jabado N, Dunn SE. Inhibition of Y-box binding protein-1 slows the growth of glioblastoma multiforme and sensitizes to temozolomide independent O6-methylguanine-DNA methyltransferase. Mol Cancer Ther 8:3276-84, 12/2009. e-Pub 12/2009. PMID: 19996271.
13. Cheung H, Hai T, Zhu W, Baggerly K, Tsavachidis S, Krahe R, Cote GJ. Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines. Brain 132:2277-88, 2009. e-Pub 6/2009. PMID: 19506066.
14. Zhu W, Hai T, Ye L, Cote GJ. Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on RET proto-oncogene activity. J Clin Endocrinol Metab 95(1):439-44, 1/2010. e-Pub 11/6/2009. PMCID: PMC2805480.
15. Ayala-Ramirez M, Habra MA, Busaidy N, Cote G, Rich T, Waguespack S, Jimenez C. A catecholamine crisis on Mount Kilimanjaro: a hypoxia effect? J Travel Med 17(6):424-6, Nov-Dec, 11/2010. PMID: 21050326.
16. Jasim S, Ying AK, Waguespack SG, Rich TA, Grubbs EG, Jimenez C, Hu MI, Cote G, Habra MA. Multiple endocrine neoplasia type 2B with a RET proto-oncogene A883F mutation displays a more indolent form of medullary thyroid carcinoma compared with a RET M918T mutation. Thyroid 21(2):189-92, 2/2011. e-Pub 12/27/2010. PMCID: PMC3025175.
17. Ayala-Ramirez M, Feng L, Johnson MM, Ejaz S, Habra MA, Rich T, Busaidy N, Cote GJ, Perrier N, Phan A, Patel S, Waguespack S, Jimenez C. Clinical Risk Factors for Malignancy and Overall Survival in Patients with Pheochromocytomas and Sympathetic Paragangliomas: Primary Tumor Size and Primary Tumor Location as Prognostic Indicators. J Clin Endocrinol Metab 96(3):717-25, 3/2011. e-Pub 12/29/2010. PMID: 21190975.

Editorials

1. Hu MI, Cote GJ. Medullary Thyroid Carcinoma - Who's on First? Thyroid 22(5):451-3, 5/2012. PMID: 22545752.

Book Chapters

1. Cote GJ, Gagel RF. Molecular diagnosis of bone and mineral disorders. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 7th. American Society for Bone and Mineral Research, Cadmus Professional Communications, 2008.
2. Cote GJ, Gagel RF. Summary of gene disorders of serum mineral metabolism or skeleton formation. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 7th. American Society for Bone and Mineral Research, Cadmus Professional Communications, 2008.
3. Bruno IB, Cheung HC, Cote, GJ. Alternative RNA Splicing of Fibroblast Growth Factor Receptor 1 in Glioma. In: Alternative Splicing in Cancer. Ed(s) Venables J. Research Signpost: Kerala, 209-233, 2006.
4. Gagel RF, Cote GJ. Molecular diagnosis of bone and mineral disorders. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed. Ed(s) MJ Favus. American Society for Bone and Mineral Research, Cadmus Professional Communications, 169-73, 2006.
5. Gagel RF, Shefelbine S, Hayashi H, Cote GJ. Multiple Endocrine Neoplasia Type 2. In: Principles of Molecular Medicine, 2nd ed. Ed(s) Runge MS, Patterson C. Humana Press: Totowa, 393-9, 2006. ISBN: 978-1-59259-963-9.
6. Gagel RF, Cote GJ. Summary of gene disorders of serum mineral metabolism or skeleton formation. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed. Ed(s) MJ Favus. American Society for Bone and Mineral Research, Cadmus Professional Communications, 498-503, 2006.
7. Cote GJ, Bruno IG, Jin W. Abnormal regulation of RNA splicing in gliomas. In: Genomic and Molecular Neuro-Oncology. Ed(s) Zhang W, Fuller GN. Jones and Bartlett Publishers, Inc: Sudbury, 165 -183, 2003.
8. Gagel, RF, Cote, GJ. Molecular diagnosis of bone and mineral disorders. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. Ed(s) Favus MJ. Lippincott Williams & Wilkins: Philadelphia, 220-224, 2003.
9. Hoff AO, Cote GJ, Gagel RF. Neuroendocrine Cancers of the Gastrointestinal Tract: Islet Cell Carcinoma of the Pancreas and Other Neuroendocrine Carcinomas. In: Gastrointestinal Oncology. Ed(s) Abbruzzee JL, Evans DB, Willett C, Feoglio-Preiser. Oxford University Press, 780-800, 2003.
10. Gagel, RF, Cote, GJ. Summary of gene disorders of serum mineral metabolism or skeleton formation. In: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 5th ed. Ed(s) Favus MJ. Lipincott Williams & Wilkins: Philadelphia, 551-556, 2003.
11. Song SW, Cote GJ, Wu C, Zhang W. Alternative Splicing: Genetic Complexity in Cancer. In: Computational And Statistical Approaches to Genomics. Ed(s) Zhang W, Shmulevich I. Kluwer Acadmic Publishers: Boston, 277-297, 2002.
12. Hoff AO, Cote GJ, Gagel RF. Laboratory Evaluation and Screening of Genetic Endocrine Diseases. In: Modern Endocrinology. Genetics in Endocrinology. Ed(s) Martini L, Baxter, JD, Melmed S, New MI. Lippincott Williams & Wilkins: Philadelphia, 189 -220, 2002.
13. Hoff AO, Cote GJ, Lee JE, Evans DB, Gagel RF. Multiple Endocrine Neoplasia, Type 2. In: Oxford Textbook of Endocrinology and Diabetes. Oxford University Press: Oxford, 865-870, 2002.
14. Gagel RF, Cote GJ. The Role of the RET Proto-oncogene in Multiple Endocrine Neoplasia, Type 2. In: Principles of Bone Biology, 2nd ed. Ed(s) Bilezikian JP, Raisz LG, Rodan GA. Academic Press, 1067 - 1078, 2002.
15. Hoff AO, Cote GJ, Gagel RF. Calcitonin. In: Osteoporosis, 2nd ed. Academic Press: San Diego, CA, 247-255, 2001.
16. Kikumori T, Evans, D, Lee, JE, Cote, GJ, Gagel, RF. Genetic abnormalities in multiple endocrine neoplasia type 2. In: Surgical Endocrinology. Ed(s) Dohery GM Skogseid B. Lippincott Williams & Wilkins: Philadelphia, 531-540, 2000.
17. Gagel RF, Cote G. The RET Signaling System and Its Role in Hereditary Medullary Thyroid Carcinoma. In: The Genetics of Osteoporosis and Metabolic Bone Disease. Ed(s) Econs M. Humana Press: Totowa, NJ, 295-308, 2000.

Last updated: 1/8/2014