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Heath D Skinner, M.D, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2007 West Virginia University School of Medicine, Morgantown, WV, MD, Medicine
2007 West Virginia University School of Medicine, Morgantown, WV, PHD, Microbiology Immunology Cell Biology
2000 West Virginia University, Morgantown, WV, BA, Biology

Postgraduate Training

7/2008-6/2012 Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2007-6/2008 Internship, Internal Medicine, The University of Texas at Houston Medical School, Houston, TX

Experience/Service

Institutional Committee Activities

Member, Radiation Oncology Physics Curriculum committee, 2011-present
Member, Radiation Oncology Anderson Award 2010 Committee, 2010
Member, Radiation Oncology Quality and Safety Committee, 2009-2011

Honors and Awards

2012 Merit Award, American Society of Clinical Oncology
2012 The Lupe C. Garcia Fellowship in Cancer Research, The University of Texas MD Anderson Cancer Center
2012 The Thomas H. and Mayme P. Scott Fellowship in Cancer Research, The University of Texas MD Anderson Cancer Center
2011 Roentgen Resident/Fellow Research Award, Radiological Society of North America
2011 Trainee of the Quarter, The University of Texas MD Anderson Cancer Center
2010 Poster Walk Selection ASTRO Annual Meeting, Association of Residents in Radiation Oncology
2010 Trainee Research Day Award Finalist, The University of Texas MD Anderson Cancer Center
2010 Travel Award and Plenary Session Honors, American Society for Radiation Oncology
2009 Poster Walk Selection, ASTRO Annual Meeting, Association of Residents in Radiation Oncology
2005 First Place Honors in Oral Presentation, Graduate Student Division, Van Liere Research Convocation
2005 Second Place Honors in Poster Presentation Graduate Student Division, West Virginia University School of Medicine Van Liere Research Convocation
2004 Scholar-in-Training Award, American Association of Cancer Research
2000 Overall First Place Honors in Oral Presentation, West Virginia University School of Medicine Van Liere Research Convocation

Selected Publications

Peer-Reviewed Original Research Articles

1. Skinner HD, Lee JH, Bhutani MS, Weston B, Hofstetter W, Komaki R, Shiozaki H, Wadhwa R, Sudo K, Elimova E, Song S, Ye Y, Huang M, Ajani J, Wu X. A validated miRNA profile predicts response to therapy in esophageal adenocarcinoma. Cancer. e-Pub 8/2014. PMID: 25091571.
2. Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol 45(2):567-574, 8/2014. e-Pub 5/2014. PMID: 24859412.
3. Taketa T, Sudo K, Correa AM, Wadhwa R, Shiozaki H, Elimova E, Campagna MC, Blum MA, Skinner HD, Komaki RU, Lee JH, Bhutani MS, Weston BR, Rice DC, Swisher SG, Maru DM, Hofstetter WL, Ajani JA. Post-chemoradiation surgical pathology stage can customize the surveillance strategy in patients with esophageal adenocarcinoma. J Natl Compr Canc Netw 12(8):1139-1144, 8/2014. PMID: 25099446.
4. Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X. Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clin Pharmacol Ther. e-Pub 7/2014. PMID: 25054431.
5. Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies. Head Neck 36(6):819-825, 6/2014. e-Pub 9/2013. PMID: 23720126.
6. Shiozaki H, Sudo K, Xiao L, Wadhwa R, Elimova E, Hofstetter WL, Skinner HD, Lee JH, Weston B, Bhutani MS, Blum MA, Maru DM, Ajani JA. Distribution and Timing of Distant Metastasis after Local Therapy in a Large Cohort of Patients with Esophageal and Esophagogastric Junction Cancer. Oncology 86(5-6). e-Pub 6/2014. PMID: 24925190.
7. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation. Mol Cell 54(6):960-974, 6/2014. e-Pub 5/2014. PMCID: PMC4067806.
8. Sandulache VC, Hamblin J, Lai S, Pezzi T, Skinner HD, Khan NA, Dioun SM, Hartman C, Kramer J, Chiao E, Zhou X, Zevallos JP. Oropharyngeal squamous cell carcinoma (OPSCCA) in the veteran population is associated with traditional carcinogen exposure and poor clinical outcomes. Head Neck. e-Pub 5/2014. PMID: 24801106.
9. Hoffman KE, Voong KR, Pugh TJ, Skinner HD, Levy LB, Takiar V, Choi S, Du W, Frank SJ, Johnson J, Kanke J, Kudchadker RJ, Lee AK, Mahmood U, McGuire SE, Kuban DA. Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial. Int J Radiat Oncol Biol Phys 88(5):1074-1084, 4/2014. PMID: 24661661.
10. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol 8(1):142-149, 2/2014. e-Pub 10/2013. PMCID: PMC3946849.
11. Sandulache VC, Chen Y, Lee J, Rubinstein A, Ramirez MS, Skinner HD, Walker CM, Williams MD, Tailor R, Court LE, Bankson JA, Lai SY. Evaluation of hyperpolarized [1-¹³C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time. PLoS One 9(1):e87031, 2014. e-Pub 1/2014. PMCID: PMC3903593.
12. Chuang HC, Yang LP, Fitzgerald AL, Osman A, Woo SH, Myers JN, Skinner HD. The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells. PLoS One 9(8):e104821, 2014. e-Pub 8/2014. PMCID: PMC4132078.
13. Sudo K, Taketa T, Correa AM, Campagna MC, Wadhwa R, Blum MA, Komaki R, Lee JH, Bhutani MS, Weston B, Skinner HD, Maru DM, Rice DC, Swisher SG, Hofstetter WL, Ajani JA. Locoregional Failure Rate After Preoperative Chemoradiation of Esophageal Adenocarcinoma and the Outcomes of Salvage Strategies. J Clin Oncol 31(34):4306-4310, 12/2013. e-Pub 10/2013. PMCID: PMC3837091.
14. Suzuki A, Xiao L, Taketa T, Sudo K, Wadhwa R, Blum MA, Skinner HD, Komaki R, Weston B, Lee JH, Bhutani MS, Rice DC, Maru DM, Erasmus J, Swisher SG, Hofstetter WL, Ajani JA. Results of the baseline positron emission tomography can customize therapy of localized esophageal adenocarcinoma patients who achieve a clinical complete response after chemoradiation. Ann Oncol, 11/2013.
15. Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner HD, Bell D, Rosenthal DI, Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN. Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival. Head Neck 35(10):1454-1460, 10/2013. e-Pub 9/2012. PMID: 23018868.
16. Sandulache VC, Kubik MW, Skinner HD, Malsky JA, Gelbard AH, Zevallos JP. Impact of race/ethnicity on laryngeal cancer in patients treated at a Veterans Affairs Medical Center. Laryngoscope 123(9):2170-2175, 9/2013. e-Pub 5/2013. PMID: 23729204.
17. Hamilton JD, Ahmed S, Sandulache VC, Daram SP, Ow TJ, Skinner HD, Rao A, Ginsberg LE, Kumar AJ, Myers JN. Improving imaging diagnosis of persistent nodal metastases after definitive therapy for oropharyngeal carcinoma: specific signs for CT and best performance of combined criteria. AJNR Am J Neuroradiol 34(8):1637-1642, 8/2013. e-Pub 3/2013. PMCID: PMC3939678.
18. Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O'Reilly MS, Hofstetter WL, Ajani JA, Komaki R, Cox JD, Sandulache VC, Myers JN, Guerrero TM. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol 52(5):1002-1009, 6/2013. e-Pub 9/2012. PMID: 22950385.
19. Sandulache VC, Hamblin JS, Skinner HD, kubik MW, Myers JN, Zevallos JP. Metfromin use is associated with improved survival in patients with laryngeal squamous cell carcinoma. Head and Neck. e-Pub 6/2013.
20. Skinner HD, Sturgis EM, Klopp Ah, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially HPV-related malignancies. Head and Neck. e-Pub 5/2013.
21. Skinner HD, Crane CH, Garrett CR, Eng C, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Kelly P, Sandulache VC, Delclos ME, Krishnan S, Das P. Metformin use and improved response to therapy in rectal cancer. Cancer Med 2(1):99-107, 2/2013. e-Pub 2/2013. PMCID: PMC3797563.
22. Wadhwa R, Taketa T, Correa AM, Sudo K, Campagna MC, Blum MA, Komaki R, Skinner HD, Lee JH, Bhutani MS, Weston B, Maru DM, Rice DC, Swisher S, Hofstetter WL, Ajani JA. Incidence of brain metastases after trimodality therapy in patients with esophageal or gastroesophageal cancer: implications for screening and surveillance. Oncology 85(4):204-207, 2013. e-Pub 9/2013. PMID: 24051869.
23. Taketa T, Xiao L, Sudo K, Suzuki A, Wadhwa R, Blum MA, Lee JH, Weston B, Bhutani MS, Skinner HD, Komaki R, Maru DM, Rice DC, Swisher SG, Hofstetter WL, Ajani JA. Propensity-based matching between esophagogastric cancer patients who had surgery and who declined surgery after preoperative chemoradiation. Oncology 85(2):95-99, 2013. e-Pub 7/2013. PMID: 23860252.
24. Skinner HD, Strom EA, Motwani SB, Woodward WA, Green MC, Babiera G, Booser DJ, Meric-Bernstam F, Buchholz TA. Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy. Radiat Oncol 8:13, 2013. e-Pub 1/2013. PMCID: PMC3552737.
25. Sandulache VC, Skinner HD, Wang Y, Chen Y, Dodge CT, Ow TJ, Bankson JA, Myers JN, Lai SY. Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation. Mol Cancer Ther 11(6):1373-1380, 6/2012. e-Pub 5/2012. PMID: 22572813.
26. Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 18(1):290-300, 1/2012. e-Pub 11/2011. PMCID: PMC3251726.
27. Sandulache VC, Skinner HD, Ow TJ, Zhang A, Xia X, Luchak JM, Wong LC, Pickering CR, Zhou G, Myers JN. Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Cancer 118(3):711-712, 2012.
28. Skinner HD, Garden AS, Rosenthal DI, Ang KK, Morrison WH, Esmaeli B, Pinnix CC, Frank SJ. Outcomes of malignant tumors of the lacrimal apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer 117(12):2801-2010, 2011.
29. Skinner HD, Sharp HJ, Kaseb AO, Javle MN, Vauthey JN, Abdalla EK, Delclos ME, Das P, Crane CH, Krishanan S. Radiation treatment outcomes for unresectable hepatocellular carcinoma. Acta Oncol 50(8):1191-1198, 2011.
30. Jiang Y, Cukic B, Adjeroh DA, Skinner HD, Lin J, Shen QJ, Jiang BH. An algorithm for identifying novel targets of transcription factor families: application to hypoxia-inducible factor 1 targets. Cancer Infom 7:75-89, 2009.
31. Zhong XS, Liu LZ, Skinner HD, Cao Z, Ding M, Jiang BH. Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells. Biochem Biophys Res Commun 358(1):92-98, 2007.
32. Frankenberry K, Skinner HD, Somasundar P, McFadden D, Vona-Davis L. Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28(4):985-993, 2006.
33. Griffin WC 3rd Skinner HD, Birkle DL. Prenatal stress influences 8-OH-DPAT modulated startle responding and [(3)]-8-OH-DPAT binding in rats. Pharmacol Biochem Behav 81(3):601-607, 2005.
34. Skinner HD, Zhong XS, Gao N, Jiang BH. Arsenite induces p70S6K1 activation and HIF-1α levels in prostate cancer cells. Mol Cell Biochem 255(1-2):19-23, 2004.
35. Somasudar P, Krankenberry K, Skinner HD, Vedula G, McFadden D, Riggs D, Jackson B, Vangilder R, Hileman S, Vona-Davis L. Prostate cancer cell proliferation is influenced by leptin. J Surg Res 1(118):71-82, 2004.
36. Skinner HD, Zheng J, Gao N, Agani F, Jiang BH. VEGF transcriptional acrtivity via HIF-1α expression is dependent upon P13K-mediated activation of p70S6K and hdm2 in ovarian cancer. J Biol Chem 279(44):45643-45651, 2004.
37. Griffin WC 3rd, Skinner HD, Salm AK, Birkle DL. Mild prenatal stress in rats is associated with enhanced conditioned fear. Physiol Behav 79(2):209-215, 2003.

Invited Articles

1. Woo SH, Sandulache VC, Yang L, Skinner HD. Evaluating Response to Metformin/Cisplatin Combination in Cancer Cells via Metabolic Measurement and Clonogenic Survival. Methods Mol Biol 1165:11-18, 2014. PMID: 24839015.
2. Sandulache VC, Yang L, Skinner HD. Use of biguanides to improve response to chemotherapy. Methods Mol Biol 1165:3-9, 2014. PMID: 24839014.
3. Blum MA, Taketa T, Sudo K, Wadhwa R, Skinner HD, Ajani JA. Chemoradiation for esophageal cancer. Thorac Surg Clin 23(4):551-558, 11/2013. PMID: 24199704.
4. Ow TJ, Sandulache VC, Skinner HD, Myers JN. Integration of cancer genomics with treatment selection: from genome to predictive biomarkers. Cancer, 8/2013.
5. Skinner HD, Holsinger FC, Beadle BM. Oropharynx cancer. Curr Probl Cancer 36(6):334-415, 12/2012.
6. Skinner HD, Holsinger C, Beadle BM. Cancer of the oropharynx. Curr Probl Cancer. e-Pub 9/2012.
7. Skinner HD, Hong T, Krishnan S. Charged particle therapy for hepatocellular carcinoma. Semin Radiat Oncol 21(4):278-286, 2011.
8. Skinner HD, Krishnan S. Predicting, preventing, treating and understanding radiation nephropathy. J Gastrointest Oncol 1(1):2-4, 9/2010.

Book Chapters

1. Skinner HD, Minsky BD. Radiation therapy for locally advanced esophageal cancer. In: Esophageal Cancer and Barrett's Esophagus, 3rd. Ed(s) P Sharma, R Sampliner, E Van Cutsem. Wiley-Blackwell. In Press.
2. Skinner HD, Deorukhkar AA, Krishnan S. Molecular basis of cancer radiation treatment. In: Principles of Molecular Diagnostics and Personalized Cancer Medicine, 1st. Ed(s) D Tan, HT Lynch. Lippincott Williams & Wilkins: Philadelphia, 646-654, 2013.
3. Manon RR, Myers JN, Skinner HD, Harari P. Oral cavity cancer. In: Principles and Practice of Radiation Oncology, 6th. Ed(s) EC Halperin, DE Wazer, CA Perez, LW Brady. Lippincott Williams & Wilkins: Philadelphia, 795-816, 2013.
4. Skinner HD, Komaki R. Radiotherapy: patient selection and clinical outcomes. In: Personalized Management of Lung Cancer, 1st. Future Medicine: London, 76-86, 2013.
5. Skinner HD, Chen Q, Elimova E, Wadhwa R, Song S, Ajani JA. Predictive biomarkers for therapy in adenocarcinoma of the upper digestive tract. In: Biomarkers in Translational Research. Ed(s) R Bast, M Mackman, E Hawk. Wiley-Blackwell. Submitted.

Letters to the Editor

1. Sudo K, Elimova E, Skinner HD, Hofstetter WL, Ajani JA. Reply to R. Gertler et al. J Clin Oncol 32(19):2112-2113, 7/2014. e-Pub 5/2014. PMID: 24868018.

Last updated: 8/21/2014