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Heath D Skinner, M.D, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2007 West Virginia University School of Medicine, Morgantown, WV, MD, Medicine
2007 West Virginia University School of Medicine, Morgantown, WV, PHD, Microbiology Immunology Cell Biology
2000 West Virginia University, Morgantown, WV, BA, Biology

Postgraduate Training

7/2008-6/2012 Residency, Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
7/2007-6/2008 Internship, Internal Medicine, The University of Texas at Houston Medical School, Houston, TX

Experience/Service

Institutional Committee Activities

Member, Radiation Oncology Physics Curriculum committee, 2011-present
Member, Radiation Oncology Anderson Award 2010 Committee, 2010
Member, Radiation Oncology Quality and Safety Committee, 2009-2011

Honors and Awards

2012 Merit Award, American Society of Clinical Oncology
2012 The Lupe C. Garcia Fellowship in Cancer Research, The University of Texas MD Anderson Cancer Center
2012 The Thomas H. and Mayme P. Scott Fellowship in Cancer Research, The University of Texas MD Anderson Cancer Center
2011 Roentgen Resident/Fellow Research Award, Radiological Society of North America
2011 Trainee of the Quarter, The University of Texas MD Anderson Cancer Center
2010 Poster Walk Selection ASTRO Annual Meeting, Association of Residents in Radiation Oncology
2010 Trainee Research Day Award Finalist, The University of Texas MD Anderson Cancer Center
2010 Travel Award and Plenary Session Honors, American Society for Radiation Oncology
2009 Poster Walk Selection, ASTRO Annual Meeting, Association of Residents in Radiation Oncology
2005 First Place Honors in Oral Presentation, Graduate Student Division, Van Liere Research Convocation
2005 Second Place Honors in Poster Presentation Graduate Student Division, West Virginia University School of Medicine Van Liere Research Convocation
2004 Scholar-in-Training Award, American Association of Cancer Research
2000 Overall First Place Honors in Oral Presentation, West Virginia University School of Medicine Van Liere Research Convocation

Selected Publications

Peer-Reviewed Original Research Articles

1. Gunn GB, Blanchard P, Garden AS, Zhu XR, Fuller CD, Mohamed AS, Morrison WH, Phan J, Beadle BM, Skinner HD, Sturgis EM, Kies MS, Hutcheson KA, Rosenthal DI, Mohan R, Gillin MT, Frank SJ. Clinical Outcomes and Patterns of Disease Recurrence After Intensity Modulated Proton Therapy for Oropharyngeal Squamous Carcinoma. Int J Radiat Oncol Biol Phys 95(1):360-367, 5/2016.
2. Meyn RE, Krishnan S, Skinner HD. Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer. Clin Cancer Res 22(8):1834-1836, 4/2016.
3. Skinner HD, Giri U, Yang L, Woo SH, Story MD, Pickering CR, Byers LA, Williams MD, El-Naggar A, Wang J, Diao L, Shen L, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV. Proteomic profiling identifies PTK2/FAK as a driver of radioresistance in HPV negative head and neck cancer. Clin Cancer Res. e-Pub 4/2016.
4. Sandulache VC, Vandelaar LJ, Skinner HD, Cata J, Hutcheson K, Fuller CD, Phan J, Siddiqui Z, Lai SY, Weber RS, Zafereo ME. Salvage total laryngectomy after external-beam radiotherapy: A 20-year experience. Head and Neck Suppl 38, 4/2016.
5. Spratt DE, Beadle BM, Zumsteg ZS, Rivera A, Skinner HD, Osborne JR, Garden AS, Lee NY. The Influence of Diabetes Mellitus and Metformin on Distant Metastases in Oropharyngeal Cancer: A Multicenter Study. Int J Radiat Oncol Biol Phys 94(3):523-531, 3/2016.
6. Sudo K, Wang X, Xiao L, Wadhwa R, Shiozaki H, Elimova E, Rice DC, Lee JH, Weston B, Bhutani MS, Hiremath A, Charalampakis N, Komaki R, Blum MA, Swisher SG, Maru DM, Skinner HD, Garris JL, Rogers JE, Hofstetter WL, Ajani JA. A Nomogram to Predict Distant Metastases After Multimodality Therapy for Patients With Localized Esophageal Cancer. J Natl Compr Canc Netw 14(2):173-179, 2/2016.
7. Grossberg AJ, Chamchod S, Fuller CD, Mohamed AS, Heukelom J, Eichelberger H, Kantor ME, Hutcheson KA, Gunn GB, Garden AS, Frank S, Phan J, Beadle B, Skinner HD, Morrison WH, Rosenthal D. Association of Body Composition With Survival and Locoregional Control of Radiotherapy-treated head and neck squamous cell carcinoma. JAMA Oncol, 2/2016.
8. Sandulache VC, Chen Y, Skinner HD, Lu T, Feng L, Court LE, Myers JN, Meyn RE, Fuller CD, Bankson JA, Lai SY. Acute Tumor Lactate Perturbations as a Biomarker of Genotoxic Stress: Development of a Biochemical Model. Mol Cancer Ther 14(12):2901-8, 12/2015. e-Pub 9/16/2015. PMID: 26376962.
9. Nien HH, Sturgis EM, Kies MS, El-Naggar AK, Morrison WH, Beadle BM, Johnson FM, Gunn GB, Fuller CD, Phan J, Gold KA, Frank SJ, Skinner H, Rosenthal DI, Garden AS. Comparison of systemic therapies used concurrently with radiation for the treatment of human papillomavirus-associated oropharyngeal cancer. Head Neck. e-Pub 11/23/2015. PMID: 26595157.
10. Tanaka N, Patel AA, Wang J, Frederick MJ, Kalu NN, Zhao M, Fitzgerald AL, Xie TX, Silver NL, Caulin C, Zhou G, Skinner HD, Johnson FM, Myers JN, Osman AA. Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins. Clin Cancer Res 21(21):4831-44, 11/1/2015. e-Pub 6/29/2015. PMCID: PMC4631620.
11. Elimova E, Wang X, Etchebehere E, Shiozaki H, Shimodaira Y, Wadhwa R, Planjery V, Charalampakis N, Blum MA, Hofstetter W, Lee JH, Weston BR, Bhutani MS, Rogers JE, Maru D, Skinner HD, Macapinlac HA, Ajani JA. 18-fluorodeoxy-glucose positron emission computed tomography as predictive of response after chemoradiation in oesophageal cancer patients. Eur J Cancer 51(17):2545-52, 11/2015. e-Pub 8/28/2015. PMCID: PMC4663130.
12. Chen Q, Song S, Wei S, Liu B, Honjo S, Scott A, Jin J, Ma L, Zhu H, Skinner HD, Johnson RL, Ajani JA. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget 6(28):25883-96, 9/22/2015. PMID: 26317542.
13. Woo SH, Yang LP, Chuang HC, Fitzgerald A, Lee HY, Pickering C, Myers JN, Skinner HD. Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence. Head Neck. e-Pub 5/20/2015. PMID: 25994759.
14. Neishaboori N, Wadhwa R, Nogueras-González GM, Elimova E, Shiozaki H, Sudo K, Charalampakis N, Hiremath A, Lee JH, Bhutani MS, Weston B, Blum MA, Rogers JE, Garris JL, Rice DC, Komaki R, Swisher SG, Skinner HD, Hofstetter WL, Ajani JA. Distribution of Resistant Esophageal Adenocarcinoma in the Resected Specimens of Clinical Stage III Patients after Chemoradiation: Its Clinical Implications. Oncology. e-Pub 3/5/2015. PMID: 25765719.
15. Shiozaki H, Slack R, Sudo K, Elimova E, Wadhwa R, Chen HC, Skinner HD, Komaki R, Lee JH, Weston B, Bhutani MS, Blum MA, Rogers JE, Maru DM, Hofstetter WL, Ajani JA. Geographic Distribution of Regional Metastatic Nodes Affects the Outcome of Trimodality-Eligible Patients with Esophageal Adenocarcinoma. Oncology. e-Pub 2/28/2015. PMID: 25765098.
16. Nesky DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary action score of TP53 (EAp53) identifies high risk mutations associated with decreased survival and increased distant metastases in head and neck cancer. Cancer Res. e-Pub 2/2015.
17. Osman AA, Neskey DM, Katsonis P, Patel AA, Ward AM, Hsu TK, Hicks SC, McDonald TO, Ow TJ, Ortega Alves M, Pickering CR, SkinnerHD, Zhao M, Sturgis EM, Kies MS, El-Naggar A, Perrone F, Licitra L, Bossi P, Kimmel M, Frederick MJ, Lichtarge O, Myers JN. Evolutionary action score of TP53 coding variants (EAp53) is predictive of platinum response in head and neck cancer patients. Cancer Res. e-Pub 2/2015.
18. Neskey DM, Osman AA, Ow TJ, Katsonis P, McDonald T, Hicks SC, Hsu TK, Pickering CR, Ward A, Patel A, Yordy JS, Skinner HD, Giri U, Sano D, Story MD, Beadle BM, El-Naggar AK, Kies MS, William WN, Caulin C, Frederick M, Kimmel M, Myers JN, Lichtarge O. Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer. Cancer Res. e-Pub 1/29/2015. PMID: 25634208.
19. Castillo R, Pham N, Castillo E, Aso-Gonzalez S, Ansari S, Hobbs B, Palacio D, Skinner H, Guerrero TM. Pre-Radiation Therapy Fluorine 18 Fluorodeoxyglucose PET Helps Identify Patients with Esophageal Cancer at High Risk for Radiation Pneumonitis. Radiology. e-Pub 1/13/2015. PMID: 25584706.
20. Raju U, Molkentine DP, Valdecanas DR, Deorukhkar A, Mason KA, Buchholz TA, Meyn RE, Ang KK, Skinner H. Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit. Cancer Med. e-Pub 10/30/2014. PMID: 25355701.
21. Wen CP, Zhang F, Liang D, Wen C, Gu J, Skinner HD, Chow WH, Ye Y, Pu X, Hildebrandt MA, Huang M, Chen CH, Hsiung CA, Tsai MK, Tsao CK, Lippman SM, Wu X. The ability of bilirubin in identifying smokers with higher risk of lung cancer: a large cohort study in conjunction with global metabolomic profiling. Clin Cancer Res. e-Pub 10/21/2014. PMID: 25336700.
22. Sudo K, Xiao L, Wadhwa R, Shiozaki H, Elimova E, Taketa T, Blum MA, Lee JH, Bhutani MS, Weston B, Ross WA, Komaki R, Rice DC, Swisher SG, Hofstetter WL, Maru DM, Skinner HD, Ajani JA. Importance of Surveillance and Success of Salvage Strategies After Definitive Chemoradiation in Patients With Esophageal Cancer. J Clin Oncol. e-Pub 9/2014. PMID: 25225435.
23. Skinner HD, Lee JH, Bhutani MS, Weston B, Hofstetter W, Komaki R, Shiozaki H, Wadhwa R, Sudo K, Elimova E, Song S, Ye Y, Huang M, Ajani J, Wu X. A validated miRNA profile predicts response to therapy in esophageal adenocarcinoma. Cancer. e-Pub 8/2014. PMID: 25091571.
24. Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol 45(2):567-574, 8/2014. e-Pub 5/2014. PMID: 24859412.
25. Taketa T, Sudo K, Correa AM, Wadhwa R, Shiozaki H, Elimova E, Campagna MC, Blum MA, Skinner HD, Komaki RU, Lee JH, Bhutani MS, Weston BR, Rice DC, Swisher SG, Maru DM, Hofstetter WL, Ajani JA. Post-chemoradiation surgical pathology stage can customize the surveillance strategy in patients with esophageal adenocarcinoma. J Natl Compr Canc Netw 12(8):1139-1144, 8/2014. PMID: 25099446.
26. Sandulache VC, Hamblin JS, Skinner HD, kubik MW, Myers JN, Zevallos JP. Associationi betweenmetforminuse and improved survival in patients with laryngeal squamous cell carcinoma. Head and Neck 36(7):1039-1043, 7/2014.
27. Sudo K, Elimova E, Skinner HD, Hofstetter WL, Ajani JA. Critical appraisal of locoregional failure and systemic disease progression after preoperative chemoradiation of esophageal adenocarcinoma. Reply to R. Gertler et al. J Clin Oncol 32(19):2112-2113, 7/2014.
28. Zevallos JP, Sandulache VC, Hamblin J, Skinner HD, Kramer J, Hartmen CM, Horter KL, Lai S, Zhou X, Chiao EY. Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans. Head Neck. e-Pub 7/2014.
29. Pu X, Wang L, Chang JY, Hildebrandt MA, Ye Y, Lu C, Skinner HD, Niu N, Jenkins GD, Komaki R, Minna JD, Roth JA, Weinshilboum RM, Wu X. Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer. Clin Pharmacol Ther. e-Pub 7/2014. PMID: 25054431.
30. Skinner HD, Sturgis EM, Klopp AH, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially human papillomavirus-related malignancies. Head Neck 36(6):819-825, 6/2014. e-Pub 9/2013. PMID: 23720126.
31. Shiozaki H, Sudo K, Xiao L, Wadhwa R, Elimova E, Hofstetter WL, Skinner HD, Lee JH, Weston B, Bhutani MS, Blum MA, Maru DM, Ajani JA. Distribution and Timing of Distant Metastasis after Local Therapy in a Large Cohort of Patients with Esophageal and Esophagogastric Junction Cancer. Oncology 86(5-6). e-Pub 6/2014. PMID: 24925190.
32. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation. Mol Cell 54(6):960-974, 6/2014. e-Pub 5/2014. PMCID: PMC4067806.
33. Sandulache VC, Hamblin J, Lai S, Pezzi T, Skinner HD, Khan NA, Dioun SM, Hartman C, Kramer J, Chiao E, Zhou X, Zevallos JP. Oropharyngeal squamous cell carcinoma (OPSCCA) in the veteran population is associated with traditional carcinogen exposure and poor clinical outcomes. Head Neck. e-Pub 5/2014. PMID: 24801106.
34. Hoffman KE, Voong KR, Pugh TJ, Skinner HD, Levy LB, Takiar V, Choi S, Du W, Frank SJ, Johnson J, Kanke J, Kudchadker RJ, Lee AK, Mahmood U, McGuire SE, Kuban DA. Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial. Int J Radiat Oncol Biol Phys 88(5):1074-1084, 4/2014. PMID: 24661661.
35. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol 8(1):142-149, 2/2014. e-Pub 10/2013. PMCID: PMC3946849.
36. Woo SH, Sandulache VC, Yang L, Skinner HD. Evaluating response to metformin/cisplatin combination in cancer cells via metabolic measurement and clonogenic survival. Methods Mol Biol 1165(11-18), 2014.
37. Sandulache VC, Chen Y, Lee J, Rubinstein A, Ramirez MS, Skinner HD, Walker CM, Williams MD, Tailor R, Court LE, Bankson JA, Lai SY. Evaluation of hyperpolarized [1-¹³C]-pyruvate by magnetic resonance to detect ionizing radiation effects in real time. PLoS One 9(1):e87031, 2014. e-Pub 1/2014. PMCID: PMC3903593.
38. Chuang HC, Yang LP, Fitzgerald AL, Osman A, Woo SH, Myers JN, Skinner HD. The p53-Reactivating Small Molecule RITA Induces Senescence in Head and Neck Cancer Cells. PLoS One 9(8):e104821, 2014. e-Pub 8/2014. PMCID: PMC4132078.
39. Sandulache VC, Yang L, Skinner HD. Use of biguanides to improve response to chemotherapy. Methods Mol Biol 1165(3-9), 2014.
40. Sudo K, Taketa T, Correa AM, Campagna MC, Wadhwa R, Blum MA, Komaki R, Lee JH, Bhutani MS, Weston B, Skinner HD, Maru DM, Rice DC, Swisher SG, Hofstetter WL, Ajani JA. Locoregional Failure Rate After Preoperative Chemoradiation of Esophageal Adenocarcinoma and the Outcomes of Salvage Strategies. J Clin Oncol 31(34):4306-4310, 12/2013. e-Pub 10/2013. PMCID: PMC3837091.
41. Blum MA, Taketa T, Sudo K, Wadhwa R, Skinner HD, Ajani JA. Chemoradiation for esophagel cancer. Thorac Surg Clin 23(4):551-558, 11/2013.
42. Ow TJ, Sandulache VC, Skinner HD, Myers JN. Integration of cancer genomics with treatment selection:from the genome to predictive biomarkers. Cancer 119(22):3914-3928, 11/2013.
43. Suzuki A, Xiao L, Taketa T, Sudo K, Wadhwa R, Blum MA, Skinner HD, Komaki R, Weston B, Lee JH, Bhutani MS, Rice DC, Maru DM, Erasmus J, Swisher SG, Hofstetter WL, Ajani JA. Results of the baseline positron emission tomography can customize therapy of localized esophageal adenocarcinoma patients who achieve a clinical complete response after chemoradiation. Ann Oncol, 11/2013.
44. Sandulache VC, Ow TJ, Daram SP, Hamilton J, Skinner HD, Bell D, Rosenthal DI, Beadle BM, Ang KK, Kies MS, Johnson FM, El-Naggar AK, Myers JN. Residual nodal disease in patients with advanced-stage oropharyngeal squamous cell carcinoma treated with definitive radiation therapy and posttreatment neck dissection: Association with locoregional recurrence, distant metastasis, and decreased survival. Head Neck 35(10):1454-1460, 10/2013. e-Pub 9/2012. PMID: 23018868.
45. Sandulache VC, Kubik MW, Skinner HD, Malsky JA, Gelbard AH, Zevallos JP. Impact of race/ethnicity on laryngeal cancer in patients treated at a Veterans Affairs Medical Center. Laryngoscope 123(9):2170-2175, 9/2013. e-Pub 5/2013. PMID: 23729204.
46. Hamilton JD, Ahmed S, Sandulache VC, Daram SP, Ow TJ, Skinner HD, Rao A, Ginsberg LE, Kumar AJ, Myers JN. Improving imaging diagnosis of persistent nodal metastases after definitive therapy for oropharyngeal carcinoma: specific signs for CT and best performance of combined criteria. AJNR Am J Neuroradiol 34(8):1637-1642, 8/2013. e-Pub 3/2013. PMCID: PMC3939678.
47. Skinner HD, McCurdy MR, Echeverria AE, Lin SH, Welsh JW, O'Reilly MS, Hofstetter WL, Ajani JA, Komaki R, Cox JD, Sandulache VC, Myers JN, Guerrero TM. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol 52(5):1002-1009, 6/2013. e-Pub 9/2012. PMID: 22950385.
48. Skinner HD, Sturgis EM, Klopp Ah, Ang KK, Rosenthal DI, Garden AS, Morrison WH, Gunn GB, Beadle BM. Clinical characteristics of patients with multiple potentially HPV-related malignancies. Head and Neck. e-Pub 5/2013.
49. Skinner HD, Crane CH, Garrett CR, Eng C, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Kelly P, Sandulache VC, Delclos ME, Krishnan S, Das P. Metformin use and improved response to therapy in rectal cancer. Cancer Med 2(1):99-107, 2/2013. e-Pub 2/2013. PMCID: PMC3797563.
50. Wadhwa R, Taketa T, Correa AM, Sudo K, Campagna MC, Blum MA, Komaki R, Skinner HD, Lee JH, Bhutani MS, Weston B, Maru DM, Rice DC, Swisher S, Hofstetter WL, Ajani JA. Incidence of brain metastases after trimodality therapy in patients with esophageal or gastroesophageal cancer: implications for screening and surveillance. Oncology 85(4):204-207, 2013. e-Pub 9/2013. PMID: 24051869.
51. Taketa T, Xiao L, Sudo K, Suzuki A, Wadhwa R, Blum MA, Lee JH, Weston B, Bhutani MS, Skinner HD, Komaki R, Maru DM, Rice DC, Swisher SG, Hofstetter WL, Ajani JA. Propensity-based matching between esophagogastric cancer patients who had surgery and who declined surgery after preoperative chemoradiation. Oncology 85(2):95-99, 2013. e-Pub 7/2013. PMID: 23860252.
52. Skinner HD, Strom EA, Motwani SB, Woodward WA, Green MC, Babiera G, Booser DJ, Meric-Bernstam F, Buchholz TA. Radiation dose escalation for loco-regional recurrence of breast cancer after mastectomy. Radiat Oncol 8:13, 2013. e-Pub 1/2013. PMCID: PMC3552737.
53. Skinner HD, Holsinger FC, Beadle BM. Oropharynx Cancer. Curr Probl Cancer 36(6):334-415, 11/2012.
54. Sandulache VC, Skinner HD, Wang Y, Chen Y, Dodge CT, Ow TJ, Bankson JA, Myers JN, Lai SY. Glycolytic inhibition alters anaplastic thyroid carcinoma tumor metabolism and improves response to conventional chemotherapy and radiation. Mol Cancer Ther 11(6):1373-1380, 6/2012. e-Pub 5/2012. PMID: 22572813.
55. Skinner HD, Sandulache VC, Ow TJ, Meyn RE, Yordy JS, Beadle BM, Fitzgerald AL, Giri U, Ang KK, Myers JN. TP53 disruptive mutations lead to head and neck cancer treatment failure through inhibition of radiation-induced senescence. Clin Cancer Res 18(1):290-300, 1/2012. e-Pub 11/2011. PMCID: PMC3251726.
56. Sandulache VC, Skinner HD, Ow TJ, Zhang A, Xia X, Luchak JM, Wong LC, Pickering CR, Zhou G, Myers JN. Individualizing anti-metabolic treatment strategies for head and neck squamous cell carcinoma based on TP53 mutational status. Cancer 118(3):711-712, 2012.
57. Skinner HD, Hong TS, Krishnan S. Charged-particle therapy for hepatocellular carcinoma. Semin Radiat Oncol 21(4):278-286, 10/2011.
58. Skinner HD, Garden AS, Rosenthal DI, Ang KK, Morrison WH, Esmaeli B, Pinnix CC, Frank SJ. Outcomes of malignant tumors of the lacrimal apparatus: The University of Texas MD Anderson Cancer Center Experience. Cancer 117(12):2801-2010, 2011.
59. Skinner HD, Sharp HJ, Kaseb AO, Javle MN, Vauthey JN, Abdalla EK, Delclos ME, Das P, Crane CH, Krishanan S. Radiation treatment outcomes for unresectable hepatocellular carcinoma. Acta Oncol 50(8):1191-1198, 2011.
60. Skinner HD, Krishnan S. Predicting, preventing, treating and understanding radiation nephropathy. J Gastrointest Oncol 1(1):2-4, 9/2010.
61. Jiang Y, Cukic B, Adjeroh DA, Skinner HD, Lin J, Shen QJ, Jiang BH. An algorithm for identifying novel targets of transcription factor families: application to hypoxia-inducible factor 1 targets. Cancer Infom 7:75-89, 2009.
62. Zhong XS, Liu LZ, Skinner HD, Cao Z, Ding M, Jiang BH. Mechanism of vascular endothelial growth factor expression mediated by cisplatin in human ovarian cancer cells. Biochem Biophys Res Commun 358(1):92-98, 2007.
63. Frankenberry K, Skinner HD, Somasundar P, McFadden D, Vona-Davis L. Leptin receptor expression and cell signaling in breast cancer. Int J Oncol 28(4):985-993, 2006.
64. Griffin WC 3rd Skinner HD, Birkle DL. Prenatal stress influences 8-OH-DPAT modulated startle responding and [(3)]-8-OH-DPAT binding in rats. Pharmacol Biochem Behav 81(3):601-607, 2005.
65. Skinner HD, Zhong XS, Gao N, Jiang BH. Arsenite induces p70S6K1 activation and HIF-1α levels in prostate cancer cells. Mol Cell Biochem 255(1-2):19-23, 2004.
66. Somasudar P, Krankenberry K, Skinner HD, Vedula G, McFadden D, Riggs D, Jackson B, Vangilder R, Hileman S, Vona-Davis L. Prostate cancer cell proliferation is influenced by leptin. J Surg Res 1(118):71-82, 2004.
67. Skinner HD, Zheng J, Gao N, Agani F, Jiang BH. VEGF transcriptional acrtivity via HIF-1α expression is dependent upon P13K-mediated activation of p70S6K and hdm2 in ovarian cancer. J Biol Chem 279(44):45643-45651, 2004.
68. Griffin WC 3rd, Skinner HD, Salm AK, Birkle DL. Mild prenatal stress in rats is associated with enhanced conditioned fear. Physiol Behav 79(2):209-215, 2003.

Invited Articles

1. Woo SH, Sandulache VC, Yang L, Skinner HD. Evaluating Response to Metformin/Cisplatin Combination in Cancer Cells via Metabolic Measurement and Clonogenic Survival. Methods Mol Biol 1165:11-18, 2014. PMID: 24839015.
2. Sandulache VC, Yang L, Skinner HD. Use of biguanides to improve response to chemotherapy. Methods Mol Biol 1165:3-9, 2014. PMID: 24839014.
3. Blum MA, Taketa T, Sudo K, Wadhwa R, Skinner HD, Ajani JA. Chemoradiation for esophageal cancer. Thorac Surg Clin 23(4):551-558, 11/2013. PMID: 24199704.
4. Ow TJ, Sandulache VC, Skinner HD, Myers JN. Integration of cancer genomics with treatment selection: from genome to predictive biomarkers. Cancer, 8/2013.
5. Skinner HD, Holsinger FC, Beadle BM. Oropharynx cancer. Curr Probl Cancer 36(6):334-415, 12/2012.
6. Skinner HD, Holsinger C, Beadle BM. Cancer of the oropharynx. Curr Probl Cancer. e-Pub 9/2012.
7. Skinner HD, Hong T, Krishnan S. Charged particle therapy for hepatocellular carcinoma. Semin Radiat Oncol 21(4):278-286, 2011.
8. Skinner HD, Krishnan S. Predicting, preventing, treating and understanding radiation nephropathy. J Gastrointest Oncol 1(1):2-4, 9/2010.

Book Chapters

1. Skinner HD, Deorukhkar AA, Krishnan S. Molecular basis of cancer radiation treatment. In: Principles of Molecular Diagnostics and Personalized Cancer Medicine, 1st. Ed(s) D Tan, HT Lynch. Lippincott Williams & Wilkins: Philadelphia, 646-654, 2013.
2. Manon RR, Myers JN, Skinner HD, Harari P. Oral cavity cancer. In: Principles and Practice of Radiation Oncology, 6th. Ed(s) EC Halperin, DE Wazer, CA Perez, LW Brady. Lippincott Williams & Wilkins: Philadelphia, 795-816, 2013.
3. Skinner HD, Komaki R. Radiotherapy: patient selection and clinical outcomes. In: Personalized Management of Lung Cancer, 1st. Future Medicine: London, 76-86, 2013.

Letters to the Editor

1. Sudo K, Elimova E, Skinner HD, Hofstetter WL, Ajani JA. Reply to R. Gertler et al. J Clin Oncol 32(19):2112-2113, 7/2014. e-Pub 5/2014. PMID: 24868018.

Last updated: 5/1/2016