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Hector V. Martinez-Valdez, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 902
Houston, TX 77054
Room Number: SCR4.2015

Education & Training

Degree-Granting Education

1983 National University of Mexico, Mexico City, Mexico, PHD, Molecular Biology
1977 National University of Mexico, Mexico City, Mexico, MD, Biochemistry
1970 Autonomous University of Chihuahua, Chihuahua, Mexico, BS, Cell Biology

Postgraduate Training

1986-1990 Postdoctoral Fellowship, Immunology, The Hospital for Sick Children, Toronto, Ontario, Canada, Dr. Amos Cohen
1983-1985 Postdoctoral Fellowship, Biology, Indiana University, Bloomington, IN, Dr. Milton W. Taylor

Experience/Service

Academic Appointments

Regular Member, Graduate Faculty, The University of Texas Graduate School of Biomedical Sciences, Houston, TX, 1996-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Martinez-Valdez H, Fernandez L, Arroyo-Begovich A. Protein solubility in hydrophobic media. Anuario de la Sociedad Mexicana de Bioquimica 8:62, 1974.
2. Martinez-Valdez H, Andrade J, Lopez-Vitolas A, Miyasaki JL. Inhalation of Pb2+ provokes ionic disequilibrium associated to circulations Ca2+ replacement. Archivos del Instituto Mexicano Del Seguro Social (IMMS) 125:39, 1977.
3. Martinez-Valdez H, Madrid-Marina V, Sanchez CV, Gutierrez-Juarez R, Pina E. La adenosina aumenta los niveles de ATP dependiente de la glucolisis, durante la isquemia cardiaca experimental. Anuario de la Sociedad Mexicana de Bioquimica 10:83, 1980.
4. Madrid-Marina V, Martinez-Valdez H, Gutierrez-Juarez R, Espinoza-San Vicente VM, Pina E. La adenosina regula la actividad de las enzimas glucoliticas que se traduce en un incremento de la carga energetica en el eritrocito. Anuario de la Sociedad Mexicana de Bioquimica 10:95, 1980.
5. Pina-Garza E, Madrid-Marina V, Martinez-Valdez H, Gutierrez-Juarez R, Espinoza-San Vicente VM. Glycolysis as a probe in studies on the regulation of energy metabolism. Gac Med Mex 118:141-9, 1982. PMID: 7117729.
6. Martinez-Valdez H, Madrid-Marina V, Pina E. In vivo effect of adenosine on adenine nucleotides and inorganic phosphate in rat blood. Life Sci 30:191-7, 1982. PMID: 7054645.
7. Martinez-Valdez H, Kothari RM, Hershey HV, Taylor MW. Rapid and reliable method for the analysis of nucleotide pools by reversed-phase high-performance liquid chromatography. J Chromatogr 247:307-14, 1982. PMID: 6292247.
8. Taylor MW, Kothari RM, Holland GD, Martinez-Valdez H, Zeige G. A comparison of purine and pyrimidine pools in Bloom's syndrome and normal cells. Cancer Biochem Biophys 7:19-25, 1983. PMID: 6667451.
9. Martinez-Valdez H, Taylor MW, Kothari RM. A rapid and reliable method for separation of ribonucleotides, deoxynucleotides, and cyclic nucleotides by reversed phase HPLC. Adv Exp Med Biol 165 Pt A:269-75, 1984. PMID: 6326482.
10. Downing J, Martinez-Valdez H, Long T, et. al. Enhancement of heat-Induced antiviral activity. Antiviral Res 1:3, 1984.
11. Taylor MW, Long T, Martinez-Valdez H, Downing J, Zeige G. Induction of gamma-interferon activity by elevated temperatures in human B-lymphoblastoid cell lines. Proc Natl Acad Sci U S A 81:4033-36, 1984. PMID: 6330733.
12. Martinez-Valdez H, Downing J, Long T, et. al. Interferon-gamma induction requires two major steps: sensitization and activation. Antiviral Res 1:7, 1984.
13. Martinez-Valdez H, Doherty PJ, Thompson E, Benedict SH, Gelfand EW, Cohen A. Antagonistic effects of calcium ionophores and phorbol esters on T cell receptor mRNA levels in human thymocytes. J Immunol 140:361-6, 1988. PMID: 3257235.
14. Martinez-Valdez H, Thompson E, Cohen A. Coordinate transcriptional regulation of alpha and gamma chains of the T-cell antigen receptors by phorbol esters and cyclic adenosine 5'-monophosphate in human thymocytes. J Biol Chem 263:9561-4, 1988. PMID: 2838469.
15. Downing JF, Martinez-Valdez H, Elizondo RS, Walker EB, Taylor MW. Hyperthermia in humans enhances interferon-gamma synthesis and alters the peripheral lymphocyte population. J Interferon Res 8(2):143-50, 1988. PMID: 3132509.
16. Martinez-Valdez H, Thompson E, Cohen A. Phorbol esters and calcium ionophores differentially regulate the transcription of gamma-T-cell antigen receptor gene in human thymocytes. J Biol Chem 263:4043-6, 1988. PMID: 3257962.
17. Roifman CM, Hummel D, Martinez-Valdez H, Thorner P, Doherty PJ, Pan S, Cohen F, Cohen A. Depletion of CD8+ cells in human thymic medulla results in selective immune deficiency. J Exp Med 170:2177-82, 1989. PMID: 2511270.
18. Madrid-Marina V, Martinez-Valdez H, Cohen A. Phorbol esters induce changes in adenosine deaminase, purine nucleoside phosphorylase, and terminal deoxynucleotidyl transferase messenger RNA levels in human leukemic cell lines. Cancer Res 50(10):2891-4, 1990. PMID: 2110502.
19. Martinez-Valdez H, Takihara Y, Champagne E, Minden M, Mak TW, Cohen A. Differential regulation of gamma and delta T cell antigen receptor gene expression by phorbol esters and Ca2+ ionophores in the acute lymphocyte leukemia DND41 cell line. Eur J Immunol 21:2625-8, 1991. PMID: 1833206.
20. Gutierrez-Juarez R, Castrejon-Sosa M, Martinez-Valdez H, Blancas-Torres PG, Pina E, Madrid-Marina V. Activating effect of adenosine on rat erythrocyte glycolysis. Int J Biochem 24:433-6, 1992. PMID: 1532368.
21. Miossec P, Briolay J, Dechanet J, Wijdenes J, Martinez-Valdez H, Banchereau J. Inhibition of the production of proinflammatory cytokines and immunoglobulins by interleukin-4 in an ex vivo model of rheumatoid synovitis. Arthritis Rheum 35:874-83, 1992. PMID: 1642654.
22. Pandrau D, Frances V, Martinez-Valdez H, Pages MP, Manel AM, Philippe N, Banchereau J, Saeland S. Characterization of a t(1;19) pre-B acute lymphoblastic leukemia (ALL) cell line which proliferates in response to IL-7. Leukemia 7:635-42, 1993. PMID: 8464241.
23. Briere F, Bridon JM, Chevet D, Souillet G, Bienvenu F, Guret C, Martinez-Valdez H, Banchereau J. Interleukin 10 induces B lymphocytes from IgA-deficient patients to secrete IgA. J Clin Invest 94:97-104, 1994. PMID: 7518836.
24. Fernandez-Mejia C, Peralta-Zaragoza O, Cerezo-Roman J, Navarro-Duque C, Barrera-Rodriguez R, Martinez-Valdez H, Madrid-Marina V. Regulation of gene expression of adenosine deaminase, purine nucleoside phosphorylase and terminal deoxynucleotidyl transferase by dexamethasone and cAMP in human leukemic cells. Adv Exp Med Biol 370:249-52, 1994. PMID: 7660900.
25. Martinez-Valdez H, Malisan F, de Bouteiller O, Guret C, Banchereau J, Liu YJ. Molecular evidence that in vivo isotype switching occurs within the germinal centers. Ann N Y Acad Sci 764:151-4, 1995. PMID: 7486514.
26. Liu YJ, de Bouteiller O, Arpin C, Briere F, Galibert L, Ho S, Martinez-Valdez H, Banchereau J, Lebecque S. Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcripts. Immunity 4:603-13, 1996. PMID: 8673707.
27. Peralta-Zaragoza O, Martinez-Valdez H, Madrid-Marina V. Regulation of gamma T-cell antigen receptor expression by intracellular calcium in acute lymphoblastic leukemia cell line DND41. Arch Med Res 27(3):305-10, 1996. PMID: 8854386.
28. Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Guret C, Madrid-Marina V, Sun Y, Martinez-Valdez H. Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA. Nature 410:383-7, 2001. PMID: 11268217.
29. Martinez-Valdez H, Madrid-Marina V, Cohen A. Phorbol esters and cAMP differentially regulate the expression of CD4 and CD8 in human thymocytes. BMC Immunol 3:1, 2002. PMID: 11835689.
30. Challa A, Eliopoulos AG, Holder MJ, Burguete AS, Pound JD, Chamba A, Grafton G, Armitage RJ, Gregory CD, Martinez-Valdez H, Young L, Gordon J. Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells. Blood 99:3411-8, 2002. PMID: 11964311.
31. Aldrich MB, Chen W, Blackburn MR, Martinez-Valdez H, Datta SK, Kellems RE. Impaired germinal center maturation in adenosine deaminase deficiency. J Immunol 171:5562-70, 2003. PMID: 14607964.
32. Rangel R, McKeller MR, Sims-Mourtada JC, Kashi C, Cain K, Wieder ED, Molldrem JJ, Pham LV, Ford RJ, Yotnda P, Guret C, Frances V, Martinez-Valdez H. Assembly of the kappa preB receptor requires a V kappa-like protein encoded by a germline transcript. J Biol Chem 280:17807-14, 2005. PMID: 15757909.
33. Sims-Mourtada JC, Bruce S, McKeller MR, Rangel R, Guzman-Rojas L, Cain K, Lopez C, Zimonjic DB, Popescu NC, Gordon J, Wilkinson MF, Martinez-Valdez H. The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. DNA Cell Biol 24:325-38, 2005. PMID: 15869410.
34. Georgakis GV, Li Y, Rassidakis GZ, Martinez-Valdez H, Medeiros LJ, Younes A. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death. Clin Cancer Res 12(2):584-90, 2006. PMID: 16428504.
35. Zhou Y, Mohsenin A, Morschl E, Young HW, Molina JG, Ma W, Sun CX, Martinez-Valdez H, Blackburn MR. Enhanced airway inflammation and remodeling in adenosine deaminase-deficient mice lacking the A2B adenosine receptor. J Immunol 182(12):8037-46, 6/15/2009. PMID: 19494329.
36. McKeller MR, Herrera-Rodriguez S, Ma W, Ortiz-Quintero B, Rangel R, Candé C, Sims-Mourtada JC, Melnikova V, Kashi C, Phan LM, Chen Z, Huang P, Dunner K, Kroemer G, Singh KK, Martinez-Valdez H. Vital function of PRELI and essential requirement of its LEA motif. Cell Death Dis 1(e21):doi:10.1038/cddis.2009.19, 2010. PMCID: PMC3032331.
37. Buglio D, Khaskhely NM, Voo KS, Martinez-Valdez H, Liu YJ, Younes A. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood 117(10):2910-7, 3/10/2011. e-Pub 1/14/2011. PMCID: PMC3062301.
38. Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S, Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW, Zhou Y, Blackburn MR, Martinez-Valdez H. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res 21(11):1564-77, 11/2011. e-Pub 5/24/2011. PMID: 21606955.

Invited Articles
1. McKeller MR, Martinez-Valdez H. The kappa-like pre-B receptor: surplus biology or a missing link? Semin Immunol 18(1):40-3, 2006. PMID: 16307892.
2. Guzman-Rojas L, Sims-Mourtada JC, Rangel R, Martinez-Valdez H. Life and death within germinal centres: a double-edged sword. Immunology 107(2):167-75, 2002. PMCID: PMC1782796.

Book Chapters
1. Martinez-Valdez H, Ortiz-Quintero B. Part III Functional Assessment of Discovered Genes Mutations: Chapter 14 Multi-Parameter Molecular Evaluation. In: Gene Discovery and Disease Models. Ed(s) W. Gu. Wiley & Sons, Inc: Hoboken, NJ, USA, 2010. PMID: 047049946X.
2. Martinez-Valdez H, Downing F, Elizondo R, Taylor M. Characterization of Heat-Induced Interferon. In: The Biology of the Interferon System. Ed(s) WE Stewart, H Schellekens. Elsvier Science: Amsterdam, 1985.
3. Downing J, Martinez-Valdez H, Long T, et al. In Vivo Induction of Interferon at Febrile Temperatures. In: The Biology of the Interferon System. Ed(s) WE Stewart, H Schellekens. Elsvier Science: Amsterdam, 1985.
4. Martinez-Valdez H, Taylor M, and Kothari R. A Rapid and Reliable Method for Separation of Ribonucleotides, Deoxynucleotides, and Cyclic Nucleotides by Reversed Phase HPLC. In: Purine Metabolism in Man IV. Ed(s) CHMM Bruyn, MM Muller, HA Simmons. Plenum Press: New York, 1982.
5. Martinez-Valdez H. Epidemiological, Economic and Social Studies of the Rural Community Naica, Chihuahua. In: Thesis/Report to obtain the M.D. Degree. Archives of Instituto Mexicano Del Seguro Social, 1977.

Last updated: 3/6/2012