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Holly M. Holmes, M.D., M.S.

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of General Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2000 University of Texas Health Science Center, Houston, TX, MD, Medicine
1996 University of Texas, Austin, TX, BS, Pharmacy

Postgraduate Training

8/2004-5/2006 Clinical Research Training Program, University of Chicago, Chicago, IL, Dr. Fred Coe and Dr. Ronald Thisted
7/2003-6/2005 Geriatric Medicine Clinical and Research Fellowship, University of Chicago Hospitals, Chicago, IL, Dr. Daniel Brauner
6/2000-6/2003 Internal Medicine Residency, University of Chicago Hospitals, Chicago, IL, Dr. Holly Humphrey

Board Certifications

2003 American Board of Internal Medicine, Recertification Date: 2013
2004 Geriatric Medicine, American Board of Internal Medicine, Recertification Date: 2013


Academic Appointments

Assistant Professor, Department of General Internal Medicine, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 10/2007-8/2013

Other Appointments/Responsibilities

Board Member, Commission for Certification in Geriatric Pharmacy, Alexandria, VA, 2012-present
Fellow, Sealy Center on Aging, University of Texas Medical Branch, Galveston, TX, 2011-2013
Member, National Comprehensive Cancer Network Senior Adult Oncology Panel, Fort Washington, PA, 4/2008-present
Staff Pharmacist, Walgreen's Pharmacy, Houston, TX, 1996-2000

Institutional Committee Activities

Chair, The University of Texas MD Anderson Cancer Center Division of Internal Medicine Research Committee, 2011-2013
Member, The University of Texas MD Anderson Cancer Center Faculty Senate, 2010-2013
Member, The University of Texas MD Anderson Cancer Center Division of Internal Medicine Research Committee, 2008-2013

Honors and Awards

2011-2016 K23 Mentored Career Development Award
2011 The University of Texas MD Anderson Cancer Center, Division of Internal Medicine Research Retreat, Best Poster Award
2008-2010 Hartford Geriatrics Health Outcomes Research Scholar Award
1995 Phi Lambda Sigma Pharmacy Leadership Society
1994 Kappa Epsilon National Pharmacy Sorority

Professional Memberships

American Academy of Hospice and Palliative Medicine
Research Committee Member, 2009-2010
Member, 2006-2010
American College of Physicians
Member, 2003-present
American Geriatrics Society
Co-Chair, Polypharmacy Special Interest Group, 2010-2013
Member, Cancer Aging Special Interest Group, 2009-present
Member, 2000-present
American Medical Association
Member, 2001-2008
American Society of Clinical Oncology
Member, 2009-present
Gerontological Society of America
Member, 2007-2012
Harris County Medical Society
Member, 2007-present
Societe Internationale d'Oncologie Geriatrique (SIOG)
Member, 2011-present
Texas Geriatrics Society
Member, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Holmes HM, Nguyen HT, Nayak P, Oh JH, Escalante CP, Elting LS. Chronic conditions and health status in older cancer survivors. Eur J Intern Med 25(4):374-8, 1/2014. PMID: 24389373.
2. Hurria A, Wildes T, Blair SL, Browner IS, Cohen HJ, Deshazo M, Dotan E, Edil BH, Extermann M, Ganti AK, Holmes HM, Jagsi R, Karlekar MB, Keating NL, Korc-Grodzicki B, McKoy JM, Medeiros BC, Mrozek E, O'Connor T, Rugo HS, Rupper RW, Silliman RA, Stirewalt DL, Tew WP, Walter LC, Weir AB, Bergman MA, Sundar H. Senior Adult Oncology, Version 2.2014: Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 12(1):82-126, 1/2014. PMID: 24453295.
3. Sera L, McPherson ML, Holmes HM. Commonly prescribed medication in a population of hospice patients. Am J Hospice Palliat Med(31):126-31, 2014. PMCID: PMC3830696.
4. Parelkar P, Nguyen HT, Holmes H, Etling LS. Adherence to physical activity guidelines after cancer diagnosis among cancer survivors ages 45-64 in Texas. Texas Public Health Assoc J 65(1):32-36, 2013.
5. Holmes HM, Luo R, Kuo YF, Baillargeon J, Goodwin JS. Association of potentially inappropriate medication use with patient and prescriber characteristics in Medicare Part D. Pharmacoepi Drug Safety 22(7):728-34, 2013. PMCID: PMC3701724.
6. Holmes HM, Min LC, Yee M, Varadhan R, Basran J, Dale W, Boyd CM. Rationalizing prescribing for older patients with multimorbidity: considering time to benefit. Drugs Aging 30(9):655-66, 2013. PMCID: PMC3755031.
7. Baillargeon J, Wang Y, Kuo YF, Holmes HM, Goodwin JS, Sharma G. Temporal trends in hospitalization rates for older adults with chronic obstructive pulmonary disease. Am J Med 126(7):607-14, 2013. PMCID: PMC3837582.
8. Baillargeon J, Holmes HM. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Amer J Med 125(2):183-9, 2012. PMCID: PMC3712345.
9. Holmes HM, Luo R, Hanlon JT, Elting LS, Suarez-Almazor M, Goodwin JS. Ethnic disparities in adherence to antihypertensive medications of Medicare Part D beneficiaries. J Am Geriatr Soc 60(7):1298-303, 2012. PMCID: PMC3396714.
10. Morris GS, des Bordes JKA, Holmes HM, Giralt SA. Frailty and stem cell transplantation in the older cancer patient. J Geriatr Oncol 3:273-78, 2012.
11. American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Guiding principles for the care of older adults with multimorbidity: an approach for clinicians: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc 60(10):E1-E25, 2012. PMID: 22994865.
12. American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. Patient-centered care for older adults with multiple chronic conditions: a stepwise approach from the American Geriatrics Society: American Geriatrics Society Expert Panel on the Care of Older Adults with Multimorbidity. J Am Geriatr Soc 60(10):1957-68, 2012. PMID: 22994844.
13. Hurria A, Browner IS, Cohen HJ, Denlinger CS, deShazo M, Extermann M, Ganti AK, Holland JC, Holmes HM, Karlekar MB, Keating NL, McKoy J, Medeiros BC, Mrozek E, O'Connor T, Petersdorf SH, Rugo HS, Silliman RA, Tew WP, Walter LC, Weir AB, Wildes T. Senior adult oncology. J Natl Compr Canc Netw 10(2):162-209, 2012. PMCID: PMC3656650.
14. Hwang JP, Holmes HM, Kallen MA, Ensor J, Etchegaray J, Saab R, Arbuckle RB, King KM, Escalante CP. Accuracy of reporting current medications by cancer patients presenting to an emergency center. Support Care Cancer 18(10):1347-54, 2010. PMID: 19838868.
15. Tjia J, Rothman MR, Kiely DK, Shaffer ML, Holmes HM, Sachs GA, Mitchell SL. Daily medication use in nursing home residents with advanced dementia. J Am Geriatr Soc 58(5):880-8, 2010. PMCID: PMC2910133.
16. Morris GS, Grubbs EG, Hearon CM, Gantela S, Lee JE, Evans DB, Holmes HM, Busaidy NL, Jimenez C, Perrier ND. Parathyroidectomy improves functional capacity in "asymptomatic" older patients with primary hyperparathyroidism: a randomized control trial. Ann Surg 251(5):832-7, 2010. PMID: 20395857.
17. McPherson ML, Holmes HM. Precision pharmacopalliation: the Goldilocks approach to medication management at end of life. Progress in Palliative Care 18(3):140-6, 2010.
18. Holmes HM, Bain KT, Zalpour A, Luo R, Bruera E, Goodwin JS. Predictors of anticoagulation in hospice patients with lung cancer. Cancer 116(20):4817-24, 2010. PMCID: PMC3153417.
19. Holmes HM, Kaiser K, Jackson S, McPherson ML. Soliciting an herbal medicine and supplement use history at hospice admission. J Palliat Med 13(6):685-94, 2010. PMID: 20557233.
20. Holmes HM. Quality of life and ethical concerns in elderly thoracic surgery patients. Thorac Surg Clin 19(3):401-7, 2009. PMID: 20066951.
21. Holmes HM. Rational prescribing for patients with a reduced life expectancy. Clin Pharmacol & Ther 85(1):103-7, 2009. PMID: 19037198.
22. Holmes HM, Goodwin JS. Screening for prostate cancer in long-term care. Ann Long-Term Care 17(11):22-28, 2009.
23. Bain KT, Holmes HM, Beers MH, Maio V, Handler SM, Pauker SG. Discontinuing medications: a novel approach for revising the prescribing stage of the medication-use process. J Am Geriatr Soc 56(10):1946-1952, 2008. PMCID: PMC3119470.
24. Holmes HM, Sachs GA, Shega JW, Hougham GW, Cox Hayley D, Dale W. Integrating palliative medicine into the care of persons with advanced dementia: identifying appropriate medication use. J Am Geriatr Soc 56(7):1306-11, 2008. PMID: 18482301.
25. Scholz BA, Holmes HM, Marcus DM. Use of herbal medications in elderly patients. Annals of Long Term Care 16(12):24-8, 2008.
26. Pickens S, Burnett J, Naik AD, Holmes HM, Dyer CB. Is pain a significant factor in elder self-neglect? J Elder Abuse Negl 18(4):51-61, 2006. PMID: 17972659.
27. Alexander GC, Sayla MA, Holmes HM, Sachs GA. Prioritizing and stopping prescription medicines. CMAJ 174(8):1083-4, 2006. PMCID: PMC1421477.
28. Holmes HM, Hayley DC, Alexander GC, Sachs GA. Reconsidering medication appropriateness for patients late in life. Arch Intern Med 166(6):605-9, 2006. PMID: 16567597.

Invited Articles

1. Holmes HM. Polypharmacy. Clin Geriatr Med 28(2):xiii-xiv, 2012. PMID: 22500547.
2. Gokula M, Holmes HM. Tools to reduce polypharmacy. Clin Geriatr Med 28(2):323-41, 2012. PMID: 22500546.


1. Holmes HM, and Brauner DJ. Renal transplantation in the older patient: a case report and literature review. J Am Geriatr Soc 2004; 52(4): S71, 2004.
2. Holmes HM, Cox Hayley D, Hougham GW, Shega JW, Dale W, and Sachs GA. Overuse of medications in palliative care patients. J Am Geriatr Soc 2005 53(4): S63., 2005.
3. Scholz BA, Holmes HM, Marcus D. Herbals: Potentially inappropriate medicines in the elderly. Poster presentation at the Gerontological Society of America Annual Meeting. San Francisco, California, 2007.
4. Shin HS, Holmes HM, Bao R, Jiminez C, Evan D, Lee JE, Perrier N. Parathyroidectomy for elderly patients is safe. J Amer Coll Surg 207(35):S48, 2008.
5. Holmes HM, Bain KT, Luo R, Zalpour A, Bruera E, Goodwin JS. Anticoagulation in cancer patients in hospice. J Clin Oncol 27 suppl, 2009.
6. Holmes HM, Bain KT, Luo R, Zalpour A, Bruera E, Goodwin JS. Suboptimal anticoagulation in hospice patients with lung cancer. Support Care Cancer 17(967), 2009.
7. Holmes HM, Bain KT, Luo R, Bruera E, Suarez-Almazor, ME. Use of statins in patients with cancer in hospice care. Support Care Cancer 18(Suppl 3), 2010.
8. Holmes HM, Nguyen HT, Vidrine JI, Freedman RS, Theriault RL, Wetter DW, Elting LS. The burden of comorbid illness in cancer survivors in the United States. Support Care Cancer 19(Suppl 2):S196, 2011.
9. Holmes HM, Des Bordes JKA, Luo R, Kebriaei P, Yennu S, Mohile S. Abnormalities on comprehensive geriatric assessment in older persons prior to allogeneic stem cell transplantation. J Geriatr Oncol 2(Suppl 1):S44, 2011.
10. Holmes HM, des Bordes J, Kebriaei P, Luo R, Yennu S, Morris GS, Giralt S, Mohile S. Vulnerable elders survey and comprehensive geriatric assessment results in stem cell transplant patients. J Amer Geriatr Soc 61(Suppl 1):S35, 2013.

Book Chapters

1. Holmes HM. Dyslipidemia. In: Internal Medicine Issues in Palliative Cancer Care. Oxford University Press. In Press.
2. Steinman MA and Holmes HM. Principles of prescribing for older adults. In: Current Geriatric Diagnosis and Treatment. McGraw-Hill. In Press.
3. Holmes HM and Allbrand G. Organizing the geriatrician/oncologist partnership: one size fits all? Practical solutions. In: Interdisciplinary topics in gerontology: cancer and aging. 38. Karger, 132-8, 2013.
4. Holmes HM, Stein R. Alleviating psychological and spiritual pain in patients with life-limiting illness. In: UNIPAC Two, third edition: Glenview, IL, 2008.
5. Holmes HM, Shega JW. Vision Loss. In: Geriatric Clinical Advisor: Instant Diagnosis and Treatment. Elsevier: Philadelphia, PA, 2006.

Grant & Contract Support

Title: Utility of Medications for Patients with Cancer in Hospice Care
Funding Source: Hartford Foundation and the AGS Foundation for Health in Aging
Role: Principal Investigator
Duration: 7/2008 - 6/2010

Last updated: 7/8/2015