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Hong Dou, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Cardiology - Research, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Research Interests

Roles of ubiquitin and ubiquitin-like proteins in genomic stability and development of cancer.

Education & Training

Degree-Granting Education

2000 China Second Military Medical University, Shanghai, China, PHD, Biochemistry
1994 China Second Military Medical University, Shanghai, China, MS, Biochemistry

Postgraduate Training

2/2005-12/2007 Post-doctoral Fellow, The University of Texas Health Science Center at Houston Institute of Molecular Medicine, Houston, TX, Dr. Edward Yeh
2/2002-2/2005 Post-doctoral Fellow, The University of Texas Medical Branch at Galveston, Galveston, TX, Dr. Sankar Mitra

Selected Publications

Peer-Reviewed Original Research Articles
1. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET. Regulation of DNA Repair through De-SUMOylation and SUMOylation of Replication Protein a Complex. Mol Cell 39(3):333-345, 8/13/2010. PMCID: PMC2928994.
2. Dou H, Theriot CA, Das A, Hegde ML, Matsumoto Y, Boldogh I, Hazra TK, Bhakat KK, Mitra S. Interaction of the human DNA glycosylase Neil1 with proliferating cell nuclear antigen: the potential for replication-associated repair of oxidized bases in mammalian genomes. J Biol Chem 283(6):3130-40, 2/2008. e-Pub 11/2007. PMID: 18032376.
3. Ali M, Hazra T, Dou H, Kow YW. Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil. DNA Repair (Amst) 4(6):679-86, 6/2005. PMID: 15907775.
4. Zhang Z, Yang S, Dou H, Mao J, Li K. Expression, purification, and C-terminal amidation of recombinant human glucagon-like peptide-1. Protein Expr Purif 36(2):292-9, 8/2004. PMID: 15249052.
5. Dou H, Mitra S, Hazra TK. Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J Biol Chem 278(50):49679-84, 12/12/2003. e-Pub 9/30/2003. PMID: 14522990.
6. Wang Y, Dou H, Cao C, Zhang N, Ma J, Mao J, Wu H. Solution structure and biological activity of recombinant salmon calcitonin S-sulfonated analog. Biochem Biophys Res Commun 306(2):582-9, 6/2003. PMID: 12804605.
7. Xiu Z, Li M, Zhou S, Dou H, Zhou H, Chen C. A new method for the preparation of human parathyroid hormone 1-34 peptides. Biotechnol Appl Biochem 36(Pt 2):111-7, 2002. PMID: 12241552.
8. Zhang Z, Mao J, Dou H, Yang S. Expression of recombinant human glucagons like peptide-1 by high density culture of E.coli. Acad J Sec Mil Med Univ 23(3):254-256, 2002.
9. Zhang Z, Mao J, Dou H, Yang S. Cloning and expression of human glucagon-like peptide-1cDNA. Acad J Sec Mil Med Univ 22(4):361-363, 2001.
10. Hong D, Mingqiang Z, Min L, Changqing C, Jifang M. Production of recombinant salmon calcitonin by amidation of precursor peptide using enzymatic transacylation and photolysis in vitro. Biochem Biophys Res Commun 267(1):362-7, 1/7/2000. PMID: 10623625.
11. Dou H, Li M, Chen C, Mao J. High cell-density culture of E.coli TG1/pGEX-hCT and high expression of recombinant human calcitonin. Acad J Sec Mil Med Univ 21(3):213-215, 2000.
12. Dou H, Mao J, Wang G. Preparation of recombinant human calcitonin analogue by gene engineering. Chinese Journal of Biochemistry and Molecular Biology 16(4):468-472, 2000.
13. Wang G, Mao J, Dou H. Expression and purification of recombinant human clacitonin in E.coli. Acad J Sec Mil Med Univ 19(3):287-288, 1998.
14. Cai Z, Dou H, Mao J, Zou L, Ww J, Wang G. Chemical synthesis and cloninc of human calcitonin (hCT) cDNA. Acad J Sec Mil Med Univ 17(5):447-449, 1996.
15. Zou L, Mao J, Dou H, Wang G, Wu J, Cai Z. Construction of a new expression vector. Acad J Sec Mil Med Univ 17(4):133-134, 1996.
16. Dou H, Sha J., Wei Y. Study of Ca2+ -Mg2+ -ATPase activities, Ca2+ and H2O2 cytochemistry of renal cortex cell during early burn. Acad J Sec Mil Med Univ 17(2):141-144, 1996.
17. He L, Feng W, Zhao L, Dou H, Wei Y. Erythrocyte membrane protein and carbohydrates in hereditary ellipatocytosis. Acad J Sec Mil Med Univ 15(5):434-437, 1994.
18. Li Q, Li W., Dou H, et al. Study of clinic and biochemistry on hereditary ellipatocytosis. Chinese Journal of Hematology 15(8):417-418, 1994.

Book Chapters
1. Mitra S, Wiederhold L, Dou H, Izumi T, Hazra T. New Paradigms of DNA Excision Repair in Mammals. In: DNA Damage Recognition. Ed(s) W Siede, YW Kow, P Doetsch. Taylor & Francis Group, LLC, 403-417, 2006.

Last updated: 2/27/2013