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Hong Jiang, Ph.D.

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Blvd
Unit Number: 1002
Houston, TX 77030
Room Number: BSRB S5.8424
Phone: 713-834-6251
Fax: 713-834-6230
Email: hjiang@mdanderson.org

Education & Training

Degree-Granting Education

1997 Beijing Normal University, Beijing, China, PHD, Cell and Molecular Biology
1990 Wuhan University, Wuhan, China, BS, Virology and Molecular Biology

Postgraduate Training

8/1997-5/2001 Post-Doctoral Fellowship, Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, Dr. Li-Ying Yang

Experience/Service

Academic Appointments

Instructor, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 9/2003-6/2008
Research Associate, Department of Neuro-Oncology - Research, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 6/2001-8/2003

Honors and Awards

1997 Excellent Thesis Award, Beijing Normal University, Beijing, China

Selected Publications

Peer-Reviewed Original Research Articles

1. Jiang H,* White EJ, Ríos-Vicil CI, Xu J, Gomez-Manzano C, Fueyo J. Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity. J Virol 85(10):4720-9, 5/2011. e-Pub 3/2011. PMCID: PMC3126198.
2. Piao Y, Jiang H, Alemany R, Krasnykh V, Marini FC, Xu J, Alonso MM, Conrad CA, Aldape KD, Gomez-Manzano C, Fueyo J. Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther 16(3). e-Pub 10/2008. PMID: 18927600.
3. Alonso MM, Jiang H, Yokoyama T, Xu J, Bekele NB, Lang FF, Kondo S, Gomez-Manzano C, Fueyo J.. Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Mol Ther 16(3):487-493, 2/2008. e-Pub 2/2008. PMID: 18253154.
4. Jiang H, Gomez-Manzano C, Aoki H, Alonso MM, Kondo S, McCormick F, Xu J, Kondo Y, Bekele BN, Colman H, Lang FF, Fueyo J. Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death. J Natl Cancer Inst 99(18). e-Pub 9/2007. PMID: 17848677.
5. Alonso MM, Cascallo M, Gomez-Manzano C, Jiang H, Bekele BN, Perez-Gimenez A, Lang FF, Piao Y, Alemany R, Fueyo J. ICOVIR-5 shows E2F1-addiction and potent anti-glioma effect in vivo. Cancer Res 67(17):8255-8263, 9/2007. PMID: 17804740.
6. Olson MV, Johnson DG, Jiang H, Xu J, Alonso MM, Aldape KD, Fuller GN, Bekele BN, Yung WK, Gomez-Manzano C, Fueyo J. Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors. Cancer Res 67(9):4005-4007, 5/2007. PMID: 17483310.
7. Lee OK, Xu J, Fueyo J, Alonso MM, Liu D, Martin V, Jiang H, Piao Y, Liu TJ, Gomez-Manzano C. Angiopoietin-2 decreases vascular endothelial growth factor expression by modulating NIF-1a levels in gliomas. Oncogene 27(9):1310-1314, 2007. e-Pub 8/2007. PMID: 17704802.
8. Alonso MM, Gomez-Manzano C, Jiang H, Bekele NB, Piao Y, Yung WKA, Alemany R, Fueyo J.. Combination of the oncolytic adenovirus ICOVIR-5 with chemotherapy provides enhanced anti-glioma effect in vivo. Cancer Gene Ther 14(8):756-761, 2007. e-Pub 6/2007. PMID: 17557108.
9. Jiang H, Olson MV, Medrano DR, Lee OH, Xu J, Piao Y, Alonso MM, Gomez-Manzano C, Hung MC, Yung WK, Fueyo J. A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. Faseb J 20:2603-5, 12/2006. PMID: 17065226.
10. Jiang H, Alonso MM, Gomez-Manzano C, Piao Y, Fueyo J. Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas. Expert Rev Anticancer Ther 6(11):1585-92, 11/2006. PMID: 17134363.
11. Jiang H, McCormick F, Lang FF, Gomez-Manzano C, Fueyo J. Oncolytic adenoviruses as antiglioma agents. Expert Rev Anticancer Ther 6(5):697-708, 5/2006. PMID: 16759161.
12. Guo W, Zhu H, Zhang L, Davis J, Teraishi F, Roth JA, Stephens C, Fueyo J, Jiang H, Conrad C, Fang B. Combination effect of oncolytic adenovirotherapy and TRAIL gene therapy in syngeneic murine breast cancer models. Cancer Gene Ther 13(1):82-90, 1/2006. e-Pub 7/2006. PMCID: PMC1343537.
13. Gomez-Manzano C, Alonso MM, Yung WK, McCormick F, Curiel DT, Lang FF, Jiang H, Bekele BN, Zhou X, Alemany R, Fueyo J. Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan. Clin Cancer Res 12(2):556-62, 1/2006. PMID: 16428500.
14. Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, Yung WK, Gomez-Manzano C. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. J Natl Cancer Inst 97(21):1589-600, 11/2005. PMID: 16264179.
15. Jiang H, Alemany R, Gomez-Manzano C, Medrano DR, Lemoine MG, Olson MV, Alonso MM, Lee OH, Conrad CC, Yung WK, Fueyo J. Downmodulation of E1A protein expression as a novel strategy to design cancer-selective adenoviruses. Neoplasia 7(8):723-9, 8/2005. PMCID: PMC1501891.
16. Jiang H, Gomez-Manzano C, Alemany R, Medrano D, Alonso M, Bekele BN, Lin E, Conrad CC, Yung WK, Fueyo J. Comparative effect of oncolytic adenoviruses with E1A-55 kDa or E1B-55 kDa deletions in malignant gliomas. Neoplasia 7(1):48-56, 2005. PMID: 15720816.
17. Stolarek R, Gomez-Manzano C, Jiang H, Suttle G, Lemoine MG, Fueyo J. Robust infectivity and replication of Delta-24 adenovirus induce cell death in human medulloblastoma. Cancer Gene Ther 11(11):713-20, 11/2004. PMID: 15332115.
18. Gomez-Manzano C, Balague C, Alemany R, Lemoine MG, Mitlianga P, Jiang H, Khan A, Alonso M, Lang FF, Conrad CA, Liu TJ, Bekele BN, Yung WK, Fueyo J. A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 23(10):1821-8, 3/2004. PMID: 15014451.
19. Yang LY, Jiang H, Rangel KM, Plunkett W. Cisplatin-induced ubiquitination of RNA polymerase II large subunit and suppression of induction by 7-hydroxystaurosporine (UCN-01). Oncol Rep 10(5):1489-95, 9/2003. PMID: 12883729.
20. Jiang H, Conrad C, Fueyo J, Gomez-Manzano C, Liu TJ. Oncolytic adenoviruses for malignant glioma therapy. Front Biosci 8:d577-88, 5/2003. PMID: 12700119.
21. Fueyo J, Alemany R, Gomez-Manzano C, Fuller GN, Khan A, Conrad CA, Liu TJ, Jiang H, Lemoine MG, Suzuki K, Sawaya R, Curiel DT, Yung WK, Lang FF. Preclinical characterization of the antiglioma activity of a tropism-enhanced adenovirus targeted to the retinoblastoma pathway. J Natl Cancer Inst 95(9):652-60, 5/2003. PMID: 12734316.
22. Yang LY, Jiang H, Rangel KM. RNA polymerase II stalled on a DNA template during transcription elongation is ubiquitinated and the ubiquitination facilitates displacement of the elongation complex. Int J Oncol 22(3):683-9, 3/2003. PMID: 12579324.
23. Gomez-Manzano C, Fueyo J, Jiang H, Glass TL, Lee HY, Hu M, Liu JL, Jasti SL, Liu TJ, Conrad CA, Yung WK. Mechanisms underlying PTEN regulation of vascular endothelial growth factor and angiogenesis. Ann Neurol 53(1):109-17, 2003. PMID: 12509854.
24. Yang LY, Li L, Jiang H, Shen Y, Plunkett W. Expression of ERCC1 antisense RNA abrogates gemicitabine-mediated cytotoxic synergism with cisplatin in human colon tumor cells defective in mismatch repair but proficient in nucleotide excision repair. Clin Cancer Res 6(3):773-81, 3/2000. PMID: 10741696.
25. Jiang H, Yang LY. Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins. Cancer Res 59(18):4529-34, 9/1999. PMID: 10493501.
26. Jiang H, Feng J, Wang YC. Differential cell cycle regulation between V79 and V79-8 cells. Acta Anatomica Sinica 29(4):387-3896, 5/1998.
27. Jiang H, Feng J, Wang YC. Effect of p21Cip1 gene on the cell cycle regulation of V79-8 cells. Acta Anatomica Sinica 29(3):264-2697, 5/1998.
28. Jiang H, Feng J, Wang YC. P21 Cip1 antisense RNA inhibits the differentiation of HL-60 cells induced by all-trans retinoic acid. Progress in Natural Sciences 8(5):513-5205, 5/1998.
29. Jiang H, Wang YC. Mechanism of cell cycle regulation. Trends in Cell Biology 2:1-16 9, 4/1998.
30. Jiang H, Wang YC. Research progress in cyclin-dependent kinase inhibitor p21Cip1. Progress in Physiological Science 29(4):339-3418, 4/1998.
31. Jiang H, Wang YC. Cyclin-dependent kinase inhibitors in mammalian cells. Progress in Physiological Science 27(2):107-112, 4/1996.

Invited Articles

1. Jiang H, White EJ, Gomez-Manzano C, Fueyo J.. Adenovirus's last trick: You say lysis, we say autophagy. Autophagy 4(1):118-20, 2008. e-Pub 11/2007. PMID: 18032923.
2. Gomez-Manzano C, Alonso M, Jiang H, Fueyo J. Interspecies adenovirus fiber shows "evolutionary" advantage for oncolytic therapy of gliomas. Cancer Biol Ther 11(7):794-6, 2008. PMID: 18756625.
3. Jiang H, Conrad C, Fueyo J, Gomez-Manzano C, Liu TJ. Oncolytic adenoviruses for malignant glioma therapy. Front Biosci 8:577-588, 2003.

Abstracts

1. Jiang H, White E, Gumá S, Ji Y, Gomez-Manzano C, Conrad CA, Fueyo J. Enhanced oncolysis of glioma cells by Delta-24-RGD combining with 2-deoxyglucose through autophagic cell death. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; (#3785), 4/2009.
2. White EJ, Jiang H, Xu J, Gomez-Manzano C, Fueyo J. Involvement of autophagy in oncolysis: E1A is required but not sufficient. Proceedings of the 100th Annual Meeting of the American Association for Cancer Research; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; (#774), 4/2009.
3. Jiang H, Xu X, Lang F, Colman H, Gomez-Manzano C, Bogler O, Latha K, Yung WKA, Fueyo J. Delta-24-RGD induces autophagy in brain tumor stem cells and prolongs survival in glioma-bearing mice. 99th AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA (#3304), 4/2008.
4. Jiang H, Gomez-Manzano C, Yokoyama T, Alonso MM, Kondo S, Xu J, Bekele BN, Colman H, Lang FF, Fueyo J. Oncolytic adenovirus Delta-24-RGD induces efficacious antiglioma activity in brain tumor stem cell models. 12th Annual Meeting of the Society for Neuro-Oncology (SNO), In: Neuro Oncol, 11/2007.
5. Piao Y, Jiang H, Xu J, Alonso M, Lee OH, Conrad C, Yung WKA, Gomez-Manzano C, Fueyo J. Delta24-RIVER oncolytic adenovirus: targeting mutant EGFR glioma cells. 98th AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA (#3297), 4/2007.
6. Jiang H, Aoki H, Lee OH, Kondo S, Lang F, Yung WKA, Colman H, Gomez-Manzano C, Fueyo J. Cancer stem cells undergo autophagy after infection with oncolytic adenoviruses. 59th Annual Symposium on Cancer Research, 10/2006.
7. Alonso MM, Gomez-Manzano C, Lee OH, Jiang H, Piao Y, Alemany R, Lang F, Yung WKA, Fueyo J. Oncolytic strategies to target brain tumor stem cells and overcome MGMT-mediated temozolomide resistance. 59th Annual Symposium on Cancer Research, 10/2006.
8. Piao Y, Jiang H, Xu J, Ji YJ, Gomez-Manzano C, Conrad C, Fueyo J. Targeting mutant EGF receptor for glioma therapy using oncolytic adenoviruses. 10th Annual Trainee Recognition Day & Research Exposition, 5/2006.
9. Jiang H, Olson MV, Xu J, Lee OH, Piao Y, Yung WKA, Fueyo J. Exportin 1-mediated nuclear export of adenovirus E1A protin: A novel target for generation of oncolytic viruses. Proc Amer Assoc Cancer Res 47:702-a (#2981), 4/2006.
10. Olson MV, Johnson DG, Aldape K, Fuller GN, Jiang H, Alonso MM, Yung WKA, Guha A, Gomez-Manzano C, Fueyo J. Transgenic mouse model provides the first direct evidence supporting the oncogenic role of E2F1 in brain. Proc Amer Assoc Cancer Res 47:643 (#2735), 4/2006.
11. Olson M, Medrano D, Jiang H, Gomez-Manzano C, Alonso M, Aldape K, Price R, Yung WKA, Fueyo J. Developmental abnormalities and oncogenesis in the brain of a transgenic E2F1 mouse model. Neuro-Oncology 7:289, 5/2005.
12. Olson M, Jiang H, Medrano D, Gomez-Manzano C, Aldape K, Fueyo J. GFAP-E2F1 transgenic mouse provides the first evidence of an oncogenic role of E2F1 in brain tumor formation. Keystone Conferences: Cellular Senescence and Cell Death, Keystone, Colorado, 5/2005.
13. Jiang H, Medrano D, Gomez-Manzano C, Lemoine M, Alemany R, Olson M, Alonso M, Conrad C, Yung WKA, Fueyo J. Downmodulation of E1A Protein Expression as a Novel Strategy to Design Cancer Selective Adenoviruses. 96th annual meeting AACR, Anaheim, 4/2005.
14. Olson MV, Alonso M, Medrano D, Sheng X, Gomez-Manzano C, Jiang H, Yung WKA, Fueyo J. E2F1 transcriptionally activates PTEN. 96th annual meeting AACR, Anaheim, 4/2005.
15. Alonso M, Alemany R, Gomez-Manzano C, Yung WKA, Jiang H, Fueyo J. Icovir-2, an old friend with a new face: E2F-1 mediated glioma selectivity for Delta24-RGD. Neuro-Oncology 7:377, 4/2005.
16. Alonso M, Alemany R, Gomez-Manzano C, Yung WKA, Jiang H, Fueyo J. Oncolytic adenovirus Icovir-2 shows improved therapeutic index than D24-RGD for glioma. 96th annual meeting AACR, Anaheim, 4/2005.
17. Jiang H, Alemany R, Gomez-Manzano C, Yung WK, Sawaya R, Lang FF, Fueyo J. Comparison of the Antiglioma Effect of E1A and E1B-55kD-Mutant Oncolytic Adenoviruses. [Oral Presentation] 2004 AANS/CNS Section on tumors Sixth Biennal Sattelite Symposium, San Francisco, 8/2004.
18. Medrano D, Jiang H, Gomez-Manzano C, Olson M, Lemoine M, Yung WKA, Fueyo J. Replication-competent adenoviruses with impaired p300/CBP binding express low E1A protein levels: implications for oncolytic therapy. 8th Annual trainee recognition day and research exposition. UTMDACC, Houston, 5/2004.
19. Medrano D, Jiang H, Johnson DG, Aldape K, Olson M, Gomez-Manzano C, Fueyo J. Transgenic overexpression of E2F1 in the brain in E2F4 null background results in severe hydrocephalus similar to E2F5 null mice. Special AACR Conference on Cell Cycle and Cancer: Pathways and Therapies, Fort Lauderdale, Florida, 5/2004.
20. Alonso MM, Gomez-Manzano C, Aldape K, Jiang H, Xu J, Kondo Y, Fueyo J. E2F1 upregulates telomerase: cell-cycle related telomerase activity in sarcoma cells. 95th. Annual Meeting, American Association for Cancer Research, Orlando, FL, 3/2004.
21. Jiang H, Gomez-Manzano C, Medrano D, Cass A, Alonso M, Alemany R, Yung WKA, Fueyo J. The level of E1A as a factor for tumor selectivity in oncolytic adenoviruses. 95th. Annual Meeting, American Association for Cancer Research, Orlando, FL, 3/2004.
22. Jiang H, Medrano D, Gomez-Manzano C, Courmier F, Yung WKA, Fueyo J. Replication competent adenoviruses with impaired p300/CBP binding express low E1A proteins levels: implication for oncolytic therapy. Neuro-Oncology 5:301-302, 3/2003.
23. Gomez-Manzano C, Jiang H, Stolarek R, Lang FF, Yung WK, Fuller GN, Fueyo J. U-87 MG Animal Model: predictability of growth kinetics and its use in oncolytic therapy for gliomas. Special AACR meeting, Orlando, FL, 2/2003.
24. Fueyo J, Gomez-Manzano C, Jiang H, Lemoine M, Stolarek R, Courmier F, Jasti S, Conrad C, Yung WKA. Oncolytic adenoviruses, CPT-11, and topoisomerase I: Mechanisms underlying chemosensitization. Neuro-Oncology 4:322, 9/2002.
25. Fueyo J, Gomez-Manzano C, Alemany R, Lemoine MG, Stolarek R, Jasti S , Courmier F, Jiang H, Lamfers M, Dirven C, Curiel DT, Yung WK. Oncolytic adenoviruses for gliomas therapy. 5th Congress of the European Association for Neuro-Oncology. Florence, Italy, 9/2002.

Book Chapters

1. Gomez-Manzano C, Jiang H, Alonso MM, Yung WKA, Fueyo J. Gene Therapy. In: Neuro-Oncology. In series: Handbook of Clinical Neurology, 3rd ed. Ed(s) W Grisold, R Siffietti. Elsevier: Edinburgh, UK. In Press.
2. Jiang H, White EJ, Conrad C, Gomez-Manzano C, Fueyo J. Autophagy pathways in glioblastoma. In: Methods in Enzymology: Autophagy in Disease and Clinical Applications. 453, Part C. Ed(s) DL Klionsky. Academic Press, 273-86, 2009. ISBN: 0123749360, 978-0123749369.
3. Alonso MM, Gomez-Manzano C, Alemany R, Jiang H, McCormick F, Fueyo J. Conditionally replicative adenoviruses as antitumoral agents: Past, present and future. In: Cancer and Gene Therapy. Ed(s) PL Hermonat. Transworld Research Network: Kerala, India, 41-54, 2007. ISBN: 8178952521, 978-8178952529.
4. Jiang H, McCormick F, Gomez-Manzano C, Curiel DT, Lang FF, Yung WKA, Fueyo J. Replicating viruses for brain tumor treatment. In: Gene Therapy for Neurological Disorders. Ed(s) MG Castro, PR Lowenstein. Taylor and Francis Group: New York, NY, 293-326, 2006. ISBN: 0824728475, 978-0824728472.
5. Stolarek R, Fueyo J, Gomez-Manzano C, Jiang H, Yung WKA. Gene Therapy for Gliomas: Targeting the Cancer Genome. In: Genomic and Molecular Neuro-Oncology. In series: Molecular Oncology and Cancer Genomics. Ed(s) W Zhang, GN Fuller. Jones and Bartlett Publishers: Sudbury, MA, 281-302, 2003. ISBN: 0763722618, 978-0763722616.

Books (edited and written)

1. Jiang H, Li R. Reforming of Life. In: An Introduction to Genetic Engineering. Hainan Publishing House: China, 1993.

Last updated: 8/6/2013