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Hui-Lin Pan, M.D., Ph.D.

Present Title & Affiliation

Primary Appointment

NG and Helen T Hawkins Distinguished Professor (with tenure) and Deputy Division Head for Research, Department of Anesthesiology and Perioperative Medicine - Research, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX
Graduate Faculty Member, Program in Neuroscience, Program in Experimental Therapeutics, The University of Texas Graduate School of Biomedical Science, Houston, TX

Research Interests

  1. Cellular and molecular mechanisms of pain transduction and transmission; circuitry and plasticity of the spinal dorsal horn associated with chronic neuropathic pain.
  2. Regulation of excitatory and inhibitory synaptic transmision in the spinal cord, brainstem and hypothalamus.
  3. Visceral pain and sensory innervation of visceral organs.
  4. Integrative control of central sympathetic drive in hypertension.
  5. Signaling transduction mechanisms involved in opioid tolerance and G protein-coupled receptors.
  6. Regulation of voltage-and ligand-gated ion channels in primary sensory neurons and spinal dorsal horn neurons.

Office Address

The University of Texas MD Anderson Cancer Center
1515 Holcombe Boulevard
Department of Anesthesiology & Perioperative Medicine - Research
Unit Number: 110
Houston, TX 77030
Room Number: Y6.5825
Phone: 713-563-5838
Fax: 713-745-2956
Email: huilinpan@mdanderson.org

Education & Training

Degree-Granting Education

1991 Tongji Medical University, Wuhan, China, PHD, Pathophysiology
1988 Tongji Medical University, Wuhan, China, MS, Neurobiology
1982 Qingdao Medical College, Qingdao, China, MD, Medicine

Postgraduate Training

9/1991-9/1994 Postdoctoral Fellow, Cardiovascular and Neurophysiology, University of California, Davis, CA

Experience/Service

Academic Appointments

Director, Division of Anesthesiology and Critical Care, Center for Neuroscience and Pain Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 9/2011-present
Schumpert Medical Center Endowed Chair and Vice Chairman for Research, Department of Neurosurgery, Louisiana State University Health Sciences Center, (declined), Shreveport, LA, 2/2005
Professor, Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey, PA, 10/2003-1/2006
Julien F. Biebuyck Professor (with tenure) and Director of Basic Research in Anesthesiology, Department of Anesthesiology, Pennsylvania State University College of Medicine, Hershey, PA, 7/2003-1/2006
Associate Professor and Director of Basic Research in Anesthesiology, Departments of Anesthesiology and Perioperative Medicine - Research and Neuroscience & Anatomy, Division of Basic Science Research, Pennsylvania State University College of Medicine, Hershey, PA, 7/2000-6/2003
Assistant Professor, Anesthesiology and Physiology & Pharmacology, Wake Forest University School of Medicine, Winston-Salem, NC, 7/1996-6/2000
Instructor, Beth-Israel Hospital, Harvard Medical School, (declined), Boston, MA, 4/1996
Assistant Research Physiologist, Cardiovascular Medicine, University of California School of Medicine, Davis, CA, 10/1994-6/1996
Attending Physician, Internal Medicine, Xinwen Central Hospital, Shandong, China, 8/1982-8/1985

Administrative Appointments/Responsibilities

Deputy Division Head for Research, Department of Anesthesiology and Perioperative Medicine - Research, Division of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX, 2/2006-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Ye ZY, Li DP, Li L, Pan HL. Protein kinase CK2 increases glutamatergic input in the hypothalamus and sympathetic vasomotor tone in hypertension. J Neurosci 31(22):8271-9, 6/2011. PMCID: PMC3123887.
2. Chen SR, Chen H, Yuan WX, Pan HL. Increased presynaptic and postsynaptic a2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy. J Pharmacol Exp Ther 337(1):285-92, 4/2011. e-Pub 1/2011. PMCID: PMC3063741.
3. Zhou HY, Chen SR, Chen H, Pan HL. Functional Plasticity of Group II Metabotropic Glutamate Receptors in Regulating Spinal Excitatory and Inhibitory Synaptic Input in Neuropathic Pain. J Pharmacol Exp Ther 336(1):254-64, 1/2011. e-Pub 10/2010. PMCID: PMC3014296.
4. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem 285(52):40427-37, 12/2010. e-Pub 10/2010. PMCID: PMC3003341.
5. Zhang J, Chen L, Su T, Cao F, Meng X, Pei L, Shi J, Pan HL, Li M. Electroacupuncture Increases CB2 Receptor Expression on Keratinocytes and Infiltrating Inflammatory Cells in Inflamed Skin Tissues of Rats. J Pain 11(12):1250-1258, 12/2010. e-Pub 6/2010. PMID: 20627823.
6. Li DP, Pan HL. Role of GABAB receptors in autonomic control of systemic blood pressure. Adv Pharmacol 58:257-86, 2010. PMID: 20655486.
7. Chen SR, Cai YQ, Pan HL. Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. J Neurochem 110(1). e-Pub 4/30/2009. PMID: 19457113.

Invited Articles

1. Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol 4(3):379-388, 5/2011. PMCID: PMC3113704.

Last updated: 11/20/2013