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Izabela D. Fokt, Ph.D.

Present Title & Affiliation

Primary Appointment

Instructor, Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

1993 Silesian Technical University, Gliwice, Poland, PHD, Chemistry
1987 Silesian Technical University, Gliwice, Poland, Msc, Organic Chemistry

Honors and Awards

1993 Scholarship of the Foundation of Polish Science
1990 Polish Academy Science
1989 National Education Minister

Professional Memberships

American Chemical Society
Member, 1999-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Fokt I, Szymanski S, Skora S, Cybulski M, Madden T, Priebe W. D-Glucose- and D-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2halo-D-glucoses and -D-mannoses. Carbohydr Res 344(12):1464-1473, 8/17/2009. e-Pub 6/21/2009. NIHMSID: NIHMSNIHMS125973.
2. Kong LY, Wei J, Sharma AK, Barr J, Abou-Ghazal MK, Fokt I, Weinberg J, Rao G, Grimm E, Priebe W, Heimberger AB. A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells. Cancer Immunol Immunother 58(7):1023-32, 7/2009. e-Pub 11/11/2008. PMCID: PMC2674523.
3. Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE, Sampson JH, Priebe W, Heimberger AB. A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res 14(18):5759-68, 9/15/2008. PMCID: PMC2583362.
4. Corvis Y, Korchowiec B, Korchowiec J, Badis M, Mironiuk-Puchalska E, Fokt I, Priebe W, Rogalska E. Complexation of metal ions in Langmuir films formed with two amphiphilic dioxadithia crown ethers. J Phys Chem B 112(35):10953-63, 9/4/2008. e-Pub 8/12/2008. PMID: 18698707.
5. Gruber BM, Anuszewska EL, Bubko I, Kasprzycka-Guttman T, Misiewicz I, Skupinska K, Fokt I, Piebe W. NFkappaB activation and drug sensitivity in human neoplastic cells treated with anthracyclines. Acta Pol Pharm 65(2):267-71, Mar-Apr, 3/2008. PMID: 18666436.
6. Antonovic L, Johansen M, Fokt I, Szymanski S, Conrad C, Priebe W, Madden T. 2-Deoxy-D-glucose induces Type II cell death in pancreatic cancer. Molecular Cancer Therapeutics 6(12):3443S, Part 2, 12/2007.
7. Antonovic L, Fokt I, Szymanski S, Conrad C, Priebe W, Madden T. Inhibition of glycolysis and induction of autophagy in gliomas by 2-fluoro-deoxy-D-glucose. Molecular Cancer Therapeutics 6(12):3443S-3443S, 12/2007.
8. Schroeder C, Fokt I, Johansen M, Rhea R, Allen TL, Madden T, Priebe W. WP760, a new DNA-binding agent with unique melanoma selectivity. Molecular Cancer Therapeutics 6(12):3407S-3407S, 12/2007.
9. Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res 67(20):9630-6, 10/15/2007. PMID: 17942891.
10. Kong LY, Hussain SF, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. A novel small molecule inhibitor of STAT3 reverses immune tolerance in malignant glioma patients. Neuro-Oncology 9(4):507, 10/2007.
11. Zheng M, Priebe W, Walch ET, Roth KG, Han M, Tang CH, Lee S, Poindexter NJ, Fokt I, Grimm EA. WP760, a melanoma selective drug. Cancer Chemother Pharmacol 60(5):625-633, 10/2007. e-Pub 12/29/2006. PMID: 17195067.
12. Bidwell GL, Davis AN, Fokt I, Priebe W, Raucher D. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest New Drugs 25(4):313-26, 8/2007. e-Pub 5/2007. PMID: 17483874.
13. Gruber BM, Anuszewska EL, Bubko I, Gozdzik A, Fokt I, Priebe W. Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells. Arch Immunol Ther Exp (Warsz) 55(3):193-8, May-Jun, 5/2007. e-Pub 6/8/2007. PMCID: PMC2765644.
14. Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, Hess K, Conrad C, Madden T, Sawaya R, Kondo S, Priebe W, Kondo Y. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene 26(17):2435-44, 4/12/2007. e-Pub 10/16/2006. PMID: 17043651.
15. Bidwell GL, Fokt I, Priebe W, Raucher D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem Pharmacol 73(5):620-31, 3/1/2007. e-Pub 11/10/2006. PMID: 17161827.
16. Bidwell P, Gene L, Fokt I, Priebe W, Raucher D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubin. Biochemical Pharmacology 73(5):620-631, 2007.
17. Lampidis TJ, Kurtoglu M, Maher JC, Liu H, Krishan A, Sheft V, Szymanski S, Fokt I, Rudnicki WR, Ginalski K, Lesyng B, Priebe W. Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing 'hypoxic tumor cells'. Cancer Chemother Pharmacol 58(6):725-36, 12/2006. e-Pub 3/23/2006. PMID: 16555088.
18. Gruber BM, Anuszewska EL, Roman I, Gozdzik A, Priebe W, Fokt I. Topoisomerase II alpha expression and cytotoxicity of anthracyclines in human neoplastic cells. Acta Pol Pharm 63(1):15-8, Jan-Feb, 1/2006. PMID: 17515324.
19. Iwamaru A, Szymanski S, Fokt I. Inhibition of STAT3 by WP1066 a novel tyrosine kinase inhibitor in malignant glioma cells in vitro and in vivo. Clinical Cancer Research 11(24):9021S-9021S Part 2 Suppl. S, 2005.
20. Fanale MA, Liu Y, McKenzie TS, Fokt I, Priebe W. Investigation of whether expression of bcl-2 influences the apoptotic response of doxorubicin-resistant breast cancer cells to a novel anthracycline. Journal of Clinical Oncology 23(16):155S-155S, part 1, Suppl. S, 2005.
21. Grynkiewicz G, Fokt I, Skibicki P, Przewloka T, Szeja W, Priebe W. Synthesis of 1-O-Silylated 3-Azido- and 3-N-Trifluoroacetamido-2,3,6-trideoxy-L-arabino and L-lyxo-hexapyranoses, Convenient Glycosyl Donors for Preparation of Anthracycline Antibiotics and Related DNA-Binding Agents. Polish J. Chem. 79:335-347, 2005.

Last updated: 8/22/2013