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Jagannadha K. Sastry, Ph.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Veterinary Sciences, The University of Texas MD Anderson Cancer Center - Science Park, Bastrop, TX

Office Address

The University of Texas MD Anderson Cancer Center
7455 Fannin Street
Unit Number: 902
Houston, TX 77054
Room Number: SCR4.2013

Education & Training

Degree-Granting Education

1981 National Dairy Research Institute, Karnal, India, PHD, Microbiology
1974 G.B. Pant University of Agriculture and Technology, Pantnager, India, MS, Microbiology
1972 Andhra University, Andhra Pradesh, India, BS, Biology/Chemistry

Postgraduate Training

1981-1984 Postdoctoral Research Associate, Microbiology, The University of Texas Medical Branch, Galveston, TX
1979-1981 Postdoctoral Research Associate, Biology, Purdue University, West Lafayette, IN

Experience/Service

Academic Appointments

Regular Member, Graduate School of Biomedical Sciences, Graduate Faculty, University of Texas Health Science Center, Houston, TX, 9/1993-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Hutchison AT, Schmitz JE, Miller CJ, Sastry KJ, Nehete PN, Major AM, Ansari AA, Tatevian N, Lewis DE. Increased inherent intestinal granzyme B expression may be associated with SIV pathogenesis in Asian non-human primates. J Med Primatol 40(6):414-26, 12/2011. e-Pub 7/2011. PMCID: PMC3193863.
2. He H, Nehete PN, Nehete B, Wieder E, Yang G, Buchl S, Sastry KJ. Functional impairment of central memory CD4 T cells is a potential early prognostic marker for changing viral load in SHIV-infected rhesus macaques. PLoS One 6(5):e19607, 2011. e-Pub 5/2011. PMCID: PMC3094340.
3. He H, Courtney AN, Wieder E, Sastry KJ. Multicolor flow cytometry analyses of cellular immune response in rhesus macaques. J Vis Exp(38), 2010. PMID: 20414189.
4. Qin H, Nehete PN, He H, Nehete B, Buchl S, Cha SC, Sastry JK, Kwak LW. Prime-boost vaccination using chemokine-fused gp120 DNA and HIV envelope peptides activates both immediate and long-term memory cellular responses in rhesus macaques. J Biomed Biotechnol 2010:860160, 2010. PMCID: PMC2864514.
5. Courtney AN, Nehete PN, Nehete BP, Thapa P, Zhou D, Sastry KJ. Alpha-galactosylceramide is an effective mucosal adjuvant for repeated intranasal or oral delivery of HIV peptide antigens. Vaccine 27(25-26):3335-41, 2009. PMID: 19200849.
6. Weaver EA, Nehete PN, Buchl SS, Senac JS, Palmer D, Ng P, Sastry KJ, Barry MA. Comparison of replication-competent, first generation, and helper-dependent adenoviral vaccines. PLoS One 4(3):e5059, 2009. PMCID: PMC2659436.
7. Thapa P, Zhang G, Xia C, Gelbard A, Overwijk WW, Liu C, Hwu P, Chang DZ, Courtney A, Sastry JK, Wang PG, Li C, Zhou D. Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy. Vaccine 27(25-26):3484-8, 2009. PMID: 19200815.
8. Weaver EA, Nehete PN, Nehete BP, Buchl SJ, Palmer D, Montefiori DC, Ng P, Sastry KJ, Barry MA. Protection against Mucosal SHIV Challenge by Peptide and Helper-Dependent Adenovirus Vaccines. Viruses 1(3):920-938, 2009. PMCID: PMC2811377.
9. Fontenot D, He H, Hanabuchi S, Nehete PN, Zhang M, Chang M, Nehete B, Wang YH, Wang YH, Ma ZM, Lee HC, Ziegler SF, Courtney AN, Miller CJ, Sun SC, Liu YJ, Sastry KJ. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc Natl Acad Sci U S A 106(39):16776-81, 2009. PMCID: PMC2757857.
10. Wang-Johanning F, Radvanyi L, Rycaj K, Plummer JB, Yan P, Sastry KJ, Piyathilake CJ, Hunt KK, Johanning GL. Human endogenous retrovirus K triggers an antigen-specific immune response in breast cancer patients. Cancer Res 68(14):5869-77, 2008. PMID: 18632641.
11. Magnus S, White R, Aymeric P, Sastry KJ, Morris G, Grant C, Elder J.. Mapping of the CXCR4 Binding site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein. J Virol 82(18):9134-42, 2008. PMCID: PMC2546885.
12. Nehete PN, Nehete BP, Hill L, Manuri PR, Baladandayuthapani V, Feng L, Simmons J, Sastry KJ. Selective induction of cell-mediated immunity and protection of rhesus macaques from chronic SHIV(KU2) infection by prophylactic vaccination with a conserved HIV-1 envelope peptide-cocktail. Virology 370(1):130-41, 2008. PMCID: PMC2196441.
13. Fontenot D, Jones JK, Hossain MM, Nehete PN, Vela EM, Dwyer VA, Sastry KJ. Critical role of Arg59 in the high-affinity gp120-binding region of CD4 for human immunodeficiency virus type 1 infection. Virology 363(1):69-78, 2007. PMID: 17320923.
14. Fontenot D, Hollander P, Vela E, Newman R, Sastry JK, Kumar R. Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells. Biochem Biophys Res Commun 363(4):901-907, 2007. PMID: 17919453.
15. Manuri P, Nehete B, Nehete P, Reisenauer R, Wardell S, Courtney A, Gambhira R, Lomada D, Chopra A, Sastry KJ. Intranasal immunization with synthetic peptides corresponding to the E6 and E7 oncoproteins of human papillomavirus type 16 induces systemic and mucosal cellular immune responses and tumor protection. Vaccine 25:3302-3310, 2007. PMCID: PMC2043498.
16. Mercier G, Nehete P, Passeri M, Templeton N, Nehete B, Weaver E, Schluns K, Buchi S, Sastry KJ, Barry M.. Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules. Vaccine 25:8687-8701, 2007. PMCID: PMC2225545.
17. de Parseval A, Grant CK, Sastry KJ, Elder J.. Sequential CD134-CXCR4 Interactions in Feline Immunodeficiency Virus (FIV): Soluble CD134 Activates FIV Env for CXCR4-Dependent Entry and Reveals a Cryptic Neutralization Epitope. J Virol 80(80):3088-3091, 2006. PMCID: PMC1395450.
18. Hamada K, Sakaue M, Sarkar A, Buchi S, Satterfield W, Keeling M, Sastry KJ, Roth JA, Follen M.. Immune responses to repetitive adenovirus-mediated gene transfer and restoration of gene expression by cyclophosphamide or etoposide. Gynecol Oncol 99(3 Suppl 1):S177-86, 2005. PMID: 16214207.
19. Sarkar AK, Tortolero-Luna G, Follen M, Sastry KJ. Inverse correlation of cellular immune responses specific to synthetic peptides from the E6 and E7 oncoproteins of HPV-16 with recurrence of cervical intraepithelial neoplasia in a cross-sectional study. Gynecol Oncol 99(3 Suppl 1):S251-61, 2005. PMID: 16188303.
20. Nehete PN, Nehete BP, Manuri P, Hill L, Palmer JL, Sastry KJ. Protection by dendritic cells-based HIV synthetic peptide cocktail vaccine: preclinical studies in the SHIV-rhesus model. Vaccine 23(17-18):2154-9, 2005. PMID: 15755586.
21. Hill LR, Nehete PN, Schapiro SJ, Nehete BP, Sastry KJ. SHIV transmission and susceptibility to re-exposure through social contact following vaccination with an HIV synthetic peptide-cocktail: a case study. J Med Primatol 33(1):10-5, 2/2004. PMID: 15061727.
22. Lomada D, Gambhira R, Nehete PN, Guhad FA, Chopra AK, Peterson JW, Sastry KJ. A two-codon mutant of cholera toxin lacking ADP-ribosylating activity functions as an effective adjuvant for eliciting mucosal and systemic cellular immune responses to peptide antigens. Vaccine 23(4):555-65, 2004. PMID: 15530705.
23. Starost MF, Hill LR, Nehete PN, Sastry KJ. Extramedullary hematopoiesis in the mandibular lymph node of simian-human immunodeficiency virus-infected rhesus monkeys (Macaca mulatta): a report of three cases. Vet Pathol 41(2):186-90, 2004. PMID: 15017035.
24. Nehete PN, Gambhira R, Nehete BP, Sastry KJ. Dendritic cells enhance detection of antigen-specific cellular immune responses by lymphocytes from rhesus macaques immunized with an HIV envelope peptide cocktail vaccine. J Med Primatol 32(2):67-73, 2003. PMID: 12823628.
25. Keeney TS, Nomura LE, Maecker HT, Sastry KJ. Flow cytometric analysis of macaque whole blood for antigen-specific intracellular cytokine production by T lymphocytes. J Med Primatol 32(1):23-30, 2003. PMID: 12733599.
26. Nehete PN, Vela EM, Hossain MM, Sarkar AK, Yahi N, Fantini J, Sastry KJ. A post-CD4-binding step involving interaction of the V3 region of viral gp120 with host cell surface glycosphingolipids is common to entry and infection by diverse HIV-1 strains. Antiviral Res 56(3):233-51, 2002. PMID: 12406507.
27. Dolbier CL, Cocke RR, Leiferman JA, Steinhardt MA, Schapiro SJ, Nehete PN, Perlman JE, Sastry KJ. Differences in functional immune responses of high vs. low hardy healthy individuals. J Behav Med 24(3):219-29, 2001. PMID: 11436543.
28. Sastry KJ, Nehete PN, Savary CA. Impairment of antigen-specific cellular immune responses under simulated microgravity conditions. In Vitro Cell Dev Biol Anim 37(4):203-8, 2001. PMID: 11409684.
29. Nehete PN, Chitta S, Hossain MM, Hill L, Bernacky BJ, Baze W, Arlinghaus RB, Sastry KJ. Protection against chronic infection and AIDS by an HIV envelope peptide-cocktail vaccine in a pathogenic SHIV-rhesus model. Vaccine 20(5-6):813-25, 2001. PMID: 11738745.
30. Schapiro SJ, Nehete PN, Perlman JE, Sastry KJ. A comparison of cell-mediated immune responses in rhesus macaques housed singly, in pairs, or in groups. Appl Anim Behav Sci 68(1):67-84, 2000. PMID: 10771316.
31. Sarkar AK, Mitchell MF, Hamada K, Buchl SJ, Satterfield WC, Schapiro SJ, Keeling ME, Sastry KJ. Evaluation of cellular immune responses in rhesus monkeys subjected to adenovirus-mediated gene transfer into the cervix. Cancer Gene Ther 6(3):220-7, 1999. PMID: 10359207.
32. Nehete PN, Schapiro SJ, Johnson PC, Murthy KK, Satterfield WC, Sastry KJ. A synthetic peptide from the first conserved region in the envelope protein gp160 is a strong T-cell epitope in HIV-infected chimpanzees and humans. Viral Immunol 11(3):147-58, 1998. PMID: 9918406.
33. Schapiro SJ, Nehete PN, Perlman JE, Bloomsmith MA, Sastry KJ. Effects of dominance status and environmental enrichment on cell-mediated immunity in rhesus macaques. Appl Anim Behav Sci 56:319-32, 1998.
34. Oka T, Sastry KJ, Nehete P, Schapiro SJ, Guo JQ, Talpaz M, Arlinghaus RB. Evidence for specific immune response against P210 BCR-ABL in long-term remission CML patients treated with interferon. Leukemia 12(2):155-63, 1998. PMID: 9519777.
35. Nehete PN, Lewis DE, Tang DN, Pollack MS, Sastry KJ. Presence of HLA-C-restricted cytotoxic T-lymphocyte responses in long-term nonprogressors infected with human immunodeficiency virus. Viral Immunol 11(3):119-29, 1998. PMID: 9918403.
36. Nehete PN, Johnson PC, Schapiro SJ, Arlinghaus RB, Sastry KJ. Cross-reactive T-cell proliferative responses to V3 peptides corresponding to different geographical HIV-1 isolates in HIV-seropositive individuals. J Clin Immunol 16(2):115-24, 1996. PMID: 8690775.
37. Casement KS, Arlinghaus KB, Sastry KJ. Cytotoxic T-lymphocyte response induced by a V3 loop synthetic peptide from an African HIV-1 isolate is cross-reactive against HIV-1 strains from North America/Europe region. Aids 10(12):1440-1, 1996. PMID: 8902081.
38. Sastry KJ, Marin MC, Nehete PN, McConnell K, el-Naggar AK, McDonnell TJ. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene 13(3):487-93, 1996. PMID: 8760290.
39. Mitchell MF, Hamada K, Sastry KJ, Sarkar A, Tortolero-Luna G, Wharton JT, Roth JA. Transgene expression in the rhesus cervix mediated by an adenovirus expressing beta-galactosidase. Am J Obstet Gynecol 174(4):1094-101, 1996. PMID: 8623835.
40. Casement KS, Nehete PN, Arlinghaus RB, Sastry KJ. Cross-reactive cytotoxic T lymphocytes induced by V3 loop synthetic peptides from different strains of human immunodeficiency virus type 1. Virology 211(1):261-7, 1995. PMID: 7645219.
41. Sarkar AK, Tortolero-Luna G, Nehete PN, Arlinghaus RB, Mitchell MF, Sastry KJ. Studies on in vivo induction of cytotoxic T lymphocyte responses by synthetic peptides from E6 and E7 oncoproteins of human papillomavirus type 16. Viral Immunol 8(3):165-74, 1995. PMID: 8833270.
42. Nehete PN, Casement KS, Arlinghaus RB, Sastry KJ. Studies on in vivo induction of HIV-1 envelope-specific cytotoxic T lymphocytes by synthetic peptides from the V3 loop region of HIV-1 IIIB gp 120. Cell Immunol 160(2):217-23, 1995. PMID: 7720083.
43. Nehete PN, Murthy KK, Satterfield WC, Arlinghaus RB, Sastry KJ. Studies on V3-specific cross-reactive T-cell responses in chimpanzees chronically infected with HIV-1IIIB. Aids 9(6):567-72, 1995. PMID: 7662194.
44. Sastry KJ, Bender BS, Bell W, Small PA, Jr, Arlinghaus RB. Effects of influenza virus-specific cytotoxic T-lymphocyte responses induced by a synthetic nucleoprotein peptide on the survival of mice challenged with a lethal dose of virus. Vaccine 12(14):1281-7, 1994. PMID: 7856292.
45. Nehete PN, Arlinghaus RB, Sastry KJ. Use of helper T cell-inducing peptides from conserved regions in HIV-1 env in a noncovalent mixture with a CTL-inducing V3-loop peptide for in vivo induction of long-lasting systemic CTL response. Viral Immunol 7(4):189-97, 1994. PMID: 7576033.
46. Nehete PN, Satterfield WC, Matherne CM, Arlinghaus RB, Sastry KJ. Induction of human immunodeficiency virus-specific T cell responses in rhesus monkeys by synthetic peptides from gp160. AIDS Res Hum Retroviruses 9(3):235-40, 1993. PMID: 8471313.
47. Nehete PN, Arlinghaus RB, Sastry KJ. Inhibition of human immunodeficiency virus type 1 infection and syncytium formation in human cells by V3 loop synthetic peptides from gp120. J Virol 67(11):6841-6, 1993. PMID: 7692087.
48. Sastry JK, Nehete PN, Khan S, Nowak BJ, Plunkett W, Arlinghaus RB, Farquhar D. Membrane-permeable dideoxyuridine 5'-monophosphate analogue inhibits human immunodeficiency virus infection. Mol Pharmacol 41(3):441-5, 3/1992. PMID: 1372082.
49. Sastry KJ, Nehete PN, Venkatnarayanan S, Morkowski J, Platsoucas CD, Arlinghaus RB. Rapid in vivo induction of HIV-specific CD8+ cytotoxic T lymphocytes by a 15-amino acid unmodified free peptide from the immunodominant V3-loop of GP120. Virology 188(2):502-9, 1992. PMID: 1316670.
50. Sastry KJ, Arlinghaus RB. Identification of T-cell epitopes without B-cell activity in the first and second conserved regions of the HIV Env protein. Aids 5(6):699-707, 1991. PMID: 1715718.
51. Sastry KJ, Arlinghaus RB. A novel HIV vaccine strategy. Hematol Pathol 4(3):157-9, 1990. PMID: 2258362.
52. Sastry KJ, Reddy HR, Pandita R, Totpal K, Aggarwal BB. HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line. J Biol Chem 265(33):20091-3, 1990. PMID: 2243081.
53. Sastry KJ, Huang C, Chan TS. Adenosine kinase deficiency in tritiated deoxyadenosine-resistant mouse S49 lymphoma cell lines. Biochem Genet 25(11-12):765-77, 1987. PMID: 2835956.
54. Sastry KJ, Chan TS, Rodriguez LV. Selective overproduction of human dihydrofolate reductase in a methotrexate-resistant human-mouse somatic cell hybrid. Biochem Biophys Res Commun 132(2):795-803, 1985. PMID: 4062946.
55. Sastry KJ, Srivastava OP, Millet J, FitzJames PC, Aronson AI. Characterization of Bacillus subtilis mutants with a temperature-sensitive intracellular protease. J Bacteriol 153(1):511-9, 1983. PMID: 6401288.
56. Chaloupka J, Severin AI, Sastry KJ, Kucerova H, Stranadova M. Differences in the regulation of exocellular proteinase synthesis during growth and sporulation of Bacillus megaterium. Can J Microbiol 28:1214-8, 1982.
57. Sastry KJ, Strnadova M, Chaloupka J. Synthesis of exocellular proteins during the exponential and stationary phase of growth of Bacillus megaterium. Folia Microbiol (Praha) 26(2):73-7, 1981. PMID: 6790385.
58. Sastry KJ, Mathur DK. Studies of milk clotting enzyme from Bacillus megaterium K40: II. Effect of some environmental factors on enzyme production. J Food Sci Technol 16(1):19-21, 1979.
59. Sastry KJ, Mathur DK. Studies of milk clotting enzyme from Bacillus megaterium K40: II. Effect of some nutrients on enzyme production. J Food Sci Technol 16(1):15-8, 1979.
60. Ralhan GR, Sastry KJ, Mathur DK. Isolation, purification and characterization of nisinase producing bacterial from processed cheese. Ind J Dairy Sci 31(2):150-5, 1978.
61. Sastry KJ, Mathur DK. Bacterial nisinase. Ind Dairyman 29(9):555-9, 1977.

Invited Articles

1. Follen M, Meyskens FL, Alvarez RD, Walker JL, Bell MC, Storthz KA, Sastry KJ, Roy K, Richards-Kortum R, Cornelison TL. Cervical cancer chemoprevention, vaccines, and surrogate endpoint biomarkers. Cancer 98(9 Suppl):2044-51, 2003. PMID: 14603541.

Book Chapters

1. Sastry KJ, Nehete PN, Nehete B. "Improving the sensitivity of the ELISPOT analyses of antigen-specific cellular immune responses in rhesus macaques". In: Handbook of ELISPOT: methods and protocols, Methods in Molecular Biology series. 302. Ed(s) AE Kalyuzhny. Humana Press: Totowa, NJ, 153-166, 2005. ISBN: 15937350.
2. Sastry KJ, Nehete PN. "Animal Models for AIDS Research". In: Handbook of Laboratory Animal Science. Ed(s) J Han, GL van Hoosier. CRC Press: Boca Raton, 61-77, 2004.
3. Nehete PN, Chitta S, Hossain MM, Hill L, Bernacky B, Sastry KJ. "Synthetic peptide-based HIV vaccine induces protective immunity in SHIV-rhesus model". In: Peptides for the New Millenium, American Peptide Symposia series. 6. Ed(s) GB Fields, G Barany, JP Tam. Springer: Netherlands, 706-707, 2000.
4. Hossain MM, Nehete PN, Chitta S, Sastry KJ. "Synthetic peptide-based reagents for blocking the entry and inactivation of HIV". In: Peptides for the New Millenium, American Peptide Symposia series. 6. Ed(s) GB Fields, G Barany, JP Tam. Springer: Netherlands, 258-259, 2000.

Last updated: 8/29/2013