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James D. Cox, M.D.

Present Title & Affiliation

Primary Appointment

Professor, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Division Head, Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX
Hubert L. and Olive Stringer Distinguished Chair in Oncology in Honor of Sue Gribble Stringer, The University of Texas M. D. Anderson Cancer Center,, Houston, TX

Education & Training

Degree-Granting Education

1965 University of Rochester School of Medicine and Dentistry, Rochester, NY, MD, With Honor, Medicine
1960 Kenyon College, Gambier, OH, AB, Magna Cum Laude, Biology/Chemistry

Postgraduate Training

1963-1964 Clinical Fellowship, Clinical Oncology and Therapeutic Radiology, Penrose Cancer Hospital, Colorado Springs, CO

Selected Publications

Peer-Reviewed Original Research Articles
1. Liao Z, Komaki R, Thames HD, Liu H, Tucker SL, Mohan R, Martel M, Wei X, Fossella F, Lippman SM, Cox JD. Influence of technological advances on outcomes in patients with unresectable, locally advanced non-small cell lung cancer receiving concomitant chemoradiotherapy. Int J Radiat Oncol Biol Phys. In Press.
2. Arjomandy B, Sahoo N, Cox JD, Lee A, Gillin M. Comparison of surface doses from spot scanning and passively scattered proton therapy beams. Phys Med Biol 54:295-302, 06/23/2009, 6/2009.
3. Jin Hekun, Tucker SL, Liu HH, Wei X, Yom S, Wang S, Komaki R, Chen Y, Martel M, Mohan R, Cox JD, Liao Z. Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in imoperable non-small cell lung cancer treated with definitive radiotherapy radiotherapy and oncology. Radiother Oncol 91(3):427-432, 5/2009.
4. Starkschall G, Britton K, McAleer M, Jeter M, Kaus M, Bzdusek K, Mohan R, Cox JD. Potential dosimetric benefits of four-dimensional radiation treatment planning. Int J Radiat Oncol Biol Phys 73(5):1560-1565, 4/2009.
5. Britton KR, Starkschall G, Liu H, Chang JY, Bilton S, Ezhil M, John-Baptiste S, Kantor M, Cox JD, Komaki R, Mohan R. Consequences of anatomic changes and respiratory motion on radiation dose distributions in conformal radiotherapy for locally advanced non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 73(1):94-102, 1/1/2009, 1/2009.
6. Zinner RG, Komaki R, Cox JD, Glisson BS, Pisters KM, Herbst RS, Kies M, Liao Z, Hong WK, Fossella FV. Dose escalation of gemcitabine is possible with concurrent chest three-dimensional rather than two-dimensional radiotherapy: A phase I trial in patients with stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 73(1):119-127, 1/1/2009, 1/2009. PMID: 18556142.
7. Zhang Z, Chen Y, Chen Y, Jeter M, Hofstetter WL, Ajani J, Swisher S, Chang JY, Allen PK, Cox JD, Komaki R, Liao Z. Outcomes with esophageal cancer radiation therapy. J Thorac Oncol 4(7):880-888, 2009.
8. Smith GL, Smith BD, Buchholz TA, Liao Z, Jeter M, Swisher SG, Hofstetter WL, Ajani JA, McAleer MF, Komaki R, Cox JD. Patterns of care and locoregional treatment outcomes in older esophageal cancer patients: The SEER-medicare cohort. Int J Radiat Oncol Biol Phys 74(2):482-489, 2009.
9. Hui Z, Zhang X, Starkschall G, Li Y, Mohan R, Komaki R, Cox JD, Chang JY. Effects of interfractional motion and anatomic changes on proton therapy dose distribution in lung cancer. Int J Radiat Oncol Biol Phys 72(5):1385-1395, 12/2008.
10. Rosen B, Starkschall G, Britton K, Mohan R, Cox JD. Utility of four-dimensional computed tomography for analysis of intrafractional and interfractional variation in lung volumes. Int J Radiat Oncol Biol Phys 72(1):288-294, 9/2008.
11. Wang S, Liao Z, Wei X, Liu HH, Tucker SL, Hu C, Ajani JA, Phan A, Swisher SG, Mohan R, Cox JD, Komaki R. Association between systemic chemotherapy prior to chemoradiation and increased risk of treatment related pneumonitis in esophageal cancer patients treated with definitive chemotherapy. J Thorac Oncol 3(3):277-282, 3/2008.
12. Wei X, Liu HH, Tucker SL, Wang S, Mohan R, Cox JD, Komaki R, Liao Z. Risk factors for pericardial effusion in inoperable esophageal cancer patients treated with definitive chemoradiation therapy. Int J Radiat Oncol Biol Phys 70(3):707-714, 3/2008.
13. Kased N, Erasmus JJ, Komaki R, Cox JD. Prognostic value of posttreatment [18F] fluorodeoxyglucose uptake of primary non-small cell lung carcinoma treated with radiation therapy with or without chemotherapy: a brief review. J Thorac Oncol 3(5):534-538, 2008. PMID: 18449010.
14. Kang Y, Zhang X, Chang JY, Wang H, Wei X, Liao Z, Komaki R, Cox JD, Balter PA, Liu H, Zhu XR, Mohan R, Dong L. 4D Proton treatment planning strategy for mobile lung tumors. Int J Radiat Oncol Biol Phys 67:906-914, 2007. PMID: 17293240.
15. Liu HH, Balter P, Tutt T, Choi B, Zhang J, Wang C, Chi M, Luo D, Pan T, Hunjan S, Starkschall G, Rosen I, Prado K, Liao Z, Chang J, Komaki R, Cox JD, Mohan R, Dong L. Assessing respiration-induced tumor motion and internal target volume using four-dimensional computed tomography for radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys 68:531-540, 2007.
16. Yom SS, Liao Z, Liu HH, Tucker SL, Ha CS, Wei X, Wang X, Wang S, Mohan R, Cox JD, Komaki R. Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 68:94-102, 2007.
17. Klopp AH, Chang JY, Tucker SL, Sulman EP, Balter PA, Liu HH, Bucci MK, Macapinlac HA, Komaki R, Cox JD. Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation. Int J Radiat Oncol Biol Phys 69:1409-1416, 2007.
18. Mason KA, Gillin MT, Mohan R, Cox JD. Preclinical biologic assessment of proton beam relative biologic effectiveness at Proton Therapy Center Houston. Int J Radiat Oncol Biol Phys 68:968-970, 2007.
19. Shioyama Y, Jang SY, Liu HH, Guerrero T, Wang X, Gayed IW, Erwin WD, Liao Z, Chang JY, Jeter M, Yaremko BP, Borghero YO, Cox JD, Komaki R, Mohan R. Preserving functional lung using perfusion imaging and intensity-modulated radiation therapy for advanced-stage non-small cell lung cancer. Int J Radiat Oncol Biol Phys 68:1349-1358, 2007.
20. Liao Z, Cox JD, Komaki R. Radiochemotherapy of esophageal cancer. J Thorac Oncol 2:553-568, 2007.
21. Yaremko BP, Guerrero TM, Noyola-Martinez J, Guerra R, Lege DG, Nguyen LT, Balter PA, Cox JD, Komaki R. Reduction of normal lung irradiation in locally advanced non-small-cell lung cancer patients, using ventilation images for functional avoidance. Int J Radiat Oncol Biol Phys 68(2):562-571, 2007.
22. Fang LC, Komaki R, Allen P, Guerrero T, Mohan R, Cox JD. Comparison of outcomes for patients with medically inoperable Stage I non-small-cell lung cancer treated with two-dimensional vs. three-dimensional radiotherapy. Int J Radiat Oncol Biol Phys 66(1):108-16, 9/2006. PMID: 16904517.
23. Chang JY, Zhang X, Wang X, Kang Y, Riley B, Bilton S, Mohan R, Komaki R, Cox JD. Significant reduction of normal tissue dose by proton radiotherapy compared with three-dimensional conformal or intensity-modulated radiation therapy in Stage I or Stage III non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 65(4):1087-96, 7/2006. PMID: 16682145.
24. Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Woo SY, Cox JD, Smith AR. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys 63(2):362-72, 10/2005. PMID: 16168831.
25. Ha CS, Cabanillas F, Lee MS, Tucker SL, McLaughlin P, Rodriguez MA, Younes A, Romaguera JE, Mesina OM, Cox JD. A prospective randomized study to compare the molecular response rates between central lymphatic irradiation and intensive alternating triple chemotherapy in the treatment of stage I-III follicular lymphoma. Int J Radiat Oncol Biol Phys 63(1):188-93, 9/2005. PMID: 16111588.
26. de Crevoisier R, Tucker SL, Dong L, Mohan R, Cheung R, Cox JD, Kuban DA. Increased risk of biochemical and local failure in patients with distended rectum on the planning CT for prostate cancer radiotherapy. Int J Radiat Oncol Biol Phys 62(4):965-73, 7/2005. PMID: 15989996.
27. Michalski JM, Winter K, Purdy JA, Parliament M, Wong H, Perez CA, Roach M, Bosch W, Cox JD. Toxicity after three-dimensional radiotherapy for prostate cancer on RTOG 9406 dose Level V. Int J Radiat Oncol Biol Phys 62(3):706-13, 7/2005. PMID: 15936549.
28. Liao Z, Komaki R, Milas L, Yuan C, Kies M, Chang JY, Jeter M, Guerrero T, Blumenschien G, Smith CM, Fossella F, Brown B, Cox JD. A phase I clinical trial of thoracic radiotherapy and concurrent celecoxib for patients with unfavorable performance status inoperable/unresectable non-small cell lung cancer. Clin Cancer Res 11(9):3342-8, 5/2005. PMID: 15867233.
29. Komaki R, Lee JS, Milas L, Lee HK, Fossella FV, Herbst RS, Allen PK, Liao Z, Stevens CW, Lu C, Zinner RG, Papadimitrakopoulou VA, Kies MS, Blumenschein GR, Jr, Pisters KM, Glisson BS, Kurie J, Kaplan B, Garza VP, Mooring D, Tucker SL, Cox JD. Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable non-small-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys 58(5):1369-77, 4/2004. PMID: 15050312.
30. Liao Z, Komaki R, Stevens C, Kelly J, Fossella F, Lee JS, Allen P, Cox JD. Twice daily irradiation increases locoregional control in patients with medically inoperable or surgically unresectable stage II-IIIB non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 53(3):558-65, 7/2002. PMID: 12062597.
31. Cox JD. Evidence in oncology. The Janeway lecture 2000. Cancer J 6(6):351-7, 11/2000. PMID: 11131481.
32. Michalski JM, Purdy JA, Winter K, Roach M, 3rd, Vijayakumar S, Sandler HM, Markoe AM, Ritter MA, Russell KJ, Sailer S, Harms WB, Perez CA, Wilder RB, Hanks GE, Cox JD. Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG/RTOG 9406. Int J Radiat Oncol Biol Phys 46(2):391-402, 1/2000. PMID: 10661346.
33. Grignon DJ, Caplan R, Sarkar FH, Lawton CA, Hammond EH, Pilepich MV, Forman JD, Mesic J, Fu KK, Abrams RA, Pajak TF, Shipley WU, Cox JD. p53 status and prognosis of locally advanced prostatic adenocarcinoma: a study based on RTOG 8610. J Natl Cancer Inst 89(2):158-65, 1/1997. PMID: 8998185.
34. Cox JD. Evolution and accomplishments of the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys 33(3):747-54, 10/1995. PMID: 7558966.
35. Pilepich MV, Krall JM, Al-Sarraf M, John MJ, Doggett RL, Sause WT, Lawton CA, Abrams RA, Rotman M, Rubin P, Shipley WU, Grignon D, Caplan R, Cox JD. Androgen deprivation with radiation therapy compared with radiation therapy alone for locally advanced prostatic carcinoma - a randomized comparative trial of the Radiation Therapy Oncology Group. Urology 45:616-623, 8/1995.
36. Sause WT, Scott CB, Taylor S, Johnson DH, Livingston RB, Komaki R, Emami B, Curran WJ, Turrisi AT, Dar A, Cox JD. Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: Preliminary results of a phase III trial in regionally advanced unresectable non-small cell lung cancer. J Nat'l Cancer Inst 87:198-205, 5/1995.
37. Cox JD. Brief history of comparative clinical trials in radiation oncology: perspectives from the silver anniversary of the Radiation Therapy Oncology Group. Radiology 192(1):25-32, 7/1994. PMID: 8208947.
38. Jacobs JP, Murray KJ, Schultz CJ, Wilson JF, Goswitz MS, Stevens CW, Cox JD. Central lymphatic irradiation for stage III nodular malignant lymphoma: long-term results. J Clin Oncol 11(2):233-8, 2/1993. PMID: 8426199.
39. Cox JD, Pajak TF, Marcial VA, Coia L, Mohiuddin M, Fu KK, Selim HM, Byhardt RW, Rubin P, Ortiz HG, et al. Interruptions adversely affect local control and survival with hyperfractionated radiation therapy of carcinomas of the upper respiratory and digestive tracts. New evidence for accelerated proliferation from Radiation Therapy Oncology Group Protocol 8313. Cancer 69(11):2744-8, 6/1992. PMID: 1571904.
40. Diener-West M, Pajak TF, Bauer M, Cox JD. Randomized dose-searching phase ILE/II trials of fractionation in radiation therapy for cancer. J Natl Cancer Inst 83(15):1065-71, 8/1991. PMID: 1875413.
41. Cox JD, Pajak TF, Marcial VA, Coia L, Mohiuddin M, Fu KK, Selim H, Rubin P, Ortiz H. ASTRO plenary: interfraction interval is a major determinant of late effects, with hyperfractionated radiation therapy of carcinomas of upper respiratory and digestive tracts: results from Radiation Therapy Oncology Group protocol 8313. Int J Radiat Oncol Biol Phys 20(6):1191-5, 6/1991. PMID: 2045293.
42. Cox JD, Azarnia N, Byhardt RW, Shin KH, Emami B, Pajak TF. A randomized phase I/II trial of hyperfractionated radiation therapy with total doses of 60.0 Gy to 79.2 Gy: possible survival benefit with greater than or equal to 69.6 Gy in favorable patients with Radiation Therapy Oncology Group stage III non-small-cell lung carcinoma: report of Radiation Therapy Oncology Group 83-11. J Clin Oncol 8(9):1543-55, 9/1990. PMID: 2167952.
43. Cox JD. Fractionation: a paradigm for clinical research in radiation oncology. Int J Radiat Oncol Biol Phys 13(9):1271-81, 9/1987. PMID: 3305446.
44. Toohill RJ, Duncavage JA, Grossmam TW, Malin TC, Teplin RW, Wilson JF, Byhardt RW, Haas JS, Cox JD, Anderson T, et al. The effects of delay in standard treatment due to induction chemotherapy in two randomized prospective studies. Laryngoscope 97(4):407-12, 4/1987. PMID: 3550340.
45. Cox JD, Byhardt RW, Wilson JF, Haas JS, Komaki R, Olson LE. Complications of radiation therapy and factors in their prevention. World J Surg 10(2):171-88, 4/1986. PMID: 3518250.
46. Cox JD. Failure analysis in diagnostic and treatment strategies in cancer management. Cancer Treat Symp 2:1-3, 10/1983.
47. Cox JD, Stanley K, Petrovich Z, Paig C, Yesner R. Cranial irradiation in cancer of the lung of all cell types. JAMA 245:469-472, 2/1981. PMID: 7452872.
48. Cox JD, Byhardt RW, Komaki R, Greenberg M. Reduced fractionation and the potential of hypoxic cell sensitizers in irradiation of malignant epithelial tumors. Int J Radiat Oncol Biol Phys 6(1):37-40, 1980. PMID: 6245044.
49. Cox JD, Yesner R, Mietlowski W, Petrovich Z. Influence of cell type on failure pattern after irradiation for locally advanced carcinoma of the lung. Cancer 44(1):94-8, 7/1979. PMID: 222435.
50. Cox JD. Central lymphatic irradiation to low dose for advanced nodular lymphoreticular tumors (non-Hodgkin's lymphoma). Radiology 126(3):767-72, 3/1978. PMID: 343169.
51. Cox JD, Koehl RH, Turner WM, King FM. Irradiation in the local control of malignant lymphoreticular tumors (non-Hodgkin's malignant lymphoma). Radiology 112(1):179-85, 7/1974. PMID: 4208964.
52. Cox JD, Tijerina A. Preliminary results of biopsies following irradiation for locally advanced adenocarcinoma of the prostate. Radiology 112:215-6, 7/1974. PMID: 4832498.

Last updated: 8/5/2009