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James M. Reuben, Ph.D., M.B.A.

Present Title & Affiliation

Primary Appointment

Professor, Department of Hematopathology, Division of Pathology/Lab Medicine, UTMDACC, Houston, TX

Dual/Joint/Adjunct Appointment

Professor, Department of Symptom Research, Division of Internal Medicine, UTMDACC, Houston, TX

Education & Training

Degree-Granting Education

1996 University of Houston, Houston, TX, MBA, Business Administration
1979 McGill University, Montreal, Quebec, Canada, PHD, Immunology
1976 Texas Southern University, Houston, TX, MS, Biology
1972 Concordia University, Montreal, Quebec, Canada, BS, Biochemistry

Postgraduate Training

10/1979-5/1981 Research Fellowship, Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, Evan M. Hersh, M.D.


Academic Appointments

Associate Professor, Department of Symptom Research, Division of Internal Medicine, UTMDACC, Houston, TX, 2001-2009
Associate Professor, Department of Hematopathology, Division of Pathology/Lab Medicine, UTMDACC, Houston, TX, 2001-2009
Member, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, 1985-present

Institutional Committee Activities

Associate Member, Office of Protocol Research, Institutional Review Board 5, 2012-present
Member, Conflict of Interest Committee, 11/2011-present
Associate Member, Office of Protocol Research, Institutional Review Board 3, 2010-present
Vice Chair, Office of Protocol Research, Institutional Review Board 2, 2007-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Mego M, De Giorgi U, Broglio K, Dawood S, Valero V, Andreopoulou E, Handy B, Reuben JM, Cristofanilli M. Circulating tumour cells are associated with increased risk of venous thromboembolism in metastatic breast cancer patients. Br J Cancer 101(11):1813-6, 12/2009. PMCID: PMC2788266.
2. Mego M, De Giorgi U, Hsu L, Ueno NT, Valero V, Jackson S, Andreopoulou E, Kau SW, Reuben JM, Cristofanilli M. Circulating tumor cells in metastatic Inflammatory Breast Cancer. Ann Oncol 20(11):1824-8, 11/2009. PMID: 19556320 PMC journal in process.
3. Shearer WT, Ochs HD, Lee BN, Cohen EN, Reuben JM, Cheng I, Thompson B, Butel JS, Blancher A, Abbal M, Aviles H, Sonnenfeld G. Immune responses in adult female volunteers during the bed-rest model of spaceflight: Antibodies and cytokines. J Allergy Clin Immunol 123(4):900-5, 4/2009. e-Pub 2/2009. PMID: 19232702.
4. Ferrajoli A, Lee BN, Schlette EJ, O'Brien SM, Gao H, Wen S, Wierda WG, Estrov Z, Faderl S, Cohen EN, Li C, Reuben JM, Keating MJ. Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia. Blood 111(11):5291-7, 6/2008. PMID: 18334676.
5. Lang JE, Mosalpuria K, Cristofanilli M, Krishnamurthy S, Reuben J, Singh B, Bedrosian I, Meric-Bernstam F, Lucci A. HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer. Breast Cancer Res Treat, 3/2008. PMID: 18327638 PMC journal in process.
6. Cristofanilli M, Broglio KR, Guarneri V, Jackson S, Fritsche HA, Islam R, Dawood S, Reuben JM, Kau SW, Lara JM, Krishnamurthy S, Ueno NT, Hortobagyi GN, Valero V. Circulating tumor cells in metastatic breast cancer: biologic staging beyond tumor burden. Clin Breast Cancer 7(6):471-479, 2/2007. PMID: 17386124.
7. Shearer WT, Zhang S, Reuben JM, Lee B-N, Butel JS.. Predictors of immune function in space flight. Acta Astronautica 60:247-253, 2/2007.
8. Körbling M, Reuben JM, Gao H, Lee BN, Harris DM, Cogdell D, Giralt SA, Khouri IF, Saliba RM, Champlin RE, Zhang W, Estrov Z. Recombinant human granulocyte-colony-stimulating factor-mobilized and apheresis-collected endothelial progenitor cells: a novel blood cell component for therapeutic vasculogenesis. Transfusion 46(10):1795-802, 10/2006. PMID: 17002637.
9. Lee BN, Follen M, Rodriquez G, Shen DY, Malpica A, Shearer WT, Reuben JM. Deficiencies in myeloid antigen-presenting cells in women with cervical squamous intraepithelial lesions. Cancer 107(5):999-1007, 9/2006. PMID: 16874820.
10. Reuben JM, Lee BN, Li C, Gomez-Navarro J, Bozon VA, Parker CA, Hernandez IM, Gutierrez C, Lopez-Berestein G, Camacho LH. Biologic and immunomodulatory events after CTLA-4 blockade with ticilimumab in patients with advanced malignant melanoma. Cancer 106(11):2437-2444, 6/2006. PMID: 16615096.
11. Cata JP, Weng HR, Lee BN, Reuben JM, Dougherty PM. Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy. Minerva Anestesiol 72(3):151-169, 3/2006. PMID: 16493391.
12. Yang CH, Gonzalez-Angulo AM, Reuben JM, Booser DJ, Pusztai L, Krishnamurthy S, Esseltine D, Stec J, Broglio KR, Islam R, Hortobagyi GN, Cristofanilli M. Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits. Ann Oncol 17(5):813-817, 1/2006. PMID: 16403809.
13. Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, Comin-Anduix B, Reuben JM, Seja E, Parker CA, Sharma A, Glaspy JA, Gomez-Navarro J. Antitumor activity in melanoma and anti-self responses in a Phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody. CP-675,206. J Clin Oncol 23(35):8968-8977, 12/2005. PMID: 16204013.
14. Gao H, Lee BN, Talpaz M, Donato NJ, Cortes JE, Kantarjian HM, Reuben JM. Imatinib mesylate suppresses cytokine synthesis by activated CD4 T cells of patients with chronic myelogenous leukemia. Leukemia 19(11):1905-11, 11/2005. PMID: 16151467.
15. Shearer WT, Zhang S, Reuben JM, Lee BN, Butel JS. Effects of radiation and latent virus on immune responses in a space flight model. J Allergy Clin Immunol 115(6):1297-303, 6/2005. PMID: 15940150.
16. Cristofanilli M, Hayes DF, Budd GT, Ellis MJ, Stopeck A, Reuben JM, Doyle GV, Matera J, Allard WJ, Miller MC, Fritsche HA, Hortobagyi GN, Terstappen LW. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 23(7):1420-30, 3/2005. PMID: 15735118.
17. Resetkova E, Gonzalez-Angulo AM, Sneige N, Mcdonnell TJ, Buzdar AU, Kau SW, Yamamura Y, Reuben JM, Hortobagyi GN, Cristofanilli M. Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinoma. Cancer 101(5):913-7, 9/2004. PMID: 15329897.
18. Cristofanilli M, Budd GT, Ellis MJ, Stopeck A, Matera J, Miller MC, Reuben JM, Doyle GV, Allard WJ, Terstappen LW, Hayes DF. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351(8):781-91, 8/2004. PMID: 15317891.
19. Reuben JM, Korbling M, Gao H, Lee BN. The effect of low dose gamma irradiation on the differentiation and maturation of monocyte derived dendritic cells. J Gravit Physiol 11(2):P49-52, 7/2004. PMID: 16231453.
20. Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB. Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis. Blood 103(8):3175-84, 4/2004. PMID: 15070700.
21. Lee BN, Follen M, Shen DY, Malpica A, Adler-Storthz K, Shearer WT, Reuben JM. Depressed type 1 cytokine synthesis by superantigen-activated CD4+ T cells of women with human papillomavirus-related high-grade squamous intraepithelial lesions. Clin Diagn Lab Immunol 11(2):239-44, 3/2004. PMID: 15013969.
22. Pusztai L, Mendoza TR, Reuben JM, Martinez MM, Willey JS, Lara J, Syed A, Fritsche HA, Bruera E, Booser D, Valero V, Arun B, Ibrahim N, Rivera E, Royce M, Cleeland CS, Hortobagyi GN. Changes in plasma levels of inflammatory cytokines in response to paclitaxel chemotherapy. Cytokine 25(3):94-102, 2/2004. PMID: 14698135.
23. Lee BN, Dantzer R, Langley KE, Bennett GJ, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Cleeland CS. A cytokine-based neuroimmunologic mechanism of cancer-related symptoms. Neuroimmunomodulation 11(5):279-92, 2004. PMID: 15316238.
24. Cleeland CS, Bennett GJ, Dantzer R, Dougherty PM, Dunn AJ, Meyers CA, Miller AH, Payne R, Reuben JM, Wang XS, Lee BN. Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism? A cytokine-immunologic model of cancer symptoms. Cancer 97(11):2919-25, 6/2003. PMID: 12767108.
25. Duzkale H, Pagliaro LC, Rosenblum MG, Varan A, Liu B, Reuben JM, Wierda WG, Korbling M, McMannis JD, Glassman AB, Scheinberg DA, Freireich EJ. Bone marrow purging studies in AML using the recombinant anti-CD33 immunotoxin HuM195/rGel. Biol Blood Marrow Transplant 9:346-372, 2003.
26. Mattiuzzi GN, Cortes JE, Talpaz M, Reuben JM, Rios,MB, Shan J, Kontoyiannis D, Giles FJ, Raad I, Verstovsek S, Ferrajoli A, Kantarjian H. Development of varicella-zoster infection (VZV) in patients with chronic myelogenous leukemia treated with imatinib mesylate. Clin Cancer Res 9:976-980, 2003.
27. Reuben JM, Lee BN, Paul M, Kline MW, Cron SG, Abramson S, Lewis D, Kozinetz CA, Shearer WT. Magnitude of IFN-gamma production in HIV-1-infected children is associated with virus suppression. J Allergy Clin Immunol 110(2):255-61, 8/2002. PMID: 12170266.
28. Shearer WT, Lee BN, Cron SG, Rosenblatt HM, Smith EO, Lugg DJ, Nickolls PM, Sharp RM, Rollings K, Reuben JM. Suppression of human anti-inflammatory plasma cytokines IL-10 and IL-1RA with elevation of proinflammatory cytokine IFN-gamma during the isolation of the Antarctic winter. J Allergy Clin Immunol 109(5):854-7, 5/2002. PMID: 11994711.
29. Shearer WT, Rais M, Teran JM, Abramson SL, Brouwers PY, Evankovich KD, Glaze DG, Jefferson LS, Seilheimer DK, Smith EO, Wise MS, Lee B-N, Reuben JM. sTNF-RI levels in childhood asthma. Pediatr Asthma Allergy Immunology 15:233-234, 2002.
30. Fayad L, Keating MJ, Reuben JM, O'Brien S, Lee BN, Lerner S, Kurzrock R. Interleukin-6 and interleukin-10 levels in chronic lymphocytic leukemia: correlation with phenotypic characteristics and outcome. Blood 97(1):256-63, 1/2001. PMID: 11133769.
31. Shearer WT, Lugg DJ, Rosenblatt HM, Nickolls PM, Sharp RM, Reuben JM, Ochs HD. Antibody responses to bacteriophage phi X-174 in human subjects exposed to the antarctic winter-over model of spaceflight. J Allergy Clin Immunol 107(1):160-4, 2001. PMID: 11150006.
32. Olsen E, Duvic M, Frankel A, Kim Y, Martin A, Vonderheid E, Jegasothy B, Wood G, Gordon M, Heald P, Oseroff A, Pinter-Brown L, Bowen G, Kuzel T, Fivenson D, Foss F, Glode M, Molina A, Knobler E, Stewart S, Cooper K, Stevens S, Craig F, Reuben JM, Bacha P, Nichols J. Pivotal phase lll trial of two dose levels of Denileukin Diftitox for treatment of cutaneous T-cell lymphoma. J Clin Oncol 19(2):376-388, 2001.
33. Lee BN, Hammill H, Popek EJ, Cron S, Kozinetz C, Paul M, Shearer WT, Reuben JM. Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women. Infect Dis Obstet Gynecol 9(2):95-104, 2001. PMID: 11495560.
34. Lee BN, Hammill H, Popek EJ, Cron S, Kozinetz C, Paul M, Shearer WT, Reuben JM. Production of interferons and beta-chemokines by placental trophoblasts of HIV-1-infected women. Infect Dis Obstet Gynecol 9(2):95-104, 2001. PMCID: PMCPMC1784647.
35. Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J Allergy Clin Immunol 107(1):165-70, 2001. PMID: 11150007.
36. Reuben JM, Lee BN, Johnson H, Fritsche H, Kantarjian HM, Talpaz M. Restoration of Th1 Cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha. Clin Cancer Res 6(5):1671-1677, 5/2000. PMID: 10815885.
37. Fahey, Aziz, N, Spritzler, J, Plaeger, S, Nishanian, P, Lathey, J, Seigel, J, Landay AL, Kilarui, R, Schmitz, JL, White, C, Wara, DW, Akridge, R, Cutili, J, Douglas, SD, Reuben, JM, Shearer, WT, Nokta, M, Pollard, R, Schooley, R, Asthana, D, Mizrachi, Y, Waxdal, M. Need for external proficiency testing program for cytokines, chemokines, and plasma markers of immune activation. . Clin Diagn Lab Immunol 7:540-548, 2000.
38. Lee BN, Follen M, Tortolero-Luna G, Eriksen N, Helfgott A, Hammill H, Shearer WT, Reuben JM. Synthesis of IFN-gamma by CD8(+) T cells is preserved in HIV-infected women with HPV-related cervical squamous intraepithelial lesions. Gynecol Oncol 75(3):379-86, 12/1999. PMID: 10600293.
39. Lee BN, Duvic M, Tang CK, Bueso-Ramos C, Estrov Z, Reuben JM. Dysregulated synthesis of intracellular type 1 and type 2 cytokines by T cells of patients with cutaneous T-cell lymphoma. Clin Diagn Lab Immunol 6(1):79-84, 1/1999. PMID: 9874668.
40. Saleh MN, LeMaistre CF, Kuzel TM, Foss F, Platanais LC, Schwartz G, Ratain M, Rook A, Freytes CO, Craig F, Reuben JM, Sams MW, Nichols JC. Antitumor activity of DAB389IL-2 fusion toxin in mycosis fungoides. J Am Acad Dermatol 39:63-73, 1998.
41. LeMaistre CL, Saleh MN, Kuzel TM, Foss F, Platanias L, Schwartz G, Ratain M, Rook A, Freytes CO, Craig F, Reuben JM, Nichols JC. Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2. Blood 91:399-405, 1998.
42. Lee BN, Ordonez N, Popek EJ, Lu JG, Helfgott A, Eriksen N, Hammill H, Kozinetz C, Doyle M, Kline M, Langston C, Shearer WT, Reuben JM. Inflammatory cytokine expression is correlated with the level of human immunodeficiency virus (HIV) transcripts in HIV-infected placental trophoblastic cells. J Virol 71(5):3628-35, 5/1997. PMID: 9094636.
43. Lee BN, Lu JG, Shen DY, Li S, Shearer WT, Reuben JM. Quantification of IL-2 and IL-2 receptor mRNA in peripheral blood mononuclear cells by the RT-PCR based SHARP Signal system. Cytokines Cell Mol Ther 3(1):33-40, 3/1997. PMID: 9287242.
44. Heresi, Caceres, E, Atkins, JT, Reuben, JM, Doyle, M. Pneumocystis carinii pneumonia in human immunodeficiency virus (HIV) exposed HIV uninfected infants: an exception to the AIDS surveillance case definition. . Clin Infect Dis 25:739-40, 1997.
45. Shearer WT, Reuben JM, Lee B-N, Popek E, Lewis D, Hammill H, Hanson C, Langston C. Role of placental cytokines and chronic inflammation in vertical transmission of HIV infection. Acta Pediatr suppl 417:33-38, 1997.
46. Reuben JM, Turpin JA, Lee BN, Doyle M, Gonik B, Jacobson R, Shearer WT. Induction of inflammatory cytokines in placental monocytes of gravidae infected with the human immunodeficiency virus type 1. J Interferon Cytokine Res 16(11):963-71, 11/1996. PMID: 8938574.
47. Lee BN, Lu JG, Kline MW, Paul M, Doyle M, Kozinetz C, Shearer WT, Reuben JM. Type 1 and type 2 cytokine profiles in children exposed to or infected with vertically transmitted human immunodeficiency virus. Clin Diagn Lab Immunol 3(5):493-9, 9/1996. PMID: 8877124.
48. Schmitt DA, Schaffar L, Taylor GR, Loftin KC, Schneider VS, Koebel A, Abbal M, Sonnenfeld G, Lewis DE, Reuben JM, Ferebee R. Use of bed rest and head-down tilt to simulate spaceflight-induced immune system changes. J Interferon Cytokine Res 16:151-157, 1996.
49. Kozinetz CA, Kline MW, Lewis DE, Hollinger BF, Reuben JM, Rosenblatt H, Hanson IC, Hammill H, Shearer WT. Early detection of HIV in infants: aspects of design and analysis for diagnostic test studies. Pediatr AIDS HIV Infect 6(1):3-13, 2/1995. PMID: 11361742.
50. Lewis DE, Adu-Oppong A, Hollinger FB, Rosenblatt HM, Hanson IC, Reuben JM, Kline MW, Kozinetz CA, Shearer WT. Sensitivity of immune complex-dissociated p24 antigen testing for early detection of human immunodeficiency virus in infants. Clin Diagn Lab Immunol 2(1):87-90, 1995. PMID: 7719918.
51. Kline MW, Lewis DE, Hollinger FB, Reuben JM, Hanson LC, Kozinetz CA, Dimitrov DH, Rosenblatt HM, Shearer WT. A comparative study of human immunodeficiency virus culture, polymerase chain reaction and anti-human immunodeficiency virus immunoglobulin A antibody detection in the diagnosis during early infancy of vertically acquired human immunodeficiency virus infection. Pediatr Infect Dis J 13(2):90-4, 2/1994. PMID: 8190557.
52. Fischer, Reuben, JM. Human immunodeficiency virus type 2: Implications for blood donors. Curr Issues Transfusion Med 2:1-4, 1994.
53. Sewell KL, Parker KC, Woodworth TG, Reuben JM, Swartz W, Trentham DE. DAB486IL-2 fusion toxin in refractory rheumatoid arthritis. Arthritis Rheumatism 36:1223-1233, 1993.
54. LeMaistre CF, Craig F, Meneghetti C, McMullin B, Parker K, Reuben JM, Deisseroth A, Woodworth T. Phase I trial of a 90-minute infusion of the fusion toxin DAB486IL-2 in hematological cancers. Cancer Res 53:3930-3934, 1993.
55. Reuben JM, Liang L, Atmar RL, Greenberg S. B-cell activation and differentiation by HIV-1 antigens among volunteers vaccinated with VaxSyn HIV-1. J Acquir Immune Defic Syndr 5(7):719-25, 1992. PMID: 1613672.
56. LeMaistre CF, Meneghetti C, Rosenblum M, Reuben JM, Parker K, Shaw J, Deisseroth A, Woodworth T, Parkinson DR. Phase I trial of an IL-2 fusion toxin (DAB486IL-2) in hematologic malignancies expressing the IL-2 receptor. . Blood 79:2547-2554, 1992.
57. Reuben JM, Gonik B, Li S, Loo L, Turpin J. Induction of cytokines in normal placental cells by the human immunodeficiency virus. Lymphokine Cytokine Res 10(3):195-9, 6/1991. PMID: 1883914.
58. LeMaistre CF, Rosenblum MG, Reuben JM, Parkinson DR, Meneghetti CM, Parker K, Shaw JP, Deisseroth AB, Woodworth T. Therapeutic effects of genetically engineered toxin (DAB486IL-2) in patient with chronic lymphocytic leukaemia. Lancet 337(8750):1124-5, 5/1991. PMID: 1674015.
59. Dexeus FH, Logothetis CJ, Sella A, Fitz K, Amato R, Reuben JM, Dozier N. Phase II study of coumarin and cimetidine in patients with metastatic renal cell carcinoma. J Clin Oncol 8(2):325-9, 2/1990. PMID: 2137163.
60. Brewton GW, Hersh EM, Rios A, Mansell PW, Hollinger B, Reuben JM. A pilot study of diethyldithiocarbamate in patients with acquired immune deficiency syndrome (AIDS) and the AIDS-related complex. Life Sci 45(26):2509-20, 1989. PMID: 2559272.
61. Childs C, Hirsch-Ginsberg C, Walters RS, Anderson BS, Reuben JM, Trujillo JM, Cork A, Stass SA, Freireich EJ, Zipf TF. Myeloid surface antigen-positive acute lymphoblastic leukemia (My+ALL): Immunophenotypic, ultrastructural, cytogenetic, and molecular characteristics. Leukemia 3:777-783, 1989.
62. Hersh EM, Murray JL, Hong WK, Rosenblum MG, Reuben JM, Weilbaecher R, Sarwal AN, Bradley EC, Konrad M, Arnett FC. Phase I study of cancer therapy with recombinant interleukin-2 administered by intravenous bolus injection. Biotherapy 1(3):215-26, 1989. PMID: 2642025.
63. Schantz SP, Savage HE, Brown BW, Reuben JM, Hong WK, Rossen RD. Association of levels of circulating C1q binding macromolecules with induction chemotherapy response in head and neck cancer patients. Cancer Res 48(20):5868-73, 10/1988. PMID: 3262415.
64. Reuben JM, LaRocco, M. Cellular response in Acquired Immunedeficiency Syndrome. Clin Lab Sci 1:90-95, 1988.
65. Hersh EM, Peterson EA, Yocum DE, Goman SR, Darragh MJ, Gschwind CR, Brewton GW, Reuben JM. Immunological characteristics and potential approaches to immunotherapy of HIV infection. Recent Results Cancer Res 112:17-26, 1988.
66. Childs C, Hirsch-Ginsberg C, Culbert SJ, Ahearn M, Reuben JM, Trujillo JM, Cork A, Walters RR, Freireich EJ, Stass SA. Lineage heterogeneity in acute leukemia with the t(4;11) abnormality: Implications for acute mixed lineage leukemia. Hematologic Pathol 2:145-157, 1988.
67. Lopez-Berestein G, Turpin J, Hester JP, Gschwind C, Reuben JM. Liposomal amphotericin B on human peripheral blood monocytes and lymphocytes. J Liposomal Res 1:81-92, 1988.
68. LeMaistre CF, Powers C, Reuben JM. Monoclonal antibodies and flowcytometry in characterization of acute leukemias. Clin Lab Sci 1:29-31, 1988.
69. Hirsch-Ginsberg C, Childs C, Chang K, Beran M, Cork A, Reuben JM, Freireich EJ, Chang LCM, Bollum FJ, Trujillo J, Stass SA. Phenotypic and molecular heterogeneity in Philadelphia chromosome positive (Ph1) acute leukemia. Blood 71:186-195, 1988.
70. Daiger SP, Brewton GW, Rios A, Mansell PWA. Reuben JM. Genetic susceptibility to AIDS: Absence of an association with group-specific component (Gc). NEJM 317:630-632, 9/1987.
71. Talpaz M, Rosenblum M, Kurzrock R, Reuben J, Kantarjian H, Gutterman J. Clinical and laboratory changes induced by alpha interferon in chronic lymphocytic leukemia--a pilot study. Am J Hematol 24(4):341-50, 4/1987. PMID: 3494396.
72. Drewinko B, Moskwa P, Reuben J. Expression of transferrin receptors is unrelated to proliferative status in cultured human colon cancer cells. Anticancer Res 7(2):139-41, 3/1987. PMID: 3592625.
73. Murray JL, Reuben JM, Smith TL, Gehan EA, Koretz SM, Hersh EM. A pilot clinical trial of the toxicity and immunorestorative effects of T cell reconstituting factor (SR 270258) in immunosuppressed cancer patients. J Biol Response Mod 6(1):56-68, 2/1987. PMID: 2951501.
74. Murray JL, Bywaters DW, Reuben JM, Mansell PW, Hersh EM. Decreased 5'-nucleotidase activity in suppressor (OKT8) T lymphocytes from homosexuals with AIDS-related complex: nonassociation with enhanced deoxynucleoside toxicity. Clin Immunol Immunopathol 42(1):10-7, 1/1987. PMID: 3024891.
75. Lepe-Zuniga JL, Quesada JR, Baron S, Reuben J, Gutterman JU. Alpha interferon production in patients with hairy cell leukemia: correlations with disease activity and remission status. Hematol Pathol 1(3):157-65, 1987. PMID: 3150846.
76. Pollock R, Ames F, Rubio P, Jones J, Reuben J, Wong W, Mavligit G. Protracted severe immune dysregulation induced by cardiopulmonary bypass: a predisposing etiologic factor in blood transfusion-related AIDS? J Clin Lab Immunol 22(1):1-5, 1987. PMID: 2882027.
77. Sumaya CV, Boswell RN, Ench Y, Kisner DL, Hersh EM, Reuben JM, Mansell PW. Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex. J Infect Dis 154(5):864-70, 11/1986. PMID: 3021868.
78. Hortobagyi GN, Hersh EM, Papadopoulos NE, Frye D, Rios A, Reuben JM, Plager C, Rosenblum M, Quesada J. Initial clinical studies with copovithane. J Biol Response Mod 5(4):319-29, 8/1986. PMID: 2942646.
79. Quesada JR, Hersh EM, Manning J, Reuben J, Keating M, Schnipper E, Itri L, Gutterman JU. Treatment of hairy cell leukemia with recombinant alpha-interferon. Blood 68(2):493-7, 8/1986. PMID: 3730612.
80. Kurzrock R, Quesada JR, Talpaz M, Hersh EM, Reuben JM, Sherwin SA, Gutterman JU. Phase I study of multiple dose intramuscularly administered recombinant gamma interferon. J Clin Oncol 4(7):1101-9, 7/1986. PMID: 3088221.
81. Patt YZ, Mavligit GM, Reuben J, Mansell PW, Li S, Newell G, Talpaz M, Hersh EM. Modulation in vitro of immune parameters in homosexual males with the preclinical complex of symptoms related to acquired immune deficiency syndrome by azimexon. J Biol Response Mod 5(3):263-9, 6/1986. PMID: 3088215.
82. Murray JL, Reuben JM, Smith TL, Gehan EA, Koretz SH, Hersh EM. A pilot clinical trial of the toxicity and immunorestorative effects of T cell reconstituting factor (SR270258) in immunosuppressed cancer patients. J Biol Res Modifiers 6:56-68, 1986.
83. Murray JL, Bywaters DW, Reuben JM, Mansell PWA, Hersh EM. Decreased 5' nucleotidase activity in suppressor (OKT-8) T lymphocytes from homosexuals with AIDS-Related Complexes: Nonassociation with enhanced deoxynucleoside toxicity. Clin Immunol Immunopathol 42:10-17, 1986.
84. Patt YZ, Mansell PW, Reuben JM, Claghorn L, Li S, Gehan E, Hersh EM. Effect of azimexon therapy on host defense parameters and disease-associated symptoms in the acquired immune deficiency syndrome (AIDS) and AIDS-related complex (ARC). AIDS Res 2(3):191-209, 1986. PMID: 3755909.
85. Hortobagyi GN, Papadoupoulos NE, Frye D, Ajani J, Reuben JM. Phase I clinical study of nafazatrom. Invest New Drugs 4(3):251-5, 1986. PMID: 3818230.
86. Reuben JM, LaRocco JM, Gschwind CR, Stroud C, Rios A, Hersh EM, Mansell PW. Relationship of exposure to human T lymphotropic virus and T helper cells in homosexual men. AIDS Res 2(2):117-26, 1986. PMID: 3013220.
87. Quesada JR, Reuben J, Hopfer RL, Mundon FK, Hersh EM. Serologic studies in hairy cell leukemia: high prevalence of Epstein-Barr and cytomegalovirus antibodies and absence of human T-cell lymphotrophic viruses antibodies. Leuk Res 10(10):1169-73, 1986. PMID: 3022079.
88. Loftin KC, Reuben JM, Dalton W, Hersh EM, Sujansky D. Terminal transferase in leukemias by flow cytometry. Diagn Immunol 4(3):165-9, 1986. PMID: 3460728.
89. Zander AR, Reuben JM, Johnston D, Vellekoop L, Dicke KA, Yau JC, Hersh EM. Immune recovery following allogeneic bone marrow transplantation. Transplantation 40(2):177-83, 8/1985. PMID: 3895625.
90. Murray JL, Loftin KC, Munn CG, Reuben JM, Mansell PW, Hersh EM. Elevated adenosine deaminase and purine nucleoside phosphorylase activity in peripheral blood null lymphocytes from patients with acquired immune deficiency syndrome. Blood 65(6):1318-24, 6/1985. PMID: 3922455.
91. Newell GR, Mansell PW, Spitz MR, Reuben JM, Hersh EM. Volatile nitrites. Use and adverse effects related to the current epidemic of the acquired immune deficiency syndrome. Am J Med 78(5):811-6, 5/1985. PMID: 2859805.
92. Murray JL, Hersh EM, Reuben JM, Munn CG, Mansell PW. Abnormal lymphocyte response to exogenous interleukin-2 in homosexuals with acquired immune deficiency syndrome (AIDS) and AIDS related complex (ARC). Clin Exp Immunol 60(1):25-30, 4/1985. PMID: 3924451.
93. Lopez-Berestein G, Fainstein V, Hopfer R, Mehta K, Sullivan MP, Keating M, Rosenblum MG, Mehta R, Luna M, Hersh EM, et al. Liposomal amphotericin B for the treatment of systemic fungal infections in patients with cancer: a preliminary study. J Infect Dis 151(4):704-10, 4/1985. PMID: 3973417.
94. Rios A, Mansell PW, Newell GR, Reuben JM, Hersh EM, Gutterman JU. Treatment of acquired immunodeficiency syndrome--related Kaposi's sarcoma with lymphoblastoid interferon. J Clin Oncol 3(4):506-12, 4/1985. PMID: 3872349.
95. Loftin KC, Reuben JM, Hersh EM, Sujansky D. Cytoplasmic IgM in leukemic B cells by flow cytometry. Leuk Res 9(11):1379-87, 1985. PMID: 3935880.
96. Sprigley, Barlogie, B, Butler, J, Osborne, B, Blick, M, Johnston, D, Kantarjian, H, Reuben, JM, Batsakis, J, Freireich, EM. Hetergeneity of non-Hodgkin's lymphoma probed by nucleic acid cytometry. Blood 65:1090-1096, 1985.
97. Reuben JM, Hersh EM, Murray JL, Munn CG, Mehta SR, Mansell PW. IL-2 production and response in vitro by the leukocytes of patients with acquired immune deficiency syndrome. Lymphokine Res 4(2):103-16, 1985. PMID: 2987624.
98. Hersh EM, Reuben JM, Mansell PWA, Rios A, Gutterman JU, Munn CG, Murray JL, Spector SP, Goldstein AL, Newell GR. Immunological studies of the acquired immune deficiency syndrome relationship of immunodeficiency to extent of disease. Ann NY Acad Sci 437:364-372, 1985.
99. Hersh EM, Gutterman JU, Spector S, Friedman H, Greenberg SB, Reuben JM, LaPushin R, Matza M, Mansell PW. Impaired in vitro interferon, blastogenic, and natural killer cell responses to viral stimulation in acquired immune deficiency syndrome. Cancer Res 45(1):406-10, 1985. PMID: 2578099.
100. Murray JL, Reuben JM, Munn CG, Newell G, Mansell PW, Hersh EM. In vitro modulation of purine enzyme metabolism and lymphocyte surface marker expression by thymosin fraction 5 in homosexual males. Int J Immunopharmacol 7(5):661-9, 1985. PMID: 2995264.
101. Hersh EM, Mansell PW, Reuben JM, Rios A, Newell GR. Immunological characterizations of patients with acquired immune deficiency syndrome, acquired immune deficiency syndrome-related symptom complex, and a related life-style. Cancer Res 44(12 Pt 1):5894-901, 12/1984. PMID: 6209006.
102. Murray JL, Reuben JM, Munn CG, Mansell PW, Newell GR, Hersh EM. Decreased 5' nucleotidase activity in lymphocytes from asymptomatic sexually active homosexual men and patients with the acquired immune deficiency syndrome. Blood 64(5):1016-21, 11/1984. PMID: 6091811.
103. Reuben JM, Hersh EM. Delayed hypersensitivity responses of cancer patients to recall antigens using a new "Multitest" applicator. Ann Allergy 53(5):390-4, 11/1984. PMID: 6594072.
104. Quesada JR, Reuben J, Manning JT, Hersh EM, Gutterman JU. Alpha interferon for induction of remission in hairy-cell leukemia. N Engl J Med 310(1):15-8, 1/1984. PMID: 6689734.
105. Hersh EM, Reuben JM, Mansell PW, Rios A, Gutterman JU, Munn G, Murray JL, Spector SP, Goldstein AL, Newell GR. Immunologic studies of the acquired immune deficiency syndrome: relationship of immunodeficiency to extent of disease. Ann N Y Acad Sci 437:364-72, 1984. PMID: 6242001.
106. Munn CG, Reuben JM, Hersh EM, Mansell PW, Newell GR. T cell surface antigen expression on lymphocytes of patients with AIDS during in vitro mitogen stimulation. Cancer Immunol Immunother 18(3):141-8, 1984. PMID: 6334551.
107. Garcia I, Fainstein V, Rios A, Luna M, Mansell P, Reuben J, Hersh E. Nonbacterial thrombotic endocarditis in a male homosexual with Kaposi's sarcoma. Arch Intern Med 143(6):1243-4, 6/1983. PMID: 6305296.
108. Hersh EM, Mansell PW, Reuben JM, Frank J, Rios A, LaPushin R, Newell G. Suppressor cell activity among the peripheral blood leukocytes of selected homosexual subjects. Cancer Res 43(4):1905-9, 4/1983. PMID: 6219738.
109. Reuben JM, Hersh EM, Mansell PW, Newell G, Rios A, Rossen R, Goldstein AL, McClure JE. Immunological characterization of homosexual males. Cancer Res 43(2):897-904, 2/1983. PMID: 6600216.
110. Lopez-Berestein G, Reuben J, Hersh EM, Kilbourn R, Hester JP, Bielski M, Talpaz M, Mavligit GM. Comparative functional analysis of lymphocytes and monocytes from plateletapheresis. Transfusion 23(3):201-6, 1983. PMID: 6679372.
111. Hersh EM, Reuben JM, Bogerd H, Rosenblum M, Bielski M, Mansell PW, Rios A, Newell GR, Sonnenfeld G. Effect of the recreational agent isobutyl nitrite on human peripheral blood leukocytes and on in vitro interferon production. Cancer Res 43(3):1365-71, 1983. PMID: 6186374.
112. Hersh EM, Reuben JM, Rios A, Mansell PW, Newell GR, McClure JE, Goldstein AL. Elevated serum thymosin alpha 1 levels associated with evidence of immune dysregulation in male homosexuals with a history of infectious diseases or Kaposi's sarcoma. N Engl J Med 308(1):45-6, 1983. PMID: 6847923.
113. Hersh EM, Reuben JM, Mansell PW, Rios A, Newell GR, Frank J, Goldstein AL. Immunological studies of male homosexuals with the prodrome of the acquired immunodeficiency syndrome (AIDS). Adv Exp Med Biol 166:285-93, 1983. PMID: 6606304.
114. Hersh EM, Mansell PW, Reuben JM, Rios A, Newell GR, Goldstein AL, Lynch K. Leukocyte subset analysis and related immunological findings in acquired immunodeficiency disease syndrome (AIDS) and malignancies. Diagn Immunol 1(3):168-73, 1983. PMID: 6238750.
115. Reuben JM, Tanner CE. Protection against experimental echinococcosis by non-specifically stimulated peritoneal cells. Parasite Immunol 5(1):61-6, 1983. PMID: 6338457.
116. Quesada JR, Reuben, JM, Scouros MA, Murphy SG. Autologous mixed lymphocyte reaction in lymphoid malignancies. Lack of correlation with disease activity or clinical remission. Cancer Immunol Immunother 12:231-239, 1982.
117. Reuben JM, Tanner CE, Portelance V. Protection of cotton rats against experimental Echinococcus multilocularis infections with BCG cell walls. Infect Immun 23(3):582-6, 3/1979. PMID: 378829.
118. Reuben JM, Tanner CE, Rau ME. Immunoprophylaxis with BCG of experimental Echinococcus multilocularis infections. Infect Immun 55(1):105-108, 1979. PMID: 711311.
119. Hillar M, Reuben J. Hormonal induction of glutamate dehydrogenase in rat liver. Experientia 32(5):653-5, 5/1976. PMID: 179844.

Invited Articles

1. Reuben JM, Krishnamurthy S, Woodward W, Cristofanilli M. The role of circulating tumor cells in breast cancer diagnosis and prediction of therapy response. Expert Opinion on Medical Diagnostics 2(4):339-348, 2008.


1. Dawood S, Broglio K, Reuben JM, Handy B, Han X, Ginsberg C, Remus L, Sun X, Islam R, Kau SW, Fritsche H, Valero V, Ueno N, Hortobagyi GN, Massimo Cristofanilli M. Circulating Tumor Cells (CTCs) and Prognostic Stratification in Metastatic Breast Cancer (MBC): Need for a Modification of the AJCC Staging System?. 2007 San Antonio Breast Cancer Symposium (#111), 2007.

Book Chapters

1. Reuben JM, Cristofanilli M. Detection and Clinical Implications of Occult Systemic Micrometastatic Breast Cancer. In: The Breast:Comprehensive Management of Benign and Malignant Disorders, Fourth. Ed(s) KI Bland, EM Copeland. Saunders-Elsevier: Philadelphia, PA, 1203-1210, 2009. ISBN: 978-1-4160-5221-0.

Grant & Contract Support

Title: Phase 1b pilot study to evaluate reparixin in combination with chemotherapy with weekly Taxol in patients with metastatic breast cancer
Funding Source: Dompe S.p.a.
Role: Principal Investigator
Duration: 8/1/2013 - 12/31/2014
Title: Development of Sialyl-Lex ) CSLEX as novel diagnostic assay for breast cancer
Funding Source: Nitto Boseki Co, Ltd
Role: Principal Investigator
Duration: 7/16/2009 - 7/15/2012
Title: Mechanisms of symptoms of multiple myeloma and its treatment
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: C.S. Cleeland, MD
Duration: 9/1/2008 - 6/30/2013
Title: Novel targets for treatment and detection of inflammatory breast cancer
Funding Source: American Airlines Susan G. Komen Promise Grant
Role: Co-Investigator
Principal Investigator: Fredika Roberston, MD and Massimo Cristofanilli, MD
Duration: 9/1/2008 - 8/31/2011
Title: Neuropathic pain alliance
Funding Source: Astra Zeneca
Role: Co-Investigator
Duration: 12/1/2007 - 11/30/2013
Title: Identifying the Role of Inflammatory Cytokines in Symptom Production in Multiple Myeloma
Funding Source: Astra Zeneca
Role: Co-Investigator
Principal Investigator: CS Cleeland, MD
Duration: 11/26/2007 - 11/30/2013
Title: Mechanisms of Symptoms Related to Lung Cancer Therapy
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Cleeland
Duration: 1/1/2005 - 12/31/2007
Title: HIV sleep study in adolescents and older children.
Funding Source: NIH/NHLBI
Role: Co-Investigator
Principal Investigator: William T. Shearer, MD, PhD
Duration: 11/1/2004 - 5/31/2009
Title: Sleep Studies in HIV+ Older Children/Adolescents,
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: William T. Shearer, M.D., Ph.D. (PI)
Duration: 9/24/2004 - 6/30/2008

Last updated: 8/17/2015