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Jason B. Fleming, M.D., F.A.C.S.

Present Title & Affiliation

Primary Appointment

Professor, Term Tenure, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX

Bio Statement

Dr. Fleming is a pancreatic surgeon at MD Anderson and serves as director of the tissue acquisition and biorepository core for the Pancreas Cancer Research Program at MD Anderson. Dr. Fleming initiated and developed the first direct xenograft program in GI cancer at MD Anderson. These are derived from human pancreatic adenocarcinomas that Dr. Fleming and his surgical colleagues surgically remove from patients at MD Anderson. Direct xenografts recapitulate the tumor microenvironment and provide a unique platform to examine pancreatic adenocarcinoma.

Office Address

The University of Texas MD Anderson Cancer Center
1400 Pressler Street
Unit Number: 1484
Houston, TX 77030
Room Number: FCT17.5048
Phone: 713-745-0890
Fax: 713-745-4426
Email: jbflemin@mdanderson.org

Education & Training

Degree-Granting Education

1990 University of Tennessee Center of Health Science, Memphis, TN, MD, Doctor of Medicine
1986 Vanderbilt University, Nashville, TN, BS, Molecular Biology

Postgraduate Training

1997-1999 Clinical Fellowship, Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, Raphael E. Pollock, M.D.
1993-1995 Research Fellowship, University of Texas Southwestern Medical Center, Hamon Center for Therapeutic Oncology, Dallas, TX, John D. Minna, M.D.
1990-1997 Clinical Residency, General Surgery, University of Texas Southwestern Medical Center, Dallas, TX, C. James Carrico, M.D.

Board Certifications

12/2008 American Board of Surgery Certification

Experience/Service

Academic Appointments

Associate Professor, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006-2012
Associate Professor, Surgery, Surgical Oncology, The University of Texas Southwestern Medical Center, Dallas, TX, 2005-2006
Graduate Faculty, Integrative Biology and Cancer Biology Programs, Basic Science, The University of Texas Southwestern Graduate School of Biomedical Sciences, Dallas, TX, 2002-2006
Assistant Professor, The University of Texas Southwestern Medical Center, Dallas, TX, 1999-2005

Administrative Appointments/Responsibilities

Chief, Section on Pancreas Surgery, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-present
Program Director, Surgical Oncology Fellowship, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-present
Program Director, International Surgical Oncology Fellowship, Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 2009-present

Other Appointments/Responsibilities

Member, Dan L. Duncan Cancer Center at Baylor College of Medicine, Data and Safety Monitoring Board (DSMB), Houston, TX, 9/2011-present

Honors and Awards

2012-present Guide to America's Top Surgeons, Consumer Research Council of America
2012-present Texas Super Doctors 2011, Texas Monthly, December
2011-2012 Texas Super Doctors 2011, Texas Monthly, December
2009 Outstanding Teaching Award, Department of Surgical Oncology
2008 J Bradley Aust Award, Western Surgical Society
1989 Alpha Omega Alpha

Professional Memberships

Alpha Omega Alpha Fraternity
Member, 1989
American Association for Cancer Research
Member, 2003-present
American Board of Surgery Certifying Examination, Dallas, TX
Associate Examiner, 2010-present
American Cancer Society
Member, 2001
American College of Surgeons
Fellow, 2003
American Medical Association
Member, 1990
American Society of Clinical Oncology
Member, 2002-present
Association of Program Directors in Surgery
Member, 2002
Juvenile Diabetes Research Foundation, Greater Dallas Chapter, Dallas, TX
Board of Directors, 2002-present
North Texas Chapter of the American College of Surgeons
Member, 2000
Pancreas Cancer Action Network
Medical Advisory Board, 2008-present
Member, 2008-present
Pancreas Club
Member, 2006-present
Parkland Surgical Society
Member, 1995
Pharmacy & Therapeutics Committee, MD Anderson Cancer Center, Houston, TX
Member, 9/2011-present
Society of Surgical Oncology
Appointed Member, Education Council, 2011-2014
Scientific Committee, 2006-present
Member, 2002
Society of University Surgeons (SUS)
Member, 2003-present
Texas Medical Association
Expert Panel Member, 2005
Member, 1990
Western Surgical Society
Chair, 2013 Membership Committee, 2012-present
Member, 2013 Executive Committee, 2012-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, Abbruzzese JL, Chiao PJ. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther 7(4):829-840, 2008.
2. Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A, Evans DB. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 26(18):3063-3072, 2008.
3. Katz MH, Hwang R, Fleming JB, Evans DB. Tumor-node-metastasis staging of pancreatic adenocarcinoma. CA Cancer J Clin 58(2):111-25, 2008. PMID: 18272835.
4. Hwang RF, Wang H, Lara A, Gomez H, Chang T, Sieffert N, Moon Y, Ram S, Zimmerman S, Lee JH, Pisters PW, Tamm EP, Fleming JB, Abbruzzese JL, Evans DB. Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer. Ann Surg Oncol 15(5):1356-66, 2008. PMID: 18256882.
5. Blazer DG, Ramirez PT, Wang H, Fleming JB. Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas. JOP 9(1):56-60, 2008. PMID: 18182745.
6. Katz MH, Fleming JB, Pisters PW, Lee JE, Evans DB. Anatomy of the superior mesenteric vein with special reference to the surgical management of first-order branch involvement at pancreaticoduodenectomy. Ann Surg 248(6):1098-102, 2008. PMID: 19092356.
7. Crane CH, Varadhachary G, Settle SH, Fleming JB, Evans DB, Wolff RA. The integration of chemoradiation in the care of patient with localized pancreatic cancer. Cancer Radiother 13(2):123-43, 4/2009. PMID: 19167921.
8. Katz MH, Wang H, Fleming JB, Sun CC, Hwang RF, Wolff RA, Varadhachary G, Abbruzzese JL, Crane CH, Krishnan S, Vauthey JN, Abdalla EK, Lee JE, Pisters PW, Evans DB. Long-term survival after multidisciplinary management of resected pancreatic adenocarcinoma. Ann Surg Oncol 16(4):836-47, 4/2009. PMID: 19194760.
9. Kim MP, Evans DB, Vu TM, Fleming JB. The recognition and surgical management of heritable lesions of the pancreas. Surg Oncol Clin N Am 18(1):99-119, 1/2009. PMID: 19056044.
10. Mummadi RR, Nealon WH, Artifon EL, Fleming JB, Bhutani MS. Pancreatic Schwannoma presenting as a cystic lesion. Gastrointest Endosc 69(2):discussion 341, 2/2009. PMID: 19185694.

Grant & Contract Support

Title: Tissue pharmacokinetics of intraoperative gemcitabine in resectable PC: A novel preoperative platform in pancreatic cancer for mechanistic studies
Funding Source: UT MD Anderson Cancer Center
Role: Collaborator
Principal Investigator: Varadhachary
Duration: 7/1/2011 - 6/30/2013
 
Title: Intraoperative Gemcitabine for Resectable Adenocarcinoma of the Pancreas: A Pharmacokinetic Clinical Trial
Funding Source: NIH/NCI
Role: Mentor
Principal Investigator: Truty
Duration: 6/30/2011 - 6/30/2012
 
Title: A Novel Preoperative Platform in Pancreatic Cancer for Mechanistic Studies
Funding Source: Lustgarten Foundation
Role: Collaborator
Principal Investigator: Varadhachary
Duration: 5/1/2011 - 4/30/2013
 
Title: Expression of TGFBR II or IGFBP-3 and the Effectiveness of TGFB/SMAD Pathway Targeted Therapy Human Pancreatic Cancer
Funding Source: ImClone Systems
Role: Principal Investigator
Duration: 9/1/2010 - 7/5/2013

Last updated: 2/27/2013