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Javier O. Valenzuela, PhD

Present Title & Affiliation

Primary Appointment

Instructor, Department of Symptom Research, The University of Texas M. D. Anderson Cancer Center, Houston, TX

Office Address

The University of Texas M. D. Anderson Cancer Center
1400 Pressler Street
Unit Number: 1450
Houston, TX 77030
Room Number: FCT11.5060
Phone: 713-563-1658
Fax: 713-745-3475

Education & Training

Degree-Granting Education

2003 University of Minnesota, Minneapolis, MN, PHD, Microbiology, Immunology and Cancer Biology
1996 Catholic University of Chile, Santiago, Chile, MS, Biochemistry
1994 Catholic University of Chile, Santiago, Chile, BS, Biochemistry

Postgraduate Training

2005-2008 Postdoctoral Research Fellow, Immunology, H. Lee Moffitt Cancer Center, Tampa, FL
2004-2005 Postdoctoral Research Fellow, Immunology, Columbia University, New York, NY

Experience/Service

Institutional Committee Activities

Member, Division of Internal Medicine Research Committee, 9/2009-present

Selected Publications

Peer-Reviewed Original Research Articles
1. Valenzuela J.O., Iclozan C., Hossain M.S., Prlic M., Hopwell E., Bronk C.C., Wang J., Celis E., Engelman R. W., Blazar B. R., Bevan M.J., Waller E.K., Yu X.Z., and Beg A.A. PKC-Theta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. J. Clin. Invest. (in press)., 2009.
2. Curtsinger JM, Valenzuela JO, Agarwal P, Lins D, Mescher MF. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174(8):4465-9, 4/2005. PMID: 15814665.
3. Valenzuela JO, Hammerbeck CD, Mescher MF. Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells. J Immunol 174(2):600-4, 1/2005. PMID: 15634875.
4. Valenzuela J, Schmidt C, Mescher M. The roles of IL-12 in providing a third signal for clonal expansion of naive CD8 T cells. J Immunol 169(12):6842-9, 12/2002. PMID: 12471116.
5. Valenzuela J, Bumann U, Cespedes R, Padilla L, Gonzalez B. Degradation of chlorophenols by Alcaligenes eutrophus JMP134(pJP4) in bleached Kraft mill effluent. Appl Environ Microbiol 63(1):227-232, 1/1997. PMCID: PMC1389102.
6. Gonzalez B, Clement P, Cespedes R, Valenzuela J, Matus V, Maturana A, Ehrenfeld N. Degradation of environmental pollutants by Alcaligenes eutrophus JMP134 (pJP4). Environmental Toxicology Water Quality, 1995.

Abstracts
1. Valenzuela JO, Wang X, Hussain S, Beato F, Liang Y, Yu XZ, Beg AA. The roles of PKC-Theta in the initial proliferation and cytolytic activity of naive CD8 T cells. 1st Annual Signature Interdisciplinary Program in Allergy, Immunology & Infectious Diseases, Tampa FL, 11/2007.
2. Valenzuela JO, Wang X, Hussain S, Beato F, Liang Y, Yu XZ, Beg AA. The roles of PKC-Theta in the initial proliferation and cytolytic activity of naive CD8 T cells. American Association of Immunologists 94th Annual Meeting, Miami FL, 5/2007.
3. Valenzuela J, Schmidt C, Mescher M. IL-12 promotes proliferation of naïve CD8+ T cells via CD25-dependent and independent mechanisms. 2002 Keystone Symposia on Innate Immunity: Evolution and Link to Adaptive Immunity, Taos NM, 2002.
4. Valenzuela J, Schmidt C, Mescher M. IL-12 promotes proliferation of naïve CD8+ T cells via CD25-dependent and independent mechanisms. 30th Annual Autumn Immunology Conference, Chicago IL, 2002.
5. Valenzuela JO, Mescher MF. IL-12 upregulates the survival factor Bcl-3 in activated naïve CD8 T cells. 31st Annual Autumn Immunology Conference, Chicago IL, 2002.
6. Valenzuela J, Curtsinger J, Mescher M. Naive CD8+T cell activation requires three signals. 2000 Keystone Symposia on T Lymphocyte Activation, Differentiation and Death, Keystone CO, 2000.
7. Valenzuela J, Curtsinger J, Mescher M. Naive CD8+T cell activation requires three signals. 28th Annual Autumn Immunology Conference, Chicago IL, 2000.
8. Valenzuela J, Mescher M. Regulation of the expression of IL-12R beta-1 in naive CD8+ T cells. 27th Annual Autumn Immunology Conference, Chicago IL, 1998.
9. Gonzalez B, Cespedes R, Valenzuela J, Maturana A, Matus V, Clement P. Degradation of chloroorganics by Alcaligenes eutrophus JMP134 (pJP4) of Kraft pulp bleaching effluent treatment lagoons. 7th International Symposium on Microbial Ecology, Santos, Brazil, 1995.
10. Gonzalez B, Clement P, Matus V, Ehrenfeld N, Maturana A, Valenzuela J, Cespedes R. Expansion of degradative abilities towards environmental pollutants in A. eutrophus JMP134 (pJP4). Juan March Workshop on Molecular Basis for Biodegradation of Pollutants, Madrid, Spain, 1995.
11. Valenzuela J, Mora G. Gene homology comparison between S. typhimurium and S. typhi by measuring homologous recombination frequencies of phage P22 transductions. Chilean Society of Biology 6th Annual Meeting, Puyehue, Chile, 1994.

Last updated: 10/20/2009