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Jian Chen, MD, Ph.D

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2003 Hokkaido University, Sapporo, Sapporo, Japan, PHD, Cancer Pathology
1990 Tianjin Medical University, Tianjin, China, MD, Medicine

Postgraduate Training

3/2006-11/2008 Postdoctoral Fellowship, Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
10/2003-9/2005 Postdoctoral Fellowship, Hakkaido University, Sapporo, Japan
8/1994-3/1997 Clinical Residency, Cardiothoracic Surgery, Tianjin Medical University, Tianjin, China
8/1991-7/1994 Clinical Fellowship, Surgical Oncology, Tianjin Medical University, Tianjin, China
8/1990-7/1991 Clinical Internship, General Surgery, Tianjin Medical University, Tianjin, China

Honors and Awards

2003-2005 Postdoctoral Fellowship for Foreign Researchers of the Japan Society for Promotion of Science
2001-2002 Hokkaido Outstanding Foreign Student Scholarship
1999-2001 NPO Tsukusi Scholarship
1998-2001 Hokkaido Foreign Student Scholarship, Hokkaido University

Professional Memberships

American Association for Cancer Research
Member, 2012-present
Japanese Cancer Association, Japan
Member, 2002-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Shin J, Phan L, Chen J, Lu Z, Lee MH. CSN6 positively regulates c-Jun in a MEKK1-dependent manner. Cell Cycle. e-Pub 8/2015. PMID: 26237449.
2. Shetty K, Chen J, Shin JH, Jogunoori W, Mishra L. PATHOGENESIS OF HEPATOCELLULAR CARCINOMA DEVELOPMENT IN NON ALCOHOLIC FATTY LIVER DISEASE. Curr Hepatol Rep 14(2):119-127, 6/2015. PMCID: PMC4476538.
3. Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nat Commun 6:7530, 2015. e-Pub 7/2015. PMCID: PMC4507299.
4. Muñoz NM, Katz LH, Shina JH, Gi YJ, Menon VK, Gagea M, Rashid A, Chen J, Mishra L. Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption. Genes Cancer 5(9-10):348-52, 9/2014. PMCID: PMC4209606.
5. Fuentes-Mattei E, Velazquez-Torres G, Phan L, Zhang F, Chou PC, Shin JH, Choi HH, Chen JS, Zhao R, Chen J, Gully C, Carlock C, Qi Y, Zhang Y, Wu Y, Esteva FJ, Luo Y, McKeehan WL, Ensor J, Hortobagyi GN, Pusztai L, Fraser Symmans W, Lee MH, Yeung SC. Effects of obesity on transcriptomic changes and cancer hallmarks in estrogen receptor-positive breast cancer. J Natl Cancer Inst 106(7), 7/2014. e-Pub 6/2014. PMCID: PMC4110474.
6. Chen J, Shin JH, Zhao R, Phan L, Wang H, Xue Y, Post SM, Ho Choi H, Chen JS, Wang E, Zhou Z, Tseng C, Gully C, Velazquez-Torres G, Fuentes-Mattei E, Yeung G, Qiao Y, Chou PC, Su CH, Hsieh YC, Hsu SL, Ohshiro K, Shaikenov T, Wang H, Yeung SC, Lee MH. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun 5:5384, 2014. e-Pub 11/2014. PMCID: PMC4234183.
7. Katz LH, Li Y, Chen JS, Muñoz NM, Majumdar A, Chen J, Mishra L. Targeting TGF-β signaling in cancer. Expert Opin Ther Targets. e-Pub 5/2013. PMID: 23651053.
8. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 11(22):4181-90, 11/15/2012. e-Pub 10/24/2012. PMCID: PMC3524214.
9. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 109(24):E1513-22, 6/12/2012. e-Pub 5/18/2012. PMCID: PMC3386093.
10. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. Oncogene 30(48):4791-801, 12/1/2011. e-Pub 5/30/2011. PMCID: PMC3358116.
11. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med 15(4):825-36, 4/2011. PMCID: PMC2930937.
12. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 3/2011. e-Pub 2/7/2011. PMCID: PMC3049400.
13. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res 71(3):884-94, 2/1/2011. e-Pub 12/6/2010. PMCID: PMC3358120.
14. Zhao R, Fuentes-Mattei E, Velazquez-Torres G, Su CH, Chen J, Lee MH, Yeung SC. Exenatide improves glucocorticoid-induced glucose intolerance in mice. Diabetes Metab Syndr Obes 4:61-5, 2011. e-Pub 1/26/2011. PMCID: PMC3064408.
15. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer 9:42, 2010. e-Pub 2/22/2010. PMCID: PMC2839967.
16. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage. Mol Cancer 9:243, 2010. e-Pub 9/15/2010. PMCID: PMC2949799.
17. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene 28(28):2581-92, 7/16/2009. e-Pub 6/1/2009. PMCID: PMC3358117.
18. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol 175(1):400-11, 7/2009. e-Pub 6/15/2009. PMCID: PMC2708825.
19. Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem 103(4):1219-30, 3/1/2008. PMID: 17879958.
20. Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M. All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J Immunol 179(7):4616-25, 10/1/2007. PMID: 17878359.
21. Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Cancer Gene Ther 14(1):39-44, 1/2007. e-Pub 7/14/2006. PMID: 16841081.
22. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M. Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol 35(12):3468-77, 12/2005. PMID: 16259004.
23. Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, Esumi H. Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem 280(36):31557-63, 9/9/2005. e-Pub 7/13/2005. PMID: 16014625.
24. Chiba K, Zhao W, Chen J, Wang J, Cui HY, Kawakami H, Miseki T, Satoshi H, Tanaka J, Asaka M, Kobayashi M. Neutrophils secrete MIP-1 beta after adhesion to laminin contained in basement membrane of blood vessels. Br J Haematol 127(5):592-7, 12/2004. PMID: 15566363.
25. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A 101(21):8132-7, 5/25/2004. e-Pub 5/12/2004. PMCID: PMC419569.
26. Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162(4):1283-91, 4/2003. PMCID: PMC1851236.
27. Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M. Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis. Oncogene 22(8):1238-42, 2/27/2003. PMID: 12606950.
28. Chen J. [Dominant negative HIF-1 alpha reduces tumorigenicity of a human pancreatic cancer cell line]. Hokkaido Igaku Zasshi 77(4):367-78, 7/2002. PMID: 12187833.
29. Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada JI, Seth P, Katoh H, Watanabe H, Raz A, Hosokawa M. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br J Cancer 86(12):1914-9, 6/17/2002. PMCID: PMC2375441.
30. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura Ki , Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61(17):6548-54, 9/1/2001. PMID: 11522653.
31. Chen J, Shi NK, FU GZ. Analysis of 24 hours esophageal pH monitoring in cardiac cancer before and after cardiectomy. China National J New Gastroenterology 2 1-M36-184:121-122, 9/1996.
32. Chen J, Shi NK, FU GZ. Analysis of 24 hours esophageal pH monitoring in esophageal and cardiac cancer. China National J New Gastroenterology 2 1-M37, 9/1996.


1. Chen J, Chen J-S, Zhang J, Gi YJ, Phan L, Muñoz NM, Katz LH, Shin JH, Jeong YS, Menona VK, Jogunoori W, Mishra B, Javle M, Su X , Farci P, Shetty K, Wu X, Hung MC, Herlong HF, Davila M, Stroehlein JR, Shaw KR, Wang X, Morris J, Akbani R, Mishra L. Prognostic Significance of TGF-β Signaling in Human Hepatocellular Carcinoma. Gastroenterology 148(4):S-1024, 4/2015.
2. Chen J, Chen J-S, Yao Z, Jogunoori W, Mishra B, Herlong FH, Jeong YS, Mistrya NA, Zhang J, Su X, Rashida A, Davila M, Stroehlein JR, Shay JW, Mishra L. TGF-β-CTCF Regulated Pathway Suppresses Stem Cell Associated Tumor Progression. Gastroenterology 148(4):S-106, 4/2015.
3. Chen J, Gottumukula R , Menon V, Majumdar A, Chen J-S, Gi YJ, Mistry NA, Zhang J, Su X, Li S, Lin SH, Javle M, Mishra B, White J, Rashid A, Beauchemin N, Stroehlein JR, Davila M, Weston BR, Hafemeister L, Shafi MA, Wu X, and Mishra. The Genomic Landscape of Human Colon Adenomas Reveals Early Driver Mutations and a TGF-β-CEA Regulated Profile. Gastroenterology 148(4):S-353-S-354, 4/2015.
4. Ji-Hyun Shin, Lior H. Katz, Nina M. Muñoz, Andrea Cortes, Vivek Shukla, Sang-Bae Kim, Franklin Herlong, Keigo Machida, and others. Vitamin D Deficiency Promotes Hepatocellular Cancer via Regulating TLR7 in the Context of Loss of TGF-β/Smad3. Gastroenterology 148(4):S-366, 4/2015.
5. Jian Chen, Jiun-Sheng Chen, Zhixing Yao, Wilma Jogunoori, Bibhuti Mishra, Lopa Mishra. Targeting TGF-β? Regulated Telomerase: A Novel Therapeutic Approach for Liver and Gastrointestinal Cancers. Gastroenterology 146(5):S-919, 5/2014.
6. Chen J, Chen JS, Gi YJ, Katz L, Shin JH, Phan L, Jogunoori W, Shukla V, Mishra B, Li S, Javle M, Hung MC, Mishra L. TGF-β? Regulated E3 Ligase Are Novel Therapeutic Targets for Primary Liver Cancer. Gastroenterology 146(5):S-918, 5/2014.
7. Lior H. Katz, Andrea Cortes, Vivek Shukla, Keigo Machida, Hidekazu Tsukamoto, Kirti Shetty, Aiwu R. He, Lynt B. Johnson, and others. Vitamin D As a Chemopreventive Agent for Hepatocellular Carcinoma in the Context of Impaired TGF-β? Signaling Pathway. Gastroenterology 146(5):S-927, 5/2014.
8. Avijit Majumdar, Jian Chen, Sue-Hwa Lin, Lior H. Katz, Gottumukkala S. Raju, Kirti Shetty, Jon White, Xifeng Wu, and others. Whole Genome Analysis of Colon Adenomas Reveals Novel Prognostic and Therapeutic Targets. Gastroenterology 146(5):S-331, 5/2014.
9. Chen J, Chen JS, Gi YJ, Katz L, Shin JH, Phan L, Jogunoori W, Shukla V, Mishra B, Li S, Javle M, Hung MC, Mishra L. Targeting TGF-β regulated E3 ligases: a novel therapeutic approach for primary liver cancer(A2784), 4/2014.
10. Chen J, Chen JS, Yao Z, Jogunoori W, Mishra B, MishraL. Telomerase modulation in a human cancer stem cell syndrome with loss of TGF-β signaling is a promising treatment strategy in liver and gastrointestinal cancers(A115), 4/2014.
11. Jian Chen, Vivek Shukla, Ying Li, Jiun-Sheng Chen, Lior H. Katz, Avijit Majumdar, Lei Li, Walter N. Hittelman, and others. A Novel Somatic Mutation of β2sp Inactivates the TGF-β Pathway and Promotes Alcohol Induced HCC. Gastroenterology 144(5):S-954, 5/2013.
12. Jian Chen, Jiun-Sheng Chen, Vivek Shukla, Zhixing Yao, Wilma S. Jogunoori, Bibhuti Mishra, Lopa Mishra. The Oncogenic Role of Praja1 on Disrupting TGF-β Signaling in Hepatocellular Cancer. Gastroenterology 144(5):S-953, 5/2013.
13. ior H. Katz, Vivek Shukla, Sara Peleg, Kirti Shetty, Jian Chen, Steven Curley, Powel H. Brown, Lopa Mishra. Vitamin D for Prevention of Liver Cancer. Gastroenterology 144(5):S-942-S-943, 5/2013.
14. Pavlo L. Kovalenko, Lyudmyla Kunovska, Jian Chen, Kathleen A. Gallo, Marc D. Basson. Suppression of MLK3 Signaling Selectively Modulates MAPK and PTEN Signaling During Intestinal Mucosal Cell Migration. Gastroenterology 142(5):S-728-S-729, 5/2012.
15. Chen J, Yao Z, Saha T, Piao HL, Song S, Jogunoori W, Mishra B, Mishra L,. Targeting E3 ligases in liver cancer stem cells with disruption of TGF-B signaling 72(Suppl 8), 4/2012.
16. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang Hu, Wang HU, Yeung SC, Lee MH. Hypoxia-mediated upregulation of Pim-1 contributes to tumor survival. 70(Suppl 8), 4/2010.

Grant & Contract Support

Title: Cellular and Molecular Mechanisms of Gastrointestinal Cancers
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra
Duration: 9/1/2008 - 8/31/2014
Title: Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra
Title: Targeting E3 Ligase PRAJA in Hepatocellular Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra

Last updated: 8/19/2015