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Jian Chen, MD, Ph.D

Present Title & Affiliation

Primary Appointment

Assistant Professor, Department of Gastroenterology, Hepat,& Nutr, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX

Education & Training

Degree-Granting Education

2003 Hokkaido University, Sapporo, Sapporo, Japan, PHD, Cancer Pathology
1990 Tianjin Medical University, Tianjin, China, MD, Medicine

Postgraduate Training

3/2006-11/2008 Postdoctoral Fellowship, Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
10/2003-9/2005 Postdoctoral Fellowship, Hakkaido University, Sapporo, Japan
8/1994-3/1997 Clinical Residency, Cardiothoracic Surgery, Tianjin Medical University, Tianjin, China
8/1991-7/1994 Clinical Fellowship, Surgical Oncology, Tianjin Medical University, Tianjin, China
8/1990-7/1991 Clinical Internship, General Surgery, Tianjin Medical University, Tianjin, China

Honors and Awards

2003-2005 Postdoctoral Fellowship for Foreign Researchers of the Japan Society for Promotion of Science
2001-2002 Hokkaido Outstanding Foreign Student Scholarship
1999-2001 NPO Tsukusi Scholarship
1998-1999 Hokkaido Foreign Student Scholarship, Hokkaido University

Professional Memberships

American Association for Cancer Research
Member, 2012-present
Japanese Cancer Association, Japan
Member, 2002-present

Selected Publications

Peer-Reviewed Original Research Articles

1. Xue Y, Chen J, Choi HH, Phan L, Chou PC, Zhao R, Yang H, Santiago J, Liu M, Yeung GE, Yeung SC, Lee MH. HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 11(22):4181-90, 11/15/2012. e-Pub 10/24/2012. PMCID: PMC3524214.
2. Gully CP, Velazquez-Torres G, Shin JH, Fuentes-Mattei E, Wang E, Carlock C, Chen J, Rothenberg D, Adams HP, Choi HH, Guma S, Phan L, Chou PC, Su CH, Zhang F, Chen JS, Yang TY, Yeung SC, Lee MH. Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 109(24):E1513-22, 6/12/2012. e-Pub 5/18/2012. PMCID: PMC3386093.
3. Choi HH, Gully C, Su CH, Velazquez-Torres G, Chou PC, Tseng C, Zhao R, Phan L, Shaiken T, Chen J, Yeung SC, Lee MH. COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 ubiquitin ligase for 14-3-3σ. Oncogene 30(48):4791-801, 12/1/2011. e-Pub 5/30/2011. PMCID: PMC3358116.
4. Feng YH, Velazquez-Torres G, Gully C, Chen J, Lee MH, Yeung SC. The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med 15(4):825-36, 4/2011. PMCID: PMC2930937.
5. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest 121(3):851-65, 3/2011. e-Pub 2/7/2011. PMCID: PMC3049400.
6. Su CH, Zhao R, Zhang F, Qu C, Chen B, Feng YH, Phan L, Chen J, Wang H, Wang H, Yeung SC, Lee MH. 14-3-3sigma exerts tumor-suppressor activity mediated by regulation of COP1 stability. Cancer Res 71(3):884-94, 2/1/2011. e-Pub 12/6/2010. PMCID: PMC3358120.
7. Gully CP, Zhang F, Chen J, Yeung JA, Velazquez-Torres G, Wang E, Yeung SC, Lee MH. Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer. Mol Cancer 9:42, 2010. e-Pub 2/22/2010. PMCID: PMC2839967.
8. Su CH, Zhao R, Velazquez-Torres G, Chen J, Gully C, Yeung SC, Lee MH. Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage. Mol Cancer 9:243, 2010. e-Pub 9/15/2010. PMCID: PMC2949799.
9. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Yeung SC, Lee MH. Pim-1 plays a pivotal role in hypoxia-induced chemoresistance. Oncogene 28(28):2581-92, 7/16/2009. e-Pub 6/1/2009. PMCID: PMC3358117.
10. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang H, Wang H, Yeung SC, Lee MH. Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. Am J Pathol 175(1):400-11, 7/2009. e-Pub 6/15/2009. PMCID: PMC2708825.
11. Zhang XC, Chen J, Su CH, Yang HY, Lee MH. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem 103(4):1219-30, 3/1/2008. PMID: 17879958.
12. Darmanin S, Chen J, Zhao S, Cui H, Shirkoohi R, Kubo N, Kuge Y, Tamaki N, Nakagawa K, Hamada J, Moriuchi T, Kobayashi M. All-trans retinoic acid enhances murine dendritic cell migration to draining lymph nodes via the balance of matrix metalloproteinases and their inhibitors. J Immunol 179(7):4616-25, 10/1/2007. PMID: 17878359.
13. Miseki T, Kawakami H, Natsuizaka M, Darmanin S, Cui HY, Chen J, Fu Q, Okada F, Shindo M, Higashino F, Asaka M, Hamuro J, Kobayashi M. Suppression of tumor growth by intra-muscular transfer of naked DNA encoding adrenomedullin antagonist. Cancer Gene Ther 14(1):39-44, 1/2007. e-Pub 7/14/2006. PMID: 16841081.
14. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M. Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol 35(12):3468-77, 12/2005. PMID: 16259004.
15. Suzuki A, Kusakai G, Shimojo Y, Chen J, Ogura T, Kobayashi M, Esumi H. Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation. J Biol Chem 280(36):31557-63, 9/9/2005. e-Pub 7/13/2005. PMID: 16014625.
16. Chiba K, Zhao W, Chen J, Wang J, Cui HY, Kawakami H, Miseki T, Satoshi H, Tanaka J, Asaka M, Kobayashi M. Neutrophils secrete MIP-1 beta after adhesion to laminin contained in basement membrane of blood vessels. Br J Haematol 127(5):592-7, 12/2004. PMID: 15566363.
17. Koike T, Kimura N, Miyazaki K, Yabuta T, Kumamoto K, Takenoshita S, Chen J, Kobayashi M, Hosokawa M, Taniguchi A, Kojima T, Ishida N, Kawakita M, Yamamoto H, Takematsu H, Suzuki A, Kozutsumi Y, Kannagi R, Kanangi R. Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A 101(21):8132-7, 5/25/2004. e-Pub 5/12/2004. PMCID: PMC419569.
18. Chen J, Zhao S, Nakada K, Kuge Y, Tamaki N, Okada F, Wang J, Shindo M, Higashino F, Takeda K, Asaka M, Katoh H, Sugiyama T, Hosokawa M, Kobayashi M. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 162(4):1283-91, 4/2003. PMCID: PMC1851236.
19. Ishikawa T, Chen J, Wang J, Okada F, Sugiyama T, Kobayashi T, Shindo M, Higashino F, Katoh H, Asaka M, Kondo T, Hosokawa M, Kobayashi M. Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis. Oncogene 22(8):1238-42, 2/27/2003. PMID: 12606950.
20. Chen J. [Dominant negative HIF-1 alpha reduces tumorigenicity of a human pancreatic cancer cell line]. Hokkaido Igaku Zasshi 77(4):367-78, 7/2002. PMID: 12187833.
21. Niizeki H, Kobayashi M, Horiuchi I, Akakura N, Chen J, Wang J, Hamada JI, Seth P, Katoh H, Watanabe H, Raz A, Hosokawa M. Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells. Br J Cancer 86(12):1914-9, 6/17/2002. PMCID: PMC2375441.
22. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura Ki , Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61(17):6548-54, 9/1/2001. PMID: 11522653.
23. Chen J, Shi NK, FU GZ. Analysis of 24 hours esophageal pH monitoring in cardiac cancer before and after cardiectomy. China National J New Gastroenterology 2:121-122, 9/1996.
24. Chen J, Shi NK, FU GZ. Analysis of 24 hours esophageal pH monitoring in esophageal and cardiac cancer. China National J New Gastroenterology 2, 9/1996.


1. Chen J, Yao Z, Saha T, Piao HL, Song S, Jogunoori W, Mishra B, Mishra L,. Targeting E3 ligases in liver cancer stem cells with disruption of TGF-B signaling, 4/2012.
2. Chen J, Kobayashi M, Darmanin S, Qiao Y, Gully C, Zhao R, Kondo S, Wang Hu, Wang HU, Yeung SC, Lee MH. Hypoxia-mediated upregulation of Pim-1 contributes to tumor survival. 4/2010.

Grant & Contract Support

Title: Cellular and Molecular Mechanisms of Gastrointestinal Cancers
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra
Duration: 9/1/2008 - 8/31/2014
Title: Role of Beta Spectrin and Smad in Alcohol Induced Liver and GI Cell Proliferation
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra
Title: Targeting E3 Ligase PRAJA in Hepatocellular Cancer
Funding Source: NIH/NCI
Role: Co-Investigator
Principal Investigator: Mishra

Last updated: 3/5/2014