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Jianhua Hu

Present Title & Affiliation

Primary Appointment

Associate Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX

Dual/Joint/Adjunct Appointment

Associate Professor, Statistics, Texas A&M University, College Station, TX

Education & Training

Degree-Granting Education

2003 University of North Carolina-Chapel Hill, Chapel Hill, NC, PHD, Biostatistics
2000 National University of Singapore, Singapore, Singapore, MS, Statistics
1998 East China Normal University, Shanghai, China, BS, Applied Mathematics

Postgraduate Training

1/2004-6/2004 Postdoctoral training, Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC

Experience/Service

Academic Appointments

Assistant Professor, Department of Biostatistics, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 7/2004-8/2009

Selected Publications

Peer-Reviewed Original Research Articles

1. Jung Y, Huang J, Hu J. Biomarker detection in association studies: modeling SNPs simultaneously via logistic ANOVA. Journal of the American Statistical Association. In Press.
2. Hu J., Zhu H., Hu F. Covariate-Adjusted Response-Adaptive Randomization:Optimization and Ethics. Journal of the American Statistical Association. In Press.
3. Maadooliat M, Huang J, Hu J. Integrating data transformation in principal components Analysis. Journal of Computational and Graphical Statistics. In Press.
4. Hu J, Wang P, Qu A. Nonparametric correlation estimation for clustered data with unspecified structure. Journal of Computational and Graphical Statistics. In Press.
5. Tang G, Zhang L, Fu B, Hu J, Lu X, Hu S, Patel A, Goswami M, Khoury JD, Garcia-Manero G, Medeiros LJ, Wang SA. Cytogenetic Risk Stratification of 417 Patients with Chronic Myelomonocytic Leukemia from a Single Institution. Am J Hematol. e-Pub 4/30/2014. PMID: 24782398.
6. Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, Cortes J, Deangelo DJ, Debose L, Mu H, Döhner H, Gaidzik VI, Galinsky I, Golfman LS, Haferlach T, Harutyunyan KG, Hu J, Leverson JD, Marcucci G, Müschen M, Newman R, Park E, Ruvolo PP, Ruvolo V, Ryan J, Schindela S, Zweidler-McKay P, Stone RM, Kantarjian H, Andreeff M, Konopleva M, Letai AG. Selective BCL-2 Inhibition by ABT-199 Causes On Target Cell Death in Acute Myeloid Leukemia. Cancer Discov. e-Pub 2/2014. PMCID: PMC3975047.
7. Ferrajoli A, Shanafelt TD, Ivan C, Shimizu M, Rabe KG, Nouraee N, Ikuo M, Ghosh AK, Lerner S, Rassenti LZ, Xiao L, Hu J, Reuben JM, Calin S, You MJ, Manning JT, Wierda WG, Estrov Z, O'Brien S, Kipps TJ, Keating MJ, Kay NE, Calin GA. Prognostic value of miR-155 in individuals with monoclonal B-cell lymphocytosis and patients with B chronic lymphocytic leukemia. Blood 122(11):1891-1899, 9/2013. e-Pub 7/2013. PMCID: PMC3779381.
8. Hu J, He X. Searching for Alternative Splicing with a Joint Model on Probe Measurability and Expression Intensities. Journal of the American Statistical Association 107(499):935-945, 10/2012.
9. Maadooliat M, Huang JZ, Hu J. Analyzing multiple-probe microarray: estimation and application of gene expression indexes. Biometrics 68(3):784-92, 9/2012. e-Pub 7/2012. PMCID: PMC3989902.
10. Li B, Liang F, Hu J, He AX. Reno: Regularized Nonparametric Analysis of Protein Lysate Array Data. Bioinformatics 28(9):1223-1229, 5/1/2012. e-Pub 3/30/2012. PMCID: PMC3338020.
11. Feng X, He X, Hu J. Wild bootstrap for quantile regression. Biometrika 98(4):995-999, 12/2011. e-Pub 11/3/2011. PMCID: PMC3413178.
12. Rossi S, Shimizu M, Barbarotto E, Nicoloso MS, Dimitri F, Sampath D, Fabbri M, Lerner S, Barron LL, Rassenti LZ, Jiang L, Xiao L, Hu J, Secchiero P, Zauli G, Volinia S, Negrini M, Wierda W, Kipps TJ, Plunkett W, Coombes KR, Abruzzo LV, Keating MJ, Calin GA. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood 116(6):945-52, 8/2010. e-Pub 4/2010. PMID: 20393129.
13. Suraneni MV, Schneider-Broussard R, Moore JR, Davis TC, Maldonado CJ, Li H, Newman RA, Kusewitt D, Hu J, Yang P, Tang DG. Transgenic expression of 15-lipoxygenase 2 (15-LOX2) in mouse prostate leads to hyperplasia and cell senescence. Oncogene 29(30):4261-4275, 7/29/2010. e-Pub 5/31/2010. PMCID: PMC3042242.
14. Judy Wang H, Hu J. Identification of Differential Aberrations in Multiple-sample Array CGH Studies. Biometrics. e-Pub 7/2010. PMCID: PMC2955763.
15. Byers LA, Holsinger FC, Kies MS, William WN, El-Naggar AK, Lee JJ, Hu J, Lopez A, Tran HT, Yan S, Du Z, Ang KK, Glisson BS, Raso MG, Wistuba II, Myers JN, Hong WK, Papadimitrakopoulou V, Lippman SM, Heymach JV. Serum signature of hypoxia-regulated factors is associated with progression after induction therapy in head and neck squamous cell cancer. Mol Cancer Ther 9(6):1755-1763, 6/2010. e-Pub 6/8/2010. PMCID: PMC2913168.
16. Leng X, Ding T, Lin H, Wang Y, Hu L, Hu J, Feig B, Zhang W, Pusztai L, Symmans WF, Wu Y, Arlinghaus RB. Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis. Cancer Res 69(22):8579-8584, 11/15/2009. e-Pub 11/3/2009. PMID: 19887608.
17. Hu J, He X, Cote GJ, Krahe R. Singular Value Decomposition-based Alternative Splicing Detection. J Am Stat Assoc 104(487):944-953, 9/2009. PMCID: PMC2841408.
18. Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in Chronic Lymphocytic Leukemia: a novel therapeutic approach. Blood 113(22):5549-57, 5/2009. e-Pub 3/2009. PMID: 19318683.
19. Hu J, Johnson VE. Bayesian Model Selection Using Test Statistics. J R Stat Soc Series B Stat Methodol 71(1):143-158, 10/2008. PMCID: PMC2760999.
20. Hu J. Cancer outlier detection based on likelihood ratio test. Bioinformatics 24(19):2193-9, 10/2008. e-Pub 8/2008. PMCID: PMC2732272.
21. Bhatia B, Jiang M, Suraneni M, Patrawala L, Badeaux M, Schneider-Broussard R, Multani AS, Jeter CR, Calhoun-Davis T, Hu L, Hu J, Tsavachidis S, Zhang W, Chang S, Hayward SW, Tang DG. Critical and distinct roles of p16 and telomerase in regulating the proliferative life span of normal human prostate epithelial progenitor cells. J Biol Chem 283(41):27957-72, 10/2008. e-Pub 7/2008. PMCID: PMC2562067.
22. Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A 105(27):9367-72, 7/2008. e-Pub 6/2008. PMCID: PMC2453716.
23. Hu F, Guise T, Hu J. Optimal biased coins for two-arm clinical trials. Statistics and Its Interface 1:125-135, 2008. PMID: Not in PubMed.
24. Hu J, He X, Baggerly KA, Coombes KR, Hennessy BT, Mills GB. Non-parametric quantification of protein lysate arrays. Bioinformatics 23(15). e-Pub 6/2007. PMID: 17599930.
25. Hu J, Wright FA. Assessing differential gene expression with small sample sizes in oligonucleotide arrays using a mean-variance model. Biometrics 63(1):41-9, 3/2007. PMID: 17447928.
26. Hu J, He X. Enhanced quantile normalization of microarray data to reduce loss of information in gene expression profiles. Biometrics 63(1):50-9, 3/2007. PMID: 17447929.
27. He J, Pan Y, Hu J, Albarracin C, Wu Y, Dai JL. Profile of Ets gene expression in human breast carcinoma. Cancer Biol Ther 6(1):76-82, 1/2007. PMID: 17172821.
28. Hu J, Wright FA, Zou F. Estimation of expression indexes for oligonucleotide arrays using the singular value decomposition. Journal of the American Statistical Association 101:41-50, 3/2006. PMID: Not in PubMed.
29. Hu J, Kapoor M, Zhang W, Hamilton SR, Coombes KR. Analysis of dose-response effects on gene expression data with comparison of two microarray platforms. Bioinformatics 21(17):3524-9, 9/2005. PMID: 16081476.
30. Hu J, Zou F, Wright FA. Practical FDR-based sample size calculations in microarray experiments. Bioinformatics 21(15):3264-72, 8/2005. PMID: 15932903.
31. Coombes KR, Morris JS, Hu J, Edmonson SR, Baggerly KA. Serum proteomics profiling--a young technology begins to mature. Nat Biotechnol 23(3):291-2, 3/2005. PMID: 15765078.
32. Hu J, Coombes KR, Morris JS, Baggerly KA. The importance of experimental design in proteomic mass spectrometry experiments: some cautionary tales. Brief Funct Genomic Proteomic 3(4):322-31, 2/2005. PMID: 15814023.
33. Zou F, Fine JP, Hu J, Lin DY. An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci. Genetics 168:2307-16, 12/2004. PMID: 15611194.
34. Hu F, Hu J. A note on breakdown theory for bootstrap methods. Statistics & Probability Letters 50:49-53, 10/2000.
35. Jun M, Hu J, Johnson VE. Assessing fit in Bayesian models for spatial processes. Submitted.
36. Pan Y, Wu Y, Weinman E, Hu J, Sahin A, Shenolikar S, Dai J. Defective mammary gland development in NHERF1 knockout mice: Relevance to human breast cancer. Submitted.
37. Hu J, Wang HJ. Detection of copy number variation regions via model selection. Submitted.
38. Qin J, Choy G, Suraneni M, Calhoun-Davis T, Li H, Honorio SM, Patrawala L, Hu J, Pang S, Tang, DG. Distinct tumorigenic and biological properties and potential plasticity of undifferentiated (PSA-) and differentiated (PSA+) prostate cancer cells in response to androgen. Submitted.
39. Li Y, Luthra R, Hu J, Shen L, Luthra MG, Broaddus RR, Resetkova E, Dawood S, Arun B, CT Albarracin CT. FOXO1 mRNA is targeted microRNA-183 in endometrial endometrioid cancers. Submitted.
40. Li J, Sultana MP, Hu J. High dimensional ROC analysis for correlated proteomic data. Submitted.
41. Wei B, Ding T, Xing Y, Tian Z, Tang F, Wei W, Hu J, Hsu L, Albarracin CT, Gonzalez-Angulo A, Nayeemuddin K, Hunt KH, Wu Y. Invasive neuroendocrine carcinoma of the breast. Submitted.

Book Chapters

1. Hu J, Zhang W. Alternative splicing with bioinformatics technology. In: Alternative Splicing in Cancer. Ed(s) Julian P. Venables. Research Signpost, 2006.
2. Hu J, Yin G, Morris JS, Zhang L, Wright FA. Entropy and survival-based weights to combine affymetrix array types in the analysis of differential expression and survival. In: Methods of Microarray Data Analysis IV. Ed(s) J.S. Shoemaker and S.M. Lin (eds). Springer US, 95-108, 2005. ISBN: 978-0-387-23074-0 (Print) 978-0-387-23077-1 (Online).

Grant & Contract Support

Title: Consistent model selection in the p>>n setting
Funding Source: NIH/NCI
Role: Co-Principal Investigator
Principal Investigator: Valen Johnson
Duration: 4/15/2013 - 3/31/2015

Last updated: 7/31/2014